Clinical trials: Movement Abnormalities
Parkinson's Disease
Video Based Mindfulness Based Stress Reduction
To evaluate the feasibility of a video based mindfulness intervention for stress reduction and to evaluate the cortisol response in persons with PD and their caregivers.
- Trial name
- vMBSR (NCT02705586)
- Testing
- Mindfulness
- Where
- 2 sites in United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Parkinsons
Investigations of Dementia in Parkinson Disease
The purpose of this study is to use a brain imaging method called Pittsburgh B (PIB) Positron Emission Tomography (PET) and Vesicular Cholinergic Transport (VAT) PET to determine dementia subtypes in patients with Parkinson…
- Trial name
- PIB (NCT02763683)
- Testing
- PiB and VAT
- Where
- United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Acoustic Stimulation, Parkinson Disease
Effects and Mechanisms of RAS Training on Upper-limb Movements in PD Patients
Introduction Bradykinesia (i.e., slow movements) is one of the most prominent symptoms of Parkinson's disease (PD) and has a negative impact on quality of life.
- Conditions
- Acoustic Stimulation, Parkinson Disease, Electroencephalography
- Trial name
- NCT05782322
- Testing
- Upper-limb training involving RAS, Upper-limb training without the aid of RAS
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Parkinson's Disease (PD)
Pairing Subjective Patient Rating and DBS Programming
This multicenter, prospective and retrospective diagnostic study investigates personalized programming strategies for deep brain stimulation (DBS) in patients with Parkinson's disease.
- Trial name
- PERCEPT-DBS (NCT07336199)
- Testing
- No intervention (observational study)
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Parkinson's Disease
An Extension Study of Entacapone in Patients With Parkinson's Disease With End-of-dose Wearing-off. This Study is Not Recruiting in the United States
The purpose of this study is to evaluate the safety and efficacy of the long-term treatment of entacapone in patients with Parkinson's disease with end-of-dose wearing-off.
- Trial name
- NCT00237263
- Testing
- Entacapone
- Where
- United States
- Volunteers
- 285 people
- Sponsor
- Novartis
Parkinson Disease, Gait Disorders, Neurologic
Immersive Virtual Reality to Improve Gait in Parkinson's Disease
Parkinson's Disease (PD) patients suffer from gait impairments responsible for falls and bad quality of life: reduced speed and stride length, randomness in stride duration variability (reduced Long-Range Autocorrelations (LRA)).
- Trial name
- NMSK-LH02 (NCT03727529)
- Testing
- Treadmill + VR, Treadmill
- Where
- Belgium
- Volunteers
- 46 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Alzheimer's Disease, Lewy Body Dementia
Pulsed Electromagnetic Field Treatment With Dementia Patients
An open label pilot study in mild to moderate AD/ADRD patients to assess the effects of treatment with ECHS AD/ADRD pulsed electromagnetic treatment device on disease progression. Enrolled patients will receive active devices.
- Conditions
- Alzheimer's Disease, Lewy Body Dementia, Vascular Dementia
- Trial name
- NCT06862557
- Testing
- ECHS AD Device
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Herrick Medical LLC
Parkinson Disease
Effect of Auricular Stimulation on Locomotion in Patients With Parkinson's Disease
The effect of auricular stimulation on the locomotion capability in patients with Parkinson's Disease was investigated.
- Trial name
- NCT03907007
- Testing
- Percutaneous electrical nerve stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Inventram
Parkinson's Disease
Antigen Presentation and Lymphocyte Response in Parkinson's Disease
The way the immune system responds to certain PD-related proteins in PD donors compared to the way it responds in persons without or fewer PD related proteins is not well studied and this study aims to analyze the autoimmune…
- Trial name
- NCT02939534
- Where
- 3 sites in United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Columbia University
Parkinson's Disease
Physiopathological Study of Autonomic Failure in Parkinson's Disease
The aim of the study is to evaluate the autonomic failure in Parkinson's disease by clinical, electrophysiological and neuropathological examination.
- Trial name
- SYNAPark (NCT01748409)
- Testing
- Biopsies of peripheral autonomic nervous system, Autonomic dysfunction questionnaires, Electrophysiological tests
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Nantes University Hospital
Parkinson's Disease
A Clinical Study Investigating the Efficacy, Tolerability, and Safety of Continuous Subcutaneous ND0612 Infusion Given as Adjunct Treatment to Oral Levodopa in Patients With Parkinson's Disease With Motor Fluctuations
This is a multicenter, randomized, double blind, placebo controlled parallel group clinical study. Following a screening period of up to 28 days, eligible subjects will be randomized to receive adjunct treatment to oral LD/DDI…
- Trial name
- NCT02782481
- Testing
- ND0612
- Where
- Israel
- Sponsor
- NeuroDerm Ltd.
Cough, Parkinson's Disease
Respiratory Kinematics of Cough in Healthy Older Adults and Parkinson's Disease
The purpose of this research study is to test cough function in individuals with Parkinson's disease and healthy older adults. Cough is a complex, defensive function which involves movement of the chest and lungs.
- Trial name
- NCT02183519
- Testing
- Capsaicin, Voluntary cough test
- Where
- 2 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Florida
Parkinson Disease
Genetic Study in Young Onset Parkinson's Disease
Parkinson's disease (PD) is the second most frequent neurodegenerative disorder after Alzheimer's disease. It causes motor dysfunctions, such as bradykinesia, resting tremor, rigidity and postural instability.
- Trial name
- NCT01529970
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Parkinson Disease
Non-interventional Observational Study on WHO-5 Questionnaire Application in Parkinson's Disease
To assess the predictive value of sequential administration of WHO-5 and MDI (Major Depression Inventory) for the clinical management of Parkinson Disease (PD) patients by determination of the prevalence of depression in PD…
- Trial name
- NCT00752388
- Where
- 278 sites in Germany
- Volunteers
- 1,588 people
- Sponsor
- Boehringer Ingelheim
Parkinson's Disease
Long Term Follow-Up Study for rAAV-GAD Treated Subjects
The purpose of this observational study is the long term follow-up of Parkinson's patients who participated in a clinical trial in which they received AAV-GAD gene transfer into the subthalamic nucleus (STN) region of the brain.
- Trial name
- NCT01301573
- Testing
- rAAV-GAD
- Where
- 6 sites in United States
- Volunteers
- 40 people
- Sponsor
- Neurologix, Inc.
Parkinson Disease
Effects of Telerehabilitation-Based Motor and Cognitive Dual-Task Exercise in Patients With Parkinson's Disease
The ability to respond to multiple stimuli is impaired in Parkinson's patients. Traditional rehabilitation approaches focus only on balance and gait training, but individuals with Parkinson's disease need to perform multiple…
- Trial name
- NCT05894473
- Testing
- Motor-Motor Dual Task Physical Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
Parkinson Disease
Pilot Study of Maintenance Therapy With Intravenous AMANTADINE
This is a pilot study for Maintenance Intravenous Treatment with AMANTADINE in patient with PARKINSON'S Disease who are not well balanced with medical treatment.
- Trial name
- NCT01190553
- Testing
- Amantadine
- Volunteers
- 20 people
- Sponsor
- Rabin Medical Center
Parkinson's Disease
Early Parkinson's Disease (PD) Cross-Sectional
Purpose: 1. To see if cytokine levels and oligomeric alpha-synuclein levels in blood and cerebrospinal fluid could be used as biological markers for Parkinson's disease (PD) onset and progression. 2.
- Trial name
- EPDX (NCT00817453)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Tourette Syndrome, Chronic Tic Disorder
Median Nerve Stimulation for Tourette Syndrome and Chronic Tic Disorder
Tourette syndrome (TS) and chronic tic disorder (CTD) are neurodevelopmental disorders that impact approximately 1% of 5-18 year olds worldwide.
- Trial name
- NeSTS (NCT05269953)
- Testing
- Active stimulation
- Where
- United Kingdom
- Volunteers
- 135 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Parkinson's Disease
Treadmill and Music Cueing for Gait Training in Mild to Moderate Parkinson's Disease
Sensory and motor cueing have been demonstrated as useful ambulation training techniques for Parkinson's disease (PD). This study is aimed to evaluate the effectiveness of treadmill training program with music cueing for mild to…
- Trial name
- NCT00750945
- Testing
- Music and treadmill walking program, Treadmill walking program, Home program
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University
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