Clinical trials: Mucus; Plug
Bronchiectasis, Mucus; Plug
Simeox 200 US Study
The purpose of this single arm post-market observational study is to evaluate the short-term effectiveness of the Simeox 200 airway clearance device in improving airway clearance in adult patients aged 18 to 85 with…
- Trial name
- IMPACT (NCT07443124)
- Testing
- Intermittent intrapulmonary deflation
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Inogen Inc.
Bronchitis, Bronchitis, Chronic
Study to Evaluate the Effects of Oral Glyceryl Guiacolate (Guaifenesin, GGE) on Sputum Rheology in Subjects With Mucus Hypersecretion
A Randomized, Dosing vs Standard of Care, Single-Center, Multiple Dose Study to Evaluate the Effects of Oral Glyceryl Guiacolate (Guaifenesin, GGE) on Sputum Rheology in Subjects With Mucus Hypersecretion
- Trial name
- NCT07873632
- Testing
- Glycerol Guiacolate, SOC (Standard of care)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of North Carolina, Chapel Hill
Critical Illness, Tracheostomy Complication
Nebulized hypErtonic Saline for Better Prevention of mUcus pLug in Critical Adult Tracheostomized Patients
Tracheostomy is an important tool in the management of respiratory failure in the critically ill patient under mechanical ventilation.
- Conditions
- Critical Illness, Tracheostomy Complication, Mechanical Ventilation Complication, Plug; Mucus
- Trial name
- NEBULA (NCT03870646)
- Testing
- Hypertonic saline of NaCl (7%) in combination with hyaluronic acid, Isotonic saline of NaCl (0,9%)
- Where
- Spain
- Volunteers
- 164 people
- Sponsor
- Hospital Universitario Virgen de la Arrixaca
Asthma
Lung Function Outcomes Following Removal of Airway Mucus Plugs in Patients With Asthma (FOCUS)
This is a single-center study that will evaluate the safety and tolerability of removal of mucus plugs by bronchoscopy in patients with asthma.
- Trial name
- FOCUS (NCT05748912)
- Testing
- Therapeutic bronchoscopy for removal of mucus plugs
- Where
- United States
- Sponsor
- University of California, San Francisco
Asthma in Children
Study on Hospitalization of Children With Bronchial Asthma
Bronchial asthma is the most common chronic respiratory disease in children. At present, more attention has been paid to the treatment of airway inflammation and smooth muscle spasm, while the related research on the risk factors…
- Trial name
- NCT05800379
- Where
- China
- Volunteers
- 470 people
- Sponsor
- Beijing Children's Hospital
Chronic Obstructive Pulmonary Disease
A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants Aged ≥40 to ≤85 Years With Chronic Obstructive Pulmonary Disease.
LPS18583 is a multinational, randomized, double-blind, placebo-controlled, parallel-group, Phase 4 study with 2 treatment groups.
- Trial name
- AEOLUS (NCT07053423)
- Testing
- Dupilumab
- Where
- 85 sites in United States, Argentina and 20 more
- Volunteers
- 218 people
- Sponsor
- Sanofi
Bronchiectasis
Feasibility Study of the AffloVest in Bronchiectasis
Feasibility study of High Frequency Chest Wall Oscillation (HFCWO) using the AffloVest in 30 patients with Bronchiectasis over a 6 week period.
- Trial name
- NCT04266873
- Testing
- AffloVest
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Asthma
DETACT sEvere asThmAtiC paTients - a Pilot Study
The objective of this study is to investigate the effect of dupilumab treatment on mucus plugging in severe asthma patients with severe eosinophilic asthma.
- Trial name
- DETACT (NCT07025200)
- Testing
- Dupilumab
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Vienna
COVID-19 Pneumonia, Bromelains Adverse Reaction
Nebulised BromAc in Healthy Volunteers
COVID-19 is a disease that has multiple facets including an inflammatory storm, it promotes blood clotting and causes kidney damage, mucinous secretions in the lung are of great importance to outcome.
- Conditions
- COVID-19 Pneumonia, Bromelains Adverse Reaction, Acetylcysteine Adverse Reaction, Mucus; Plug
- Trial name
- NCT05220605
- Testing
- BromAc
- Where
- Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mucpharm Pty Ltd
Asthma
Impact of Metabolic Dysfunction and Mucus Plugging on Asthma Physiology
This is a single-center study of 80 subjects with asthma including those with obesity and metabolic dysfunction (MD), those with obesity and without metabolic dysfunction, those with severe asthma and mucus plugging and those…
- Trial name
- IMAP (NCT05757583)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, San Francisco
Asthma, Mucus; Plug, Tracheobronchial
Study of Focal Airway Disease in Asthma Using Image Guided Bronchoscopy
This is a single center study of 60 subjects including those with asthma and mucus plugging, those with asthma and without mucus plugging, and healthy controls.
- Trial name
- SOFA (NCT04514913)
- Testing
- Multidetector Computed Tomography (MDCT) Scan, Virtual Navigation Bronchoscopy (VNB)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
ABPA, Allergic Bronchopulmonary Aspergillosis
A Study of the Efficacy and Safety of Bronchoscopic Airway Clearance and Amphotericin B Spraying in Patients With ABPA
To evaluate the efficacy and safety of bronchoscopic airway clearance and amphotericin B spraying in the treatment of allergic bronchopulmonary aspergillosis
- Conditions
- ABPA, Allergic Bronchopulmonary Aspergillosis, Allergic Bronchopulmonary Aspergillosis (ABPA), Airway Clearance
- Trial name
- NCT07362667
- Testing
- The patients were treated with bronchoscopic airway clearance and amphotericin B spraying
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Qianfoshan Hospital
Asthma
The Effect of Dupilumab on Lung Inflammation and Related Changes in Airway Volumes Detectable by Functional Respiratory Imaging in Patients With Moderate-severe Asthma
Primary Objective: To assess the effect of dupilumab on lung inflammation and related changes in airway volumes detectable by functional respiratory imaging Secondary Objective: To evaluate the effect of dupilumab at Week 24 on…
- Trial name
- VESTIGE (NCT04400318)
- Testing
- Dupilumab
- Where
- 65 sites in United States, Bulgaria and 11 more
- Volunteers
- 109 people
- Sponsor
- Sanofi
Severe Asthma, COPD
Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Muco-Obstructive Lung Disease
In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with muco-obstructive pulmonary disease.
- Conditions
- Severe Asthma, COPD, Non-CF Bronchiectasis, Cystic Fibrosis (CF)
- Trial name
- NCT06985225
- Testing
- Hyperpolarized 129 Xenon
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Kansas Medical Center
Asthma
Effect of OPEP on Mucus Plugging and Airflow Obstruction in Patients with Moderate-to-severe Asthma
The goal of this randomized clinical trial is to evaluate the effect of daily AerobikaTM Oscillating Positive Expiratory Pressure (OPEP) device use on mucus plugging and airway function in adult patients with moderate-to-severe…
- Trial name
- AeroMUC (NCT06147453)
- Testing
- Aerobika OPEP device
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Asthma, COPD
The Effects of Positive Airway Pressure on the Mucolytic Effects of NAC (TEAM)
The goal of this clinical trial is to determine if positive pressure during inspiration will improve penetration of aerosolized N-Acetylcysteine (NAC) into airway mucus plugs in the lungs of patients with asthma or Chronic…
- Trial name
- TEAM (NCT06152653)
- Testing
- n-acetylcystine (NAC)+ albuterol, AeroEclipse-VersaPAP System
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Severe Asthma
Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma
In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with severe asthma.
- Trial name
- NCT07139899
- Testing
- Hyperpolarized Xenon 129
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Bastiaan Driehuys
Lung Fibrosis
Impact of Airway Mucus Plugs on Secondary Pulmonary Fibrosis in COPD Patients: A Single-Center Case-Control Study
Chronic obstructive pulmonary disease (COPD) is frequently accompanied by airway mucus plugs, which are closely associated with airflow obstruction, acute exacerbations, and increased mortality.
- Trial name
- NCT07236541
- Testing
- No intervention; observational biospecimen collection only
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Ming Zhong
Mucus Retention, Mechanical Ventilation Complication
Efficacity and Safety of Mechanical Insufflation-exsufflation on ICU
Critically ill and intubated patients on mechanical ventilation (IMV) often present retention of respiratory secretions, increasing the risk of respiratory infections and associated morbidity.
- Conditions
- Mucus Retention, Mechanical Ventilation Complication, Mucus; Plug, Tracheobronchial
- Trial name
- NCT03316079
- Testing
- Chest physiotherapy techniques, Mechanical insufflation-exsufflation
- Where
- 3 sites in France
- Volunteers
- 26 people
- Sponsor
- University Hospital, Bordeaux
Asthma, Asthma in Children
Prospective Multicentre Study on Symptoms in First-onset Bronchial Asthma in Children and Adolescents
Bronchial asthma may present with symptoms other than the commonly reported complaints (cough, chest tightness, shortness of breath and wheezing).
- Conditions
- Asthma, Asthma in Children, Dyspnea, Cough
- Trial name
- NCT06201494
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- Charles University, Czech Republic