Clinical trials: Multiple Cancers
Breast Cancer
Serum Biomarkers to Characterize the Effects of Therapy on Ovarian Reserve in Premenopausal Women With Early-stage Breast Cancer or BRCA Mutations
The purpose of this study is to learn more about the effects of your BRCA mutation on the ovaries. The BRCA gene can make it hard to conceive a child in the future. It may also bring on early menopause.
- Trial name
- NCT00823654
- Testing
- Blood draw and questionnaires
- Where
- 8 sites in United States
- Volunteers
- 609 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Vitamin D Receptor Target Gene Expression, Serum 25(OH)D Concentration
The Effect of a High-dose Oral Vitamin D3 Bolus on Serum 25(OH)D3 and Vitamin D Receptor Target Gene Expression
The purpose of the study is to investigate whether a high-dose vitamin D3 oral bolus (2000 micrograms) produces marked vitamin D receptor target gene expression response and whether there is large inter-individual variation.
- Trial name
- VitDbol (NCT02063334)
- Testing
- Vitamin D3
- Where
- Finland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Prostate Cancer, Endometriosis
A Phase 1 Study to Evaluate the Effects of Fluconazole and Atorvastatin on the Pharmacokinetics of TAK-385 in Healthy Subjects
This is a nonrandomized, open-label, fixed-sequence, 2-arm study designed to assess the effect of multiple doses of fluconazole or atorvastatin on the single-dose pharmacokinetics of TAK-385 in healthy adult subjects.
- Trial name
- NCT02093390
- Testing
- TAK-385, Fluconazole, Atorvastatin
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Millennium Pharmaceuticals, Inc.
HIV Infections, Men
Improving HIV Testing, Linkage, and Retention in Care for Men Through U=U Messaging
This study will evaluate the impact of U=U messaging and counseling on gaps in the HIV care cascade for men, including testing uptake and ART initiation (Aim 1), achieving viral suppression and retention in care (Aim 2) in two…
- Conditions
- HIV Infections, Men, Treatment Adherence
- Trial name
- NCT05602376
- Testing
- U=U testing messaging scripts, U=U adherence messaging scripts
- Where
- 2 sites in South Africa
- Volunteers
- 3,642 people, healthy volunteers welcome
- Sponsor
- Desmond Tutu HIV Foundation
MULTIPLE MYELOMA
UARK 2005-05, Coagulation-Related Effects of Velcade Treatment in Patients With Relapsed or Refractory Multiple Myeloma
To evaluate changes in coagulation (blood clotting) factors and platelet function in multiple myeloma participants undergoing VELCADE treatment for the first time.
- Trial name
- NCT00569868
- Testing
- Velcade
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Breast Cancer, Ductal Carcinoma in Situ
The Ultrasound-guided Multiple-injection Costotransverse Block for Mastectomy and Primary Reconstructive Surgery.
The investigators have developed a novel ultrasound-guided nerve block indicated primarily for breast cancer surgery that mimic a thoracic paravertebral block (TPVB) - hitherto the internationally accepted regional anesthesia…
- Trial name
- NCT04248179
- Testing
- Ropivacaine injection, Saline 0.9%, Sufentanil and PONV prophylaxis
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
PRE-HYPERTENSION
Cardiovascular Effects of Purple-Fleshed Potatoes
This study is being done to evaluate the effect on cardiovascular biomarkers and anthocyanin-derived plasma metabolites of Peruvian native purple-fleshed potato consumed over a 4-week period by prehypertensive men ages 18-40…
- Trial name
- NCT07734948
- Testing
- Purple flesh potato, White flesh potato
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigacion Nutricional, Peru
Multiple Myeloma, Multiple Myeloma and Malignant Plasma Cell Neoplasms
68Ga-BCMA PET/CT in Multiple Myeloma
This is a prospective, multicenter diagnostic imaging study designed to evaluate the diagnostic accuracy and clinical utility of BCMA-targeted positron emission tomography/computed tomography (PET/CT) in patients with multiple…
- Conditions
- Multiple Myeloma, Multiple Myeloma and Malignant Plasma Cell Neoplasms, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT07319897
- Testing
- 68Ga-BCMA PET/CT
- Where
- 5 sites in China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Haematological Malignancy, Leukemia, Acute
Rehabilitation Needs of the Malaysian Haematological Cancer Survivors
Many cancers are being treated more effectively nowadays due to the raised awareness and early detection as well as advancement in researches and technology.
- Conditions
- Haematological Malignancy, Leukemia, Acute, Lymphoma, Myeloma Multiple
- Trial name
- NCT04236063
- Testing
- WHODAS 2.0 Questionnaire
- Where
- Malaysia
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Stomach Neoplasms, Gut Microbiota
Gut Microbiota and Metabonomics
To evaluate the correlation between gut microbiota and metabolites in Borrmann type IV gastric cancer; To find the effects of microflora and metabolites on target organs; To detect the mechanism of key flora and metabolite by in…
- Conditions
- Stomach Neoplasms, Gut Microbiota, Metabolomics
- Trial name
- MBS (NCT05205187)
- Testing
- Healthy control specimen collection, Non-Borrmann IV patient specimen collection, Borrmann IV patient specimen collection
- Where
- 6 sites in China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- First Hospital of China Medical University
Lymphoma, Multiple Myeloma
Chaplain-Delivered Compassion Meditation to Improve Spiritual Care of Patients Receiving Stem Cell Transplantation
This clinical trial tests the feasibility, implementation and acceptability of chaplain delivered compassion meditation in order to improve spiritual care for patients receiving stem cell transplantation.
- Trial name
- NCT06328699
- Testing
- Spiritual Therapy, Best Practice
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Emory University
Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men, Hot Flashes
A Study to Learn More About How Much of the Study Treatment Elinzanetant (or BAY3427080) Gets Absorbed, How Safe it is and How it Affects the Body in Healthy Female and Male Participants
Researchers are looking for a better way to treat men and women with vasomotor symptoms, a condition of having hot flashes caused by hormonal changes.
- Conditions
- Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men, Hot Flashes, Healthy Volunteers
- Trial name
- NCT05351892
- Testing
- Elinzanetant (BAY3427080)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Bayer
Overweight and Obesity, Men
Evaluation of a Supplement for Weight Management in Obese and Overweight Individuals
The purpose of this trial is to examine the effects of a novel, orally consumed dietary supplement (composed of naturally occurring components) on weight management and metabolic rate in individuals who are overweight or obese…
- Conditions
- Overweight and Obesity, Men, Women
- Trial name
- NCT03812211
- Testing
- Active Supplement
- Where
- Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- McMaster University
Stress Reduction
The Impact of a Self-help Coping App on Distress Levels in Men Experiencing Infertility
The purpose of this study is to determine if the use of a new app, FertiStrong, is associated with decreased levels of anxiety and depression in men who have infertility or whose partner has infertility.
- Trial name
- NCT03519607
- Testing
- FertiStrong App
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fertility Centers of Illinois
Advanced Cancer
Patient and Family Decision Making in the Palliative Care Setting
The goal of this research study is to learn about any differences in certain health-related preferences between patients with cancer and their families.
- Trial name
- NCT00682994
- Testing
- Interview, Questionnaire
- Where
- 4 sites in United States, Argentina and 2 more
- Volunteers
- 780 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Cancer Survivors, Healthy Participant
A Study to Evaluate the Effects of the Combination of GI-102 With GIB-7 on Biomarkers of Aging in Healthy Adults and Cancer Survivors
This Phase 2a clinical study (GIANTS-1) aims to evaluate a novel dual-combination strategy using GI-102 and GIB-7 to address key pathological features of aging, including immunosenescence (the aging of the immune system)…
- Conditions
- Cancer Survivors, Healthy Participant, Elderly
- Trial name
- GIANTS-1 (NCT07363057)
- Testing
- GI-102 in combination with GIB-7
- Where
- 2 sites in Australia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- GI Innovation, Inc.
Cervical Dysplasia
Sexual Function and Quality of Life After LEEP: a Prospective Multi-Center Study
The goal of this prospective study is to investigate the sexual function and quality of life of women undergoing loop electrosurgical excision procedure (LEEP) due to HPV-related cervical lesion.
- Trial name
- SEQUEL (NCT06078514)
- Testing
- Loop electrosurgical excision procedure (LEEP)
- Where
- 5 sites in Finland
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Multiple Osteochondromas
Registry of Multiple Osteochondromas
REM is a retrospective and prospective registry, finalized for care and research purposes. It is articulated in main sections - strongly related and mutually dependent on each other - corresponding to different data domains…
- Trial name
- REM (NCT04133285)
- Where
- Italy
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Luca Sangiorgi
Pain
An Exploratory Study to Assess the Effects of JNJ-39439335 on the Relief of Pain Using a Thermal-Grill Experimental Model
This exploratory study will use a thermal-grill experimental model to assess the effects of JNJ-39439335 (50 mg, single oral dose) on the relief of pain.
- Trial name
- NCT01006304
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Overweight, Healthy
Specificities of the Eccentric Exercise: Energy Expenditure and Nature of Oxidized Substrates
Main objective of this clinical trial is to compare the oxidation rates of main carbohydrate and lipid substrates during exercises carried out in eccentric dynamic pedaling mode on a cycloergometer compared to concentric…
- Conditions
- Overweight, Healthy, Men
- Trial name
- Speed-Enso (NCT05319704)
- Testing
- Test of effort on cycle on concentric or excentric mode, Kinetics on concentric or excentric mode during test of effort
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand