Clinical trials: Movement Disorder
Alpha Synuclein Pathology, Alpha-Synuclein
Alpha-Synuclein PET/CT in Various α-Syn-Related Disease
To evaluate the potential usefulness of 18F-FIAT-2, 18F-C05-05, 18F-SPAL-T-06 positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various α-Syn-related disease patients.
- Conditions
- Alpha Synuclein Pathology, Alpha-Synuclein, Parkinson Disease
- Trial name
- NCT06949670
- Testing
- 18F-FIAT-2, 18F-C05-05, 18F-SPAL-T-06
- Where
- 3 sites in China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University
Parkinson's Disease, MRI
Nucleipark:High Field MR Imaging (7T and 3T) of the Brainstem, the Deep Nuclei and Their Connections in the Parkinsonian Syndromes. Applications to Prognosis, Pathophysiology and Improvement of Therapeutic Strategies
To date except for the larger striato-pallidal complex, there are no reliable imaging markers of small deep nuclei. Major improvement of the spatial resolution resulting from the use of ultra-high field MRI systems offers new…
- Trial name
- Nucleipark (NCT01085253)
- Testing
- 3T and 7T MR imaging
- Where
- France
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Vestibular Disease, Vestibular Function Disorder
Show Me How You Move and I Will Tell You Who You Are
The aim of this experiment is to gain a better understanding of the body movement patterns of patients with balance disorders (following damage to the vestibular system), as well as their cognitive performance profile.
- Trial name
- NCT06739577
- Testing
- Evaluation of walking abilities (manual Timed-Up & Go - TUG and automatic -OpenTUG)), Neuropsychological assesment is provide to measure objective and subjective cognition/emotional aspects.
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Parkinson Disease (PD), Healthy (Controls)
Clinical Validity of the DANU Sports System for Gait and Balance Assessment in Parkinson's Disease
This observational study aims to explore the use of the DANU Smart Socks for gait and balance assessment in people with Parkinson's (PwP).
- Trial name
- NCT07281794
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Occupational Injuries, Heat Stress
Effect of Rapid Heat Stress on Firefighters Musculoskeletal Injury Risk
This study will examine the effect of heat stress on factors that influence musculoskeletal injury risk in firefighters. Participants will attend 4 data collection sessions. 1: informed consent, screening, and familiarization.
- Conditions
- Occupational Injuries, Heat Stress, Leg Injury, Back Injuries
- Trial name
- NCT06442956
- Testing
- Rapid Heat Condition, Gradual Heat Condition
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
PARKINSON DISEASE (Disorder)
Integrated Digital and Neurogenic Exosome Biomarkers for Early Diagnosis of Parkinson's Disease: Development and Application
Based on the high-quality Parkinson's disease cohort population and biological sample database in the early stage of the team, multi-dimensional intelligent wearable device technology and machine learning were used to screen and…
- Trial name
- NCT07679256
- Where
- China
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Essential Tremor
Functional Outcomes of Awake vs. Asleep Deep Brain Stimulation (DBS) for Essential Tremor
Recently, there has been increasing interest in performing DBS under general anesthesia, where the stimulated targets are located anatomically (i.e.
- Trial name
- NCT02418858
- Testing
- Deep Brain Stimulation surgery
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Huntington Disease
Dosimetry of [11C]CHDI-180R and [11C]CHDI-626.
A better understanding of the HD pathogenesis mechanisms may lead to a better understanding of disease pathology, progression and development of targeted therapies.
- Trial name
- NCT05224115
- Testing
- [11C]CHDI-00485180-R, [11C]CHDI-00485626
- Where
- Belgium
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Amyotrophic Lateral Sclerosis, Alzheimer's Disease
Advances in Telephone-based Cognitive Screening Procedures
1. Background Cognitive screening procedures via performance-based tests represent an essential, albeit preliminary, element within the diagnostic and interventional process as addressed to patients with chronic neurological…
- Conditions
- Amyotrophic Lateral Sclerosis, Alzheimer's Disease, Lewy Body Dementia, Frontotemporal Degeneration
- Trial name
- TBCS (NCT06337578)
- Testing
- Telephone-based neuropsychological assessment - ALS, Telephone-based neuropsychological assessment - AD, LBD, FTD and CVD, Telephone-based and in-person cognitive screening - NIs
- Where
- Italy
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Amyotrophic Lateral Sclerosis, Parkinson Disease
A Systematic Investigation of Phonetic Complexity Effects on Articulatory Motor Performance in Progressive Dysarthria
The goal is to improve the fundamental knowledge about articulatory motor performance in people with Lou Gehrig's disease (also known as ALS) and Parkinson's disease (PD), in order to develop more sensitive assessments for…
- Trial name
- NCT03613038
- Testing
- Phonetic complexity effects on speech motor performance
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Parkinson Disease, REM Sleep Behavior Disorder
Detecting Parkinson's Disease Through Speech Analysis
Speech is an important indicator of motor function and movement coordination and can be extremely sensitive to involvement in the course of neurologic diseases.
- Trial name
- NCT03133611
- Testing
- Speech assessment, Routine clinical assessment
- Where
- 7 sites in United States, Austria and 5 more
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
Healthy Volunteers, Spinal Cord Injury Cervical
Evaluating Neuromuscular Stimulation for Restoring Hand Movements
The specific aim of this study is to evoke functional movement in the hand of both healthy individuals and individuals diagnosed with a stable cervical spinal cord injury with non-functional movement of the fingers.
- Conditions
- Healthy Volunteers, Spinal Cord Injury Cervical, Physical and Rehabilitation Medicine
- Trial name
- NCT03385005
- Testing
- Participants will receive neuromuscular electrical stimulation via an investigational (not FDA approved) neuromuscular stimulator.
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Parkinson's Disease
Motor Skill Learning in People With Parkinson's Disease
This study will compare brain changes in people with Parkinson's disease with those of normal control subjects while they learn motor skills.
- Trial name
- NCT00396942
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease, Gaucher Disease
Drug Discovery for Parkinson's With Mutations in the GBA Gene
The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to accelerate Parkinson's disease research and drug development by using cells from the body (such as skin or blood cells) to make stem…
- Conditions
- Parkinson Disease, Gaucher Disease, Healthy, GBA Gene Mutation
- Trial name
- NCT05536388
- Testing
- Biological Sample Collection
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- New York Stem Cell Foundation Research Institute
Healthy, Parkinson Disease
Lu AF82422 in Healthy Non-Japanese and Japanese Subjects and in Patients With Parkinson's Disease
The purpose of this study is to investigate the safety of a single dose of Lu AF82422, how well it is tolerated, how the drug effects the body and what the body does to the drug in healthy non-Japanese and Japanese subjects and…
- Trial name
- NCT03611569
- Testing
- Lu AF82422
- Where
- 4 sites in United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Dementia, Neurodegenerative Diseases
Retinal Hyperspectral Imaging in Neurodegenerative Diseases
Hyperspectral retinal imaging is a non-invasive imaging modality in which a series of images of the retina are captured using light of different wavelengths.
- Conditions
- Dementia, Neurodegenerative Diseases, Alzheimer Disease, Parkinson Disease
- Trial name
- NCT07545473
- Testing
- Hyperspectral camera
- Where
- Australia
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- Center for Eye Research Australia
Premature Birth, Cerebral Palsy
Neuro-biomechanical Determinants for Motor Behavior in High-risk Infants
This project focuses on motor development, muscle growth and muscle activity. Using advanced, instrumented tests such as , the link between muscles and the movement characteristics will be studied.
- Conditions
- Premature Birth, Cerebral Palsy, Neurodevelopmental Disorders, Brain Injuries
- Trial name
- BAMBI (NCT06111898)
- Testing
- No Intervention
- Where
- Switzerland
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Huntington Disease
Evaluation of Three Tests to Assess Social Cognition in Huntington Disease
The goal of this observational study is to learn about the usefulness of a test of social functioning in persons with Huntington disease.
- Trial name
- NCT07253038
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Region Skane
Parkinson Disease, Articular Cartilage Disorder
Femoral Cartilage Thickness in Parkinson's Disease
Parkinson's Disease (PD) is a chronic, progressive, degenerative movement disorder characterized by motor and non-motor findings, and the incidence increases with age.There are different methods for the evaluation of articular…
- Conditions
- Parkinson Disease, Articular Cartilage Disorder, Ultrasonography
- Trial name
- NCT05424848
- Testing
- Ultasonographic measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Healthy
Use of Real-Time Functional Magnetic Resonance Imaging Neurofeedback to Improve Motor Function in Cerebellar Ataxia
This project will study the feasibility of motor rehabilitation in people with cerebellar ataxia using real-time functional magnetic resonance imaging neurofeedback (rt-fMRI NF) in conjunction with motor imagery.
- Trial name
- fMRI (NCT05436249)
- Testing
- Neurofeedback treatment, At-home therapy
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
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