Clinical trials: Movement Disorders, Functional
Parkinson Disease
The Relationship Between Upper Extremity Function and Balance and Functional Mobility in Parkinson's Disease
Parkinson's Disease (PD) is the second most common neurodegenerative disease, affecting 2-3% of the population aged 65 and over, characterized by the loss of dopaminergic neurons.
- Trial name
- NCT06591975
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Gazi University
Subacromial Impingement Syndrome
Manual Therapy Versus Conventional Rehabilitation Protocol on Subacromial Pain Syndrome
This study compares the periodic effects of Accelerated rehabilitation protocol (ARP) and Mulligan mobilization with mowement method (MWM) in subacromial pain syndrome patients rehabilitation.
- Trial name
- NCT04057170
- Testing
- accelerated protocol and mulligan method
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Cukurova University
Parkinson Disease
Cognitive-driven ADL Impairment as a Predictor for PDD
Mild cognitive impairment in Parkinson's disease (PD-MCI) is the highest risk factor for Parkinson's disease dementia (PDD). The core feature for differentiating PDD from PD-MCI is the loss of the ability to perform activities of…
- Trial name
- NCT03687203
- Testing
- Functional Activities Questionnaire
- Where
- Germany
- Volunteers
- 182 people
- Sponsor
- University Hospital Tuebingen
Multiple Sclerosis
Adaptive Plasticity Following Rehabilitation in Multiple Sclerosis
Motor learning can induce significant changes in the human brain through neural plasticity processes, which play a crucial role in the brain functional reorganization in response to external stimuli and/or to pathological…
- Trial name
- NCT03608527
- Testing
- Voluntary-based upper limb motor rehabilitation, Passive upper limb mobilization
- Volunteers
- 30 people
- Sponsor
- Fondazione Italiana Sclerosi Multipla
Cerebral Palsy, Congenital
CIMT and BIMT Affect Functional Outcome in CP
The aim of this randomized controlled trial is to determine the effects of constraint induced movement therapy CIMT and BIM bimanual activities on functional outcome in hemiplegic CP.
- Trial name
- NCT04211623
- Testing
- Constraint induced movement therapy, Bimanual activities
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Parkinson Disease, Nervous System Disorder
Molecular and Functional Imaging in Monogenic PD.
In this study, the investigators aim to find a biomarker of Parkinson's disease. This is done using imaging scans called Positron Emission tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Magnetic…
- Conditions
- Parkinson Disease, Nervous System Disorder, Neurodegenerative Diseases, Neurodegenerative Disease, Hereditary
- Trial name
- FOX_1 (NCT05518617)
- Testing
- Positron Emission Tomography (PET) scan using DASB tracer
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Exeter
Stroke
Brain State-dependent PCMS in Chronic Stroke
After stroke, people often have difficulty using their hands. Combined brain and nerve stimulation can strengthen the neural pathways that control hand function.
- Trial name
- NCT04830163
- Testing
- Brain state-dependent paired corticomotoneuronal stimulation (PCMS)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Texas at Austin
Parkinson´s Disease
Functional Improvement in Patients With Parkinson's Disease After Training in Real or Virtual Environment
The objective of this work was to compare the effects of two balance training programs, one Nintendo Wii Fit-based and the other traditionally-based without the use of a gaming system, on the balance, functionality and cognition…
- Trial name
- NCT01580787
- Testing
- Balance Training with Nintendo Wii Fit, Physical Therapy
- Volunteers
- 32 people
- Sponsor
- Sao Camilo University Center
Parkinson Disease, Gait Disorders
Effects of Biofeedback Footwear in Parkinson's Disease: Assessment of Functional Motor Abilities and Locomotion
The study aims to verify whether the use of a specific footwear providing increased plantar feedback (plantar feedback shoes) could improve gait parameters, postural control and functional performances in people with Parkinson's…
- Trial name
- NCT06453863
- Testing
- Greater plantar feedback shoes, Neutral gym shoes, Barefoot
- Volunteers
- 40 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
PARKINSON DISEASE (Disorder)
Multicontext Approach for Cognitive Function in Parkinson Disease
Mild cognitive decline is common in early Parkinson disease (PD) and is associated with disability, reduced quality of life (QOL), and increased risk for dementia.
- Trial name
- MC4PD R01 (NCT07190404)
- Testing
- A metacognitive strategy for cognitive rehabilitation called the Multicontext Approach., Cognitive (Process) Training, MC Approach Booster Session
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Washington University School of Medicine
Mild Cognitive Impairment, Alzheimer Disease
Skeletal Muscle as a Mediator of Exercise Induced Effects on Metabolism & Cognitive Function: Role for Myokines & miRNAs
The purpose of this study is to determine specific changes in muscle secretory profile (myokines, miRNA) in association with neurodegenerative disease progression and metabolic dysfunction.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Parkinson Disease, Healthy Volunteers
- Trial name
- Brain-Muscle (NCT02253732)
- Testing
- 3 months exercise intervention program
- Where
- 2 sites in Slovakia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Spinal Cord Injuries, Pain, Neuropathic
Using NI-ES to Treat Spinal Cord Injury (SCI)
NI-ES therapy is a treatment that is being studied to potentially treat pain associated with SCI and may help movement below the injury site.
- Trial name
- NCT04097015
- Testing
- Alpha-Stim M
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- SCI Research Advancement
Functional Neurological Disorder, Functional Movement Disorder
Additive Effects of Interoceptive Training to Physiotherapy in Functional Movement Disorders (interoPTfmd)
Functional movement disorder (FMD) is a common source of neurological disability that imposes a significant financial burden on healthcare systems.
- Trial name
- interoPTfmd (NCT06792760)
- Testing
- Physiotherapy, Specific Breathing Techniques
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- Charles University, Czech Republic
Huntington's Disease
A Study to Evaluate the Effect of SAGE-718 on Cognitive Function in Participants With Huntington's Disease (HD)
The primary purpose of this study is to evaluate the effect of SAGE-718 on cognitive performance and functioning in participants with HD.
- Trial name
- NCT05107128
- Testing
- SAGE-718
- Where
- 49 sites in United States, Australia and 2 more
- Volunteers
- 189 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Parkinson's Disease, Executive Function
Effects of STN DBS on Cognition and Brain Networks in PD Patients Analyzed Based on EEG and fNIRS
In recent years, deep brain stimulation (DBS) has become the primary treatment for patients with medically uncontrolled Parkinson's disease (PD).
- Conditions
- Parkinson's Disease, Executive Function, Electroencephalogram, Functional Near - Infrared Spectroscopy
- Trial name
- NCT06175897
- Testing
- Deep Brain Stimulation, non-Deep Brain Stimulation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhiqi Mao
Parkinson Disease, Virtual Reality Therapy
Virtual Reality for Parkinson's Disease
Parkinson's Disease (PD) is one of the most common neurodegenerative disease. Bradykinesia, tremor, resting tremor and postural instability are the main motor characteristics of this disease.
- Conditions
- Parkinson Disease, Virtual Reality Therapy, Functional Magnetic Resonance Imaging
- Trial name
- NCT03637023
- Testing
- Virtual Reality, Exercise Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Farzin Hajebrahimi, PT, MSc
Parkinson Disease, Essential Tremor
Functional Magnetic Resonance Imaging (fMRI) During Deep Brain Stimulation (DBS) to Treat Parkinson's Disease
This study is investigating the usefulness of using functional magnetic resonance imaging (fMRI) to monitor brain activation during deep brain stimulation for Parkinson's Disease, Essential tremor, dystonia, OCD, depression…
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia, Obsessive Compulsive Disorder
- Trial name
- NCT01809613
- Testing
- Functional Magnetic Resonance Imaging (fMRI)
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Mayo Clinic
Stroke
Effect of Thermal Stimulation for Lower Extremity Movement and Function in Patients With Stroke
The thermal stimulation have been proven effective in upper extremity of stroke patients. Therefore, this study explored the efficacy of thermal stimulation in lower extremity of stroke patients.
- Trial name
- NCT01668420
- Testing
- thermal stimulation
- Where
- Taiwan
- Volunteers
- 34 people
- Sponsor
- Hsin-Wen Hsu
Functional Movement Disorder
CBT Training for Cognitive Reappraisal as an Intervention for Patients With Functional Tremor - an EEG Study
The aim of this psychological study is to evaluate the effect of a cognitive behavioral therapy (CBT) intervention aimed at improving cognitive reappraisal on (1) Clinical and Self-Rated Health according to Patient Global…
- Trial name
- NCT06022393
- Testing
- Cognitive Reappraisal, Reflection
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Graz
Low Back Pain, Kinesiophobia (Fear of Movement)
Impact of the Receptive Music Intervention Tool (MUSIC CARE©) on Changes in the Functional Abilities of Patients With Chronic Low Back Pain
Brief Summary The goal of this clinical trial is to learn if MUSIC CARE©, a music-based therapy tool, can improve the physical abilities of people with chronic low back pain (back pain that lasts more than 3 months).
- Conditions
- Low Back Pain, Kinesiophobia (Fear of Movement), Chronic Low-back Pain (cLBP)
- Trial name
- LOMBALZIC' (NCT07731204)
- Testing
- Receptive Music Therapy
- Where
- France
- Volunteers
- 34 people
- Sponsor
- LNA SANTE