Clinical trials: Multidrug-resistant Colonization
Infection Due to Resistant Organism
FMT for MDRO Colonization in Solid Organ Transplant
This is a pilot feasibility study to determine whether fecal microbiota transplantation (FMT) can suppress or reverse gastrointestinal carriage of MDROs in hospitalized solid organ transplant recipients with a history of one or…
- Trial name
- FMT (NCT02816437)
- Testing
- OpenBiome Fecal Microbiota Transplantation retention enema
- Sponsor
- University of Miami
Lung Infection, Microbial Colonization
FMT for Lung and Associated-organ Rescue Efficacy in MDRO-infected Ventilated Patients
Multidrug-resistant organism (MDRO)-infection represents a substantial global health burden. In the intensive care unit (ICU), the concurrent administration of antibiotics, opioids, proton pump inhibitors (PPIs)…
- Conditions
- Lung Infection, Microbial Colonization, Food Intolerance Syndromes
- Trial name
- FLARE-MV (NCT06970262)
- Testing
- Fecal suspension
- Where
- China
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Intestinal Colonization With Multidrug-resistant Bacteria
Eradication of Antibiotic-resistant Bacteria Through Antibiotics and Fecal Bacteriotherapy
This investigator initiated,international, multicenter open-label, randomized controlled trial aims to assess whether a 5 day course of oral nonabsorbable antibiotics (colistin sulfate 2 million IU per os 4x/day and neomycin…
- Trial name
- R-GNOSIS WP3 (NCT02472600)
- Testing
- Colistin, Neomycin, Fecal microbiota transplantation (FMT)
- Where
- 4 sites in France, Israel and 2 more
- Volunteers
- 39 people
- Sponsor
- Stephen Harbarth
Drug Resistance, Multiple, Travel Medicine
The Effect of Hand Hygiene on Colonization Rates With Multidrug Resistant Enteric Pathogens in Travellers
Travelling to tropical and subtropical countries is a known risk factor for becoming colonized with extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae.
- Trial name
- NCT03306407
- Testing
- Improved hand hygiene
- Where
- 2 sites in Switzerland
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Christoph Hatz
Blood Disorders
Stool Transplantation to Reduce Antibiotic Resistance Transmission
During this prospective observational study, the investigators collect the information about the outcomes of fecal microbiota transplantation in patients with blood disorders, performed to eradicate gut colonization with…
- Trial name
- START (NCT02461199)
- Testing
- Fecal microbiota transplantation
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Warsaw
Infection With Multi-drug Resistant Organisms
FMT for Multidrug Resistant Organism Reversal
This proposed protocol involves the use of the fecal microbiota transplantation (FMT) to suppress or reverse colonization with multidrug resistant organisms (MDRO) in subjects with recurrent MDRO infections due to organisms of…
- Trial name
- NCT02312986
- Testing
- Fecal microbiota transplantation (FMT)
- Volunteers
- 1 people
- Sponsor
- Washington University School of Medicine
Infection Due to ESBL Escherichia Coli
Fosfomycin Versus Meropenem or Ceftriaxone in Bacteriemic Infections Caused by Multidrug Resistance in E.Coli
Enterobacterieaceae (and specially Escherichia coli) showing resistance due to multidrug-resistant Escherichia coli, plasmid mediated AmpC or quinolone resistance caused by chromosomal mechanisms have spread worldwide during the…
- Trial name
- FOREST (NCT02142751)
- Testing
- Fosfomycin sodium intravenous, Meropenem intravenous, Ceftriaxone intravenous
- Where
- 22 sites in Spain
- Volunteers
- 161 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Immunocompromised Host, Critical Care
ICU-acquired Colonization and Infection Related to MDR in Immunocompromised Patients
the number of immunocompromised patients hospitalized in the intensive care units (ICU) is increasing. They are at higher risk of colonization and/or infection with multi-resistant bacteria (MDR).
- Trial name
- CIMDREA (NCT04043793)
- Where
- 7 sites in France
- Volunteers
- 759 people
- Sponsor
- University Hospital, Lille
Multi-antibiotic Resistance
Screening of Multidrug Resistant Bacteria, and the Clinical Implication for the Patient
The goal of this observational study is to evaluate the screening for multidrug resistant bacteria in patients admitted to hospitals in Scania.
- Trial name
- NCT06370299
- Testing
- (exposure of) MDR carriage
- Volunteers
- 10,000 people
- Sponsor
- Region Skane
ICU-ecology (Multidrug Resistant Bacteria), ICU-acquired Bacteraemia
Ecological Effects of Decolonisation Strategies in Intensive Care
Previous research has shown that applying certain treatments can reduce both the number of infections and the presence of resistant bacteria in the intensive care (ICU) and its patients.
- Trial name
- RGNOSIS (NCT02208154)
- Testing
- Chlorhexidine oral care (CHX-Oro), Selective oropharyngeal decontamination (SOD), Selective Digestive Decontamination (SDD)
- Where
- 13 sites in Belgium, Italy and 4 more
- Volunteers
- 8,665 people
- Sponsor
- MJM Bonten
Antibiotic Resistant Strain, Microbial Colonization
Fecal Microbiota Transplantation for Eradication of CRE
Antibiotic resistance has emerged world wide and is of major concern. Multi-drug resistant (MDR) bacteria is widely spread and is now a major factor in morbidity and mortality in health-care settings.
- Trial name
- NCT03167398
- Testing
- Fecal Microbiota Transplantation
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Rambam Health Care Campus
Colonization, Asymptomatic
Safety and Efficacy of Lyophilized Fecal Microbiota Transplantation Via Capsules for Intestinal Multidrug-resistant Bacteria Decolonization
The goal of this clinical trial is to learn if oral capsules containing lyophilized stool from healthy donors (fecal microbiota transplantation or FMT) can safely and effectively decolonize multidrug-resistant organisms (MDROs)…
- Trial name
- FORCE (NCT07106580)
- Testing
- lyophilized FMT capsules
- Where
- Croatia
- Volunteers
- 52 people
- Sponsor
- University of Rijeka
COVID-19, Bacterial Infections
Incidence of Colonization by Multidrug-resistant Organisms in Mechanically Ventilated Patients With Severe COVID-19
Retrospective single-center cohort study to evaluate the incidence of colonization by multidrug-resistant organisms (MDRO) in mechanically ventilated patients admitted to a large intensive care unit (ICU) for severe acute…
- Conditions
- COVID-19, Bacterial Infections, Colonization, Asymptomatic
- Trial name
- MDR_in_Fiera (NCT05293418)
- Testing
- data collection
- Where
- Italy
- Volunteers
- 435 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Bacterial Colonization, Multidrug Resistant Organisms
Enteral Nutrition and Colonization Resistance Through Microbiota Modulation in Critically Ill Patients
The goal of this clinical trial is to learn whether enteral nutrition enriched with fiber can influence gut microbiota and improve resistance to colonization with multidrug-resistant bacteria in critically ill patients.
- Conditions
- Bacterial Colonization, Multidrug Resistant Organisms, Critical Illness, Gut Microbiota Dysbiosis
- Trial name
- MICRON (NCT07719673)
- Testing
- Fibre-Enriched Enteral Nutrition, Standard Enteral Nutrition
- Where
- Romania
- Volunteers
- 60 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Multi-resistant Gram-negative Bacteria Cause Infection
GRAM NEGATIVES STUDY
This is a prospective, observational, multicenter study whose main objective is to develop a predictive model of mortality in critically ill patients colonized by multidrug-resistant Gram-negative bacteria (MDR-GNB).
- Trial name
- MR-GEIPC (NCT07749508)
- Testing
- Standard of care therapy
- Where
- Spain
- Volunteers
- 1,500 people
- Sponsor
- Fundacion SEIMC-GESIDA
Bacterial Infections, HIV Infections
Risk-factors for Multidrug-resistant Bacteria Colonization Among Patients at High Risk of STIs
The aim of this study is to identify risk factors and prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) bacteria colonization among patients at high risk of STIs
- Trial name
- BMR-IST (NCT03767374)
- Testing
- Inguinal swab sample, Anal swab sample, Fecal sample
- Where
- France
- Volunteers
- 2,186 people, healthy volunteers welcome
- Sponsor
- Institut de Médecine et d'Epidémiologie Appliquée - Fondation Internationale Léon M'Ba
Viral Infection, Bacterial Infections
Distinguishing Bacterial and Viral Infections by MeMed BV® Test to Limit Gut Colonization by MDRO
The fast increase of Multidrug-resistant microorganisms (MDRO) due to the high amount of antimicrobials being poorly used may be limited by better regulating antimicrobial usage globally.
- Conditions
- Viral Infection, Bacterial Infections, Multi-antibiotic Resistance, Respiratory Tract Infections
- Trial name
- CRONUS (NCT05897801)
- Testing
- MeMed BV®
- Where
- 3 sites in Greece
- Volunteers
- 230 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Healthcare-Associated Infections (HAIs), Carbapenem-Resistant Enterobacteriaceae Colonization
Correlation Between Carbapenemase-Producing Enterobacterales Load, Environmental Contamination, and Transmission in Critical Care Units
Carbapenemase-producing Enterobacterales (CPE) are multidrug-resistant bacteria that can colonize the gastrointestinal tract of hospitalized patients and spread within intensive care units (ICUs).
- Conditions
- Healthcare-Associated Infections (HAIs), Carbapenem-Resistant Enterobacteriaceae Colonization, Antimicrobial Resistance (AMR)
- Trial name
- CPE-Load ICU S (NCT07685132)
- Where
- Argentina
- Volunteers
- 60 people
- Sponsor
- Hospital Italiano de Buenos Aires
Multidrug Resistance
Point Prevalence Study of Multidrug-Resistant Organism Carriage by Healthcare Personnel
Acquisition and transmission of MDROs in healthcare facilities is a major patient safety problem, afflicting in particular the antibiotic-exposed and immunodeficient patient populations.
- Trial name
- NCT01952158
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Infection Due to Resistant Organism
FMT for MDRO Colonization After Infection in Renal Transplant Recipients
Transplant patients are at increased risk of colonization and infection with Multidrug Resistant Organisms (MDROs) due to medications that modify their immune systems, increased healthcare and antibiotic exposure, and surgical…
- Trial name
- PREMIX (NCT02922816)
- Testing
- Fecal Microbiota Transplant (FMT), Bowel preparation, Stool or perirectal swab sampling
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Emory University