Clinical trials: Multimodal Analgesia
Pain, Postoperative, Inguinal Hernia Unilateral
Intrathecal Morphine and Transversalis Fascia Plane Block for Analgesia After Open Inguinal Hernia Repair
Inguinal hernia is a common surgical condition, and open inguinal hernia repair may be associated with significant postoperative pain.
- Conditions
- Pain, Postoperative, Inguinal Hernia Unilateral, Intrathecal Morphine, Transversalis Fascia Plane Block
- Trial name
- NCT07826741
- Testing
- Intrathecal Morphine Group, Transversalis Fascia Plane Block Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Regional Anesthesia Block, Regional Anesthesia
PENG and LFCN Block Versus FIC Block for Multimodal Analgesia After Total Hip Replacement Surgery: a Retrospective Analysis Focused on Movement (Retro-PvF)
Total hip arthroplasty is a major surgical procedure performed on a growing number of patients. Optimal pain control with limited muscle weakness is paramount for a swift initiation of physical therapy and ambulation, thus…
- Conditions
- Regional Anesthesia Block, Regional Anesthesia, Total Hip Replacement Surgery, Total Hip Arthroplasty \(THA\)
- Trial name
- Retro-PvF (NCT06342102)
- Testing
- PENG + LFCN block, FIC block
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Ospedale Edoardo Bassini
Obesity, Postoperative Pain
OFA vs OBA in Bariatric Surgery
This study compares two different anesthesia techniques in patients with obesity undergoing bariatric surgery: one that includes opioids (OBA), and one that avoids them completely (OFA).
- Conditions
- Obesity, Postoperative Pain, Bariatric Surgery, Opioid-free Anesthesia
- Trial name
- OFA VS OBA1 (NCT07075302)
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Hospital HM Nou Delfos
Head and Neck Cancer, Radiation-Induced Mucositis
Opioid Therapy vs Multimodal Analgesia in Head and Neck Cancer
The purpose of this study is to compare the daily pain level scores for patients taking opioids alone for pain relief, compared with those treated by multimodal analgesia with three medications: pregabalin, naproxen, and…
- Trial name
- NCT04221165
- Testing
- Opioids, PAiN - multimodal analgesia
- Where
- Canada
- Volunteers
- 49 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Knee Osteoarthritis, Gonarthrosis; Primary
Oral vs Intravenous Dexamethasone in Total Knee Arthroplasty
This prospective observational cohort study aims to evaluate the association between perioperative dexamethasone administration and early postoperative recovery following primary total knee arthroplasty.
- Conditions
- Knee Osteoarthritis, Gonarthrosis; Primary, Total Knee Arthroplasty
- Trial name
- TKA (NCT07442812)
- Testing
- Routine perioperative management
- Where
- Turkey (Türkiye)
- Volunteers
- 270 people
- Sponsor
- Haseki Training and Research Hospital
Postoperative Pain
The Efficacy of Periarticular Single Drug Compared With Multimodal Drug Injection in Controlling Pain After TKA
The purpose of this study is to determine the periarticular multimodal drug injection has more efficacy for controlling pain after TKA than single anaesthetic drug injection.
- Trial name
- TKA (NCT01898052)
- Testing
- single anaesthetic drug, multimodal drug injection
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Thammasat University
Total Knee Arthroplasty
IPACK Block in Total Knee Arthroplasty
100 patients ASA I-III, undergoing total knee arthroplasty under spinal anesthesia, will be randomly assigned into one of two groups, namely group A (n=50), where an adductor canal block and an IPACK block will be performed…
- Trial name
- NCT03692858
- Testing
- Adductor Canal Block plus IPACK Block, Adductor Canal Block
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Asklepieion Voulas General Hospital
Pain, Postoperative, Analgesia
IV Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy
This double-blinded, placebo-control trial clinical trial aims to investigate the effect of IV oxytocin infusion on peri-operative opioid consumption following a minimally invasive hysterectomy under general anesthesia.
- Conditions
- Pain, Postoperative, Analgesia, Postoperative Pain, Pain, Post Operative
- Trial name
- NCT05608070
- Testing
- Oxytocin
- Sponsor
- Beth Israel Deaconess Medical Center
Chronic Low-back Pain (cLBP)
Yoga and Mindfulness for Chronic Low Back Pain: A Randomized Controlled Trial
Chronic low back pain (CLBP) is a leading cause of disability, significantly impacting quality of life and work productivity. Traditional treatments often provide limited relief, necessitating alternative approaches.
- Trial name
- NCT06910982
- Testing
- Sphinx Pose Yoga Therapy
- Where
- Pakistan
- Volunteers
- 220 people
- Sponsor
- University of Karachi
Knee Osteoarthritis, Knee Pain Chronic
iPACK Block for Total Knee Arthroplasty
This randomized, double-blinded, placebo-controlled trial seeks to evaluate the efficacy of the rehabilitation process of the Interspace between the Popliteal Artery and Capsule of the Posterior Knee (iPACK) block in total knee…
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Disease
- Trial name
- NCT06087562
- Testing
- Ropivacaine 0.5% Injectable Solution 20mL, 0,9% normal saline 20mL
- Where
- Poland
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Chronic Pain
Effects of Multimodal Pain Therapy in Patients With Mixed Chronic Pain Syndromes
Complex and chronified pain syndromes requires a specialized therapeutic concept. From patients with chronic low back pain the investigators know, that an interdisciplinary multi-modal approach may improve the therapeutic…
- Trial name
- IMPERApain (NCT01346202)
- Where
- Germany
- Volunteers
- 260 people
- Sponsor
- Klinikum St. Georg gGmbH
Cholecystectomy, Laparoscopic, Ambulatory Surgical Procedures
Efficacy and Safety of Cocktail of Ropivacaine for Local Infiltration Analgesia in Patients Undergoing Laparoscopic Cholecystectomy
The goal of this clinical trial is to learn if the use of cocktail of ropivacaine,sodium bicarbonate and dexamethasone for incision local infiltration analgesia in patients undergoing ambulatory laparoscopic cholecystectomy is…
- Conditions
- Cholecystectomy, Laparoscopic, Ambulatory Surgical Procedures, Multimodal Analgesia
- Trial name
- NCT06819748
- Testing
- The cocktail of 0.5% ropivacaine ,5%sodium bicarbonate and 10 mg dexamethasone, 0.5% ropivacaine
- Where
- China
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
Single Level Lumbar Decompression and Fusion Spine Surgery
Multimodal Analgesia vs. Routine Care Pain Management for Lumbar Spine Fusion Surgery: A Prospective Randomized Study
The purpose of this study is to determine if post-operative pain and rate of recovery are improved in patients undergoing spine surgery using MMA (multimodal analgesia) compared to usual analgsic care.
- Trial name
- NCT02202369
- Testing
- Multimodal Analgesia Treatment, Standard of Care Pain Management Protocol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Postoperative Acute Pain
Efficacy and Safety of Anrikefon Injection for Multimodal Postoperative Analgesia in Patients Undergoing Laparoscopic Hepatectomy
A single-center, randomized, double-blind, placebo-controlled trial design will be adopted to investigate whether Anruikefon can significantly reduce the consumption of sufentanil via PCIA pumps within 48 hours postoperatively…
- Trial name
- NCT07801183
- Testing
- Anruikefon 1 μg/kg per dose Group, Anruikefon 100 μg per dose Group, Control group
- Where
- China
- Volunteers
- 117 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Spine Fusion, Locoregional Anaesthesia
PeriOPerative Spine Surgery COntrol Pain (POPSSCOP) Study: Intrathecal Morphine vs Erector Spinae Plane Block for Postoperative Pain Management in Spinal Fusion
This is a prospective observational study conducted at the trauma center of Città della Salute e della Scienza of Turin. The aim of the study is to compare two local regional anesthesia techniques in multimodal analgesia for…
- Conditions
- Spine Fusion, Locoregional Anaesthesia, Intrathecal Anesthesia, Erector Spina Plan Block
- Trial name
- POPSSCOP (NCT07245524)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Inflammation, Inflammatory Response
Effects of Multimodal Analgesia on Serum MCP-1, BDNF, and MiRNA-124 in Hysterectomy Surgery
The inflammatory process is the main mechanism in the occurrence of acute postoperative pain. It is also the main risk for the development of acute pain into persistent pain.
- Conditions
- Inflammation, Inflammatory Response, Acute Pain, Chronic Pain
- Trial name
- NCT05069311
- Testing
- Multimodal analgesia, Conventional intravenous analgesia
- Where
- Indonesia
- Volunteers
- 62 people
- Sponsor
- Udayana University
Anesthesia
Evaluation of the Effectiveness of an Accelerated Rehabilitation Protocol Based on Multimodal Analgesia Optimization for Uni-compartmental Knee Prosthesis Surgery
Today, prosthetic replacement for osteoarthritis of the knee is a frequent surgery. In France, nearly 100,000 knee arthroplasties are performed each year .
- Trial name
- APUC (NCT04916158)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Brest
Breast Surgery, Macromastia
Comparison of ESP and SPSIP Blocks in Breast Surgery
This study aims to compare the efficacy of the ESP and SPSIP blocks in managing postoperative pain following breast surgery. Breast surgery, particularly after oncological and reconstructive procedures, often leads to significant…
- Conditions
- Breast Surgery, Macromastia, Mammaplasty, Modified Radical Mastectomy
- Trial name
- NCT06611644
- Testing
- Erector Spinae Plane Block, SPSIPB blcok, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Çanakkale Onsekiz Mart University
Planned Abdominal Hysterectomy
Optimal Multimodal Analgesia in Abdominal Hysterectomy
The purpose of this study is to test the current standard of care (SOC) treatment for abdominal hysterectomy with a group receiving SOC minus epidural analgesia plus additional perioperative analgesics in terms of postoperative…
- Trial name
- NCT00209872
- Testing
- Gabapentin, Lidocaine, S-ketamine
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Hvidovre University Hospital
Postoperative Pain, Cholelithiasis
Effect of Labetalol, Magnesium Sulfate, or Lidocaine on Opioid Consumption During Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy (gallbladder removal) is one of the most common abdominal operations performed worldwide. Despite its minimally invasive approach, up to half of patients experience notable postoperative pain, which…
- Trial name
- NCT07865455
- Testing
- Labetalol, Magnesium Sulfate, Lidocaine
- Volunteers
- 90 people
- Sponsor
- Assiut University