Clinical trials: Multi Vessel Coronary Artery Disease
Coronary Disease
RE-DEEM Dose Finding Study for Dabigatran Etexilate in Patients With Acute Coronary Syndrome
The purpose of this trial is to evaluate the safety and indicators of efficacy of up to 4 doses of orally administered dabigatran etexilate, administered twice daily, compared to placebo when given in addition to dual…
- Trial name
- NCT00621855
- Testing
- dabigatran etexilate
- Where
- 167 sites in United States, Belgium and 22 more
- Volunteers
- 1,878 people
- Sponsor
- Boehringer Ingelheim
Computed Tomography Angiography, Coronary Artery Disease
Techniques and Pitfalls of Multi-Slice CT Coronary Angiography
The goal of this study is to describe the techniques for coronary multi-slice CT angiography and to illustrate the spectrum of artifacts that can simulate coronary artery stenosis and lead to non-assessable segments using 128…
- Trial name
- NCT05729490
- Testing
- Coronary computed tomography angiography
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Myocardial Infarction, Acute, Multi-Vessel Coronary Artery Stenosis
Timing of FFR-guided PCI for Non-IRA in NSTEMI and MVD (OPTION-NSTEMI)
Many patients with non-ST-segment elevation myocardial infarction (NSTEMI) have multivessel coronary artery disease (MVD), which is associated with poor clinical outcomes.
- Conditions
- Myocardial Infarction, Acute, Multi-Vessel Coronary Artery Stenosis, Multi Vessel Coronary Artery Disease
- Trial name
- NCT04968808
- Testing
- Staged in-hospital complete revascularization, Immediate complete revascularization
- Where
- South Korea
- Volunteers
- 1,014 people
- Sponsor
- Chonnam National University Hospital
Coronary Artery Disease
Prospective, Multi-Center, Random. Study of CoStar Paclitaxel-Eluting Coronary Stent(Direct Stenting vs. Pre-Dilatation)
The primary objective of this study is to evaluate the safety and effectiveness of a direct stenting technique compared to conventional stenting with pre-dilatation strategy using the CoStar Paclitaxel-eluting coronary stent…
- Trial name
- DECIDE (NCT00440674)
- Testing
- CoStar Paclitaxel-eluting coronary stent system
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- Conor Medsystems
Acute Coronary Syndrome, Chronic Coronary Syndrome
A Study on the Peripheral Blood in Patients With Acute Coronary Syndrome
The goal of this study is to conduct analyses the changes of cell growth factors, inflammatory factors, metabolites, plasma proteome, etc.
- Trial name
- NCT06955143
- Where
- China
- Volunteers
- 310 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Coronary Artery Disease
VEST Venous Graft External Support Pivotal Study
Prospective, multi-center, randomized, within-subject-controlled , trial, enrolling patients with multi vessel atherosclerotic coronary artery disease, scheduled to undergo SVG CABG with arterial grafting of IMA to LAD and two or…
- Trial name
- VEST Pivotal (NCT03209609)
- Testing
- VEST, Coronary artery bypass vein grafts
- Where
- 17 sites in United States, Canada
- Volunteers
- 224 people
- Sponsor
- Vascular Graft Solutions Ltd.
Coronary Artery Disease, Multi Vessel Coronary Artery Disease
Practice Change With Drug-coated Balloon in Patients With multiVessel Coronary Artery Disease
This study is a prospective, multicenter, open-label, observational study to investigate the impact of using drug-coated balloons (DCBs) in the treatment of coronary artery lesions in patients with multivessel coronary artery…
- Trial name
- DCB-MVD (NCT06104033)
- Testing
- drug-coated balloon, drug-eluting stent
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Bon-Kwon Koo
Coronary Artery Disease
Shockwave Coronary Rx Lithoplasty® Study (Disrupt CAD I)
Prospective, multi-center, single arm study designed to evaluate the safety and performance of the Shockwave Coronary Rx Lithoplasty® System to treat calcified lesions in the coronary arteries for the purpose of enhancing the…
- Trial name
- NCT02650128
- Testing
- Shockwave Coronary Rx Lithoplasty® System
- Where
- 7 sites in Australia, France and 3 more
- Volunteers
- 60 people
- Sponsor
- Shockwave Medical, Inc.
Coronary Artery Disease
Comparison of One-stop Hybrid Revascularization Versus Off-pump Coronary Artery Bypass for the Treatment of Multi-vessel Disease
The "one-stop" hybrid coronary revascularization combines minimally invasive direct coronary artery bypass (MIDCAB) and PCI to be performed in the hybrid operating suite, an enhanced operating room equipped with radiographic…
- Trial name
- NCT01034371
- Testing
- Minimally invasive direct coronary artery bypass, PCI-Drug eluting stents, Off-pump coronary artery bypass
- Where
- 2 sites in China
- Volunteers
- 400 people
- Sponsor
- China National Center for Cardiovascular Diseases
Cardiovascular Disease
The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects
This study evaluates the PCSK9 inhibitor, Bococizumab (PF-04950615;RN316), compared to placebo, in reducing the occurrence of major cardiovascular events, including cardiovascular death, myocardial infarction, stroke, and…
- Trial name
- SPIRE-1 (NCT01975376)
- Testing
- bococizumab (PF-04950615)
- Where
- 1,745 sites in United States, Argentina and 34 more
- Volunteers
- 16,784 people
- Sponsor
- Pfizer
Pulmonary Hypertension, Heart Failure With Reduced Ejection Fraction
A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease
The goal of this clinical study is to evaluate the safety and efficacy of percutaneous pulmonary artery denervation with the Multi-Pole Pulmonary Artery Radiofrequency Ablation Enhancor System in patients with combined pre- and…
- Conditions
- Pulmonary Hypertension, Heart Failure With Reduced Ejection Fraction, Hypertension, Vascular Diseases
- Trial name
- The PULSE-LHD (NCT07214376)
- Testing
- Pulmonary Artery Denervation (PADN)
- Where
- 18 sites in United States, China
- Volunteers
- 750 people
- Sponsor
- Pulnovo Medical, Inc.
Acute Myocardial Infarction, Ischemia-reperfusion Injury
Combined Antioxidant Therapy Against Myocardial Reperfusion Injury. Phase I Study.
Background: Acute myocardial infarction (AMI) has remained a leading cause of mortality and disability worldwide. Although percutaneous coronary angioplasty (PCA) is the best treatment for these patients, paradoxically this…
- Conditions
- Acute Myocardial Infarction, Ischemia-reperfusion Injury, Reperfusion Injury, Myocardial, Reperfusion Arrhythmias
- Trial name
- NCT05215743
- Testing
- Antioxidant therapy, NaCl 0.9%
- Where
- Chile
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Chile
Aortopathies, Thoracic Aortic Aneurysm
Pathogenetic Basis of Aortopathy and Aortic Valve Disease
The main purpose of this study is to define the complex genetic and pathogenic basis of thoracic aortic aneurysm (TAA) and other forms of aortopathy and/or aortic valve disease by identifying novel disease-causing genes and by…
- Conditions
- Aortopathies, Thoracic Aortic Aneurysm, Aortic Valve Disease, Thoracic Aortic Disease
- Trial name
- TAA (NCT03440697)
- Where
- 2 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Yale University
Coronary Disease
The REAL Registry for Utilization of iFR in Assessing Coronary Stenoses
The purpose of this registry is to collect real life information and to document the performance and user friendliness of iFR in daily diagnostic practice and treatment strategies for MVD patients undergoing cardiac…
- Trial name
- DEFINE REAL (NCT02281110)
- Testing
- iFR/FFR
- Where
- Belgium
- Volunteers
- 500 people
- Sponsor
- Volcano Corporation
Coronary Artery Disease
TAXUS ARRIVE: TAXUS Peri-Approval Registry: A Multi-Center Safety Surveillance Program
The TAXUS ARRIVE study is a multi-center safety and surveillance study designed to to compile safety surveillance and clinical outcomes data for the TAXUS™ Express2™ Paclitaxel-Eluting Coronary Stent System in routine clinical…
- Trial name
- ARRIVE (NCT00569491)
- Testing
- TAXUS Express 2™
- Where
- 50 sites in United States
- Volunteers
- 2,585 people
- Sponsor
- Boston Scientific Corporation
Multivessel Coronary Artery Disease, STEMI
The Use Of FFR Guided PCI Versus Complete Revascularization and Treatment Of Infarct Related Artery Only In Patients With STEMI
In patients with ST elevation myocardial infarction (STEMI) the treatment goal is revascularization of the occluded artery with the use of primary percutaneous coronary intervention (PCI).
- Conditions
- Multivessel Coronary Artery Disease, STEMI, FFR Guided PCI
- Trial name
- FAIO (NCT02637440)
- Testing
- FFR guided PCI, Angio guided PCI
- Where
- 2 sites in Ireland
- Volunteers
- 560 people
- Sponsor
- University of Limerick
Coronary Heart Disease, Chronic Kidney Disease
Prevalence of Chronic Kidney Disease and Its Association With Clinical Outcome in Patients With Coronary Heart Disease
This is a prospective, multi-center, hospital-based observational study. The aim of the study is to evaluate the prevalence of chronic kidney disease in patients with stable coronar heart disease.
- Trial name
- NCT02509013
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Peking University First Hospital
Elevated LDL-C and High Cholesterol
A Study of STX-1150 in Participants With Elevated Low-Density Lipoprotein Cholesterol (LDL-C)
STX-1150 is an investigational therapy designed to lower LDL-C by silencing a gene called PCSK9 in the liver. STX-1150 does not edit or permanently change the gene.
- Trial name
- STX-1150-01 (NCT07428473)
- Testing
- STX-1150
- Where
- 3 sites in Australia, New Zealand
- Volunteers
- 64 people
- Sponsor
- Monash University
Coronary Artery Disease
A Study of the Presillion Stent in de Novo Coronary Lesions
The PRESILLION Study is a non-randomized, multi-center, single-arm study evaluating the safety of an approved Cobalt Chromium bare metal stent system for the treatment of ischemic heart disease attributable to a stenotic de novo…
- Trial name
- PRESILLION (NCT00722579)
- Testing
- PRESILLION cobalt chromium stent
- Where
- Belgium
- Volunteers
- 101 people
- Sponsor
- Cordis US Corp.
Drug-Coated Balloon, De Novo Stenosis
Safety and Efficacy of Drug-Coated Balloon for De-novo Lesions in Patients With Acute Coronary Syndromes (DCB-ACS)
The DCB-ACS trial is a prospective, multi-center, non-inferiority, randomized controlled trail. The purpose of this trial is to evaluate the safety and efficacy of drug-coated balloon(DCB) in de novo lesions for acute coronary…
- Conditions
- Drug-Coated Balloon, De Novo Stenosis, Acute Coronary Syndromes, ACS
- Trial name
- DCB-ACS (NCT04937803)
- Testing
- Drug-coated balloon, Zotarolimus-Eluting Coronary Stent
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Harbin Medical University