Clinical trials: Multiple Organ Dysfunction
Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome, Septic Shock
Early Continuous Renal Replacement Therapy for Pediatric Septic Shock
Septic shock is a major cause of morbidity and mortality in critically ill children. Continuous renal replacement therapy (CRRT) is increasingly used as adjunctive support in pediatric septic shock to improve hemodynamic…
- Trial name
- NCT07370753
- Where
- Vietnam
- Volunteers
- 50 people
- Sponsor
- National Children's Hospital, Vietnam
Septic Shock, Vasopressor Resistance, Multiple Organ Dysfunction
Biological Effects of Hemoadsorption in Septic Shock
Septic shock is the most severe form of sepsis and continues to carry an in-hospital mortality of between 30% and 50% despite advances in compliance with the Surviving Sepsis Campaign care bundles.
- Conditions
- Septic Shock, Vasopressor Resistance, Multiple Organ Dysfunction, Sepsis, Hemoperfusion
- Trial name
- Bio-HA380 (NCT07715110)
- Testing
- Hemoadsorption cartridge
- Where
- 2 sites in Spain
- Volunteers
- 16 people
- Sponsor
- Miguel Sanchez Garcia
Sepsis
Biomarkers in Exhaled Breath Condensates of Septic Patients to Predict Development of Multi-organ Dysfunction Syndrome
In this proposal, the investigators wish to investigate, identify and validate potential biomarkers in collected exhaled breath condensates (EBC) from patients with sepsis.
- Trial name
- NCT01503684
- Testing
- Determined by intended physician
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Brain Injuries
Feasibility Trial of Traumatic Brain Injured Patients Randomized in the Prehospital Setting to Either Hypertonic Saline and Dextran Versus Normal Saline
This clinical trial will evaluate the ease of conducting a randomized trial on patients with severe head injury who are cared for by paramedics in the out of hospital setting.
- Trial name
- TOPHR HIT (NCT00878631)
- Testing
- hypertonic saline mixed with dextran, Normal Saline
- Where
- 2 sites in Canada
- Volunteers
- 113 people
- Sponsor
- Unity Health Toronto
Sepsis, Septic Shock
Assessment of Heparin Binding Protein for the Prediction of Severe Sepsis
The purpose of this prospective, non-interventional, multi-centre clinical study is to assess the clinical validity of the Heparin Binding Protein (HBP) assay for indicating the presence, or outcome, of severe sepsis (including…
- Conditions
- Sepsis, Septic Shock, Sepsis With Acute Organ Dysfunction
- Trial name
- NCT03113721
- Where
- 5 sites in United States
- Volunteers
- 571 people
- Sponsor
- Axis Shield Diagnostics Ltd
Sepsis, Septic Shock
Neutrophil FFA2/GPR43 Receptor Expression in Patients With the Diagnosis of Sepsis
This study seeks to elucidate the quantitative expression of G - protein receptor 43/free fatty acid (GPR43/FFA2) receptors in patients with the diagnosis of sepsis and specifically, its expression as it relates to the severity…
- Conditions
- Sepsis, Septic Shock, Multiple Organ Dysfunction, Intra-abdominal Sepsis
- Trial name
- GPR43Sepsis (NCT02699905)
- Testing
- phlebotomy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Covid19
Allocetra-OTS in COVID-19, Phase II
This is a multi-center, open-label study evaluating the safety of Allocetra-OTS, in up to 24 subjects with severe COVID-19 and respiratory dysfunction.
- Trial name
- NCT04590053
- Testing
- Allocetra-OTS
- Where
- 3 sites in Israel
- Volunteers
- 24 people
- Sponsor
- Hadassah Medical Organization
COVID-19
Allocetra-OTS in COVID-19
This is a multi-center, open-label study evaluating the safety of Allocetra-OTS, in 5 subjects with severe COVID-19 and respiratory dysfunction. Subjects, who will be identified as suffering from COVID-19, will be recruited.
- Trial name
- NCT04513470
- Testing
- Allocetra-OTS
- Where
- Israel
- Volunteers
- 5 people
- Sponsor
- Hadassah Medical Organization
Multiple Organ Dysfunction Syndrome
Tolerance and Safety of a Duodenal Probe Monitoring the Microcirculation
For Intensive Care Units (ICU) patients, Multiple Organ Dysfunction Syndrome (MODS) is a very common complication yielding high morbidity and mortality.
- Trial name
- MC Monitor (NCT02246036)
- Testing
- APD probe
- Where
- 3 sites in France
- Volunteers
- 10 people
- Sponsor
- Advanced Perfusion Diagnostics
Septic Shock
The Cooling And Surviving Septic Shock Study (CASS)
Septic shock is in critically ill patients is a condition associated with a high rate of organ failure and hereto attributable mortality ~45-55% Hypothesis: Mild Induced Hypothermia reduces the mortality of critically ill…
- Trial name
- CASS (NCT01455116)
- Testing
- Mild Induced Hypothermia
- Where
- 11 sites in United States, Denmark and 1 more
- Volunteers
- 433 people
- Sponsor
- Danish Procalcitonin Study Group
Septic Shock, Multiple Organ Failure
Impact of Metabolite Supplementation to Restore Mitochondrial Dysfunction During Septic Shock: a Preclinical Study
Septic shock is defined as a subset of sepsis with severe metabolism alterations, leading to organ failure. Septic shock is associated with a high mortality, around 40% according to the SEPSIS 3 definition.
- Trial name
- MEFDASE (NCT04288635)
- Testing
- Whole blood samples
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Angers
Sepsis, Burn Injury
Surgical Critical Care Initiative (SC2i) Tissue and Data Acquisition Protocol (TDAP) in Burn Patients Improving the Robustness and Generalizability of Post-burn Sepsis Prediction With the Post-Burn Sepsis Digital Twin. Group 1
This study is following adult patients with serious burn injuries to better understand how their bodies respond to treatment and recovery.
- Conditions
- Sepsis, Burn Injury, Wound Healing, Critical Illness
- Trial name
- NCT07249762
- Testing
- Observational Cohort (No Intervention)
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Burn
Colloid Improves Organs Function in Resuscitation of Extensive Burn Patients
The present study was to evaluate the effectiveness of colloid compared with crystalloids for fluid resuscitation in critical burn patients with total burn surface area ≥50%.
- Trial name
- NCT01939613
- Testing
- colloids
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Tang-Du Hospital
Acute Pancreatitis, Complication
Rectal Indomethacin as Early Treatment for Acute Pancreatitis (INDOMAP Trial)
Acute pancreatitis (AP) is an inflammatory condition of the pancreas following the activated pancreatic enzymes induced by varied causes, with or without other organ(s) dysfunction.
- Conditions
- Acute Pancreatitis, Complication, Mortality Rate, Organ Failure, Multiple
- Trial name
- INDOMAP (NCT03547232)
- Testing
- Indomethacin SR
- Where
- 17 sites in China
- Volunteers
- 1,504 people
- Sponsor
- Peking Union Medical College Hospital
Acute Pancreatitis
Early High-volume Continuous Veno-venous Hemofiltration for Patients With Severe Acute Pancreatitis
The purpose of this study is to determine the effect and safety of early high-volume continuous veno-venous hemofiltration for patients with severe acute pancreatitis.
- Trial name
- EHVCVVHSAP (NCT01595672)
- Testing
- AN69 hemofilter, conventional treatments
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Air Force Military Medical University, China
Sepsis, Pneumonia
Benefit of Clarithromycin in Patients With Severe Infections Through Modulation of the Immune System
High mortality associated with sepsis and Multiple Organ Dysfunction Syndrome (MODS) calls for alternative, individualized therapies in selected patients that might benefit form specific interventions.
- Conditions
- Sepsis, Pneumonia, Gram-Negative Bacteria Infection, Multiple Organ Failure
- Trial name
- INCLASS (NCT03345992)
- Testing
- Clarithromycin, Water for injection
- Where
- 12 sites in Belgium, Greece
- Volunteers
- 110 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
COVID-19, Organ Dysfunction Syndrome Sepsis
Mechanisms for Organ Dysfunction in Covid-19
The study aims to investigate organ dysfunction and biomarkers in patients with suspected or verified COVID-19 during intensive care at Uppsala University Hospital.
- Conditions
- COVID-19, Organ Dysfunction Syndrome Sepsis, Organ Dysfunction Syndrome, Multiple, Septic Shock
- Trial name
- UMODCOVID19 (NCT04316884)
- Where
- Sweden
- Volunteers
- 380 people
- Sponsor
- Uppsala University
Multiple Organ Dysfunction
Modulation of Microbiota Metabolism in Cardiac Surgery Patients
An imbalance in the microbiota (most often intestinal) largely determines the onset of a disease state, and often a critical state.
- Trial name
- MMMMODCS (NCT04921436)
- Testing
- cardiac surgery
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Sepsis, Severe Infection
Mechanisms of Prognostic Regulation andPrecision Phenotype Ldentification in Severe Infections Driven by SpecializedPro-Resolving Mediators
This is a prospective observational study involving adult patients with severe infection who are admitted to the intensive care unit (ICU). Severe infection and sepsis are major causes of death worldwide.
- Conditions
- Sepsis, Severe Infection, Multiple Organ Dysfunction Syndrome, Critical Illness
- Trial name
- MPR-PPI-SPMs (NCT07353970)
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Multiple Organ Dysfunction Syndrome
Reducing Elevated Heart Rate in Patients With Multiple Organ Dysfunction Syndrome (MODS) by Ivabradine
MODIfY is a prospective, single center, open label, randomized, controlled two arms, Phase II-trial to evaluate the ability of ivabradine to reduce an elevated heart rate in Multiple Organ Dysfunction Syndrome (MODS) patients.
- Trial name
- MODIfY (NCT01186783)
- Testing
- ivabradine
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg