Clinical trials: Multi-morbidity
Medication Adherence, Medication Nonadherence
Identifying Reasons for Non-adherence in Patients With Multi-morbidity
The study will be carried out during pharmacist-conducted medication reconciliation. The pharmacist will ask how the patient has been taking the prescribed medicines and whether any over-the-counter medicines and food supplements…
- Conditions
- Medication Adherence, Medication Nonadherence, Chronic Disease
- Trial name
- NCT05167578
- Testing
- Medication reconciliation
- Where
- Finland
- Volunteers
- 250 people
- Sponsor
- Helsinki University Central Hospital
Diabetes Type 2, Renal Failure
A Study of the Usefulness & Usability of a Healthcare IT System for Managing Multi-morbidity and Poly-pharmacy
To assess the acceptability of a personalised ICT tool that facilitates coordinated care planning, treatment optimisation and patient self-management for patients with multiple long term conditions and their team of health…
- Conditions
- Diabetes Type 2, Renal Failure, Heart Failure, Depression
- Trial name
- C3-Cloud (NCT03834207)
- Testing
- Use of the C3-Cloud IT system
- Where
- 3 sites in Spain, Sweden and 1 more
- Volunteers
- 672 people
- Sponsor
- Dr Christopher Marguerie
Marfan Syndrome, Marfan Syndrome Cardiovascular Manifestations
Mortality and Morbidity Outcomes in Marfans
Marfan Syndrome (MFS) is a genetic disease affecting the eyes, skeleton, heart and arteries. Despite MFS affecting multiple organ systems, cardiovascular manifestations are the most serious and life threatening.
- Trial name
- NCT04774172
- Where
- United Kingdom
- Volunteers
- 6,700 people
- Sponsor
- Barts & The London NHS Trust
Child Malnutrition, Infant Morbidity
Effectiveness of Nutritional Supplementation in Preventing Malnutrition in Children With Infection in Karamoja, Uganda
The purpose of this study is to determine whether 14 days nutritional supplementation with Ready to use therapeutic Food (RUTF) or micronutrients alone to children having an infection will prevent malnutrition and reduce the…
- Trial name
- MSF-nutcon03 (NCT01497236)
- Testing
- Dietary Supplement: Nutrition supplement with RUTF or MNP
- Where
- Uganda
- Volunteers
- 2,202 people, healthy volunteers welcome
- Sponsor
- Medecins Sans Frontieres, Spain
Congenital Heart Disease, Cardiac Surgery
Perioperative Transfusion Strategies in Adult Congenital Heart Disease Patients Undergoing Cardiac Surgery
Due to better medical care, a growing number of patients with congenital heart disease reach adulthood. A large number of these patients needs a redo cardiac surgery.
- Conditions
- Congenital Heart Disease, Cardiac Surgery, Blood Transfusion, Morbidity, Multiple
- Trial name
- NCT04973514
- Testing
- Cardiac surgery in grown-up congenital heart disease patients
- Where
- Belgium
- Volunteers
- 500 people
- Sponsor
- Brugmann University Hospital
Aneurysmal Subarachnoid Hemorrhage
Clazosentan in Reducing Vasospasm-related Morbidity and All-cause Mortality in Adult Patients With Aneurysmal Subarachnoid Hemorrhage Treated by Surgical Clipping
The aim of this study is to demonstrate that clazosentan, administered as a continuous intravenous infusion at 5 mg/h until Day 14 post aneurysmal subarachnoid hemorrhage (aSAH), reduces the incidence of cerebral vasospasm…
- Trial name
- CONSCIOUS-2 (NCT00558311)
- Testing
- Clazosentan
- Where
- 117 sites in United States, Australia and 27 more
- Volunteers
- 1,157 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Multi-morbidity, Medication Therapy Management
Team Approach to Polypharmacy Evaluation and Reduction
In an aging population, most seniors suffer from multiple chronic conditions. When the number of medications taken is ≥5 (polypharmacy), the burden of taking multiple concurrent medications can do more harm than good.
- Conditions
- Multi-morbidity, Medication Therapy Management, Polypharmacy
- Trial name
- TAPER-RCT (NCT02942927)
- Testing
- Medication reduction
- Where
- Canada
- Volunteers
- 345 people
- Sponsor
- McMaster University
Multiple Co-morbidities
Computer Assisted Symptom Evaluation of Complex Patients
Patients who have advanced or multiple chronic illnesses present management difficulties for primary care providers. Acute medical issues and limited time for patient evaluation can complicate complete assessment of physical…
- Trial name
- CASE (NCT01391026)
- Testing
- Enhanced patient-centered care
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Cook County Health
Degeneration Muscle, Multiple Morbidities
Cardiopulmonary Training in the Victims With Multiple Morbidities by Application of Novel Heart Rate Sensing Clothes
Investigators assume that the wearable clothes can be applied to home-based health care and integrated into a case management model through telehealthcare.
- Conditions
- Degeneration Muscle, Multiple Morbidities, Heart; Complications
- Trial name
- NCT04022590
- Testing
- E-clothes, Healthy consultation
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shang-Lin Chiang
Chronic Obstructive Pulmonary Disease (COPD), Asthma
Mitigating Chronic Respiratory Disease Through the Lens of Multimorbidity
The investigators aim to evaluate whether it is feasible for healthcare professionals to implement a case-finding tool to identify individuals at high risk for chronic respiratory diseases (CRDs) during routine care for…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Asthma, Preserved Ratio Impaired Spirometry
- Trial name
- MARES2 (NCT07093021)
- Where
- 2 sites in Brazil
- Volunteers
- 1,000 people
- Sponsor
- University College, London
Hypertension, Diabetes Mellitus, Type 2
Enhancing Community Health Through Patient Navigation, Advocacy and Social Support
Some patients who have multiple long-term health conditions have significant challenges accessing needed services despite available primary care and social services resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- ENCOMPASS (NCT03077386)
- Testing
- ENCOMPASS Intervention
- Where
- Canada
- Volunteers
- 176 people
- Sponsor
- University of Calgary
Hospital Adverse Event
Impact on the Adverse Event (AE) Incidence of Two Types of Experience Feedback on AE Analyzed During Local Morbidity Mortality Reviews
After implementing a French version of a trigger tool validated for computerized detection of adverse events in patient's medical record, the study will be performed in three parallel randomized arms of three identical…
- Trial name
- RMM Simulation (NCT02771613)
- Testing
- Multi professional in situ simulation, Large diffusion of information
- Where
- France
- Volunteers
- 144,000 people
- Sponsor
- Hospices Civils de Lyon
Chronic Renal Anemia
A Study to Assess All-Cause Mortality and Cardiovascular Morbidity in Participants With Chronic Kidney Disease (CKD) on Dialysis and Those Not on Renal Replacement Therapy Receiving Methoxy Polyethylene Glycol-Epoetin Beta (Mircera) or Reference Erythropoietin Stimulating Agents (ESAs)
This 2 arm safety study will compare the outcome with respect to a composite endpoint of all-cause mortality and non-fatal cardiovascular events (myocardial infarction, stroke) in CKD participants either on dialysis or not…
- Trial name
- NCT00773513
- Testing
- Darbepoetin Alfa, Epoetin Alfa, Epoetin Beta
- Where
- 196 sites in Argentina, Australia and 25 more
- Volunteers
- 2,825 people
- Sponsor
- Hoffmann-La Roche
Frailty, Morbidity, Multiple
Low-volume Cycling Training in Older People With Multimorbidity
INTRODUCTION: Physical exercise, when practiced regularly and in adequate doses, is a proven nonpharmacological measure that helps to prevent and reverse noncommunicable diseases, as well as reduce mortality rates from any cause.
- Trial name
- NCT04842396
- Testing
- Experimental:Motorized cycle ergometer
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Universidade da Coruña
Chronic Obstructive Pulmonary Disease (COPD), Asthma
Mitigating Chronic Respiratory Disease Through the Lens of Multimorbidity (MARES3)
The investigators aim to investigate how individuals attending primary healthcare (PHC) services in Brazil for treatment of non-communicable diseases (NCDs), identified there as having abnormal spirometry or as being at high risk…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Asthma, Preserved Ratio Impaired Spirometry (PRISM)
- Trial name
- NCT07134855
- Where
- 2 sites in Brazil
- Volunteers
- 473 people
- Sponsor
- University College, London
Syphilis
Multi-site Study of Rapid Diagnostic Syphilis Assays
The performance of an investigational immunochromatographic strip (ICS) test for the diagnosis of syphilis is compared with the Abbott Laboratories Determine ICS test.
- Trial name
- NCT00300534
- Testing
- Abbott Laboratories Determine test for syphilis, Investigational syphilis immunochromatographic strip test
- Where
- 5 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Meniscus Tear
Study to Evaluate the Safety and Efficacy of AM3101 to Augment Meniscal Healing
The purpose of this clinical trial is to assess the safety and efficacy of AM3101 to facilitate meniscal repair and reduce the incidence of non-healing complications and morbidities associated with a failed meniscal repair.
- Trial name
- NCT05560477
- Testing
- AM3101
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- University of Cincinnati
Gastric Cancer
Comparison of Laparoscopic Versus Open Gastrectomy for Gastric Cancer: A Prospective Randomized Trial
The purpose of this study is to assess the usefulness of laparoscopic surgery for gastric cancer in comparison with open gastrectomy.
- Trial name
- KLASS (NCT00452751)
- Testing
- laparoscopy-assisted distal gastrectomy, open distal gastrectomy
- Where
- 16 sites in South Korea
- Volunteers
- 1,400 people
- Sponsor
- National Cancer Center, Korea
Maternal Malnutrition, Growth Failure
Women First: Preconception Maternal Nutrition
Multi-country three-arm, individually randomized, non-masked, controlled trial to ascertain the benefits of ensuring optimal maternal nutrition before conception and providing an evidence base for programmatic priority directed…
- Conditions
- Maternal Malnutrition, Growth Failure, Mortality, Morbidity
- Trial name
- WF (NCT01883193)
- Testing
- Comprehensive Maternal Nutrition Intervention
- Where
- 4 sites in Democratic Republic of the Congo, Guatemala and 2 more
- Volunteers
- 7,374 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Severe Sepsis, Septic Shock
Role of Ulinastatin in Preventing Severe Sepsis and Consequent Morbidities and Mortality
The study will enhance the theory in the frame of reference on the efficacy of Ulinastatin while managing sepsis and subsequent morbidity and mortality.
- Conditions
- Severe Sepsis, Septic Shock, MODS
- Trial name
- MUNI-SEP (NCT05895240)
- Testing
- Ulinastatin
- Where
- Pakistan
- Volunteers
- 175 people
- Sponsor
- Jinnah Postgraduate Medical Centre