Clinical trials: Movement Abnormalities
Parkinson Disease
Can Dance Therapy Improve Motor Learning in Parkinson's Disease (PD)?
In order to find the most effective rehabilitative therapies for Parkinsonian patients, the present study is aimed to evaluate whether, in a multidisciplinary intensive rehabilitation treatment, the dance therapy, applied to the…
- Trial name
- NCT03549793
- Testing
- Dance Therapy, exercises without dance
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Parkinson's Disease
Open Label High Dose Ropinirole (Requip) Study for Patients With Parkinson's Disease
The purpose of this research study is to see if subjects with Parkinson's disease who are experiencing motor fluctuations ("on" and "off" states) and dyskinesias (involuntary excessive movements) would benefit from a higher dose…
- Trial name
- NCT00260793
- Testing
- Ropinirole Hydrochloride
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Agarwal, Pinky, M.D.
Spasmodic Dysphonia, Focal Dystonia
Role of Neurotransmission and Functional CNS Networks in Spasmodic Dysphonia
This study will examine how the brain controls speech in patients with spasmodic dysphonia, a voice disorder that involves involuntary spasms of muscles in the larynx (voice box), causing breaks in speech.
- Trial name
- NCT00713414
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson's Disease and Parkinsonism, Tai Chi
Seated Tai Chi Improves Dynamic Finger Pointing Task and Sitting Balance Control in Subjects With Parkinson's Disease
The goal of this prospective study is to investigate the effects of 3 months seated Tai Chi (TC) practice on the eye-hand coordination and sitting balance control of subjects with Parkinson's disease.
- Trial name
- NCT06928532
- Testing
- Seated TC
- Where
- Hong Kong
- Volunteers
- 56 people
- Sponsor
- The Hong Kong Polytechnic University
PARKINSON DISEASE (Disorder)
Stanford University Neurofiber Study
Parkinson's disease often causes constipation and changes in gut bacteria, but it is not known how quickly a daily fiber supplement changes gut physiology in people with Parkinson's, or how long any change lasts after stopping.
- Trial name
- SUNs (NCT07914387)
- Testing
- Prebiotic fiber bar
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Stanford University
Parkinson Disease
TEND Study:Telemedicine Nurse DBS for Parkinson's Disease
The central hypothesis is that home health nurses can improve access and provide high quality care when guided by a sophisticated platform that integrates bioinformatics, patient-specific computational modeling, and continuous…
- Trial name
- NCT04677621
- Testing
- Nurse Telehealth, STANDARD DBS
- Sponsor
- University of Florida
Parkinson Disease
Effects of a Rehabilitation Treatment on Balance in PD Evaluated With a Stabilometric Platform
Pharmacotherapy with dopaminergic medications and deep brain stimulation cannot provide significant improvements in postural instability in Parkinson's disease, whereas previous reports of physical interventions have suggested…
- Trial name
- SPPD002 (NCT02098707)
- Testing
- Stabilometric Platform
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Parkinson Disease
Continuous Wearable Monitor for the Detection and Release of Freezing of Gait.
The proposed system (haptic module and insole device) for daily in-community use that detects the occurrence of freezing of gait (FOG) in people with Parkinson's disease (PD).
- Trial name
- NCT06385392
- Testing
- Haptic module and insole device
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- HealthPartners Institute
Parkinson's Disease
A Clinical Trial of Parkinson's Disease Treatment by HiPSCs Derived Dopaminergic Neural Precursor Cells
XellSmart Biomedical (Suzhou) Co., Ltd. has closely collaborated with Shanghai East Hospital(East Hospital Affiliated To Tongji University) , using iPSC seed cells, on the development and establishment of a dopaminergic neural…
- Trial name
- hiPSC-DAP (NCT06145711)
- Testing
- hiPSC-DAP
- Where
- 2 sites in China
- Volunteers
- 3 people
- Sponsor
- Shanghai East Hospital
Parkinson's Disease
Mapping and Manipulating the Emotional Territories of the Basal Ganglia in PD Patients
Depressive symptoms of Parkinson's disease (PD) patients are major predictors of their prognosis and quality of life. Using subthalamic nucleus (STN) deep brain stimulation (DBS) as an antidepressant could be a promising new…
- Trial name
- NCT01267409
- Testing
- STN stimulation
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
Parkinson Disease
Managing Fatigue in People With Parkinson's Disease
This pilot study aims to evaluate the feasibility of Managing Fatigue: The Individual Program (MFIP) in people living with Parkinson's disease.
- Trial name
- MFIP (NCT04267107)
- Testing
- Individual Managing Fatigue Program
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Dalhousie University
Parkinson Disease, Exercise
Effectiveness of Video-Based Upper Extremity Exercise Program in Parkinson's Disease
Over the past decade, virtual reality (VR) has been widely recognized as a therapeutic tool that enables neurological patients to interact with simulated environments through multiple sensory channels.
- Conditions
- Parkinson Disease, Exercise, Exergame, Therapy
- Trial name
- NCT06807411
- Testing
- Conventional exercise, Video game based exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul Medipol University Hospital
Parkinson Disease
Parkinson's Disease Inpatient Clinical Knowledge and Management
This study will focus on patients with Parkinson's Disease in the adult inpatient units of Hackensack University Medical Center.
- Trial name
- PICK (NCT03888287)
- Testing
- Watch Rx system, Parkinson's Disease Inpatient Clinical Knowledge and Management Program
- Where
- United States
- Volunteers
- 477 people
- Sponsor
- Hackensack Meridian Health
Parkinson Disease, Effect of Drug
Multiple N-of-1 Trials of (Intermittent) Hypoxia Therapy in Parkinson's Disease
In recent years, mitochondrial dysfunction and oxidative stress have been implicated in PD pathophysiology. Intermittent hypoxia therapy (IHT) is an upcoming treatment used by elite athletes as well as fragile individuals in…
- Trial name
- TALISMAN (NCT05214287)
- Testing
- Hypoxic Gas Mixture
- Where
- Netherlands
- Volunteers
- 29 people
- Sponsor
- Radboud University Medical Center
Parkinson Disease
Developing Personalized Medicine Strategies to Increase Physical Activity in Parkinson's Disease (PD) Through Digital Health Technology
Under a grant from the Department of Defense's PD program, Dr. Morley's is investigating new approaches that 1) use "gamification"- applying rules of games like point scoring, achieving silver, gold or platinum levels and…
- Trial name
- NCT05529121
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Corporal Michael J. Crescenz VA Medical Center
Paediatric Patients
Markerless Motion Capture for 3D Clinical Gait Analysis (IMAGine)
Many children have trouble with walking and frequently trip and fall. To understand the extent of the changes in their walking, but also to inform and evaluate possible interventions to improve their walking, a gait analysis is…
- Trial name
- IMAGine (NCT07572214)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Alder Hey Children's NHS Foundation Trust
Parkinson's Disease
Pioglitazone in Early Parkinson's Disease
This is a multi-center, double-blind, placebo controlled clinical trial of two dosages of oral pioglitazone (15 milligram(mg) and 45 milligram (mg)) for safety, tolerability, and futility.
- Trial name
- NCT01280123
- Testing
- Pioglitazone
- Where
- 38 sites in United States
- Volunteers
- 210 people
- Sponsor
- University of Rochester
Parkinson Disease
Early Versus Late Application of STN DBS to PD Patients With Motor Complications
Although deep brain stimulation of the subthalamic nucleus(STN DBS) has become the surgical treatment of choice for Parkinson's disease(PD), a consensus on the timing of surgery is lacking.
- Trial name
- ELASS (NCT01922388)
- Testing
- Bilateral deep brain stimulation of the subthalamic nucleus
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chen Ling
Parkinson's Disease
Development of a Novel 18F-DTBZ PET Imaging as a Biomarker to Monitor Neurodegeneration of PARK6 and PARK8 Parkinsonism
The primary objective of this protocol is to access the utility of 18F-DTBZ PET imaging as an in vivo biomarker to monitor neurodegeneration of both PD mouse models and PD patients.
- Trial name
- NCT01759888
- Testing
- 18F-DTBZ
- Where
- Taiwan
- Volunteers
- 49 people
- Sponsor
- Chang Gung Memorial Hospital
Progressive Supranuclear Palsy (PSP)
Efficacy of RIVAstigmine on Motor, Cognitive and Behavioural Impairment in Progressive Supranuclear Palsy
Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease from the parkinsonian syndrome group. It represents 5 to 10% of all parkinsonian syndromes and affects 3,000 to 10,000 persons in France.
- Trial name
- RIVA-PSP (NCT02839642)
- Testing
- Rivastigmine
- Where
- France
- Volunteers
- 106 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
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