Clinical trials: Movement Abnormalities
Deep Brain Stimulation, Parkinson Disease
Consensus Statements on Deep Brain Stimulation in Patients With Parkinson's Disease
Deep brain stimulation (DBS) has become a cornerstone therapy for advanced Parkinson's disease (PD), showing superior outcomes over best medical treatment in randomized clinical trials.
- Trial name
- DBS_Consensus (NCT07173660)
- Testing
- Delphi study
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
Depressive Symptoms, Parkinson's Disease
Rasagiline in Cognitive-impairment Related Depression: AzileCt in COgnitive-impairment Related DepressiOn
The primary endpoint for this study is the clinical response after 12 weeks of treatment, defined as a change in total score from baseline depressive symptoms as measured by the Beck Depression Inventory-Amended (BDI-IA) total…
- Trial name
- ACCORDO (NCT01055379)
- Testing
- Rasagiline
- Where
- 12 sites in Italy
- Volunteers
- 121 people
- Sponsor
- Lundbeck Italia S.p.A.
Dementia, Cognitive Impairment, Mild
Cognitive Stimulation Therapy for Dementia: A Two-Armed Pragmatic Trial
Cognitive Stimulation Therapy (CST) is an evidence-based non-pharmacological group therapy shown to benefit people with mild to moderate dementia.
- Conditions
- Dementia, Cognitive Impairment, Mild, Dementia, Vascular, Dementia, Mixed
- Trial name
- NCT05860127
- Testing
- Referral for Cognitive Stimulation Therapy, No change to Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 133 people
- Sponsor
- University of Massachusetts, Amherst
Parkinson's Disease
Therapeutic Yoga to Improve Function in Parkinson's Disease
This is a single blind, randomized, wait-list controlled, phase II exploratory pilot study.
- Trial name
- NCT02902510
- Testing
- Therapeutic yoga for people with Parkinson's Disease
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Clemson University
Huntington's Disease
A Study to Evaluate the Safety and Tolerability of SAGE-718 in Participants With Huntington's Disease
The primary purpose of the study is to evaluate the safety and tolerability of SAGE-718 softgel lipid capsule in participants with Huntington's Disease (HD)
- Trial name
- NCT05655520
- Testing
- SAGE-718
- Where
- 43 sites in United States, Australia and 2 more
- Volunteers
- 153 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Parkinson's Disease (PD)
A Phase 2a Multicenter Clinical Trial of TB006 in Participants With Parkinson's Disease
The primary objectives of this study are to assess the efficacy of TB006 in improving motor function and to assess the safety of TB006 in participants with Parkinson's Disease (PD).
- Trial name
- NCT06773962
- Testing
- TB006
- Where
- 14 sites in United States
- Volunteers
- 62 people
- Sponsor
- TrueBinding, Inc.
Parkinson Disease
Safety, Tolerability, Pharmacokinetics and Efficacy Study of Radotinib in Parkinson's Disease
This is a safety, tolerability, pharmacokinetic and efficacy study in subjects with Parkinson's disease
- Trial name
- NCT04691661
- Testing
- Radotinib HCl 50 mg
- Where
- 7 sites in France
- Volunteers
- 43 people
- Sponsor
- Il-Yang Pharm. Co., Ltd.
Parkinson Disease
Diagnosis of Parkinson´s Disease by Means of Submandibular Gland Needle Biopsy
This study includes 35 PD patients who underwent submandibular gland needle biopsy. 25 neurologically healthy patients of the local otolaryngological clinic, in whom submandibular gland needle biopsy was performed due to a…
- Trial name
- NCT04264273
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Universität des Saarlandes
Parkinson Disease, Fluctuating Mood Symptoms
Validation of the Neuropsychiatric Fluctuations Scale (EFN-VALID))
Neuropsychiatric fluctuations (NF) are among the most disabling non motor fluctuations in Parkinson disease (PD). The investigators developed the NF-scale for acute assessment of non-motor neuropsychiatric fluctuations between…
- Trial name
- EFN-VALID (NCT04455074)
- Testing
- FN scale auto-questionnaire
- Where
- 6 sites in France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Grenoble
Progressive Supranuclear Palsy, Cognitive Impairment
Neuropsychological Evaluation for Early Diagnosis of PSP
The aim of this study is to better understand the nature of the cognitive decline in Progressive Supranuclear Palsy, the time of its development and the relation with the other cardinal features of the disease.
- Trial name
- NCT03478124
- Testing
- Cognitive evaluation
- Volunteers
- 112 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Parkinson Disease, Sleep Disorder
Light Therapy in Parkinson's Disease
The aim of this randomized controlled trial (RCT) is to clarify the effect of bright light therapy on motor symptoms and sleep disorders in patients with Parkinson's disease.
- Conditions
- Parkinson Disease, Sleep Disorder, Circadian Rhythm Disorders
- Trial name
- NCT06129942
- Testing
- Bright light box, Dim Light box
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Demyelinating Disease, Healthy
Magnetic Stimulation of the Human Nervous System
Transcranial Magnetic Stimulation (TMS) is a non-invasive technique to gather information about brain function. It is very useful when studying the areas of the brain related to motor activity (motor cortex, corticospinal tract…
- Conditions
- Demyelinating Disease, Healthy, Lysosomal Storage Disease, Motor Neuron Disease
- Trial name
- NCT00001780
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson's Disease
Cognitive Rehabilitation for PD
To investigate the effectiveness of a novel compensatory cognitive rehabilitation program for individuals with Parkinson's disease (PD) and mild cognitive impairment (MCI).
- Trial name
- CogSMART-PD (NCT03335150)
- Testing
- CogSMART-PD, Supportive Care
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- VA Office of Research and Development
Parkinson's Disease (PD), Parkinsonian Disorders
ZR001 Chemogenetics Gene Therapy Study in Patients With Parkinson's Disease
This study aims to evaluate the safety, tolerability, and preliminary efficacy of ZR001, a novel chemogenetic gene therapy product, in patients with moderately advanced Parkinson's disease (PD).
- Trial name
- NCT07718659
- Testing
- ZR001
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Qianfoshan Hospital
Parkinson Disease
Exercise to Improve Sleep in Parkinson's Disease
This study will investigate the impact of three common exercise modalities, cardiovascular, resistance, and multimodal (i.e., a combination of the previous two) training, on sleep quality and architecture in persons with…
- Trial name
- NCT05644327
- Testing
- Cardiovascular training (CT), Resistance training (RT), Multimodal training (MT)
- Where
- 3 sites in Canada
- Volunteers
- 150 people
- Sponsor
- McGill University
Parkinson Disease, Movement Disorders
Effect of Dual Task on Upper and Lower Extremity Skills in Parkinson's Disease
The aim of the study is to investigate the change of lower and upper extremity skills with dual task in Parkinson's disease patients and to determine the differences between Parkinson's disease patients with different stages of…
- Trial name
- NCT04267341
- Testing
- Timed Up and Go Test, 10 Meter Walk Test, Purdue Pegboard Test
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Parkinson Disease, Pain, Neck
The Effectiveness of Acupuncture Therapy on Pain in Parkinson's Disease
Parkinson's Disease (PD) is a chronic, progressive, degenerative movement disorder that is characterized by motor and nonmotor symptoms and its incidence increases with age.
- Trial name
- NCT04874090
- Testing
- Acupuncture, Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Abant Izzet Baysal University
Parkinson Disease
Identifying the Neural Signature of Exercise to Advance Treatment of PD Cognitive Declines
Twenty-five participants with PD utilizing the Medtronic Percept PC DBS system will be enrolled for this project and complete a single bout of both FE and VE.
- Trial name
- NCT05972759
- Testing
- Forced and voluntary exercise
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The Cleveland Clinic
Parkinson's Disease
Phase I/II Study of the Safety, Efficacy and Dose Evaluation of ProSavin for the Treatment of Bilateral Idiopathic Parkinson's Disease
The primary objectives of the trial are to assess the safety and efficacy of ProSavin. Patients in the trial will have been diagnosed with Parkinson's disease and will be failing on current treatment with L-DOPA but they will not…
- Trial name
- NCT00627588
- Testing
- ProSavin
- Where
- 2 sites in France, United Kingdom
- Volunteers
- 15 people
- Sponsor
- Oxford BioMedica
Parkinson Disease, Multiple System Atrophy
Differential Diagnosis Between Parkinson's Disease and Multiple System Atrophy Using Digital Speech Analysis - Part 2
Parkinson's disease (PD) is the second most common neurodegenerative disease. Multiple system atrophy (MSA) is a relentlessly progressing rare neurodegenerative disease of unknown etiology.
- Trial name
- Voice4PD-MSA (NCT05807373)
- Testing
- voice recordings
- Where
- 2 sites in France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
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