Clinical trials: Multicenter Observational Study
Liver Cirrhosis, Esophageal and Gastric Varices
Non-invasive Prediction of Esophageal Varices in Liver Cirrhosis: A Multicenter Observational Study
Esophageal variceal bleeding is one of the most lethal complications of liver cirrhosis. In the early stage of liver cirrhosis, the prediction of esophageal varices is very important for guiding the clinical decision making of…
- Trial name
- NCT02593799
- Testing
- Endoscopy
- Where
- 17 sites in China
- Volunteers
- 363 people
- Sponsor
- General Hospital of Shenyang Military Region
Anterior Blepharitis
Ocular Dysbiosis in Eyelid Disease
The goal of this observational study is to determine the presence and prevalence of fungal organisms in four distinct blepharitis populations.
- Trial name
- ODYSSEY (NCT07869498)
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Brent Kramer
Primary Sclerosing Cholangitis
National Database on Primary Sclerosing Cholangitis (PSC)
Primary sclerosing cholangitis (PSC) a rare, chronic fibroinflammatory disease of the liver. No data about the disease epidemiology exist in Italy.
- Trial name
- NCT05618145
- Testing
- Clinical information
- Where
- 63 sites in Italy
- Volunteers
- 6,000 people
- Sponsor
- University of Milano Bicocca
Sudden Cardiac Death, Ventricular Fibrillation
Prognostic Value of Ventricular Fibrillation Spectral Analysis in Sudden Cardiac Death
Ventricular fibrillation (VF)-related sudden cardiac death (SCD) is a leading cause of mortality. Patients may survive with neurological damage despite state-of-the-art treatment.
- Conditions
- Sudden Cardiac Death, Ventricular Fibrillation, Reperfusion Injury
- Trial name
- AWAKE (NCT03248557)
- Testing
- Spectral analysis of ventricular fibrillation tracings
- Where
- 5 sites in Spain
- Volunteers
- 168 people
- Sponsor
- Hospital San Carlos, Madrid
Haemorrhoids
The Russian Multicenter Observational Study "Evaluation of the HDQ for the Diagnosis of Hemorrhoidal Disease ( HDQ )
Currently in Russia there is no available self-evaluating tools with appropriate diagnostic accuracy for screening of patients with haemorrhoids.
- Trial name
- HDQ (NCT04943666)
- Testing
- Hemorrhoid Disease Questionnaire
- Where
- Russia
- Volunteers
- 725 people
- Sponsor
- Servier Russia
Mucopolysaccharidosis IV Type A, Morquio A Syndrome
A Multicenter, Multinational, Observational Morquio A Registry Study (MARS)
The objectives of this program are: to characterize and describe the Mucopolysaccharidosis IV type A (MPS IVA) population as a whole, including the heterogeneity, progression, and natural history of MPS IVA; to evaluate the…
- Conditions
- Mucopolysaccharidosis IV Type A, Morquio A Syndrome, MPS IVA
- Trial name
- MARS (NCT02294877)
- Testing
- Vimizim® (elosulfase alfa)
- Where
- 79 sites in United States, Australia and 15 more
- Volunteers
- 418 people
- Sponsor
- BioMarin Pharmaceutical
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Frailty
Immune Aging and Advanced Therapy Outcomes in Older Adults With IBD
The goal of this observational study is to learn whether signs of immune aging and frailty can help predict the balance of benefits and risks of advanced therapies in adults aged 60 years or older with inflammatory bowel disease…
- Conditions
- Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Frailty, Immunosenescence
- Trial name
- NCT07828886
- Volunteers
- 300 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Emergency Service, Hospital, Epidemiology
Analysis of Emergency Department Visits According to Incidence of Covid-19
With lockdown, Emergency Departments (ED) visits decrease, principally for visits unrelated with Covid-19. In this study, the investigators aimed to find a correlation between ED visits and incidence rate of Covid-19 in a French…
- Trial name
- NCT05126641
- Where
- 8 sites in France
- Volunteers
- 400,000 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Roubaix
Parkinson's Disease
Research on Novel Biomarkers for Early Diagnosis of Parkinson's Disease:An Observational, Multicenter, Non-Randomized Controlled Study
This observational, multicenter, non-randomized controlled study is to evaluate the detection ability of α-Synuclein Ultrafine Fluorescence Detection Method for body fluids (Such as saliva, urine, cerebrospinal fluid, and blood…
- Trial name
- NCT06232772
- Testing
- α- Synuclein Ultrafine Fluorescence Detection Method
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Yousheng Xiao
Rheumatoid Arthritis
A Non-Interventional Study of RoActemra/Actemra in Patients With Moderate to Severe Rheumatoid Arthritis
This multi-center observational study will evaluate the use of RoActemra/Actemra (tocilizumab) in patients with rheumatoid arthritis.
- Trial name
- NCT01672970
- Where
- 20 sites in Hungary
- Volunteers
- 291 people
- Sponsor
- Hoffmann-La Roche
Knee Osteoarthritis
Amtolmetin Gaucil in Knee Osteoarthritis
This study is conducted to study the efficacy and safety of Niselat in patients with osteoarthritis.
- Trial name
- AGATA (NCT02865161)
- Testing
- NISELAT
- Volunteers
- 220 people
- Sponsor
- Dr. Reddy's Laboratories Limited
Coronary Artery Disease, Myocardial Ischemia
BIOFLOW-III Sweden Satellite Registry
This registry is a clinical post-market evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES).
- Trial name
- NCT01667003
- Where
- 8 sites in Sweden
- Volunteers
- 406 people
- Sponsor
- Biotronik ApS
Pregnancy Complications, Gestational Diabetes
Early Versus Late Monitoring Among Pregnant Women With a History of Gestational Diabetes
The goal of this study investigate if pregnant women with a history of gestational diabetes (GDM) have better pregnancy outcomes if they test their blood glucose four times a day early in the pregnancy versus having an oral…
- Trial name
- NCT06545227
- Testing
- continuous blood glucose monitoring in a subset of women (n=25) in the early monitoring group., Collection of urine, maternal blood at baseline and 28 weeks in a subset of women (n=25), Collection of umbilical cord blood, placental samples and cord tissue in a subset of women (n=25)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Imperial College London
Urothelial Carcinoma (UC), Upper Tract Urothelial Carcinoma
Urinary Cell-Free DNA Liquid Biopsy for Urothelial Cancer Diagnosis and Origin Identification
Urothelial carcinoma is the most common cancer of the urinary system. It includes bladder cancer and upper urinary tract cancer, which starts in the kidney pelvis or ureter.
- Conditions
- Urothelial Carcinoma (UC), Upper Tract Urothelial Carcinoma, Bladder Cancer
- Trial name
- NCT07888374
- Where
- China
- Volunteers
- 477 people
- Sponsor
- Ruijin Hospital
Non-small Cell Lung Cancer (NSCLC)
A Study of Brigatinib as Preferred First Therapy for Adults With Non-Small Cell Lung Cancer (NSCLC) ENTIRETY
This is a study of brigatinib in adults with Non-Small Cell Lung Cancer (NSCLC). The main aim of this study is to learn about the time period in which the condition does not worsen after the participant has received brigatinib.
- Trial name
- ENTIRETY (NCT05735327)
- Testing
- No intervention
- Where
- 12 sites in Poland
- Volunteers
- 50 people
- Sponsor
- Takeda
Restless Legs Syndrome, Sleep Quality
Restless Legs Syndrome and Sleep Quality in Pes Planus
Pes planus, also known as flatfoot, is a common foot deformity that can affect the biomechanics of the lower limbs. However, its relationship with neurological conditions has not been studied extensively.
- Conditions
- Restless Legs Syndrome, Sleep Quality, Pain, Quality of Life
- Trial name
- FLAT-RLS (NCT07117591)
- Where
- Turkey (Türkiye)
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Bozok University
Acute Mesenteric Ischemia
Mesenteric Ischemia in the Emergency Department: a Retrospective Multicenter Study
Acute mesenteric ischemia is a life-threatening condition characterized by high mortality if unrecognized early. This multicenter retrospective observational study will review the emergency departments's (ED) notes of all…
- Trial name
- NCT02772913
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Genova
Parkinson Disease
Real-World Patient Experiences Using Continuous Subcutaneous Apomorphine Infusion (ONAPGOTM) in the United States:
Real-World Participants Experiences Using Continuous Subcutaneous Apomorphine Infusion (ONAPGOTM) in the United States: A Prospective, Phase 4, Multicenter, Observational Study in Parkinson's Disease
- Trial name
- NCT07219927
- Testing
- Observational study
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Crohn's Disease, Ulcerative Colitis
A Multicenter, Prospective, Long-term, Observational Registry of Pediatric Patients With Inflammatory Bowel Disease
The purpose of this study is to evaluate the long-term safety and clinical status of pediatric patients with Inflammatory Bowel Disease (IBD).
- Conditions
- Crohn's Disease, Ulcerative Colitis, Indeterminate Colitis, Inflammatory Bowel Diseases
- Trial name
- DEVELOP (NCT00606346)
- Testing
- Anti TNF therapy including infliximab, No Biologics
- Where
- 62 sites in United States, Canada
- Volunteers
- 4,970 people
- Sponsor
- Janssen Biotech, Inc.
Inflammatory Bowel Diseases
Clinical Value of Intestinal Ultrasound in Predicting Clinical Relapse in Crohn's Disease Patients in Deep Remission: a Multicenter Prospective Observational Study
Crohn's disease (CD) is a nonspecific chronic inflammatory condition characterized by a protracted course with alternating periods of relapse and remission.
- Trial name
- NCT07539727
- Testing
- Transabdominal Intestinal Ultrasound
- Where
- China
- Volunteers
- 420 people
- Sponsor
- Nanfang Hospital, Southern Medical University