Clinical trials: Multimodal Imaging
Parkinson's Disease, Magnetic Resonance Imaging
Predictive Value of Multimodal MRI in Parkinson's Disease
Deep brain stimulation (DBS) is recognized as the most safe and effective neurosurgical method for the treatment of advanced Parkinson's disease.
- Conditions
- Parkinson's Disease, Magnetic Resonance Imaging, Deep Brain Stimulation
- Trial name
- NCT05003206
- Testing
- Functional magnetic resonance imaging, Deep Brain Stimulation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Chronic Respiratory Failure, Non-invasive Ventilation
Improving Chronic Nocturnal Noninvasive Ventilation: a Multimodality Approach
The aim of the data collection is to create an advanced reliable method to remotely monitor patient on chronic home non-invasive ventilation (NIV), both regarding ventilatory efficacy and patient comfort, both in the hospital and…
- Trial name
- NOCTIVENT (NCT05756387)
- Testing
- Non-invasive ventilation
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- University Medical Center Groningen
Locally Advanced Rectal Carcinoma, Neoadjuvant Treatment
Longitudinal Multimodal Response Assessment During Neoadjuvant Treatment of Rectal Cancer
This pilot study aims to trial multimodal early response assessment to enable therapy adaptions in the context of non-operative therapy strategies of locally advanced rectal cancer (LARC) for development of a non-invasive…
- Conditions
- Locally Advanced Rectal Carcinoma, Neoadjuvant Treatment, Radiotherapy, Adaptive Treatment
- Trial name
- PRIMO (NCT05524012)
- Testing
- Blood sample, MRI scan
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Jena University Hospital
Dermatomyositis, Dermatomyositis With Calcinosis Cutis
Photoacoustic/Ultrasound Imaging in Patients of Dermatomyositis With Calcinosis Cutis: Characteristic Findings and Treatment Response Evaluation
Photoacoustic imaging (PAI) is an emerging biomedical modality that integrates the advantages of optical contrast and ultrasound imaging depth.
- Trial name
- NCT07037472
- Testing
- Multi-modal photoacoustic/ultrasonic (PA/US) imaging system, Drug treatment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Becker Muscular Dystrophy
Multimodal Study About Absence of Dp140 in Becker Muscular Dystrophy: Brain-muscle Imaging, Cognition and Muscle Function
Monitoring patients with neuromuscular disorders is crucial but doesn't always allow for a sufficiently specific approach to all aspects of the condition.
- Trial name
- MyoBrain-BMD (NCT07740057)
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Institut de Myologie, France
Aortic Valve Stenosis
The Multidisciplinary, Multimodality, But Minimalist Approach to Transfemoral Transcatheter Aortic Valve Replacement
The primary objective of this study is to determine the efficacy, safety and feasibility of next day discharge home in patients undergoing balloon-expandable transfemoral TAVR utilizing the Vancouver 3M Clinical Pathway in low…
- Trial name
- 3MTAVR (NCT02287662)
- Testing
- Vancouver 3M Clinical Pathway
- Where
- Canada
- Volunteers
- 411 people
- Sponsor
- BC Centre for Improved Cardiovascular Health
ALS
Multimodal Imaging Outcome Measures for ALS (Image ALS)
The primary aim of this study is to determine whether longitudinal neuroimaging acquired across multiple research and clinical centers is a feasible biomarker to use as an outcome measure for clinical trials in amyotrophic…
- Trial name
- NCT04490096
- Testing
- [11C]-PBR28
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Pennsylvania
Multiple Sclerosis, Cognition Disorders
Linking Cognitive Functioning to Multimodal Imaging in Multiple Sclerosis (MS)
Multiple sclerosis (MS) is the most common progressive neurologic disorder to occur in adults of working-age. Despite longstanding recognition of cognitive impairment as a symptom of MS, two obstacles in measurement have limited…
- Trial name
- NCT03723356
- Testing
- Siemens Biograph mMR (molecular MR), fMRI, Diffusion Spectrum Imaging (DSI)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Vestibular Schwannoma
Novel Multimodality Imaging for Navigation in Skull Base Surgery
Successful neurosurgery to remove tumours around the base of the skull, such as a vestibular schwannoma, depends on achieving maximal tumour removal whilst preserving crucial neurological functions such as facial movement, and…
- Trial name
- SBN (NCT04128345)
- Testing
- Use of navigation system
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University College, London
Healthy Volunteers, Imaging Evaluation
Multimodal Cardiovascular and Hepatic Population Imaging
Medical imaging is increasingly important for understanding diseases, detecting them early, and personalizing treatments. New imaging techniques, which can measure processes in the body without surgery, are opening the door to a…
- Trial name
- ICONIC (NCT06906042)
- Testing
- Imaging examinations, Paramedical examinations, Medical examination
- Where
- France
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Bladder Cancer
The iBlad App - a National, Exploratory Study on a Multimodality Smartphone App for Bladder Cancer Patients
The aims of this project are: to develop and implement a national multimodality application for patients with bladder cancer that builds upon knowledge from the iBLAD study.
- Trial name
- iBLAD-app (NCT05710159)
- Testing
- iBLAD Application to monitor symptoms and quality of life by the use of pateint-reported outcomes
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
ADHD
Multimodal Brain Imaging of Methylphenidate in Children and Adolescents With ADHD
The goal of this proposal is to develop brain imaging tools to measure the effects of methylphenidate in children and adolescents with attention deficit hyperactivity disorder (ADHD).
- Trial name
- NCT06077669
- Testing
- Methylphenidate
- Where
- United States
- Sponsor
- Johns Hopkins University
Age-related Macular Degeneration, Choroidal Neovascularization
Imaging of the Angiofibrotic Switch in Neovascular AMD
The content of this research project is to identify the angiofibrotic switch, the transition from angiogenesis to fibrosis, in neovascular age-related macular degeneration (nAMD) longitudinally.
- Trial name
- NCT03838679
- Testing
- Best-corrected Visual acuity testing (BCVA), Optical coherence tomography (OCT), Color fundus photography (CFP)
- Where
- Austria
- Volunteers
- 120 people
- Sponsor
- Medical University of Vienna
Epilepsy in Children
Mapping Epileptic Networks Using Multimodal Imaging
Currently, mapping the epileptogenic zone is based on a comprehensive preoperative assessment involving clinical, imaging and electrophysiological examinations.
- Trial name
- CREIM (NCT06202976)
- Testing
- Secondary data collection
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Imagine Institute
Multiple Myeloma
Study to Assess for Measurable Residual Disease (MRD) in Multiple Myeloma Patients
This study is to assess for Measurable Residual Disease (MRD) in multiple myeloma at a deeper level than what is currently available by combining novel imaging and laboratory techniques, determine if patients who are MRD-negative…
- Trial name
- NCT04108624
- Testing
- Screening Phase, Discontinuation Phase
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Chicago
Anomalous Coronary Artery Origin, Anomalous Coronary Artery Arising from the Opposite Sinus
New Patient-specific Functional Assessment of the Anomalous Aortic Origin of Coronary Arteries.
Anomalous Aortic Origin of the Coronary Arteries (AAOCA) is a rare congenital disease that may cause sudden death in young subjects.
- Conditions
- Anomalous Coronary Artery Origin, Anomalous Coronary Artery Arising from the Opposite Sinus, Anomalous Coronary Artery Course, Anomalous Coronary Artery with Aortic Origin and Course Between the Great Arteries
- Trial name
- NECESSARY (NCT05159791)
- Testing
- Invasive coronary blood flow assessment and simulations and fluid dynamic patient specific simulation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Policlinico S. Donato