Clinical trials: Mucosal Inflammation
Peri-Implantitis, Peri-implant Mucositis
Proteomic Analysis of Newly Restored Single Implants
In 10 systemically healthy non-smokers, free of periodontitis, one newly restored implant (baseline-T0) and one corresponding tooth were followed over 12 months (T1). All implants were screw-retained, and platform-switched.
- Conditions
- Peri-Implantitis, Peri-implant Mucositis, Periodontal Diseases
- Trial name
- NCT06379022
- Testing
- Plaque control
- Where
- Greece
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Vaginal Inflammation, Vaginal Infections
Identification of Novel Biomarkers of Cervicovaginal Mucosal Inflammation
This study investigates the response of vaginal and cervical tissue after exposure to three vaginal products: hydroxyethyl cellulose (HEC) placebo, nonoxynol-9 (N9) and imiquimod (IMQ) cream.
- Trial name
- Biomarkers (NCT01593124)
- Testing
- Imiquimod, Nonoxynol-9
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- CONRAD
Urologic Injuries, Urologic Diseases
Bladder Morphology Using 2 Different Catheter Designs
Demonstrate and compare the 3D morphology of the bladder wall in full and drained states with 2 different kinds of bladder catheters in place. (Foley Catheter vs. Cystosure Catheter)
- Conditions
- Urologic Injuries, Urologic Diseases, Bladder Infection, Urinary Tract Infections
- Trial name
- NCT03108079
- Testing
- Cystosure Urinary Access System, Foley Catheter
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- The Pelvic Floor Institute
Peri-implant Mucositis
Non Surgical Protocol for Treatment of Mucositis
Peri-implant mucositis is an important disease entity as a result of its high prevalence and the lack of a standard mode of therapy.
- Trial name
- NCT03951636
- Testing
- Mechanical debridement with curettes, Er:YAG laser, Air Powder
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Università Vita-Salute San Raffaele
Dental Implants, Cigarette Smoking
Triclosan Toothpaste as a Preventive Strategy of Mucositis in Smokers
The purpose of this trial was to determine the effect of a triclosan-containing toothpaste in the clinical parameters and in the profile of osteo-immunoinflammatory mediators in the peri-implant crevicular fluid (PICF) as a…
- Trial name
- NCT03241407
- Testing
- triclosan/copolymer/fluoride toothpaste
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Paulista University
Peri-implant Mucositis, Oral Bacterial Infection
Bacterial Microbiota Characterization on Implant-supported PEEK and Titanium Provisional Abutments
The aim of this study is to determine the relative abundances of the different bacterial phyla and families in the microbiota present on the surface of PEEK implant-supported provisional abutments compared to titanium…
- Conditions
- Peri-implant Mucositis, Oral Bacterial Infection, Bacterial Resistance
- Trial name
- NCT03998865
- Testing
- Provisional abutment material
- Where
- Chile
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Michael Wendler Ernst
Pregnancy Related, Innate Inflammatory Response
Understanding Host-pathogen Interaction in the Respiratory Mucosa During Pregnancy
The clinical presentation of the ongoing coronavirus disease-19 (COVID-19) pandemic in pregnant women is unique with more asymptomatic infection, higher morbidity when symptomatic, yet without a difference in mortality rate.
- Trial name
- NCT04962477
- Testing
- Nasal brush sampling
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Mucositis
Impact of Oral Hygiene Gels on Peri-implant Mucositis
Peri-implant mucositis is abnormal inflammation occurring around dental implants, increasing the risk of loss of bone support. The purpose of this study is to evaluate the impact of brushing the bacterial biofilm at the…
- Trial name
- NCT03243591
- Testing
- Livionex gel, Aquafresh gel
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Peri-implant Mucositis
Treatment of Peri-implant Mucositis and Supportive Peri-implant Therapy
The investigators are evaluating the therapeutic outcomes of two cleaning instruments on treating peri-implant mucositis. Peri-implant mucositis is inflammation around an implant that is limited to only the gum tissue and is…
- Trial name
- NCT06137846
- Testing
- Air-Polish, Ultrasonic
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Atherosclerosis, Endothelial Dysfunction
Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Peri-implantitis and Peri-implant Mucositis
A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment on endothelial dysfunction parameters in subjects with peri-implantitis/peri-implant mucositis…
- Conditions
- Atherosclerosis, Endothelial Dysfunction, Peri-Implantitis, Peri-implant Mucositis
- Trial name
- NCT05906810
- Testing
- Non-surgical periodontal treatment
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Catania
Peri-Implantitis, Peri-implant Mucositis
Comparison of the Accuracy of Different Periodontal Probes for Peri-implant Pocket Registration
Various types of periodontal probes (e.g., metal probes, plastic/bendable probes, electronic periodontal probes) are used for peri-implant pocket depth registration; however, depending on the shape and size of the prosthetic…
- Trial name
- NCT05332327
- Where
- Sweden
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Malmö University
Peri-implant Mucositis
Non-surgical Mechanical Debridement With or Without Full-mouth Disinfection in the Treatment of Peri-implant Mucositis
To evaluate the naturally occurring peri-implant mucositis (PM) treatment by means of non-surgical sub-marginal peri-implant instrumentation (NSPI) with or without full-mouth disinfection approach (FMD).
- Trial name
- NCT05711576
- Testing
- Full mouth disinfection
- Where
- Italy
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Catania
Peri-implant Mucositis
Non-surgical Treatment of Peri-implant Mucositis: FMUD vs FMUD and Air-Flow Master Piezon®
The aim of the present study is to evaluate the adjunctive effect of glycine-powder air-polishing (GPAP) to full-mouth ultrasonic debridement (Fm-UD) in the treatment of peri-implant mucositis, and to determine the predictive…
- Trial name
- NCT05801315
- Testing
- Glycine powder air polishing, Full mouth ultrasonic debridement
- Where
- Italy
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Siena
Burning Mouth Syndrome
Neurogenic Mechanisms in Burning Mouth Syndrome
Burning mouth syndrome (BMS) is characterized by a bilateral burning sensation in the anterior tongue, hard palate and lips in the absence of any clinical or laboratory findings.
- Trial name
- BMS17 (NCT00875537)
- Testing
- Capsaicin oral gel 0.025%, Capsaicin oral gel 0.01%
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Peri-implant Mucositis, Peri-Implantitis
Monitoring of Non-Surgical Treatment of Peri-implantitis
This study aimed to investigate the response to non-surgical treatment of peri-implantitis diseases during the maintenance phase.
- Trial name
- NCT06408467
- Testing
- aMMP-8 diagnostic test
- Where
- Finland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lahanna oy
Peri-implant Mucositis
AI-Assisted Colorimetric Diagnosis of Peri-Implant Mucosal Erythema
1. Background and Rationale The visual diagnosis of peri-implant mucosal erythema (redness), a key sign of inflammation, is highly subjective and varies significantly among clinicians, leading to inconsistencies in early…
- Trial name
- NCT07349095
- Testing
- AIa assisted diagnosis
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Inflammation
Significance of Synbiotics on Inflammation and Proliferation of Colonic Mucosa
There is a constant exchange between the gut epithelium and lumen, including microbial interplay. The aim of this study was to investigate dietary test products on inflammatory proliferation markers in the gut, and thereby if the…
- Trial name
- NCT01534572
- Testing
- Lactobacillus, Bifidobacterium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Region Skane
Methamphetamine-dependence, Rectal Gonorrhea
Inflammation in Methamphetamine and STIs (IMSTI)
This clinical trial aims to investigate the effects of a decline in methamphetamine use on rectal inflammatory cytokine levels, substance use contexts, and HIV/STI risk behavior.
- Conditions
- Methamphetamine-dependence, Rectal Gonorrhea, Rectal Chlamydia
- Trial name
- IMSTI (NCT05162391)
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Peri-Implantitis, Peri-implant Mucositis
Histological, Genetic and Epigenetic Analysis of Procedures Related with Dental Implants
In this study genomic, proteomic and histological technologies for the search and characterization of epigenetic modifications and molecular or protein markers, useful in the diagnosis and progression of peri-implant diseases and…
- Conditions
- Peri-Implantitis, Peri-implant Mucositis, Implant Complication, Implant Tissue Failure
- Trial name
- NCT04421066
- Testing
- Gingival and bone sample collection, Healthy individuals
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Simón Pardiñas López
Dental Implantation, Missing Teeth
The Effect Of Enamel Matrix Derivatives On Gingival Tissue Thickness
Scientists do research to answer important questions which might help change or improve the way we do things in the future. The investigators know that using Enamel Matrix Derivatives results in thicker gum tissues around teeth.
- Conditions
- Dental Implantation, Missing Teeth, Periodontitis, Adult, Mucositis
- Trial name
- NCT07053969
- Testing
- Enamel Matrix Derivative
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio