Clinical trials: Movement Abnormalities
Cerebral Palsy
Early Remote At-risk Diagnosis for Cerebral Palsy in Follow-up Clinics for High-risk Infants
Cerebral Palsy (CP) is the most common motor dysfunction in childhood. Traditionally, diagnosis is set between 12 and 24 months of age.
- Trial name
- In-Motion (NCT04287166)
- Where
- 3 sites in Norway
- Volunteers
- 100 people
- Sponsor
- St. Olavs Hospital
PARKINSON DISEASE (Disorder)
Integrated Digital and Neurogenic Exosome Biomarkers for Early Diagnosis of Parkinson's Disease: Development and Application
Based on the high-quality Parkinson's disease cohort population and biological sample database in the early stage of the team, multi-dimensional intelligent wearable device technology and machine learning were used to screen and…
- Trial name
- NCT07679256
- Where
- China
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Alzheimer Disease, Parkinson Disease
Posiphen® Dose-Finding, Biomarker Study in Early Alzheimer's and Parkinson's Patients
Annovis is conducting a clinical study to investigate Posiphen in patients with Early Alzheimer's Disease (AD) and Early Parkinson's Disease (PD). Investigators are looking to recruit 68 patients in two parts of the study.
- Trial name
- NCT04524351
- Testing
- Posiphen
- Where
- 13 sites in United States
- Volunteers
- 75 people
- Sponsor
- Annovis Bio Inc.
Dyskinesia, Levodopa Induced Dyskinesia (LID)
Open-Label Safety Study of ADS-5102 in PD Patients With LID
This is a 105-week open-label study to evaluate the safety and tolerability of ADS-5102 oral capsules, an extended release formulation of amantadine, in Parkinson's Disease (PD) patients with Levodopa Induced Dyskinesia (LID).
- Conditions
- Dyskinesia, Levodopa Induced Dyskinesia (LID), Parkinson's Disease (PD)
- Trial name
- NCT02202551
- Testing
- ADS-5102
- Where
- 87 sites in United States, Austria and 4 more
- Volunteers
- 223 people
- Sponsor
- Adamas Pharmaceuticals, Inc.
Parkinson's Disease
Global REsponsE During iNFusIon of a gEl With LevoDopa/Carbidopa
This multicenter, post marketing observational study (PMOS) was designed to evaluate the long-term effectiveness of levodopa/carbidopa intestinal gel (DUODOPA) on motor fluctuations (duration of OFF periods) in participants with…
- Trial name
- GREENFIELD (NCT01754129)
- Volunteers
- 148 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Parkinson's Disease (PD)
The Effects of Tele-Rehabilitation-Based Dual-Task Upper Extremity Training in Patients With Parkinson's Disease
The aim of this study is to compare the effects of tele-rehabilitation-based synchronous and asynchronous dual-task upper extremity training with clinical based dual-task upper extremity training and conventional single-task…
- Trial name
- NCT07641556
- Testing
- Conventional Single Task Upper Extremity Exercise Training, Clinic-Based Dual Task Upper Extremity Exercise Training, Tele-Rehabilitation Based Synchronous Dual Task Upper Extremity Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Saglik Bilimleri Universitesi
Parkinson's Disease, Constipation
Evaluation of Safety and Tolerability of ENT-01 for the Treatment of Parkinson's Disease Related Constipation
This is a Phase 1/2a study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of an orally-administered medication to relieve symptoms of constipation associated with Parkinson's Disease.
- Trial name
- RASMET (NCT03047629)
- Testing
- ENT-01
- Where
- 15 sites in United States
- Volunteers
- 50 people
- Sponsor
- Enterin Inc.
Parkinson's Disease
A Randomised Controlled Trial (RCT) to Evaluate Use of an Individual Auditory Cueing Device's (IACD's) on Freezing and Gait in People With Parkinson's Disease (PD)
The primary aim of the study is to evaluate the effect of an IACD i.e. Apple iPod-shuffle, on freezing and gait speed in people with a diagnosis of PD through the implementation of a randomised controlled trial.
- Trial name
- NCT00727467
- Testing
- Auditory Cueing Device
- Where
- 3 sites in Ireland
- Volunteers
- 47 people
- Sponsor
- University of Dublin, Trinity College
Parkinson Disease, Ataxia
Validation of Bulbicam for Parkinson- and Ataxia-patients
Aim is to investigate repeatability and stability of four Neurological-related Bulbicam tests in patients suffering Parkinson (PD),Ataxia (AT) and matched healthy control (HC).
- Trial name
- NCT05680571
- Testing
- BulbiCam
- Where
- Norway
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Meddoc
Parkinson's Disease
Study to Assess Participant/Caregiver/Investigator Satisfaction of Video-Assisted Telenursing in Adult Participants With Parkinson's Disease Treated With Levodopa-Carbidopa Intestinal Gel
Parkinson's disease (PD) is a neurological condition, which affects the brain. PD gets worse over time, but how quickly it progresses varies a lot from person to person.
- Trial name
- FACILITATECARE (NCT04500106)
- Where
- 13 sites in Australia, Israel and 2 more
- Volunteers
- 41 people
- Sponsor
- AbbVie
Functional Movement Disorders
Brain Activity in People With Functional Movement Disorders
This study will use functional MRI (fMRI, a technique that shows what areas of the brain are active when performing different mental tasks), to examine how the brain in people with functional movement disorders (FMD) may differ…
- Trial name
- NCT00448084
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
PSP - Progressive Supranuclear Palsy
Study Evaluating the Effect of Transcranial Direct Current Stimulation (tDCS) Targeting the Right Inferior Frontal Gyrus on Inhibitory Control in Patients With PSP
Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease with a prevalence estimated at 6 per 100,000 in France and a rapidly progressive course.
- Trial name
- TinPSP (NCT07818733)
- Testing
- tDCS, or transcranial direct current stimulation
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Nantes University Hospital
Tourette's Syndrome
Ecopipam Treatment of Tourette Syndrome
Tourette's Syndrome is a neurological disease characterized by verbal and motor tics. The currently available drug treatments are considered to be inadequate.
- Trial name
- NCT01244633
- Testing
- Ecopipam
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Psyadon Pharma
Parkinson's Disease
Open-label Investigation of the Safety and Clinical Effects of NTCELL in Patients With Parkinson's Disease
To assess the safety of xenotransplantation of NTCELL [immunoprotected (alginate-encapsulated) choroid plexus cells] in patients with Parkinson's disease, assessed over the duration of the study, by monitoring the occurrence of…
- Trial name
- NCT01734733
- Testing
- NTCELL
- Where
- New Zealand
- Volunteers
- 4 people
- Sponsor
- Living Cell Technologies
Parkinson''s Disease
Pilot Study of Safety and Efficacy of Spheramine
Tolerability and Efficacy of Spheramine will be evaluated after operative implantation (Stereotactic Intrastriatal Implantation) in patients with advanced Parkinson's Disease
- Trial name
- NCT00761436
- Testing
- Spheramine (BAY86-5280)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Bayer
Parkinson's Disease
Kinematic and Neural Dynamics of Postural Instability in Parkinson's Disease
Balance problems and falls are among the most common complaints in Veterans with Parkinson's Disease (PD), but there are no effective treatments and the ability to measure balance and falls remains quite poor.
- Trial name
- NCT06405334
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Parkinson Disease
Convection Enhanced Delivery of CSF in DBS for Parkinson's
This study will evaluate safety foremost but also the distribution and initial effectiveness of infusion-enhanced, MRI-guided DBS for patients with medication-refractory, Parkinson's disease
- Trial name
- NCT03540134
- Testing
- Intracerebral Infusion of Autologous Cerebral Spinal Fluid
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Jeff Elias, MD
Parkinson's Disease
A Study of Istradefylline (KW-6002) for the Treatment of Parkinson's Disease
To establish the efficacy of 40 mg/day doses of istradefylline for the change in Unified Parkinson's Disease Rating Scale (UPDRS) part-III (Motor examination) score in patients with Parkinson's disease (PD).
- Trial name
- NCT00250393
- Testing
- Istradefylline (KW-6002)
- Where
- Japan
- Volunteers
- 64 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Idiopathic Parkinsonism
Fall Risk Assessment in Parkinson's Disease Using Kinetikos Health
This is a single-center, prospective observational study aiming to validate the Kinetikos Health App for fall risk assessment in PD patients undergoing dopaminergic medication adjustments.
- Trial name
- PD_FALLRISK (NCT07257393)
- Testing
- No Intervention: Observational Cohort
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Tourette Syndrome
The Pathophysiology of Tourette Syndrome: a Multimodal Study
The purpose of this study is to characterize the functional and anatomical connectivity changes in Tourette syndrome and its relation with iron deficiency.
- Trial name
- PTS (NCT02497807)
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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