Clinical trials: Movement Disorder
Parkinson's Disease
Pharmacokinetic Study in Healthy Volunteers
Phase I open, randomized cross-over pharmacokinetic study.
- Trial name
- NOCOFPK2 (NCT02554734)
- Testing
- levodopa, carbidopa, ODM-104, levodopa, carbidopa, entacapone
- Where
- Finland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Orion Corporation, Orion Pharma
Cerebral Palsy
Investigating New Methods to Study Movement in Children and Young Adults With Movement Disorders.
Background: Cerebral palsy (CP) is the most common motor disorder that affects children. People with CP have weak muscles; they may have trouble controlling the movements of their arms and legs.
- Trial name
- NCT06498596
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Cardiovascular Diseases, Non-Alcoholic Fatty Liver Disease
Smart Watch Insights for Prevention of Exacerbations and Enhance Rehabilitation - Movement Study
Aims of the study: 1. To deliver a scalable wellbeing programme to the local population of Imperial College Healthcare NHS Trust, focusing on movement. 2.
- Conditions
- Cardiovascular Diseases, Non-Alcoholic Fatty Liver Disease, Respiratory Disease, Diabetes
- Trial name
- SWIPER-MOVES (NCT06011356)
- Testing
- Smartwatch
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Parkinson Disease
Effect of Doxycycline in Levodopa Treated Parkinson's Disease Patients
This study is a Randomized, Double-Blind, Placebo-Controlled Trial. The objective of the study is to assess the effect of doxycycline in levodopa treated Parkinson's disease patients regarding motor performance and cognitive…
- Trial name
- NCT05492019
- Testing
- Doxycycline
- Where
- Bangladesh
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Parkinson's Disease
Cognitive Control in Parkinson's Disease
Cognitive action control allows resisting to irrelevant information to easily produce desired goal-directed behaviors. This cognitive process is disturbed in patients with Parkinson's disease (PD).
- Trial name
- EEGControl (NCT03981913)
- Testing
- Simon Task with high-density EEG recording
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Parkinson Disease
In-Home Care for Patients With Parkinson's Disease
Advanced Parkinson's Disease is a debilitating, costly, and understudied condition. Improving access to comprehensive, specialized, in-home patient care and caregiver support offers the potential to minimize the downward spiral…
- Trial name
- NCT03189459
- Testing
- Home Visit Program, Caregiver Mentorship Program
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
OBESITY, HYPERTENSION
The Autonomic Nervous System and Obesity
In its simplest terms, obesity is the results of a positive balance between food intake and energy expenditure (EE). I.e., we take in more energy, in the form of food, than we expend, e.g., by exercise.
- Conditions
- OBESITY, HYPERTENSION, PURE AUTONOMIC FAILURE, SHY-DRAGER SYNDROME
- Trial name
- NCT00179023
- Testing
- Trimethaphan, Pseudoephedrine
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Parkinson Disease, Upper Extremity Dysfunction
Leap Motion Controller on the Functionality of Upper Limbs in Parkinson's Disease
Is treatment with the Leap Motion Controller device effective for upper limb functionality in individuals with Parkinson's Disease? The present study presents two hypotheses: True hypothesis: There is an improvement in the…
- Conditions
- Parkinson Disease, Upper Extremity Dysfunction, Therapy-Related MDS
- Trial name
- NCT04796246
- Testing
- Leap Motion Controller, Conventional Physiotherapy
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre
Lumbar Spine Surgery, Lumbar Disc Herniation
The Effect of Mobilization Protocol Assisted With Simulated Clinical Immersion Videos on Patients Undergoing Lumbar Spine Surgery
This study focused on examining the effect of mobilization protocol assisted with simulated clinical immersion videos on postoperative pain, fear of movement, mobility level and satisfaction in patients undergoing lumbar spine…
- Trial name
- NCT05462210
- Testing
- Mobilization Protocol Assisted with Simulated Clinical Immersion Videos
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Tourette Syndrome
Exploration of Glutamatergic System With PET Radiotracer in Gilles de la Tourette Patients: Pilot Study (GlutaTour)
Gilles de la Tourette syndrome is a neuropsychiatric disorder characterized by motor and vocal tics often associated with psychiatric comorbidities (obsessive compulsive disorder, anxiety and depressive syndrome, impulsivity).
- Trial name
- GlutaTour (NCT03681795)
- Testing
- Experimental MRI exam and PET scan exam with radiotracer
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Healthy Volunteers
A Study to Assess the Safety, Tolerability and PK of NPT520-34 in Healthy Subjects
To evaluate the PK, safety and tolerability of orally administered NPT520-34 in healthy subjects at single and multiple doses that may be therapeutically relevant.
- Trial name
- NCT03954600
- Testing
- NPT520-34 (125 mg)
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Neuropore Therapies Inc.
Parkinson's Disease
Study of Subcutaneous Continuous Administration of Levodopa/Carbidopa Solution (ND0612) in Healthy Volunteers
It will be a single dose, single-center, randomized, double-blind, placebo-controlled dose escalation study of SC continuously-delivered LD/CD solution (ND-0612) for 24 hours in healthy volunteers. Objectives are to determine: 1.
- Trial name
- NCT01486628
- Testing
- ND0612
- Where
- Israel
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- NeuroDerm Ltd.
Malocclusion
Comparison of the Quantity of Distal Movement of the Upper Canine and Molar
THE PURPOSE OF THE STUDY IS COMPARE THE QUANTITY OF DISTAL MOVEMENT OF THE UPPER CANINE AND MOLAR USING CLASS II ELASTICS WITH AND WITHOUT SLIDING JIG IN A PERIOD OF 3 MONTHS
- Trial name
- NCT01654419
- Testing
- Class II elastics and Sliding Jig, Class II elastic alone
- Where
- Colombia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Osteopathy, PreTerm Neonate
The Effect of Cranial Osteopathy Intervention in Preterm Babies
There are planing to have 2 groups of premature born cases. Each group will include 15 cases. Participants are need to be 28-37 weeks born and no older than post term 6 weeks. All cases are going to be evaluated.
- Conditions
- Osteopathy, PreTerm Neonate, Sensory Profiles, Colic
- Trial name
- NCT06967870
- Testing
- Osteopathic intervention, Home based exercise education
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Alzheimer's Disease, Mild Cognitive Impairment
BEAM: Brain-Eye Amyloid Memory Study
The main objectives for this study are: 1. To investigate novel, non-invasive ocular measurements including optical coherence tomography and eye tracking in a cross-sectional study of participants with various neurodegenerative…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Vascular Cognitive Impairment, Parkinson's Disease
- Trial name
- BEAM (NCT02524405)
- Testing
- Pittsburgh Compound B [11C]-PIB
- Where
- 5 sites in Canada
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Dystonic Disorder, Healthy
Transcranial Magnetic Stimulation (TMS) Studies of Dystonia
This study will use transcranial magnetic stimulation to examine how the brain controls muscle movement in focal and generalized types of dystonia.
- Trial name
- NCT00017875
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Neonatal Disease, Parenting
Neonatal Neurobehavioral And Motor Behavior In Ultra Early Physical Therapy Intervention
Investigation of the combination of neonatal neurobehaviourism and motor behavior in the assessment and ultra-early physical therapy intervention of premature neonates and parental support.
- Conditions
- Neonatal Disease, Parenting, Premature Birth
- Trial name
- NCT05565287
- Testing
- ultra early physiotherapy intervention
- Where
- 3 sites in Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Parkinson's Disease, Dementia
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
Background: About 5 million adults in the U.S. have Alzheimer s disease or another adult-onset neurodegenerative disorder. Many studies have found that inflammation in the brain contributes to these diseases.
- Conditions
- Parkinson's Disease, Dementia, Alzheimer's Disease, ALS
- Trial name
- NCT04396873
- Testing
- 11C-MC1, 11C-PS13, 18f-florbetaben
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Parkinson Disease
Randomized Study of the Effects of Glucose on Cognition in Healthy Young and Elderly People and Parkinson's Disease Patients
This study will determine whether glucose facilitates memory in healthy elderly people and those with Parkinson's disease.
- Trial name
- NCT00004451
- Testing
- Glucose
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Parkinson's Disease, Freezing of Gait
The Electrophysiological Investigation of Higher Level Neural Manifestations of Freezing of Gait in Parkinson's Disease Patient
We aim to investigate the higher level mechanism of gait disorders in PD patients by ambulatory recording of electroencephalographic (EEG) and leg electromyographic (EMG) signals during unconstrained walking.
- Trial name
- NCT02214251
- Testing
- PK-16CH EXG system
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
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