Clinical trials: Movement Abnormalities
Parkinson's Disease
The Effects of Dual Task Training in Individuals With Parkinson's Disease
The primary aim of the proposed project is to characterize dual tasking (DT) deficits to improve motor, cognitive, and quality of life outcomes in individuals with Parkinson's disease (PD).
- Trial name
- NCT02538029
- Testing
- Dual Task Group, Single Task Group
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- The Cleveland Clinic
Parkinson Disease
The Benchmark Clinic: An Interdisciplinary Comprehensive Care Model for People With Parkinson Disease
The purpose of this study is to determine if an interdisciplinary clinic can help people with Parkinson's disease care for themselves, improve their ability to follow recommended treatments, and have fewer problems like falls or…
- Trial name
- NCT04555720
- Testing
- Interdisciplinary Visit
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Duke University
Parkinson's Disease
A Dose-ranging Study for SPM 962 in Parkinson's Disease Patients
The primary objective of this trial is to establish the maximum maintenance dose of SPM 962 in patients with Parkinson's disease in a multi-center, uncontrolled, open-label study by conducting safety evaluation of each patient…
- Trial name
- NCT01634243
- Testing
- SPM 962
- Where
- 5 sites in Japan
- Volunteers
- 64 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Huntington's Disease
Study Exploring Safety, Pharmacokinetic and Pharmacodynamic of BN82451 in Male Huntington's Disease Patients
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of BN82451B versus placebo after oral administration twice daily (bid) for 28 days in patients with Huntington's Disease…
- Trial name
- NCT02231580
- Testing
- BN82451B
- Where
- Germany
- Volunteers
- 17 people
- Sponsor
- Ipsen
Parkinson's Disease
Highly Challenging Balance Program to Reduce Fall Rate in PD
This study will test the hypothesis that two highly challenging exercise programs, one based at the VA medical center and the other conducted remotely, will both significantly reduce overall fall rates in patients with…
- Trial name
- NCT03972969
- Testing
- Facility-based structured exercise, Home-based structured exercise, Health education
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- VA Office of Research and Development
Dementia With Lewy Bodies
RewinD-LB - Clinical Study of Neflamapimod in Patients With Dementia With Lewy Bodies
The purpose of this study is to determine whether neflamapimod can improve learning skills, problem solving skills, and memory loss in people diagnosed with DLB.
- Trial name
- NCT05869669
- Testing
- Neflamapimod
- Where
- 40 sites in United States, Netherlands and 1 more
- Volunteers
- 159 people
- Sponsor
- EIP Pharma Inc
Parkinson's Disease
Poised for Parkinson's - an Intervention to Increase Embodied Agency in People With Parkinson's Disease and Their Carers
The purpose of the study is to develop, deliver, and test an online Alexander-based training program for people with Parkinson's disease and their care partners.
- Trial name
- NCT04726709
- Testing
- Poised for Parkinson's
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Idaho
Idiopathic Parkinson Disease
Voice Treatment for Parkinson's Disease
This study addresses several issues related to the clinical management of speech and voice disorders associated with Parkinson's disease.
- Trial name
- NCT03700684
- Testing
- Lee Silverman Voice Treatment, SpeechVive, Control
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- University of Massachusetts, Amherst
Parkinson Disease
Follow Up Study for Treatment of Parkinson's Disease With Deep Brain Stimulation
Follow up of patients enrolled in CSP 468, a study of deep brain stimulation treatment for Parkinson's disease
- Trial name
- CSP#468F (NCT01022073)
- Where
- 12 sites in United States
- Volunteers
- 156 people
- Sponsor
- VA Office of Research and Development
Advanced Parkinson's Disease
Study of Efficacy, Safety and Tolerability of Levodopa-Carbidopa Intestinal Gel in Levodopa-Responsive Parkinson's Subjects
The primary objective of this study was to demonstrate the superiority of levodopa - carbidopa intestinal gel over treatment with optimized oral levodopa/carbidopa during 12 weeks.
- Trial name
- NCT00357994
- Testing
- Levodopa carbidopa intestinal gel (LCIG), Levodopa carbidopa (LC) oral encapsulated immediate release (IR) tablets, CADD-Legacy® 1400 ambulatory infusion pump
- Where
- 15 sites in United States, Germany
- Volunteers
- 36 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Obsessive-Compulsive Disorder, Tic Disorders
Effects of Ondansetron in Obsessive-compulsive and Tic Disorders
This project investigates the use of 4 weeks of 24 mg/day ondansetron as compared to placebo on symptoms and brain functioning in patients with obsessive-compulsive disorder (OCD) and tic disorders (TD).
- Conditions
- Obsessive-Compulsive Disorder, Tic Disorders, Tourette Syndrome
- Trial name
- NCT03239210
- Testing
- Ondansetron
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- NYU Langone Health
Chronic Dysphagia, Multiple Sclerosis
A Comparison of an Implanted Neuroprosthesis With Sensory Training for Improving Airway Protection in Chronic Dysphagia
This study will compare an implant with the technique of sensory training to determine which method may improve the ability to swallow and reduce the risk of choking.
- Conditions
- Chronic Dysphagia, Multiple Sclerosis, Parkinson Disease
- Trial name
- NCT00376506
- Testing
- Neurostimulation device for dysphagia, External vibrotactile device
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson's Disease
A Study to Compare Pharmacokinetics and Pharmacodynamics of IPX066 to Standard Carbidopa-Levodopa
This study evaluated the pharmacokinetics, motor effects, and assessed the safety of IPX066 compared with an immediate-release cabridopa-levodopa formulation in subjects with advanced Parkinson's disease.
- Trial name
- NCT00869791
- Testing
- IPX066, IR CD-LD
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Impax Laboratories, LLC
Parkinson's Disease, Motor Fluctuations
Study in Advanced Parkinson's Disease Patients With Predictable Motor Fluctuations
The primary objective of this study is to explore the efficacy and tolerability of DM-1992 compared to a standard carbidopa/Levodopa Immediate-Release (CD/LD IR) tablet (Sinemet IR) as measured by: "ON" time with no dyskinesia or…
- Trial name
- NCT01515410
- Testing
- DM-1992, Sinemet IR
- Where
- 7 sites in United States
- Volunteers
- 34 people
- Sponsor
- Depomed
Dyskinesias, Movement Disorders
Developing Objective Measures of Levodopa Induced Dyskinesia: (Study 1)
The ultimate goal of this proposal is to reduce dyskinesia in Parkinson's Disease (PD) patients. Dyskinesias are abnormal movements, often caused by the standard treatment for PD symptoms, levodopa.
- Conditions
- Dyskinesias, Movement Disorders, Parkinson Disease
- Trial name
- NCT00467597
- Testing
- Levodopa (delivered intravenously)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Essential Tremor
Assessment of the Safety and Efficacy of the Felix NeuroAI Wristband in Essential Tremor
The goal of this clinical study is to compare Felix NeuroAI Wristband and sham device in patients with essential tremor. The main question it aims to answer is: Is Felix a safe and efficacious treatment for patients with…
- Trial name
- TRANQUIL (NCT06235190)
- Testing
- Felix NeuroAI Wristband
- Where
- 12 sites in United States, China
- Volunteers
- 125 people
- Sponsor
- Fasikl Inc.
Essential Tremor
A Pilot Study to Assess the Effects of Pre-SMA LF-rTMS for the Treatment of Essential Tremor
The purpose of this study is to determine the effects of Low Frequency Repetitive Transcranial Magnetic Stimulation (LF r-TMS) of the pre-Supplementary Motor Area (pre-SMA) on tremor as measured by the tremor rating scale (TRS)…
- Trial name
- NCT02763865
- Testing
- MagVenture MagProx100 Stimulator with a Cool-B65 A/P coil
- Volunteers
- 10 people
- Sponsor
- Medical University of South Carolina
Parkinson's Disease
Transcranial Direct Current Stimulation for Freezing of Gait
This study will evaluate the effects of transcranial direct current stimulation (tDCS) in combination with locomotor training in patients with Parkinson's disease (PD) and freezing of gait (FOG).
- Trial name
- TDCS-FOG (NCT02266004)
- Testing
- Transcranial Direct Current Stimulation (tDCS), locomotor training
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Miami
Parkinson's Disease
A Study To Evaluate The Safety And Efficacy Of IPX066 In Subjects With Parkinson's Disease
This study examines the efficacy of three doses of IPX066 as compared to placebo in Parkinson's disease.
- Trial name
- APEX-PD (NCT00880620)
- Testing
- IPX066 95 mg LD, IPX066 145 mg LD, IPX066 195 mg LD
- Where
- 60 sites in United States, Canada and 5 more
- Volunteers
- 381 people
- Sponsor
- Impax Laboratories, LLC
Parkinson's Disease
A Global Study to Assess the Drug Dynamics, Efficacy, and Safety of Venglustat (GZ/SAR402671) in Parkinson's Disease Patients Carrying a Glucocerebrosidase (GBA) Gene Mutation
Primary Objectives: Part 1: To determine the safety and tolerability of 4, 8, and 15 milligrams of GZ/SAR402671 (venglustat) administered orally for 4 weeks, as compared to placebo in participants with early-stage Parkinson's…
- Trial name
- MOVES-PD (NCT02906020)
- Testing
- venglustat GZ/SAR402671
- Where
- 52 sites in United States, Austria and 14 more
- Volunteers
- 273 people
- Sponsor
- Genzyme, a Sanofi Company