Clinical trials: Movement Abnormalities
Parkinson's Disease (PD)
Observational Study Evaluating Robotic Spinal Mobilization in 16 Parkinson's Disease Participants. The Study Recorded Changes in Mobility, Sit-to-stand Performance, and Pain Scores After a 2-week Intervention With the BackHug Device.
The goal of this completed observational pilot study was to evaluate the immediate and short-term clinical effects of robotic spinal mobilization on motor and non-motor symptoms in community-dwelling adults with Parkinson's…
- Trial name
- NCT07384364
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- Pacla Medical Limited
Parkinson Disease (PD)
Robotic Apparel to Prevent Freezing of Gait in Parkinson Disease
Freezing-of-gait (FoG) in Parkinson Disease (PD) is one of the most vivid and disturbing gait phenomena in neurology. Often described by patients as a feeling of "feet getting glued to the floor," FoG is formally defined as a…
- Trial name
- XF (NCT06602544)
- Testing
- Robotic Apparel
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Harvard Medical School (HMS and HSDM)
Parkinson Disease
Telehealth Allied Health Care With People Who Have Parkinson's Disease Living in Rural Nevada and Wyoming
The investigators have developed a three-part allied health care intervention to be delivered via telehealth. These interventions are usually provided face-to-face.
- Trial name
- NCT03381898
- Testing
- Telehealth Exercise, speech therapy, medication management
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Wyoming
Parkinson Disease
Study of Subthalamic Brain Stimulation in Parkinson Disease (PD)
Deep brain stimulation (DBS) improves debilitating symptoms of movement disorders when conventional medical therapies and novel surgical therapies fail.
- Trial name
- NCT01113684
- Testing
- Implantable pulse generator (deep brain stimulator)
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- University of Alabama at Birmingham
Parkinson Disease
Study to Evaluate DNL201 in Subjects With Parkinson's Disease
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple oral doses of DNL201 in subjects with Parkinson's disease.
- Trial name
- NCT03710707
- Testing
- DNL201
- Where
- 7 sites in United States
- Volunteers
- 29 people
- Sponsor
- Denali Therapeutics Inc.
Parkinson Disease, REM Sleep Behavior Disorder
Ultra High Field Magnetic Resonance Imaging as a Biomarker for Premotor Parkinson's Disease
This is a prospective observational study investigating the utility of 7 Tesla MRI to quantify nigrosome1 signal in a cohort of individuals with recent onset Parkinson's disease and in at-risk cohorts at a premotor state of…
- Trial name
- NCT03288909
- Testing
- MRI
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Essential Tremor (ET)
Motor and Non-Motor Effects of Low-Intensity Focused Ultrasound (LIFU) as a Neuromodulation Tool in Essential Tremor
This study investigates the motor and non-motor effects of Low-Intensity Focused Ultrasound (LIFU) as a non-invasive neuromodulation technique in patients with essential tremor (ET) and refractory tremor.
- Trial name
- LIFU-ET (NCT07484152)
- Testing
- Low-Intensity Focused Ultrasound (LIFU) - NeuroFUS PRO
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo General Hospital
Parkinson Disease, Anxiety
Yoga for Anxiety in Adults
The purpose of this study is to investigate the effect of a telerehabilitation-yoga intervention delivered remotely via videoconferencing on adults with Parkinson's Disease and anxiety symptoms.
- Trial name
- NCT04240899
- Testing
- Tele-yoga
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Rutgers, The State University of New Jersey
Parkinson Disease
Effects of Aerobic Exercise in Parkinson's Disease
Motivated by reported improvements in aerobic fitness and executive functions after a 6-month aerobic walking intervention in normal sedentary elderly, we conducted a Phase I/II study to investigate effects of aerobic exercise on…
- Trial name
- NCT00784563
- Testing
- Continuous training, Interval training
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- US Department of Veterans Affairs
PARKINSON DISEASE (Disorder)
A 12-Week Study of Flexilev With the OraFID Device and App in Parkinson's Patients
Flexilev is a Parkinson's disease medicine made of small, dissolvable tablets containing low doses of levodopa and carbidopa, allowing doses to be adjusted in small, precise steps.
- Trial name
- FLORA (NCT07839793)
- Testing
- OraFID dosing device, Levodopa/Carbidopa minitablets delivered via OraFID dosing device
- Where
- 5 sites in Sweden
- Volunteers
- 58 people
- Sponsor
- Navamedic AB
Parkinson Disease
TEND Study:Telemedicine Nurse DBS for Parkinson's Disease
The central hypothesis is that home health nurses can improve access and provide high quality care when guided by a sophisticated platform that integrates bioinformatics, patient-specific computational modeling, and continuous…
- Trial name
- NCT04677621
- Testing
- Nurse Telehealth, STANDARD DBS
- Sponsor
- University of Florida
Huntington Disease
Safety and Tolerability Study With VY-HTT01, in Adults With Early Manifesting Huntington's Disease
This is the first clinical study of VY-HTT01, a gene therapy for early-stage Huntington's Disease (HD) patients. The primary goal of this trial is to evaluate the safety and tolerability of VY-HTT01.
- Trial name
- NCT04885114
- Testing
- Intraparenchymal rAAV1 - (mi)RNA HTT
- Sponsor
- Voyager Therapeutics
Alzheimer Disease, Parkinson Disease
Evaluation of [18F] FEPPA and PET Imaging as a Marker of Inflammation in Subjects With Neurological Conditions
Ultimately a marker of microglial activation could be used for large-scale quantitative brain imaging trials in Alzheimer Disease (AD), Parkinson Disease (PD) or Multiple Sclerosis (MS), specifically to investigate the agent as…
- Conditions
- Alzheimer Disease, Parkinson Disease, Multiple Sclerosis
- Trial name
- NCT00970333
- Testing
- [18F]-FEPPA
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Institute for Neurodegenerative Disorders
Tardive Dyskinesia, Intellectual Disability
Deutetrabenazine Treatment for Tardive Dyskinesia in Intellectual/Developmental Disabilities
The primary goal of this study is to investigate the efficacy of deutetrabenazine treatment of TD in this previously untreated patient population.
- Conditions
- Tardive Dyskinesia, Intellectual Disability, Developmental Disabilities
- Trial name
- TD-AIDD (NCT06997198)
- Testing
- Deutetrabenazine Oral Capsule
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University Hospitals Cleveland Medical Center
Idiopathic Parkinson's Disease
Randomized Safety Study of CVT-301 Compared to an Observational Control Group
This study is a 12-month, open-label, randomized, multicenter study which will evaluate the safety and efficacy of CVT-301 for the treatment of up to 5 OFF episodes per day in Parkinson's Disease (PD) patients experiencing motor…
- Trial name
- NCT02352363
- Testing
- CVT-301, Observational cohort
- Where
- 76 sites in United States, Austria and 12 more
- Volunteers
- 408 people
- Sponsor
- Acorda Therapeutics
Parkinson's Disease
Transplantation of Neural Stem Cell-Derived Neurons for Parkinson's Disease
This is a prospective study to demonstrate the safety and efficacy of differentiated neurons-derived from adult CNS progenitors cells transplanted in selected patients with Parkinson's disease.
- Trial name
- NCT03309514
- Testing
- Intracerebral microinjections
- Sponsor
- NeuroGeneration
Parkinson Disease, Essential Tremor
The Effects of Vibrotactile Stimulation in Patients With Movement Disorders
Vibration applied to the skin has been anecdotally reported to potentially improve motor control in patients with movement disorders including Parkinson's disease, however few devices have been studied formally.
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia
- Trial name
- NCT05106816
- Testing
- skin surface vibration
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Florida
Parkinson's Disease
Noninterventional Study Evaluating Parkinson's Disease Diary Use
This study aims to evaluate the impact of the frequency of assessments on the variability over time, reliability, and compliance for the Parkinson's disease (PD) diary in patients with PD in whom medications do not provide…
- Trial name
- NCT05363046
- Where
- 34 sites in United States, Canada and 3 more
- Volunteers
- 194 people
- Sponsor
- BlueRock Therapeutics
Huntington Disease
Transcranial Static Magnetic Stimulation (tSMS) in Huntington's Disease (HD)
Huntington's disease (HD) is a neurodegenerative pathology characterized by choreic hyperkinesias which represent the typical motor symptom and are represented by involuntary, aimless, irregular, recurrent, unpredictable and…
- Trial name
- NCT06976983
- Testing
- Portable ergonomic helmet for real tSMS
- Volunteers
- 30 people
- Sponsor
- Neuromed IRCCS
Parkinson Disease
Open Label Sumanirole Study of Safety, Tolerability, and Therapeutic Response In Patients With Parkinson's Disease
The primary objective is to assess the long term safety and tolerability of sumanirole as measured by safety labs, ECG monitoring, vital signs, and adverse event reports in subjects with Parkinson's Disease who participated in…
- Trial name
- NCT00036205
- Testing
- sumanirole
- Where
- 110 sites in United States, Argentina and 2 more
- Volunteers
- 984 people
- Sponsor
- Pfizer
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