Clinical trials: Multidrug-resistant Colonization
Antibiotic Resistant Strain
A Trial of Encapsulated Fecal Microbiota for Vancomycin Resistant Enterococcus Decolonization
The objective of this study is to provide preliminary insight into the safety and efficacy of fecal microbiota transplantation (FMT) for the eradication of gastrointestinal carriage of vancomycin-resistant Enterococcus.
- Trial name
- NCT03063437
- Testing
- Encapsulated fecal microbiota preparation
- Where
- 2 sites in United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Microbiome Health Research Institute
Clostridioides Difficile Infection, Drug Resistance, Bacterial
Effect of Oral Microbiota on MDRO Decolonization
Randomized, placebo-controlled trial to evaluate the safety and efficacy of oral intestinal microbiota capsules for decolonizing multidrug-resistant organisms (MDROs) and Clostridioides difficile in patients requiring prolonged…
- Conditions
- Clostridioides Difficile Infection, Drug Resistance, Bacterial, Gastrointestinal Microbiome, Multidrug-resistant Colonization
- Trial name
- NCT07496502
- Testing
- Microbiota capsule
- Where
- Mexico
- Volunteers
- 42 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Hemato-oncologic Patients, Colonization
Predictive Score in Patients With Hematological Malignancies Colonized by Multidrug-resistant Enterobacteriaceae
The goals of this observational study are to identify risk factors for ESBL-producing Enterobacterales and carbapenemase-producing Enterobacterales (CPE) colonization in oncohematological patients with severe neutropenia, and to…
- Conditions
- Hemato-oncologic Patients, Colonization, Neutropenia, Enterobacteria Non Susceptible to Carbapenem Carrier
- Trial name
- SCREEN-IN (NCT07396571)
- Where
- 15 sites in Spain
- Volunteers
- 535 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Ventilator Associated Pneumonia
Efficacy Study of Colistimethate Sodium Inhalation in Patients With Ventilator-associated Pneumonia
There might be additional benefit on clinical outcomes from adjunctive colistimethate sodium inhalation as therapy for multidrug resistant Gram-negative ventilator-associated pneumonia.
- Trial name
- NCT01975350
- Where
- Taiwan
- Volunteers
- 49 people
- Sponsor
- National Taiwan University Hospital
Antimicrobial Drug Resistance, Antibiotic Resistant Infection
Dynamics of Colonization and Infection by Multidrug-Resistant Pathogens in Immunocompromised and Critically Ill Patients
The goal of this observational study is to investigate how bacterial populations from the intestine and mouth of patients change during the hospitalization period and evaluate if some populations of specific bacteria increase or…
- Conditions
- Antimicrobial Drug Resistance, Antibiotic Resistant Infection, Clostridium Difficile, Carbapenem-Resistant Enterobacteriaceae Infection
- Trial name
- DYNAMITE (NCT06258551)
- Where
- 2 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
Carbapenem-Resistant Enterobacteriaceae Colonization
Fecal Microbiota Transplantation for Decolonization of Multidrug-resistant Microorganisms
The aim of the study is to see whether fecal microbiota transplantation is effective to decolonize multidrug-resistant organisms.
- Trial name
- NCT07265817
- Testing
- Fecal Microbial transplant Capsules
- Volunteers
- 60 people
- Sponsor
- Kyungpook National University Hospital
Multidrug Resistant Bacterial Infection, Enterobacteriaceae Infections
PMT for MDRO Decolonization
This is a randomized, open label, comparative Phase II trial being conducted to determine whether fecal microbiota transplant using Penn Microbiome Therapy (PMT) products helps standard therapy eradicate antibiotic-resistant…
- Conditions
- Multidrug Resistant Bacterial Infection, Enterobacteriaceae Infections, Pseudomonas Aeruginosa, VRE Infection
- Trial name
- NCT05632315
- Testing
- PMT
- Where
- 3 sites in United States
- Volunteers
- 32 people
- Sponsor
- University of Pennsylvania
Antibiotic Resistant Infection
Effectiveness of Chlorhexidine Wipe for Prevention of Multidrug-resistant Organisms in Intensive Care Unit Patients
The purpose of this study is to determine 2% chlorhexidine wipes are effective in preventing of colonization of multi-drug resistant bacteria in intensive care unit patients.
- Trial name
- NCT01989416
- Testing
- 2% chlorhexidine wipe, Soap
- Where
- Thailand
- Volunteers
- 481 people
- Sponsor
- Mahidol University
Infection
Evaluation of the American Thoracic Society Criteria for Predicting Multidrug-resistant Bacteria in Critically Ill Patients
Appropriate initial antibiotic treatment based on early diagnosis of etiology will improve the outcome of sepsis. The incidence rates of multidrug-resistant (MDR) bacteria, which are different between countries, will affect the…
- Trial name
- NCT01667991
- Volunteers
- 610 people
- Sponsor
- Southeast University, China
Multi-drug Resistant Gram-negative Bacilli Colonization
Multidrug Resistant Gram-negative Bacilli Colonization and Infection in Burn
This is a prospective observational study to determine the role of colonization and identify the timing of development of drug resistance in multidrug resistant Gram-negative bacilli (MDR-GNB) causing infection among critically…
- Trial name
- NCT02653157
- Testing
- MDR-GNB
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of North Carolina, Chapel Hill
Multidrug-resistant Colonization
Studies of the Human Microbiome in Clinical Center Patients
Background: The intestines, mouth, and skin all contain billions of bacteria and some fungi. Every person s body contains microorganisms like these. They normally do not make people sick.
- Trial name
- NCT01933620
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Sars-CoV2, Critical Illness
COVID-19 and ICU-acquired MDR Bacteria
This multicenter before-after study aimed to determine the impact of infection related to SARS-CoV-2 on the incidence of ICU-acquired multidrug resistant (MDR) bacteria.
- Trial name
- COVID-BMR (NCT04378842)
- Where
- 7 sites in France
- Volunteers
- 368 people
- Sponsor
- University Hospital, Lille
Cirrhosis, Liver, Rectal Colonization
Longitudinal Surveillance of Rectal Colonization and Transmission by Resistant Bacteria in Acutely Decompensated Cirrhosis
Antimicrobial resistance has emerged as a global threat, and multidrug resistance organisms (MDROs) form one of the foremost challenges in the setting of decompensated cirrhosis.
- Conditions
- Cirrhosis, Liver, Rectal Colonization, Multidrug Resistance Organisms
- Trial name
- NCT06511492
- Testing
- No intervention in this study
- Volunteers
- 1,289 people
- Sponsor
- Nanfang Hospital, Southern Medical University