Clinical trials: Multi-organ Failure
Systemic Inflammatory Response Syndrome (SIRS), Sepsis
Application of Biomarkers Change to Predict Outcome of Patient With Severe Sepsis
In 2004, the Surviving Sepsis Campaign (SSC) introduced guidelines for the management of severe sepsis and septic shock, as well as strategies for bedside implementation.
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Sepsis, Severe Sepsis, Septic Shock
- Trial name
- BCSS (NCT02871895)
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Chang Gung Memorial Hospital
Congenital Disease
Kids Intestinal Dysfunction in Congenital Heart Disease: the Kind Heart Study
Approximately 40,000 infants are born each year in the United States with congenital heart defects (CHD), and heart defects are the leading cause of birth defect-related deaths in the United States.
- Trial name
- NCT02824705
- Testing
- Congenital Heart Disease Surgery
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Arizona
Sepsis, Critical Illness
Metabolic and Functional Study of γδ T Cells in Critically Ill Patients
This prospective observational cohort study investigates the subset-specific metabolic adaptation and functional remodeling of cytotoxic γδ T cells in critically ill patients with and without sepsis.
- Conditions
- Sepsis, Critical Illness, Immunosuppression, MODS
- Trial name
- NCT07680816
- Where
- China
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Organ Failure, Multiple, Indigestion
The Impact and Effect of Traditional Chinese Medicine Treatment on Organ Failure in Critically Ill Patients
Critically ill patients are at risk of or suffering from one or more key organs or organ system failure. This study will measure the effect of traditional Chinese medicine(TCM) interventions on critically ill patients admitted to…
- Conditions
- Organ Failure, Multiple, Indigestion, Delayed Gastric Emptying, Respiratory Failure
- Trial name
- NCT06452966
- Testing
- traditional Chinese medicine, Routine ICU care, historical Routine ICU care
- Where
- Taiwan
- Volunteers
- 350 people
- Sponsor
- China Medical University Hospital
Multi Organ Failure, Exocrine Pancreatic Insufficiency
Evaluating the Utility of RELiZORB™ for Treating Feeding Intolerance in Critically Ill Adults With Multi-Organ Failure
The purpose of this research is to determine if the use of RELiZORB™ improves nutrition tolerance and helps critically ill patients meet their nutrition goals.
- Trial name
- NCT05710315
- Testing
- RELiZORB™
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Inova Health Care Services
Septic Shock, Multiple Organ Failure
Severe Sepsis/Septic Shock on Admission to the General Surgical ICU
Severe sepsis/septic shock are serious complications of infection with high morbidity and mortality. Recent information showed that early and aggressive resuscitation may help improving survival and outcome especially the…
- Conditions
- Septic Shock, Multiple Organ Failure, Fatal Outcome
- Trial name
- NCT01363635
- Where
- Thailand
- Volunteers
- 800 people
- Sponsor
- Mahidol University
Multiple Organ Failure, Critical Illness
Supplemental Parenteral Nutrition in Critically Ill Adults: A Pilot Randomised Controlled Trial
One of the essential treatments for assisting patients in their recovery from illness is the provision of nutrition in a liquid form which is delivered into the stomach or as a fluid into the vein.
- Trial name
- NCT01847534
- Testing
- Supplemental PN, Standard Care
- Where
- 6 sites in Australia, New Zealand
- Volunteers
- 100 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Covid19
ProAdrenomedullin Assessment of Multi-Organ Failure in COvid-19 Sepsis
COVID-19 is a worldwide pandemic. Around 5% of infected patients are admitted in ICU, mainly for respiratory failure. Outcome of these patients is linked to other organ failures. Optimal therapies are not defined so far.
- Trial name
- PAMOCOS (NCT04522310)
- Testing
- MR-Pro-ADM
- Where
- 8 sites in France
- Volunteers
- 183 people
- Sponsor
- Centre Hospitalier de Lens
Burns, Multiple Organ Failure
Early Haemadsorption in Major Burns
Major deep burns (>20% body surface, involving deep skin layers) and associated severe inflammatory reaction and their complication are one of the biggest challenge of intensive care.
- Conditions
- Burns, Multiple Organ Failure, Shock, Organ Dysfunction Syndrome, Multiple
- Trial name
- NCT04195126
- Testing
- CytoSorb haemadsorption device
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- University of Pecs
Fluid Shifts, Critical Care
Effects of Fluid Balance Control in Critically Ill Patients
Most ICU patients develop a positive fluid balance, mainly during the two first weeks of their stay. The causes are multifactorial: a reduced urine output subsequent to shock state, positive pressure mechanical ventilation, acute…
- Trial name
- POINCARE (NCT02765009)
- Testing
- diuretics, albumin, fluid restriction
- Where
- 11 sites in France
- Volunteers
- 1,411 people
- Sponsor
- Central Hospital, Nancy, France
Critical Illness, Multiple Organ Dysfunction Syndrome
AI-Based Precision Transfusion Prediction Model in Critically Ill Patients
This multicenter observational study aims to develop and validate an artificial intelligence-based precision transfusion prediction model for critically ill patients.
- Conditions
- Critical Illness, Multiple Organ Dysfunction Syndrome, Blood Transfusion
- Trial name
- NCT07762131
- Testing
- Red Blood Cell Transfusion Exposure
- Volunteers
- 2,598 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Multiple Organ Failure, Intensive Care Unit Syndrome
The Blood Pressure Analysis on Critically Ill Patients
The study is to explore the relationship between coefficient of variation of harmonic magnitude (HCV) and different organ failures among those critically ill patients.
- Trial name
- NCT03827369
- Testing
- ICU patient
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taoyuan General Hospital
Sepsis
Therapeutic Plasma Exchange in the Treatment of Sepsis Associated Multi-Organ Failure [SAMOF-TPE]
The investigators prospective, randomized adult clinical trial investigates the therapeutic efficacy of early therapeutic plasma exchange as adjunct treatment to standard therapy in patients with refractory septic shock and…
- Trial name
- SAMOF-TPE (NCT03844542)
- Testing
- Therapeutic plasma exchange
- Volunteers
- 300 people
- Sponsor
- Forsyth Medical Center
Thrombotic Microangiopathies, Atypical Hemolytic Uremic Syndrome
Eculizumab to Treat Thrombotic Microangiopathy/Atypical Hemolytic Uremic Syndrome -Associated Multiple Organ Dysfunction Syndrome in Hematopoietic Stem Cell Transplant Recipients
Hematopoietic stem cell transplantation (HCT)-associated thrombotic microangiopathy (TMA) is an understudied complication of HCT that significantly affects transplant related morbidity and mortality.
- Conditions
- Thrombotic Microangiopathies, Atypical Hemolytic Uremic Syndrome, Multiple Organ Dysfunction Syndrome
- Trial name
- NCT03518203
- Testing
- Eculizumab
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Congenital Diaphragmatic Hernia, Acute Kidney Injury
Incidence of Acute Kidney Injury and Risk Factors in Newborns With Congenital Diaphragmatic Hernia
The main aim of this project is to elucidate the incidence of acute kidney injury (AKI) in newborns with congenital diaphragmatic hernia during stay in the Pediatric intensive care unit. (PICU).
- Conditions
- Congenital Diaphragmatic Hernia, Acute Kidney Injury, Multiple Organ Failure, Pulmonary Hypertension
- Trial name
- NCT06050525
- Where
- Sweden
- Volunteers
- 109 people
- Sponsor
- Karolinska Institutet
Multiple Organ Failure
Dynamic Monitoring of Circulating microRNA Changes in Patients With or Without Multiple Organ Failure
The objectives are to: 1. validate a panel of tissue-specific miRNAs that are differentially expressed in the plasma of patients with and without multiple organ failure. 2.
- Trial name
- NCT03059524
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
COVID
Mechanisms of Multi-organ Failure in COVID-19
In the United Kingdom, there are currently 138,000 confirmed patients with coronavirus, causing 18,738 deaths. Whilst the disease may be mild in the majority of patients, a significant proportion of patients require intensive…
- Trial name
- NCT04399603
- Testing
- no intervention-mechanistic study
- Where
- 2 sites in United Kingdom
- Volunteers
- 120 people
- Sponsor
- Imperial College London
Acute Respiratory Distress Syndrome Caused by COVID-19
Efficacy of Dexamethasone Treatment for Patients With ARDS Caused by COVID-19
Background: There are no proven therapies specific for Covid-19. The full spectrum of Covid-19 ranges from asymptomatic disease to mild respiratory tract illness to severe pneumonia, acute respiratory distress syndrome (ARDS)…
- Trial name
- DEXA-COVID19 (NCT04325061)
- Testing
- Dexamethasone
- Where
- 24 sites in Spain
- Volunteers
- 19 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Liver Failure, Acute on Chronic, Liver Dysfunction
A Validation Cohort for ACLF Diagnosis and Prognosis
Acute on chronic liver failure (ACLF) is a distinct entity encompassing the acute deterioration of liver function, culminating in multiple organs failure and high short-term mortality.
- Trial name
- Ch-CANONIC-Val (NCT03641872)
- Testing
- Standary therapy
- Where
- 12 sites in China
- Volunteers
- 1,370 people
- Sponsor
- Hai Li
ASA Class III/IV Patients, COPD III/IV
Remimazolam Versus Propofol for Procedural Sedation in Gastrointestinal Endoscopy: A Single-Centre Prospective Observational Comparative Study in a High-Risk Population
Remimazolam is a new, ultra-short-acting benzodiazepine approved in Romania for procedural sedation. It shows significant clinical benefits compared to other sedatives like Propofol or Midazolam, especially in elderly or…
- Conditions
- ASA Class III/IV Patients, COPD III/IV, Age 65 and Older, Multiple Organ Failure
- Trial name
- NCT07362173
- Testing
- Administering remimazolam, Administering propofol
- Where
- Romania
- Volunteers
- 203 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy