Clinical trials: Movement Abnormalities
Parkinson Disease (PD)
Comparison of Benzhexol and Procyclidine for Tremor in Tremor-Predominant Parkinson's Disease
The goal of this clinical trial is to compare benzhexol and procyclidine for improving tremor in adults with tremor-predominant Parkinson's disease who are taking levodopa.
- Trial name
- NCT07810296
- Testing
- Benzhexol, Procyclidine
- Where
- Pakistan
- Volunteers
- 88 people
- Sponsor
- safia bano
Parkinson's Disease
Cognitive-motor Training for PD
This study will evaluate gait when individuals with Parkinson's disease (PD) are walking and how walking changes when challenged to perform a functional cognitive task simultaneously.
- Trial name
- NCT01917903
- Testing
- Gait-cognitive training, Identification of at risk variables
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Stony Brook University
Parkinson Disease, Weight-Lifting Exercise Program
Training and Parkinson's
The purpose of the current study is to compare the impacts of specifically designed power training and strength training programs on function and physical performance in Parkinson's patients.
- Trial name
- NCT03434327
- Testing
- Strength Training, Power Training
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Miami
Early Parkinson's Disease
SR-Exenatide (PT320) to Eveluate Efficacy and Safety in Patients With Early Parkinson's Disease
This study is to evaluate the safety and efficacy of sustained release (SR)-Exenatide (PT320, Q1W and Q2W) in the treatment of patients with early Parkinson's disease (PD).
- Trial name
- NCT04269642
- Testing
- PT320 2.0 mg, PT320 2.5 mg
- Where
- 5 sites in South Korea
- Volunteers
- 99 people
- Sponsor
- Peptron, Inc.
Parkinson's Disease
A Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study of the Safety, Tolerability and Efficacy of E2007 in Parkinson's Disease Patients With "Wearing Off" Motor Fluctuations and "On" Period Dyskinesias
The purpose of this study is to investigate the safety, tolerability and efficacy of E2007 in Parkinson's Disease patients who have "wearing off" motor fluctuations and "on" period dyskenisias.
- Trial name
- NCT01172379
- Testing
- E2007
- Where
- 33 sites in Czechia, France and 4 more
- Volunteers
- 2 people
- Sponsor
- Eisai Limited
Parkinson Disease
Long-term Safety Study of Open-label Pramipexole Extended Release (ER) in Patients With Early Parkinson´s Disease (PD).
The general aim of this study is to obtain long-term safety and tolerability data on pramipexole ER, in daily doses from 0.375mg to 4.5mg once daily (q.d), in patients who have previously completed a pramipexole double-blind…
- Trial name
- NCT00601523
- Testing
- Pramipexole
- Where
- 119 sites in United States, Austria and 13 more
- Volunteers
- 511 people
- Sponsor
- Boehringer Ingelheim
Parkinson Disease
Deep Brain Stimulation Lead Localization After Implantation
Deep brain stimulation (DBS) is an effective treatment for a variety of neurological and psychiatric disorders, with more than 200,000 patients implanted with DBS devices worldwide.
- Trial name
- NCT06196242
- Testing
- MRI and CT scan
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Tsinghua University
Huntington's Disease
HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease
HDClarity will seek at least 2500 research participants at different stages of Huntington's disease (HD). The primary objective is to collect a high quality CSF sample for evaluation of biomarkers and pathways that will enable…
- Trial name
- HDClarity (NCT02855476)
- Where
- 40 sites in United States, Canada and 8 more
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University College, London
Parkinson Disease
Chinese Exercise Modalities in Parkinson's Disease
This study will compare the effects of two Chinese and one Western exercise modalities on the signs and symptoms of Parkinson's disease.
- Trial name
- NCT00029809
- Testing
- Chinese exercise modalities
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Parkinson Disease(PD)
Gait Initiation Difficulty and Anticipatory Postural Adjustment (APA) Impairment in People With PD - Evaluation and Training
Gait initiation (GI) difficulty is common in people with Parkinson's disease (PD). Studies showed that the GI difficulty was related to impaired anticipatory postural adjustments (APA).
- Trial name
- NCT02656355
- Testing
- Weight shift training and APA feedback, Weight shift training without APA feedback
- Where
- Taiwan
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Idiopathic Parkinson's Disease
An Open-Label Extension Trial to Assess the Safety and Tolerability of Long Term Treatment of Rotigotine in Subjects With Idiopathic Parkinson's Disease
The objective of this open-label extension is to assess the safety and tolerability of long-term treatment of rotigotine in subjects with idiopathic PD.
- Trial name
- NCT00505687
- Testing
- Rotigotine
- Where
- 26 sites in United States, Austria and 6 more
- Volunteers
- 186 people
- Sponsor
- UCB Pharma
Parkinson's Disease
Effects of Deep Brain Stimulation in Parkinson's Disease
The purpose of this study is to identify factors predicting good results in patients treated with deep brain stimulation for Parkinson's disease.
- Trial name
- NCT00855621
- Testing
- Deep brain stimulation of the subthalamic nucleus
- Where
- Norway
- Volunteers
- 70 people
- Sponsor
- Oslo University Hospital
Parkinson Disease, Mild Cognitive Impairment
Parkinson's Disease With Mild Cognitive Impairment Treated With Nicotinic Agonist Drug
To test for the first time the potential of a nicotinic agonist on cognitive symptoms in people with mild cognitive impairment (MCI) in Parkinson's disease (PD), referred to as PD-MCI.
- Trial name
- PD-MIND (NCT04810104)
- Testing
- AZD0328
- Sponsor
- King's College London
Parkinson Disease
Nintendo WII and Exercises at Rehabilitation of Individuals With Parkinson's Disease
Patients with Parkinson's disease present motor dysfunctions such as stiffness, tremor, postural instability and bradykinesia, which leads to alterations of balance, necessitating specialized physiotherapeutic treatment.
- Trial name
- NCT03235284
- Testing
- Exercises, Nintendo Wii, Exercises and Nintendo Wii
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Federal University of Bahia
Parkinson Disease, Virtual Reality
Effects of iVR Treadmill on Gait in PD
Parkinson's Disease (PD) patients suffer from gait impairments responsible for falls and bad quality of life: reduced speed and stride length, randomness in stride duration variability (reduced Long-Range Autocorrelations (LRA)).
- Conditions
- Parkinson Disease, Virtual Reality, Gait Disorders, Neurologic, Long Range Autocorrelations
- Trial name
- NCT04019158
- Testing
- Virtual reality headset
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Parkinson Disease
"Parkinson AKTIV - Non-pharmacological Treatments in an Innovative Parkinson's Network"
The purpose of this study is to evaluate the efficacy of an online platform that allows neurologists and therapists to exchange therapy recommendations, communicate assessments and plan physical therapy, occupational therapy as…
- Trial name
- ParkinsonAKTIV (NCT05251298)
- Testing
- Coordination through the online platform "JamesAKTIV"
- Where
- Germany
- Volunteers
- 370 people
- Sponsor
- University Hospital Muenster
Parkinson Disease
Factors Associated with Falling in Parkinson's Disease
The objective of this study will be to identify multidisciplinary fall risk factors in persons with stage 3 idiopathic Parkinson's Disease compared to age and sex-matched healthy adults.
- Trial name
- NCT04440033
- Testing
- Baseline assessment of demographic, anthropometric and clinical characteristics, Locomotor assessments, Speech assessments
- Where
- 2 sites in Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Parkinson's Disease
Multi-centre UK Study of the Acetylcholinesterase Inhibitor Donepezil in Early Dementia Associated With Parkinson's Disease
To demonstrate the superiority of donepezil over placebo in improving cognitive function, neuropsychiatric burden and functional ability in people with Parkinson's disease and mild dementia after 24 months of treatment.
- Trial name
- MUSTARDD-PD (NCT01014858)
- Testing
- Donepezil
- Where
- 22 sites in United Kingdom
- Volunteers
- 64 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Parkinson Disease
Flexible-Dose, Adjunctive Therapy Trial in Adults With Parkinson's Disease With Motor Fluctuations (TEMPO-3)
The purpose of this study is to assess the effect of tavapadon on the change from baseline in total daily hours of "on" time without troublesome dyskinesia in L-Dopa-treated participants with Parkinson's Disease (PD) who are…
- Trial name
- NCT04542499
- Testing
- Tavapadon
- Where
- 146 sites in United States, Australia and 12 more
- Volunteers
- 507 people
- Sponsor
- AbbVie
Parkinson's Disease
DBS Under General Anesthesia: Comparison To The Standard Technique
There is a growing trend in functional neurosurgery toward direct anatomical targeting for deep brain stimulation (DBS). This study describes a method and reports the initial experience placing DBS electrodes under general…
- Trial name
- NCT01997398
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
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