Clinical trials: Movement Disorders, Functional
Rehabilitation, Recovery of Function
Constraint-induced Movement Therapy to Improve Gait and Mobility of People With Chronic Stroke
The purpose of this single-subject, concurrent mixed methods study is to investigate the relationship between the effect of the CIMT protocol on gait and mobility and participants' and caregivers' expectations and perceptions…
- Conditions
- Rehabilitation, Recovery of Function, Stroke, Lower Extremity Paresis
- Trial name
- NCT03114046
- Testing
- Lower extremity Constraint-induced movement therapy(LE-CIMT)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Alabama at Birmingham
Parkinson Disease(PD)
Effects of Dance on the Turning Characteristics of Patients With Parkinson's Disease
The proposed control intervention trial, aims to analyse the effects of Dance in the turning characteristics in patients with Parkinson Disease (PD) using three- dimensional (3D) analysis during the timed up and go (TUG) test.
- Trial name
- NCT05113524
- Testing
- Dance, No intervention
- Where
- 2 sites in Brazil, United Kingdom
- Volunteers
- 15 people
- Sponsor
- Federal University of Rio Grande do Sul
Parkinson Disease, Upper Extremity Dysfunction
Effectiveness of Noninvasive Vagus Stimulation for Upper Extremity in Parkinson's Disease
Vagus nerve stimulation in the treatment of PD is a non-pharmacological intervention with the potential to improve gait, cognition, fatigue, and autonomic functions, but more evidence is needed for VSS in the treatment of PD.
- Conditions
- Parkinson Disease, Upper Extremity Dysfunction, Tremor
- Trial name
- NCT05456451
- Testing
- noninvasive vagus nerve srimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 5 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Overweight, Diabetes
Functional Ingredients: Effect in Gastrointestinal System
The addition of fructans or unripe banana flour to frozen meals can change the hormonal parameters related to hunger and satiety, improve the bowel movements and increase in colonic bacteria population measured by microbiological…
- Conditions
- Overweight, Diabetes, Constipation
- Trial name
- NCT02467972
- Testing
- Ready-to-eat frozen soups added unripe banana flour, Ready-to-eat frozen soups added maltodextrin, Ready-to-eat frozen soups added inulin
- Where
- Brazil
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Parkinson Disease-tremor, Essential Tremor
Mapping Functional Networks of Brain Activity Using EEG in Patients With Essential Tremor or Parkinson Disease Before and After MR-guided Focused Ultrasound Thalamotomy for Tremor
A cornerstone in PD and ET research is the investigation of neurophysiological changes as potential bio-markers that could help in tracking disease progression and response to therapy.
- Trial name
- NCT02692183
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Parkinson Disease, Irritable Bowel Syndrome
Early Signs of Parkinsons Disease in IBS
Bowel symptoms like constipation and abdominal pain are characteristic symptoms of irritable bowel syndrome (IBS). The pathogenesis and pathophysiology are not fully understood but subject to intense research, with emphasis on…
- Trial name
- NCT05573542
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
PARKINSON DISEASE (Disorder), Parkinson Disease (PD)
Cognitive-Based Balance Rehabilitation in Parkinson's Disease: Virtual Reality vs. Dual Task
This prospective, randomized, single-blind, controlled clinical trial aims to evaluate and compare the efficacy of cognitive-based balance rehabilitation delivered via immersive Virtual Reality (VR) versus traditional Dual-Task…
- Conditions
- PARKINSON DISEASE (Disorder), Parkinson Disease (PD), Parkinson s Disease, Postural Instability
- Trial name
- NCT07660978
- Testing
- Dual Task Training (DTT), Virtual Reality Training (VRT)
- Volunteers
- 34 people
- Sponsor
- Bezmialem Vakif University
Parkinson Disease
Effects of Routine Physical Therapy With and Without Proprioceptive Neuromuscular Facilitation on Balance, Gait and Function in Patients With Parkinson's Disease
Objective of this study is to compare the effectiveness of routine physical therapy with and without Proprioceptive Neuromuscular Facilitation on Balance, gait and function in patients with Parkinson's disease.
- Trial name
- NCT05154552
- Testing
- Proprioceptive Neuromuscular Facilitation, Routine physical therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 38 people
- Sponsor
- University of Lahore
Parkinson's Disease
EMD 128130 for the Treatment of Parkinson's Disease
This study will evaluate the effects of an experimental drug called EMD 128130 on Parkinson's disease symptoms and on dyskinesias (involuntary movements) that develop as a result of long-term treatment with levodopa.
- Trial name
- NCT00009048
- Testing
- EMD 128130, IV Levodopa
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Neuromuscular Diseases, Sarcopenia
Soft-robotic Glove Support of High-demand Tasks
The hand is important to perform activities of daily living (ADL). However, many people experience a loss of hand function as result of a traumatic brain injury, spinal cord injury, stroke or orthopedic problems, or due to…
- Trial name
- NCT05318638
- Testing
- Soft robotic glove
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- Roessingh Research and Development
Cerebral Palsy
Mirror Therapy With Sensory Motor Training in Children With CP
The study compares two interventions in CP children: mirror therapy with sensory motor training versus mirror therapy with motor training.
- Trial name
- NCT06292416
- Testing
- Experimental: Mirror therapy with sensory motor training., Experimental: Mirror Therapy with motor training, Experimental: Motor Training
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
Functional Constipation, Gastrointestinal Disease
Efficacy and Safety of Vibrating Capsule in Patients With Functional Constipation
The safety and efficacy of vibrating capsule (VC) in promoting defecation by mechanical stimulation of the gastrointestinal walls have been elucidated in animal studies and pilot clinical studies.
- Conditions
- Functional Constipation, Gastrointestinal Disease, Capsule Endoscopy
- Trial name
- NCT04671264
- Testing
- Sallowing VC during six weeks
- Where
- China
- Volunteers
- 107 people
- Sponsor
- Changhai Hospital
Parkinson Disease
High Frequency and Intensive Prevention Program
The treatment of PD has made considerable advances in recent years with respect to drug therapies, as well as many new physiotherapy and drug-based methods, and there have also been great improvements in therapy thanks to deep…
- Trial name
- NCT04103255
- Testing
- High frequency and intensive prevention program
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Parkinsons Disease (PD)
Neuroimaging of Parkinson's
Parkinson's Disease (PD) is a neurodegenerative disorder caused by dysfunction in both subcortical structures and the cortex. The investigators recently discovered a new brain system called the Somato-Cognitive Action Network…
- Trial name
- NCT07024875
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Huntington Disease
28-Day Study of SAGE-718 on Functioning Capacity in Participants With Huntington's Disease
The primary purpose of this study is to assess the magnitude of the baseline difference between participants with early Huntington's Disease (HD) and healthy participants (HP) with respect to measures of cognitive performance.
- Trial name
- NCT05358821
- Testing
- SAGE-718
- Where
- 14 sites in United States, Canada
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Supernus Pharmaceuticals, Inc.
Parkinson Disease, Parkinson Disease Dementia
Phase 2 Trial of Tributyrin in People With Parkinson's Disease and Cognitive Impairments
The goal of this clinical trial is to learn if taking a tributyrin supplement works to improve memory and thinking and walking and balance in adults with Parkinson disease Parkinson disease dementia.
- Trial name
- BUTTER2 (NCT07154511)
- Testing
- Tributyrin
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Prabesh Kanel
Conversion Disorder
TMS and Attentional Bias in Functional Motor Disorder
Functional motor disorders, also called motor conversion disorder, are common reasons for attendance at neurology outpatient clinics.
- Trial name
- NCT02102906
- Testing
- Transcranial magnetic stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 13 people
- Sponsor
- University of Edinburgh
Functional Neurological Symptom Disorder, Neurological Diseases or Conditions
Modulation of Sense of Agency With Non-invasive Brain Stimulation and Mindfulness-based Stress Reduction Therapy
A conversion disorder is a dysfunction of the nervous system in which no structural damage can be demonstrated. However, it must be distinguished from other psychiatric disorders such as psychosis or depression.
- Trial name
- NCT05086380
- Testing
- Mindfulness-based stress reduction therapy, Inhibitory TMS, Psychoeducation
- Where
- Switzerland
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University of Fribourg
Parkinson Disease, Dystonia
Osteopathic Manual Treatment Parkinson's Disease and Truncal Dystonia
This study will determine if posture and heart rate variability will significantly improve in Parkinsons disease with camptocormia after osteopathic manual treatments dystonia.
- Conditions
- Parkinson Disease, Dystonia, Autonomic Dysreflexia
- Trial name
- NCT03307161
- Testing
- osteopathic manual therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- New York Institute of Technology
Movement Disorder, Focal Dystonia
Movement-Related Brain Networks Involved in Hand Dystonia
This study will use various methods to measure the activity of the motor cortex (the part of the brain that controls movements) in order to learn more about focal hand dystonia.
- Trial name
- NCT00137384
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)