Clinical trials: Movement Abnormalities
Parkinson's Disease, Coping Skills
Expressive Writing for Individuals With Parkinson's Disease and Their Caregivers
This randomized, controlled trial (RCT) evaluates the benefits of expressive compared to neutral writing in individuals with Parkinson's Disease and their support persons.
- Trial name
- PDEWS (NCT02217735)
- Testing
- Writing Intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Virginia Commonwealth University
Lewy Body Disease
Alpha-synuclein Education and Disclosure in Individuals With Preclinical and Symptomatic Lewy Body Disease
The goal of the study is to assess if learning one's Lewy Body Dementia (LBD) biomarker test result impacts longitudinal psychosocial and behavioral responses and to identify factors that moderate and mediate these outcomes.
- Trial name
- NCT07646652
- Testing
- LBD Biomarker Education and Disclosure
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Stanford University
Parkinson Disease, Progression, Disease
Neuromelanin MRI: A Progression Marker in Early PD
Prospective observational study to qualify NM-MRI as progression marker in early Parkinson's.
- Trial name
- InsIghtPD (NCT05631158)
- Testing
- MRI
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Parkinson's Disease
Consortium On Risk for Early-onset Parkinson's Disease (CORE PD)
The purpose of this study is to investigate genetic and environmental risk factors that increase susceptibility to the development of early-onset Parkinson's disease (developed at or before age 50).
- Trial name
- NCT00104585
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Columbia University
Huntington's Disease
A Study to Evaluate ALN-HTT02 in Adult Patients With Huntington's Disease
The purpose of this study is to evaluate the safety, tolerability, pharmacodynamics (PD) and pharmacokinetics (PK) of single or repeat doses of ALN-HTT02.
- Trial name
- NCT06585449
- Testing
- ALN-HTT02
- Where
- 19 sites in Canada, Germany and 1 more
- Volunteers
- 66 people
- Sponsor
- Alnylam Pharmaceuticals
Visual Impairment, Stroke
Re-Orchestration of Interregional Oscillatory Activity to Promote Visual Recovery
This project assesses the effect of bifocal cross-frequency transcranial alternating current stimulation (tACS) combined with visual training to improve visual recovery and orchestrated oscillatory activity in stroke patients…
- Conditions
- Visual Impairment, Stroke, Parkinson Disease
- Trial name
- R4V (NCT05220449)
- Testing
- Cross-frequency dual-site tACS
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Parkinson Disease
A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (PD) Participants With Motor Fluctuations
This is a Phase 2 study in people with Parkinson's disease who experience motor fluctuations while taking levodopa. The study will evaluate how effective two different doses of the study drug AP-472 are when added to levodopa…
- Trial name
- NCT07432958
- Testing
- AP-472
- Where
- 30 sites in United States
- Volunteers
- 150 people
- Sponsor
- Appello Pharmaceuticals, Inc.
Parkinson Disease
Investigating Inhibitory Control Networks in Parkinson's Disease
The purpose of this study is to investigate the brain activity associated with non-motor symptoms of movement disorders, including Parkinson's disease and essential tremor.
- Trial name
- NCT04735458
- Testing
- Procedure/Surgery: Response Inhibition and Deep Brain Stimulation in Parkinson's disease
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Alabama at Birmingham
Progressive Supranuclear Palsy
A Molecular Anatomic Imaging Analysis of Tau in Progressive Supranuclear Palsy
This study is designed to learn more about overall tau burden in the brain of patients with Progressive Supranuclear Palsy (PSP).
- Trial name
- NCT02605785
- Testing
- F-18 AV 1451
- Where
- United States
- Volunteers
- 332 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Parkinson Disease
Aerobic Exercise and Brain Health in Parkinson's
The purpose of the project is to investigate how moderate to high intensity aerobic exercise affects brain health in patients with Parkinson's disease.
- Trial name
- NCT04379778
- Testing
- Aerobic exercise
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- University of Aarhus
Parkinson Disease, Fatigue
Examination of Factors Associated With Fatigue in Individuals Diagnosed With Parkinson's Disease
Fatigue is defined as an overwhelming feeling of weariness, lack of energy, and a feeling of exhaustion. It is common in Parkinson's Disease (PD) and is one of the most disabling symptoms.
- Trial name
- NCT06230939
- Testing
- Examination
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 129 people
- Sponsor
- Nigde Omer Halisdemir University
Essential Tremor
The Swedish Essential Tremor (SWEET) Trial
To evaluate the effect of deep brain stimulation (DBS) vs best medical treatment in essential tremor (ET) in a randomized, single-blinded controlled trial.
- Trial name
- SWEET (NCT03832712)
- Testing
- Deep Brain Stimulation, Best Medical Treatment
- Where
- 6 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Huntington Disease
Longitudinal SV2A PET and MRI in Premanifest HD
AIM: to compare the sensitivity of SV2A PET and volumetric MRI to detect longitudinal striatal changes in premanifest HD. DESIGN: The investigators will include late premanifest HD mutations carriers and matched healthy controls.
- Trial name
- NCT06626412
- Testing
- Diagnostic Test: 18F-SynVesT-1 PET, Volumetric MRI
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Parkinson Disease, Multiple System Atrophy
Pain and Autonomic Symptoms in Parkinson's Disease and Atypical Parkinsonisms
The goal of this observational study is to learn about the impact of the different types of pain and of the domains involved in the autonomic disorders of inpatients and outpatients diagnosed with Parkinson disease (PD) and…
- Trial name
- NCT05748028
- Testing
- Rehabilitation, Administration of Clinical scales
- Where
- 9 sites in Italy
- Volunteers
- 280 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Parkinson Disease
A Trial to Determine the Safety and Tolerability of Transplanted Stem Cell Derived Dopamine Neurons to the Brains of Individuals With Parkinson's Disease
Parkinson's disease (PD) occurs when an area of the brain begins to lose nerve cells that produce a chemical called dopamine. Dopamine is an important chemical, and one of its functions is that it helps to regulate body movement.
- Trial name
- STEM-PD (NCT05635409)
- Testing
- STEM-PD
- Where
- 2 sites in Sweden, United Kingdom
- Volunteers
- 8 people
- Sponsor
- Region Skane
Parkinson Disease
A Study of Equfina® on the Incidences of Adverse Drug Reactions in Participants With Parkinson's Disease (Including Participants With Hepatic Impairment)
The purpose of the study is to investigate the incidences of psychiatric symptoms (example, hallucinations), somnolence and sudden onset of sleep, dyskinesia, and retinal degeneration-related events during treatment with Equfina…
- Trial name
- NCT04724109
- Testing
- Equfina
- Where
- 2 sites in Japan
- Volunteers
- 1,088 people
- Sponsor
- Eisai Co., Ltd.
Parkinson Disease
Efficacy, Safety, Tolerability, and Biomarker Effects of GT-02287 in Early Parkinson's Disease
The purpose of this study is to assess the efficacy, the safety, and the effect on biomarkers of 2 dose levels of oral GT-02287 over placebo after 48 weeks of treatment in treated and untreated participants with early PD.
- Trial name
- NCT07280299
- Testing
- Low Dose GT-02287, High Dose GT-02287
- Volunteers
- 111 people
- Sponsor
- Gain Therapeutics, Inc.
Parkinson's Disease
A Retrospective Study of the Relationship Between White Matter Hyperintensities(WMHs) Within the Cholinergic Pathways and the Cognition of PD Patients After Bilateral STN DBS
To retrospectively investigate the relationship between the Cholinergic Pathways Hyperintensities Scale (CHIPS) score and the change of cognitive status of Parkinson's disease (PD) patients after bilateral subthalamic nucleus…
- Trial name
- NCT02071693
- Where
- China
- Volunteers
- 38 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Parkinson Disease
Asymmetric DBS for PD : A Multicenter, Prospective, Single Arm, Open Label Study
Deep brain stimulation (DBS) is an efficacious neurosurgical treatment for moderate-to-late stage Parkinson's disease (PD). The subthalamic nucleus (STN) and globus pallidus interna (GPi) are two targets extensively studied and…
- Trial name
- ADP (NCT04616521)
- Testing
- Deep brain stimulation
- Volunteers
- 1,000 people
- Sponsor
- Ruijin Hospital
Parkinson's Disease
Deep Brain Stimulation for Visuomotor Function in Parkinson's Disease
Inability to align and refocus the eyes on the objects at different depths, i.e., vergence impairment, frequently affects the quality of life in patients with Parkinson's disease.
- Trial name
- DBS visuomotor (NCT05400499)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
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