Clinical trials: Multimorbidity
Frailty, Morbidity, Multiple
Low-volume Cycling Training in Older People With Multimorbidity
INTRODUCTION: Physical exercise, when practiced regularly and in adequate doses, is a proven nonpharmacological measure that helps to prevent and reverse noncommunicable diseases, as well as reduce mortality rates from any cause.
- Trial name
- NCT04842396
- Testing
- Experimental:Motorized cycle ergometer
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Universidade da Coruña
Multimorbidity, Polypharmacy
OPTImization of Medication by Transdisciplinary Assessment of Drug Treatment in Elderly Hospitalized Patients
This study is being done to find out if a multi-faceted intervention designed to optimize medication in hospitalized older people with multiple chronic medical conditions exposed to multiple medications can reduce unplanned…
- Trial name
- OPTIMATE (NCT05387096)
- Testing
- Definitive multi-faceted intervention consisting of several components
- Where
- 3 sites in Belgium, Ireland
- Volunteers
- 642 people
- Sponsor
- University College Cork
Heart Failure
Psychosocial Syndemics of Heart Failure
Heart failure (HF) is a common and debilitating chronic disease with a poor prognosis. Many patients with HFhave psychiatric problems such as depression and other medical disorders such as lung or kidney disease.This study will…
- Trial name
- NCT04637776
- Testing
- Hospitalization
- Where
- United States
- Volunteers
- 367 people
- Sponsor
- Washington University School of Medicine
Multimorbidity, Physical Deconditioning
Engaging Medically Complex Veterans in Tele-Rehabilitation Using a Biobehavioral Approach
The aims of this study are to determine the feasibility and acceptability of a multicomponent telerehabilitation program for medically complex older Veterans and to preliminarily assess participant outcomes (physical activity…
- Trial name
- NCT04942613
- Testing
- Motivational Interviewing Techniques, Physical Therapy Interventions, Education
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Multimorbidity, Polypharmacy
Optimizing PharmacoTherapy In the Multimorbid Elderly in Primary CAre: the OPTICA Trial
The objective of this randomized controlled trial (RCT) is to evaluate whether the Systematic Tool to Reduce Inappropriate Prescribing (STRIP), put into practice through the STRIP Assistant (STRIPA) and implemented by general…
- Trial name
- OPTICA (NCT03724539)
- Testing
- STRIPA intervention
- Where
- Switzerland
- Volunteers
- 323 people
- Sponsor
- University of Bern
Chronic Disease
Nursing Discharge Teaching for Multimorbid Inpatients
The objective of this study is to estimate the effect size of a nursing discharge teaching intervention on multimorbid inpatients activation level, health confidence, readiness for hospital discharge, experience with discharge…
- Trial name
- NCT04253665
- Testing
- Nursing discharge teaching
- Where
- 3 sites in Switzerland
- Volunteers
- 225 people
- Sponsor
- University of Lausanne
Osteoarthritis, Knee, Osteoarthritis, Hip
Personalized Exercise Therapy and Self-management Support for Patients With Multimorbidity
Chronic conditions such as knee or hip osteoarthritis (OA), chronic obstructive pulmonary disease (COPD), heart failure (HF), coronary heart disease (CHD), hypertension, type 2 diabetes mellitus (T2DM) and depression are among…
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Heart Failure, Coronary Heart Disease
- Trial name
- MOBILIZE (NCT04645732)
- Testing
- Personalized exercise therapy and self-management support program, Usual care
- Where
- 16 sites in Denmark
- Volunteers
- 228 people
- Sponsor
- University of Southern Denmark
Chronic Disease
Trajectories of Chronic Multimorbidity Patterns in Older Patients
Following the MRisk-COVID project, MTOP (Multimorbidity Trajectories in Older Patients) study was developed. It is a retrospective observational study using Real World Data that aims to identify patterns of chronic multimorbidity…
- Trial name
- MTOP (NCT05717309)
- Where
- Spain
- Volunteers
- 3,988 people
- Sponsor
- Corporacion Parc Tauli
Polypharmacy, Multimorbidity
Reduction of Polypharmacy in Elderly People With Multiple Diseases
Elderly GP patients are often treated with five or more medications and therefore prone to adverse drug reactions (ADR). Potentially inappropriate prescriptions (PIPs) lead to increased adverse events like falls, hospitalizations…
- Trial name
- RED (NCT05526963)
- Testing
- Medication plan review, Adherence support
- Where
- Germany
- Volunteers
- 1,146 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Multimorbidity, Continuity of Care
Continuity of Care and Use of Urgent Healthcare in Multimorbid Patients
Chronic disease management is a public health problem that faces monitoring difficulties related to complex care pathways. This study will analyze the use of unscheduled or urgent care according to the continuity of care in…
- Trial name
- MULTIPASS-2 (NCT03697772)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University of Paris 5 - Rene Descartes
Multimorbidity, Knee Arthrosis
Interprofessional Preoperative Geriatric Assessment for Older Arthroplasty Patients With Multimorbidity
The objective of this randomized control trial is to investigate effects and cost effectiveness of interprofessional preoperative assessment among older knee or hip arthroplasty patients.
- Conditions
- Multimorbidity, Knee Arthrosis, Hip Arthrosis
- Trial name
- IPPGA-RCT (NCT04001699)
- Testing
- Preoperative geriatric assessment
- Where
- Finland
- Volunteers
- 157 people
- Sponsor
- University of Eastern Finland
Physical Activity, Sedentary Behavior
Physical Activity on Prescription and Enhanced Individual Support by Physiotherapist
Multimorbidity is common, especially in the elderly population and is associated with a higher risk of mortality and disability, lower quality of life, polypharmacy, increased healthcare use and costs.
- Conditions
- Physical Activity, Sedentary Behavior, Multimorbidity
- Trial name
- NCT04350983
- Testing
- Increased physical activity
- Volunteers
- 331 people
- Sponsor
- Vastra Gotaland Region
Diabetes
The Effect of Clinic Visit Audio Recordings for Self-management in Older Adults
The objective of this study is to conduct a multisite trial evaluating the impact of adding an audio recording of clinic visits (AUDIO) to usual care in older adults with multimorbidity, including diabetes, compared to After…
- Trial name
- REPLAY (NCT05824572)
- Testing
- Clinic visit audio recordings for self-management in older adults, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 336 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Multimorbidity
Digital Technology in the Home of Elderly Patients With Multimorbidity
In this study, the objective is to evaluate available technology designed to support self-care at home of elderly patients with multimorbidity. Of people who are 85 years or older, about 60% have two or more chronic diseases.
- Trial name
- NCT04955600
- Testing
- Implementation Study
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Sormland County Council, Sweden
Stroke
Optimizing Hospital-to-home Transitions for Older Adults With Stroke and Multimorbidity
Stroke is the leading cause of death and adult disability in Canada. Sixty percent of these older adults (> 65 years) will return to their homes after a stroke and will require ongoing rehabilitation.
- Trial name
- NCT04278794
- Testing
- Transitional Care Stroke Intervention (TCSI)
- Where
- 2 sites in Canada
- Volunteers
- 90 people
- Sponsor
- McMaster University
Multimorbidity
Improving Patient and Caregiver Engagement by Sharing Annotated Audio-recorded Clinic Visits
In this project, the investigators will conduct a three-arm patient-randomized pilot trial in older adults with multimorbidity in ambulatory care settings to determine the feasibility, usability, and acceptability of an…
- Trial name
- NCT04827381
- Testing
- Annotated Audio, Audio
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Heart Failure NYHA Class III, Heart Failure NYHA Class IV
Assessment of the Effectiveness, Socio-economic Impact and Implementation of a Digital Solution for Severe Patients
ADLIFE is a EU-funded project developing innovative digital health solutions to support healthcare planning and care delivery for patients with advanced chronic conditions (chronic obstructive pulmonary disease and/or heart…
- Conditions
- Heart Failure NYHA Class III, Heart Failure NYHA Class IV, Chronic Obstructive Pulmonary Disease Severe
- Trial name
- ADLIFE (NCT05575336)
- Testing
- ADLIFE intervention
- Where
- 7 sites in Denmark, Germany and 3 more
- Volunteers
- 185 people
- Sponsor
- Biosistemak Institute for Health Systems Research
Multimorbidity, Population Medicine
Impact of Multi-Component Interventions on High Risk COPD Population
Study Participants: High-risk COPD population, defined as individuals whose score of COPD-SQ is 16 and above and whose age is 35 and above.
- Conditions
- Multimorbidity, Population Medicine, Chronic Obstructive Pulmonary Disease
- Trial name
- POPMIX-COPD (NCT06456996)
- Testing
- Multi-component intervention package
- Where
- China
- Volunteers
- 9,319 people
- Sponsor
- Peking Union Medical College
Polypharmacy, Multimorbidity
Supporting Prescribing in Irish Primary Care: General Practice Pharmacist Study
The aim of this pilot study is to develop and test an intervention (defined as the General Practice Pharmacist [GPP] intervention) involving pharmacists working with General Practitioners (GPs) to optimise prescribing in Ireland.
- Trial name
- NCT04326062
- Testing
- Main Study, PROM Study
- Where
- Ireland
- Volunteers
- 100 people
- Sponsor
- Royal College of Surgeons, Ireland
Chronic Heart Failure, Type 2 Diabetes
Prognostic Impact of Diabetes and Weight Variability in Telemonitored Heart Failure
This observational cohort study evaluates the prognostic impact of diabetes, comorbidity burden, and short-term weight variability among adults with chronic heart failure enrolled in a nationwide remote patient monitoring program…
- Conditions
- Chronic Heart Failure, Type 2 Diabetes, Diabetes (DM)
- Trial name
- DM-HF-Tele (NCT07561866)
- Testing
- Diabetes Status, Comorbidity Burden, Weight variability
- Where
- France
- Volunteers
- 16,556 people
- Sponsor
- Satelia