Clinical trials: Movement Abnormalities
Huntington Disease
GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease
This study will evaluate the safety, biomarkers, and efficacy of tominersen compared with placebo in participants with prodromal and early manifest Huntington's Disease (HD).
- Trial name
- NCT05686551
- Testing
- Tominersen
- Where
- 70 sites in United States, Argentina and 13 more
- Volunteers
- 301 people
- Sponsor
- Hoffmann-La Roche
Parkinson Disease, Essential Tremor
Investigating the Use of Complex Pulse Shapes for DBS in Movement Disorders
Parkinson's disease and essential tremor are chronic movement disorders for which there is no cure. When medication is no longer effective, deep brain stimulation (DBS) is recommended.
- Trial name
- INSHAPE_DBS (NCT04725045)
- Testing
- Boston Scientific: Study tool computer
- Where
- Belgium
- Volunteers
- 28 people
- Sponsor
- KU Leuven
Huntington Disease
Clinicopathological MRI and CSF Correlates in Huntington's Disease.
In this study the investigators will link brain iron levels obtained from quantitative susceptibility maps of HD patients with specific and well-known clinical CSF markers for iron accumulation, neurodegeneration and…
- Trial name
- NCT05534139
- Testing
- 7T MRI-scan, CSF collection via lumbar puncture, Blood withdrawal
- Where
- Netherlands
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Dystonic Disorders
Brain Inhibition of Muscle Movement in Normal Volunteers
This study will use transcranial magnetic stimulation, or TMS (described below), to examine how the brain controls muscle movement to prevent unwanted movements in surrounding muscles.
- Trial name
- NCT00047957
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Vascular Parkinsonism, Drug-induced Parkinsonism
AI-Enhanced Optimization of Acute Levodopa Challenge Test
A quantitative evaluation method was developed for Parkinson's disease and other atypical parkinonism by integrating an innovative motor paradigm with perception technologies and artificial intelligence.
- Conditions
- Vascular Parkinsonism, Drug-induced Parkinsonism, Corticobasal Degeneration (CBD), Parkinson Disease (PD)
- Trial name
- NCT06949865
- Testing
- video recording
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Beijing Tiantan Hospital
Parkinson Disease
Role of Nasal Dysbiosis in Parkinson Disease
Olfactory dysfunction is frequent in Parkinson Disease (PD) and may be present years before the motor symptoms appear. The early olfactory dysfunction could result from environmental factors acting through the nasal cavity such…
- Trial name
- SMELLPARK (NCT04249245)
- Testing
- Nasal Swab
- Where
- 2 sites in France, Guadeloupe
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Parkinson Disease
The Effects of Vitamin D and Bone Loss in Parkinson's Disease
Health care burdens from neurodegenerative diseases are expected to increase disproportionately. Increasing age also predisposes this same population to other chronic diseases including osteoporosis, a progressive systemic…
- Trial name
- PDVD3 (NCT00907972)
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Memorial Medical Center
Wilson Disease
The Exploratory Handheld Optical Coherence Tomography Study in Wilson's Disease
This is an exploratory study using anterior segment optical coherence tomography (OCT) devices to measure copper in the eye. The investigators hope to use this to diagnosis kayser flesicher rings, an important diagnostic criteria…
- Trial name
- NCT07046507
- Testing
- Diagnostic procedures
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Tourette Syndrome, Chronic Tic Disorder
Neurofeedback for Tourette Syndrome
The aim of this study is to train patients with tic disorders to control activity in a region of their brain that has been associated with the urge to tic.
- Trial name
- NCT01702077
- Testing
- Neurofeedback
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Essential Tremor
Developing a New LIFU Neuromodulation Method to Suppress Tremor
The investigators aim to apply low intensity focused ultrasound neuromodulation to patients with essential tremor to evaluate the efficacy of this intervention in reducing the amplitude of hand tremor compared to sham stimulation.
- Trial name
- NCT07103265
- Testing
- Transcranial focused ultrasound stimulation
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Parkinson Disease
Utilization of Target Ranges to Treat Persons With Parkinson's Disease by Objective Measurement Using the PKG
The main objective of this study is to evaluate whether persons with Parkinson's disease (PwP) whose Parkinson's disease (PD) symptoms are uncontrolled have improved clinical patient outcomes and quality of life when managed with…
- Trial name
- TARGET-PwP (NCT04381065)
- Testing
- Personal KinetiGraph® (PKG®) System, Personal KinetiGraph® (PKG®) Watch
- Sponsor
- Global Kinetics Corporation
REM Sleep Behavior Disorder, Parkinson Disease
North American Prodromal Synucleinopathy Consortium
This study will enroll participants with idiopathic rapid eye movement (REM) sleep behavior disorder (RBD), for the purpose of preparing for a clinical trial of neuroprotective treatments against synucleinopathies.
- Conditions
- REM Sleep Behavior Disorder, Parkinson Disease, Lewy Body Disease, Dementia With Lewy Bodies
- Trial name
- NAPS (NCT03623672)
- Where
- 10 sites in United States, Canada
- Volunteers
- 500 people
- Sponsor
- Washington University School of Medicine
Parkinson's Disease (PD)
Pharmacokinetic-pharmacodynamic Interaction Between Each of Three Different Single Doses of BIA 9-1067 and a Single-dose of Controlled-release 100/25 mg Levodopa/Carbidopa
To investigate the effect of three single oral doses of BIA 9-1067 (25 mg, 50 mg and 100 mg) on the levodopa pharmacokinetics when administered in combination with a single-dose of controlled-release levodopa/carbidopa 100/25 mg…
- Trial name
- NCT02169453
- Testing
- BIA 9-1067, Sinemet® CR 100/25
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Parkinson's Disease, Apathy
Role of Mesocorticolimbic Pathway in Apathy of Patients With Parkinson's Disease. - Study Using Diffusion Tensor Imaging and Fibres Tracking
Use lay language. Apathy is one of the most under recognised, underdiagnosed and poorly managed aspects of Parkinson's disease. Depending on methodological approach of the study, its prevalence is estimated to be between 16 and…
- Trial name
- NCT01794195
- Testing
- Diffusion tensor imaging and fibres tracking
- Where
- France
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Essential Tremor
A Study to Evaluate SAGE-217 in Participants With Essential Tremor
This study is a three-part, multicenter, Phase 2a study to evaluate the efficacy, safety, tolerability, and pharmacokinetics of SAGE-217 in adult participants with essential tremor.
- Trial name
- NCT02978781
- Testing
- SAGE-217
- Where
- 26 sites in United States
- Volunteers
- 34 people
- Sponsor
- Biogen
Parkinson Disease, Multiple System Atrophy
Augmenting Effects of L-DOPS With Carbidopa and Entacapone
An experimental drug called L-DOPS increases production in the body of a messenger chemical called norepinephrine. Cells in the brain that make norepinephrine are often gone in Parkinson disease.
- Conditions
- Parkinson Disease, Multiple System Atrophy, Autonomic Nervous System Diseases
- Trial name
- NCT00547911
- Testing
- Droxidopa, Carbidopa, Entacapone
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Writer's Cramp
Video-supervised Motor and Awareness Training in Writer's Cramp
Writer's cramp is the most common task-specific dystonia. It is characterized by involuntary co-contraction of antagonistic muscles during writing. This disabling condition may force patients to give up their occupation.
- Trial name
- NCT04611009
- Testing
- motor training, mindfulness exercises
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- University Hospital Schleswig-Holstein
Eye Diseases
Evaluation and Treatment of Pediatric, Developmental, and Genetic Eye Diseases
This study will evaluate and treat children or adults with inherited or developmental eye conditions. It will allow specialists in pediatric ophthalmology, genetic ophthalmology, and ocular motility at the National Eye Institute…
- Trial name
- NCT00076271
- Where
- 2 sites in United States
- Volunteers
- 350 people
- Sponsor
- National Eye Institute (NEI)
Essential Tremor
Non-Invasive Neuromodulation for Essential Tremor: Long-Term Safety and Effectiveness Study
This is a prospective, single-center, single-arm, open-label clinical study designed to evaluate the long-term efficacy and safety of non-invasive neuromodulation using transcutaneous afferent patterned stimulation (TAPS) in…
- Trial name
- NCT07774598
- Testing
- Transcutaneous Afferent Patterned Stimulation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Ruijin Hospital
Parkinson's Disease
Predictors of Motor Progression in Parkinson's Disease
Treatment resistant motor features, such as postural instability and freezing of gait are common in people with Parkinson's disease and major contributors to morbidity and mortality.
- Trial name
- NCT02769039
- Testing
- No intervention. Observational studies of sleep, movement and brain imaging
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
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