Clinical trials: Movement, Abnormal
Medulloblastoma, Childhood, Childhood Cancer
Dual Task Training On Children With Ataxia After Medulloblastoma Resection
Medulloblastoma is a rapidly-growing tumor of the cerebellum, this area controls balance, posture and sophisticated motor functions like finer hand movements, speech, and swallowing.
- Trial name
- NCT04860934
- Testing
- Dual Task Training Program Group, Control Group
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Children's Cancer Hospital Egypt 57357
Scapular Dyskinesis
Blackburn Exercises in Type-1 Scapular Dyskinesia
The purpose of this study is to evaluate the effects of Blackburn exercises on Scapulothoracic stability in patients with Type-1 Scapular Dyskinesia, in comparison with conventional physical therapy.
- Trial name
- NCT04747509
- Testing
- Blackburn exercises, Conventional Physical therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Huntington Disease
Handgrip and Respiratory Dysfunction in HD Patients.
Hereditary neurodegenerative diagnosis of Huntington's disease (HD) is associated with a progressive deterioration of the respiratory system function .
- Trial name
- NCT06585332
- Testing
- Assessment of respiratory paramenters (Maximal inspiratory pressure, maximal expiratory pressure, and voluntary peak cough flow))
- Where
- Czechia
- Volunteers
- 70 people
- Sponsor
- General University Hospital, Prague
Idiopathic Parkinson Disease
Safety and Tolerability of Tozadenant as Adjunctive Therapy in Levodopa-Treated Patients With Parkinson's Disease.
Phase 3, international, multicenter, open-label 12 month safety study.
- Trial name
- NCT03051607
- Testing
- Tozadenant
- Where
- 35 sites in United States, Canada and 1 more
- Volunteers
- 66 people
- Sponsor
- Biotie Therapies Inc.
Torticollis (Spasmodic)
Dose-escalating Safety and Preliminary Efficacy of DaxibotulinumtoxinA for Injection in Cervical Dystonia
This is an open-label, dose-escalation study to assess the safety and preliminary efficacy of daxibotulinumtoxinA in subjects with isolated cervical dystonia (CD).
- Trial name
- NCT02706795
- Testing
- DaxibotulinumtoxinA
- Where
- 13 sites in United States
- Volunteers
- 37 people
- Sponsor
- Revance Therapeutics, Inc.
Primary Ciliary Dyskinesia
In Vivo Measurements of Nasal Ciliary Beat Frequency by Using Interferometry
1. Assessment of a high speed video camera with a green light source for the measurement of ciliary beat frequency (CBF) in the nasal airways of patients. 2.
- Trial name
- NCT02699177
- Testing
- CBF measurements
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Hadassah Medical Organization
Spinocerebellar Ataxia Type 3
STRIDES - a Clinical Research Study of an Investigational New Drug to Treat Spinocerebellar Ataxia
Phase 2b/3 double blind, randomized, placebo-controlled trial to assess safety and efficacy of SLS-005 (trehalose injection, 90.5 mg/mL for intravenous infusion) for the treatment of adults with spinocerebellar ataxia).
- Trial name
- STRIDES (NCT05490563)
- Testing
- SLS-005
- Where
- 23 sites in United States, Australia and 6 more
- Volunteers
- 23 people
- Sponsor
- Seelos Therapeutics, Inc.
Parkinson Disease
Effect of a Vibrating Therapy Ball on Tremor and Daily Activities in Patients With Different Tremor Syndroms
Tremors, e.g. in patients with Parkinson's disease and essential tremor, are often pharmacoresistant, meaning that invasive treatment options such as deep brain stimulation are used at an early stage.
- Trial name
- NCT07134634
- Testing
- tremor device
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Parkinson's Clinic in Beelitz-Heilstatten
Dystonia, Dystonic Cerebral Palsy
Enhancing Sensorimotor Processing in Children With Dystonia
Dystonia is a severely disabling movement disorder with no cure, in which people suffer painful muscle spasms causing twisting movements and abnormal postures. There are many causes, including genetic conditions and brain injury.
- Conditions
- Dystonia, Dystonic Cerebral Palsy, Dystonia, Secondary, Dystonia, Primary
- Trial name
- NCT05612464
- Testing
- No intervention
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- King's College London
Spinocerebellar Ataxia Type 2
Clinical Trial With Riluzole in Spinocerebellar Ataxia Type 2 (ATRIL)
ATRIL is a multi-centric, double-blind randomized, two-arm controlled study. 42 SpinoCerebellar Ataxia type 2 (SCA2) patients, both gender, at least 18 years of age will be included.
- Trial name
- ATRIL (NCT03347344)
- Testing
- Riluzole
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Huntington Disease, Chorea
Risperidone for the Treatment of Huntington's Disease Involuntary Movements
The purpose of this study is to assess the safety and benefit of risperidone for the treatment of chorea (involuntary movements) in Huntington's disease.
- Trial name
- NCT04201834
- Testing
- Risperidone, BioStamp nPoint device
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Rochester
Mild Cognitive Impairment (MCI), Alzheimer Disease (AD)
Biomarkers in Neurodegenerative Diseases
The general purpose of this observational study is to examine biomarkers associated with the pathology of neurodegenerative diseases to potentially develop novel therapeutic approaches.
- Conditions
- Mild Cognitive Impairment (MCI), Alzheimer Disease (AD), Dementia With Lewy Bodies (DLB), Frontotemporal Lobar Degeneration (FTLD)
- Trial name
- NCT04055532
- Testing
- Neuraceq
- Where
- United States
- Sponsor
- University of Minnesota
Tremor, Limb
Effects of High Amplitude and Focused tACS on Entraining Physiological Tremor
Transcranial alternating current stimulation (tACS) is a noninvasive neuromodulation method that works by passing alternating electric current between electrodes where at least one of them is attached to the head.
- Trial name
- NCT03337334
- Testing
- tACS at tremor frequency
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Ataxia, Spinocerebellar Ataxias
Transcranial Alternating Current Stimulation (tACS) in Patients With Ataxia
The aim of the study is to evaluate the effects on motor and cognitive performance of transcranial alternating current stimulation (tACS) compared to transcranial direct current stimulation (tDCS) and placebo stimulation (sham)…
- Conditions
- Ataxia, Spinocerebellar Ataxias, Multiple System Atrophy, Ataxia With Oculomotor Apraxia
- Trial name
- SCAtACS (NCT05621200)
- Testing
- Transcranial stimulation over the cerebellar hemispheres
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Dyskinesias, Parkinson Disease
Open-label, Long-term Safety Extension Study of AFQ056 in Parkinson's Patients With L-dopa Induced Dyskinesias
This study is to evaluate long-term safety, tolerability and efficacy for AFQ056 in patients who have completed an AFQ056A study in Parkinson's disease L-dopa induced dyskinesias (PD-LID).
- Conditions
- Dyskinesias, Parkinson Disease, Movement Disorders, Parkinsonian Disorders
- Trial name
- NCT01491932
- Testing
- AFQ056
- Where
- 32 sites in United States, Austria and 8 more
- Volunteers
- 129 people
- Sponsor
- Novartis Pharmaceuticals
Schizophrenia, Schizoaffective Disorder
Study of the Effectiveness of Valbenazine on Patient- and Clinician-Reported Outcomes in Participants With Tardive Dyskinesia
This study will evaluate the effectiveness of valbenazine on patient- and clinician-reported outcomes assessing health-related quality of life, functioning, and treatment effect in participants with tardive dyskinesia (TD) who…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT05859698
- Testing
- Valbenazine
- Where
- 18 sites in United States
- Volunteers
- 59 people
- Sponsor
- Neurocrine Biosciences
Parkinson Disease
ExAblate Pallidotomy for Medically-Refractory Dyskinesia Symptoms or Motor Fluctuations of Advanced Parkinson's Disease
Evaluate the safety and efficacy of unilateral focused ultrasound pallidotomy using the ExAblate 4000 System in the management of dyskinesia symptoms or motor fluctuations for medication refractory, advanced idiopathic…
- Trial name
- NCT03319485
- Testing
- ExAblate Pallidotomy
- Where
- 20 sites in United States, Canada and 6 more
- Volunteers
- 92 people
- Sponsor
- InSightec
Ataxia Telangiectasia
Susceptibility to Infections, Tumor Risk and Liver Disease in Patients With Ataxia Telangiectasia
Ataxia telangiectasia (A-T) is a rare devastating human recessive disorder characterized by progressive cerebellar ataxia, immunodeficiency, chromosomal instability and cancer susceptibility.
- Trial name
- NCT03357978
- Testing
- bioelectrical impedance analysis, blood draw, transient elastography (FibroScan)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Dyskinesias, Parkinson Disease
Study of LY300164 for the Treatment of Parkinson's Disease
This study will test the effectiveness of an experimental drug called LY300164 on improving Parkinson's disease symptoms, such as movement impairments and tremor, as well as involuntary movements produced by long-term treatment…
- Trial name
- NCT00004576
- Testing
- LY300164
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cardiac Catheterization, Electrophysiology Procedure
Post Anesthesia Care Unit (PACU) Weighted Blanket Study
This study is being conducted to evaluate the safety and efficacy of weighted blankets to reduce agitation in patients in the post-procedural phase after cardiac catheterization and electrophysiology procedures in the post…
- Conditions
- Cardiac Catheterization, Electrophysiology Procedure, Pediatric Cardiology
- Trial name
- NCT05632640
- Testing
- Standard of Care, Weighted blanket
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Michigan