Clinical trials: Movement Disorder
Alzheimer Disease, Dementia
TapTalkTest Project:Development of a Non-invasive Screening Test to Detect Risk of Alzheimer's Disease Pathology
This project aims to produce a solution for the rising incidence of dementia. This is particularly pertinent in Tasmania, Australia, with a rapidly ageing population and the oldest demographics of all Australian states.
- Conditions
- Alzheimer Disease, Dementia, Movement Abnormalities, Speech Disorders
- Trial name
- TapTalkTest (NCT06114914)
- Testing
- Tap Talk online program
- Where
- Australia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Tasmania
Parkinson Disease
A Study of Neurofeedback for the Treatment of Parkinson's Disease
This study aims to reveal relationship between brain activities and the symptoms of Parkinson disease when a neurofeedback training was applied for them.
- Trial name
- NCT03837548
- Testing
- Training with Neurofeedback, The other Training with Neurofeedback
- Where
- Japan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Osaka University
Parkinson Disease
The Optimisation of Parkinson's Project
This project aims to gain a deep understanding of the available lay/professional community resources and systems of support for people with, and family carers of people with Parkinson's Disease (PD), healthcare professionals and…
- Trial name
- OPTIMPARK1 (NCT04125485)
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Parkinson's Disease (At-risk Cases)
MOVIN' CARE for PD (Risk Management)
The goal of this intervention study is to investigate the effectiveness of three preventive interventions - yoga, arts-based approaches, and somatic practices, with reference to an active control group - traditional exercises, in…
- Trial name
- jcpdmcP (NCT06147284)
- Testing
- Preventive interventions
- Where
- Hong Kong
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Parkinson Disease
Perception, Cognition, and Gait in Parkinson's Disease
The investigators are examining how aspects of daily function are perceived in persons with PD and in those who interact with them on a regular basis.
- Trial name
- NCT03241966
- Where
- United States
- Volunteers
- 439 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Parkinson Disease
Role of Nasal Dysbiosis in Parkinson Disease
Olfactory dysfunction is frequent in Parkinson Disease (PD) and may be present years before the motor symptoms appear. The early olfactory dysfunction could result from environmental factors acting through the nasal cavity such…
- Trial name
- SMELLPARK (NCT04249245)
- Testing
- Nasal Swab
- Where
- 2 sites in France, Guadeloupe
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Disorder of Consciousness, Consciousness, Loss of
SeeMe: An Automated Tool to Detect Early Recovery After Brain Injury
Early prediction of outcomes after acute brain injury (ABI) remains a major unsolved problem. Presently, physicians make predictions using clinical examination, traditional scoring systems, and statistical models.
- Conditions
- Disorder of Consciousness, Consciousness, Loss of, Trauma, Brain, Traumatic Brain Injury
- Trial name
- NCT06083441
- Testing
- SeeMe, Coma Recovery Scale-Revised (CRS-R)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Cardiovascular Diseases, Non-Alcoholic Fatty Liver Disease
Smart Watch Insights for Prevention of Exacerbations and Enhance Rehabilitation - Movement Study
Aims of the study: 1. To deliver a scalable wellbeing programme to the local population of Imperial College Healthcare NHS Trust, focusing on movement. 2.
- Conditions
- Cardiovascular Diseases, Non-Alcoholic Fatty Liver Disease, Respiratory Disease, Diabetes
- Trial name
- SWIPER-MOVES (NCT06011356)
- Testing
- Smartwatch
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Essential Tremor
Acamprosate and Methazolamide for Essential Tremor
This is an investigator initiated study is designed to evaluate the anti-tremor benefits of two marketed medications, methazolamide and acamprosate in subjects with a diagnosis of essential tremor (ET).
- Trial name
- NCT06312800
- Testing
- Acamprosate, Methazolamide
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Hip; Anomaly
Examining the Effects of a Mobilization With Movement and a Dynamic Stretch With Over Pressure on Hip Flexion.
The purpose of this study is to compare the effects of a mobilization with movement (MWM) technique performed by a physical therapist with those of a dynamic stretch with over pressure on active hip flexion range of motion (ROM)…
- Trial name
- NCT04762212
- Testing
- Mobilization with movement and stretching, stretching or control
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Parkinson Disease, Prodromal Stage
Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity
α-Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are the second most common neurodegenerative diseases.
- Conditions
- Parkinson Disease, Prodromal Stage, Neurodegenerative Diseases, Basal Ganglia Diseases
- Trial name
- ALPHA-FIT (NCT07324330)
- Testing
- Increase of physical activity volume and intensity with the use of a motivational smartphone application
- Where
- Germany
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Stroke, Motor Activity
Gait Mate: Examining Neural Networks Engaged During Lower Extremity Movement in the MRI
Less than 50% of stroke survivors progress to independent community ambulation. Even among the stroke survivors who achieve independent ambulation, significant residual deficits persist in balance and gait speed, with 60% of…
- Trial name
- NCT03604367
- Testing
- GAITRite assessment
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Stellate Ganglion, Parkinson Disease
Clinical Study of Stellate Ganglion Block in Treatment of Patients With Advanced Primary Parkinson's Disease
At present, there are no reports on the application of stellate ganglion block in the treatment of Parkinson's disease patients at home and abroad.
- Trial name
- NCT06112392
- Testing
- Treatment （Stellate ganglion block；Oral standard anti-Parkinson's drugs）, Treatment （Oral standard anti-Parkinson's drugs）
- Where
- China
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Dental Research, Orthodontics
Treatment of the Mandibular Dental Crowding With and Without Corticotomy Surgery
The use of corticotomy surgery in addition to orthodontic standard treatment could accelerate the treatment. Corticotomy involves vertical interdental incisions of the gingiva and the bone with a very low thickness.
- Conditions
- Dental Research, Orthodontics, Surgery, Oral, Maxillofacial Surgery
- Trial name
- CORTICO (NCT03967002)
- Testing
- Test group with corticotomy surgery
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ardentis Cliniques Dentaires
Parkinson's Disease
Cholinergic Mechanisms of Gait Dysfunction in Parkinson's Disease Experiments 1 & 2 - Proj #3
Varying oral doses of Varenicline (VCN), starting with very low doses, will be administered to participants with Parkinson's Disease (PD) or healthy controls without PD for several days.
- Trial name
- UdallP3 (NCT02933372)
- Testing
- Varenicline
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Healthy Volunteer, Alzheimer Disease
Evaluation of [18F]PI-2620 as a Potential Positron Emission Computed Tomography Radioligand for Imaging Tau Protein in the Brain
The overall goal of this imaging trial is to evaluate [18F]PI-2620, a tau targeted positron emission computed tomography radioligand, in individuals with tauopathies and healthy volunteers (HV).
- Conditions
- Healthy Volunteer, Alzheimer Disease, Frontotemporal Dementia, Parkinson Disease
- Trial name
- NCT03510572
- Testing
- [18F]PI-2620
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Parkinson Disease, GBA Gene Mutation
Evaluation of the Frequency and Severity of Sleep Abnormalities in Patients With Parkinson's Disease
Sleep disturbances are one of the most common non-motor symptoms in PD, with an estimated prevalence as high as 40-90%. Sleep disturbances (particularly sleep duration, sleep fragmentation, Rapid Eye Movement (REM) sleep behavior…
- Conditions
- Parkinson Disease, GBA Gene Mutation, Leucine-rich Repeat Kinase 2 (LRRK2) Gene Mutation
- Trial name
- NCT04387812
- Testing
- Xtrodes home PSG system
- Where
- Israel
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Stroke, Rehabilitation
Rhythmic-Based Training with Immersive Mirror Visual Feedback for Neuro-Rehabilitation
In the proposed study, the investigators assumed that rhythmic-based training with immersive mirror visual feedback will provide a better treatment effects than traditional mirror therapy for the patients with unilateral stroke.
- Conditions
- Stroke, Rehabilitation, Virtual Reality, Mirror Movement Therapy
- Trial name
- NCT06056219
- Testing
- Mirror therapy, Virtual reality-based mirror therapy with rhythmic skill training, Task-oriented training
- Where
- Taiwan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Parkinson's Disease
Single Ascending Dose Study of MEDI1341 in Healthy Volunteers
This is a study of single ascending intravenous doses of MEDI1341 or placebo in up to 48 healthy volunteers, aged 18 to 65 years. The study will include up to 6 planned cohorts; each cohort will comprise 8 participants.
- Trial name
- NCT03272165
- Testing
- MEDI1341
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Catabolic State, Burns
Illusory Movements in Patients With Burns
Background. Large burns are the cause of extensive skeletal muscle devastation. The possibilities of rehabilitation of such patients are very limited, which contributes to the risk of metabolic failure and long-term…
- Conditions
- Catabolic State, Burns, Illusions, Kinesthetic
- Trial name
- Immobile (NCT04467619)
- Testing
- Functional Proprioceptive Stimulation
- Where
- Czechia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
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