Clinical trials: Movement Disorder
Subluxation
Simulated vs Genuine Manual Chiropractic Adjustments
Our primary aim with this trial is to measure participant blinding following two simulated/sham or genuine/real high velocity, low amplitude (HVLA) manual chiropractic adjustments to assess if participants are able to identify…
- Trial name
- SHA (NCT06931600)
- Testing
- Chiropractic adjustment
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Life University
Parkinson's Disease
A Long-term, Phase 3 Study of TVP-1012 (1 mg) in Levodopa Treated Parkinson's Disease Participants
The purpose of this study is to evaluate long-term safety of TVP-1012 (1 mg/day) with levodopa in Japanese participants with Parkinson's disease.
- Trial name
- NCT02337764
- Testing
- TVP-1012 1mg
- Where
- 24 sites in Japan
- Volunteers
- 222 people
- Sponsor
- Takeda
Patellofemoral Pain Syndrome
The Movement Control Training Associated With Conventional Physical Therapy is More Effective Than Conventional Physical Therapy Alone in Pain and Functional Performance?
Assess pain, performance function, hip and knee strength and kinematics of trunk and lower limbs during single leg hop test after movement control training associated to hip and knee muscle strengthening.
- Trial name
- MCTACPTMECPTA (NCT02624245)
- Testing
- Conventional Physical Therapy
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- University of Nove de Julho
Parkinson Disease
Motor Learning in Parkinson's Disease: Underlying Effective Connectivity and Influential Factors
Parkinson's disease (PD) is characterized by severe motor symptoms that can only be partially alleviated by medication. It was shown previously that rehabilitation is an important therapeutic supplement for micrographia in early…
- Trial name
- NCT04269577
- Testing
- SSP training
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Parkinson Disease
Post Marketing Surveillance Study of Sifrol® in Patients With Idiopathic Parkinson's Disease
Study to document pramipexole dosing during monotherapy, occurrence of fluctuations and dyskinesias, dose increases after deterioration of Parkinson's disease (PD) symptoms, assessment of the reasons for add-on treatment with…
- Trial name
- NCT02248181
- Testing
- Pramipexole
- Volunteers
- 442 people
- Sponsor
- Boehringer Ingelheim
Parkinson's Disease
Deep Brain Stimulation Effects Study
The purpose of this study is to provide proof-of-concept that the test product can perform as intended in an intra-operative setting and the responses to the test product are perceivable in a person.
- Trial name
- NCT01098565
- Testing
- Study device HFR0001
- Where
- Germany
- Volunteers
- 6 people
- Sponsor
- MedtronicNeuro
Dementia, Alzheimer Disease
Efficacy Study of Kinto Care Coaching for Dementia Family Caregivers
The goal of this clinical trial is to evaluate Kinto's Care Coaching intervention for dementia caregivers. The main questions it aims to answer are: Does the intervention help caregivers to address their general caregiving goals…
- Conditions
- Dementia, Alzheimer Disease, Lewy Body Disease, Vascular Dementia
- Trial name
- NCT05916664
- Testing
- Kinto Care Coaching
- Where
- United States
- Volunteers
- 495 people, healthy volunteers welcome
- Sponsor
- Kinto
Frontotemporal Dementia, Amyotrophic Lateral Sclerosis
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
Background: Neurodegenerative disorders can lead to problems in movement or memory. Some can cause abnormal proteins to build up in brain cells.
- Conditions
- Frontotemporal Dementia, Amyotrophic Lateral Sclerosis, Progressive Supranuclear Palsy
- Trial name
- NCT03225144
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease, Mild Cognitive Impairment
Randomized Clinical Trial of Donepezil for the Treatment of Mild Cognitive Impairment in Parkinson's Disease
Phase II, multi-centric, randomized, double-blinded, placebo-controlled, parallel design clinical trial to evaluate the safety, tolerability and efficacy of Donepezil in patients with Mild Cognitive Impairment in Parkinson's…
- Trial name
- NCT05709301
- Testing
- Donepezil Hydrochloride
- Volunteers
- 120 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Depression, Parkinson's Disease
Efficacy of Psychotherapy for Depressed Parkinson's Disease Patients
The primary aim of this randomized controlled trial is to determine the acute antidepressant efficacy of interpersonal psychotherapy (IPT) in depressed patients with Parkinson's Disease.
- Trial name
- NCT02552836
- Testing
- Interpersonal Psychotherapy, Supportive Psychotherapy
- Where
- 2 sites in Canada
- Volunteers
- 63 people
- Sponsor
- Hopital Montfort
Parkinson's Disease (PD)
Coordinated Reset Deep Brain Stimulation
The study will explore the viability of an alternative/novel programming strategy in Deep Brain Stimulation (DBS) for patients with Parkinson's Disease (PD).
- Trial name
- RESET-DBS (NCT03732898)
- Testing
- Novel Programming (nDBS), Conventional Programming (cDBS)
- Where
- 2 sites in Germany
- Volunteers
- 15 people
- Sponsor
- Boston Scientific Corporation
Knee Osteoarthritis
Evaluation of Mobility in Subjects With Severe Knee Osteoarthritis Who Are to Undergo Total Knee Replacement
Osteoarthritis (OA) is the most common joint disease. It is characterized by a progressive destruction of all the components of the joint, especially the cartilage.
- Trial name
- MOUV-GOPRO (NCT05488093)
- Testing
- X-sens sensor
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Wilson Disease
A Controlled Study of Potential Therapeutic Effect of Oral Zinc in Manifesting Carriers of Wilson Disease
The assumption is that in some of the carriers, the increase in enzymes reflects tissue damage due to excess copper. The reduction of the amount of copper absorbed will decrease excess copper in the liver, which will result in a…
- Trial name
- NCT03659331
- Testing
- Zinc
- Volunteers
- 50 people
- Sponsor
- Prof. Elon Pras
Parkinsonism, REM Sleep Behavior Disorder
A Multimodal Prospective Cohort Study of Parkinsonism
This is a single-center, prospective, observational cohort study designed to investigate the progression and differential diagnosis of Parkinsonism using a multimodal approach.
- Trial name
- NCT07553845
- Where
- China
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Parkinson Disease
A Fixed Dose, Dose Response Study for Ropinirole Prolonged Release in Patients With Early Stage Parkinson's Disease
This study is a fixed dose, dose response study to characterize the dose response for ropinirole PR in early stage PD patients (Hoehn \& Yahr stages I-III).
- Trial name
- TANDEM-662 (NCT01485172)
- Testing
- ropinirole monotherapy
- Where
- 34 sites in United States, Estonia and 3 more
- Volunteers
- 186 people
- Sponsor
- GlaxoSmithKline
Huntington Disease
PHysical Activity and Exercise Outcomes in Huntington's Disease
Huntington's disease (HD) is a genetic, degenerative neurological disease that affects individuals in their third-fourth decade of life and individuals can live 15-20 years with manifest HD.
- Trial name
- PACE-HD (NCT03344601)
- Testing
- physical activity
- Where
- 6 sites in United States, Germany and 1 more
- Volunteers
- 116 people
- Sponsor
- Cardiff University
Parkinson's Disease (PD)
STN-tTIS With Different Intervention Intervals Versus Standard Medical Treatment for Parkinson's Disease
The goal of this clinical trial is to compare the efficacy and safety of different Intervention Intervals of subthalamic nucleus-targeted transcranial temporal interference stimulation (STN-tTIS) in patients with Parkinson…
- Trial name
- NCT07774312
- Testing
- STN-tTIS Once Weekly, STN-tTIS Twice Weekly, STN-tTIS Five Times Weekly
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ruijin Hospital
Parkinson Disease Dementia, Dementia With Lewy Bodies
ATH-1017 Treatment in Subjects With Parkinson's Disease Dementia or Dementia With Lewy Bodies (SHAPE Trial)
This study is designed to evaluate the safety and treatment effects of fosgonimeton (ATH-1017) in subjects with Parkinson's Disease Dementia or Dementia with Lewy Bodies, with a randomized treatment duration of 26 weeks.
- Trial name
- NCT04831281
- Testing
- ATH-1017
- Where
- 10 sites in United States
- Volunteers
- 28 people
- Sponsor
- LeonaBio
Movement Disorders, Neurorehabilitation
Towards Restoring Complex Movement After Paralysis: Algorithm Development With Healthy Participants
Participants will perform experiments with non-invasive activity recordings. The study will record from multiple non-invasive signal sources that reflect motor intent that may include: electroencephalography (EEG)…
- Conditions
- Movement Disorders, Neurorehabilitation, Non-invasive Activity Recording
- Trial name
- NCT07236892
- Testing
- Participants will perform experimental tasks while undergoing non-invasive activity recordings, which may include EEG, EMG, IMUs, fNIRS, eye gaze, or pupillometry.
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Cognitive Impairment
A Stand-alone Therapeutic Music-with-Movement Programme for People With Cognitive Impairment
The number of people living with cognitive impairment is increasing at an exponential rate. More than 100,000 older people are living with dementia in Hong Kong.
- Trial name
- NCT06100536
- Testing
- Music-with-movement
- Where
- Hong Kong
- Volunteers
- 750 people
- Sponsor
- The Hong Kong Polytechnic University