Clinical trials: Movement Disorder
Parkinson Disease, LRRK2
LRRK2, GBA and Other Genetic Biomarkers in Eastern European (Ashkenazi) Jews With and Without Parkinson's Disease
Single site observational study focused on elucidating the genes and biochemical pathways involved in causing Parkinson disease.
- Conditions
- Parkinson Disease, LRRK2, GBA Gene Mutation
- Trial name
- BioPD (NCT04668898)
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Parkinson Disease
The Effects of Auditory Cues on Gait Mechanics in Parkinson's Disease
The purpose of this study is to determine how using auditory cues of a metronome and music at various frequencies impacts the gait mechanics in people with Parkinson's disease when walking over ground and on a treadmill.
- Trial name
- NCT03253965
- Testing
- Metronome Normal, Metronome Slow, Metronome Fast
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Low Back Pain, Kinesiophobia (Fear of Movement)
Feasibility of an Augmented Reality Novel Approach for the Rehabilitation of Chronic Low Back Pain Patients With Kinesiophobia
The goal of this clinical trial is to evaluate the feasibility, safety, and initial effectiveness of a new augmented reality (AR) system in adults over 18 years old suffering from chronic low back pain and kinesiophobia (fear of…
- Conditions
- Low Back Pain, Kinesiophobia (Fear of Movement), Healty Volunteers
- Trial name
- NCT07527845
- Testing
- Augmented Reality (AR) Rehabilitation System
- Where
- Chile
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Parkinson Disease, Neurodegenerative Diseases
Role of Saffron and Chamomile in the Management of Parkinson's Disease
In multitudinous preclinical studies, Saffron and Chamomile are found effective in treating PD. They can mitigate the neurodegenerative progression of the disease by curtailing dopaminergic and neuronal loss and by inhibiting…
- Trial name
- SAFCHEMRxPar (NCT05696665)
- Testing
- conventional therapy, Saffron and Chamomile, Crocin and Apigenin
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Jinnah Postgraduate Medical Centre
Parkinson Disease, PD
Genetic Characterization of Parkinson's Disease
This study will explore the risks and causes of Parkinson's disease, a chronic progressive nervous system disorder. Patients typically have tremors, muscle weakness and a shuffling gait.
- Conditions
- Parkinson Disease, PD, Movement Disorder, Healthy Volunteer
- Trial name
- NCT00105131
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Progressive Supranuclear Palsy, Alzheimer Disease
Evaluation of [18F]MNI-952 as a Potential PET Radioligand for Imaging Tau Protein in the Brain
The overall goal of this imaging trial is to evaluate [18F]MNI-952 (also known as [18F]UCB-K), a tau targeted PET radioligand.
- Conditions
- Progressive Supranuclear Palsy, Alzheimer Disease, Healthy Volunteers
- Trial name
- NCT03080051
- Testing
- [18F]MNI-952, [18F]Florbetapir
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Molecular NeuroImaging
Parkinson Disease, Parkinson
Digital BIOmarkers for the Assessment of Motor Status in Parkinson's Disease Patients with CLInical and ThErapeutic Application
The goal of this observational study is to define digital biomarkers of motor symptoms in Parkinson's disease patients using wearable devices.
- Trial name
- BIOCLITE (NCT06817772)
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Politecnica de Madrid
Parkinson's Disease (PD)
The Effect of BIA 9-1067 at Steady-state on the Levodopa Pharmacokinetics
The purpose of this study is to determine the effect of repeated dosing of once-daily 25, 50 and 75 mg opicapone (OPC, development code BIA 9-1067) on the levodopa pharmacokinetics (PK), in comparison to placebo and 200 mg…
- Trial name
- NCT02170376
- Testing
- BIA 9-1067, Entacapone, Levodopa/carbidopa
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Pregnancy Complications, Placental Insufficiency
PREdelivery Placental Biomarkers- Pregnancy and Delivery Outcome
The PREPPeD study proposes that predelivery placenta-derived maternal circulating biomarkers reflect placental health, capacity and ageing, and can help predict onset and complications of delivery both in complicated pregnancies…
- Trial name
- PREPPeD (NCT03100084)
- Testing
- Blood sampling
- Where
- Norway
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Schizophrenia and Schizoaffective Disorder
Effects of RAS in SZ
The two main groups of medicated patients with schizophrenia (SZ) are those receiving second-generation antipsychotics and those receiving first-generation antipsychotics.
- Trial name
- NCT07086040
- Testing
- RAS incorporated in upper-limb movement training, Upper-limb movement training
- Where
- Taiwan
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Shu-Mei Wang
Parkinson's Disease (PD), Parkinson's Disease
Open-label Study to Evaluate Brain α-Synuclein Deposition Using PET and [18F]MK-0947 in Parkinson's Disease
This clinical study is being conducted to learn more about a new imaging drug called [18F]MK-0947, which is designed to help doctors see changes in the brain related to Parkinson's disease (PD).
- Conditions
- Parkinson's Disease (PD), Parkinson's Disease, Parkinson's Disease (Disorder)
- Trial name
- NCT07348250
- Testing
- [18F]MK-0947
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Invicro
Movement Disorder, Healthy
Study of Brain Control of Movement
This study will use transcranial magnetic stimulation to examine how the brain controls movement by sending messages to the spinal cord and muscles and what goes wrong with this process in disease.
- Trial name
- NCT00017979
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy, Schizophrenia
Neuroimaging of Dopamine Metabolism in Normal and Psychiatric Patients
Brain cells communicate with each other by releasing chemicals called neurotransmitters. In order for brain cells to transfer information, one cell will release a neurotransmitter that will be recognized by a receptor located on…
- Trial name
- NCT00001320
- Where
- United States
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Bone Loss, Tooth Movement
The Introduction of a Novel PAOO Technique
The aim of this study is to evaluate in a prospective, randomized, controlled clinical trail the effectiveness of preorthodontic piezotomy combined with a buccal bone augmentation (in other name periodontlly accelerated…
- Trial name
- NCT05264480
- Testing
- Bone augmentation with minimally invasive corticotomy (piezotomy), Bone augmentation without corticotomy
- Where
- Hungary
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
PARKINSON DISEASE (Disorder), Aged 65 Years or Older
Multidimensional Assessment of Fatigability in Older Adults Living in Southern Switzerland and Elderly With Parkinson's Disease
With our study, the investigators aim to assess the impact of the fatigue experienced during daily life activities (tiredness) and whether there is a relationship with muscle fatigue during an exercise task.
- Trial name
- LifeLike (NCT07485218)
- Where
- 5 sites in Italy, Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences and Arts of Southern Switzerland
Angelman Syndrome
Study on the Brain Network of Angelman Syndrome
The aims of study on Angelman syndrome: 1. Establish the Angelman syndrome database 2. Explore the brain Network of Angelman Syndrome Based on Multi-modal Brain Image and Neural-EEG Data
- Trial name
- NCT03358823
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fudan University
Huntington Disease, Alzheimer Disease
A Phase 1 Study To Evaluate The Effect Of Dimebon On The Pharmacokinetics Of Dextromethorphan
This drug-drug interaction study is being conducted to evaluate the potential effect of Dimebon on the pharmacokinetics on dextromethorphan, a probe substrate of the cytochrome P450 2D6 (CYP2D6) enzyme, after multiple dose…
- Trial name
- NCT00788047
- Testing
- Dextromethorphan, Dimebon + Dextromethorphan
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Pfizer
Neurodegenerative Diseases, Parkinson Disease
Molecular Imaging of Inflammation in Parkinson's Disease Using LPS and TSPO-PET/MR
It is not known what causes Parkinson's disease and what makes it worsen over time. Research conducted in the past few years has highlighted the possible role of inflammation on this process but its actual mechanisms are still…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, REM Sleep Behavior Disorder (iRBD)
- Trial name
- NCT05205291
- Testing
- Lipopolysaccharide, PET/MR with [11C]PBR28
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Alzheimer Disease, Depression
Eye Movement Recording as an Early Differential Diagnostic Tool for Alzheimer/Depression
The global aim of our study is to validate eye movement recording as an early differential diagnostic tool, in order to discriminate as early as possible between neurodegenerative dementias of Alzheimer type and depressive…
- Trial name
- MOMAD (NCT01434940)
- Testing
- Eye movements will be recorded using video-oculography techniques based on both the corneal reflection principle and an infra-red light beam
- Where
- France
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
PARKINSON DISEASE (Disorder)
Oculomotor-Pupillary AI Biomarkers in Parkinson's
The goal of this prospective observational study is to investigate whether oculomotor-pupillary abnormalities detected using a novel edge-AI eye-tracking device can serve as objective and quantitative biomarkers for the early…
- Trial name
- NCT07886450
- Testing
- Edge-AI Eye-Tracking Assessment
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.