Clinical trials: Multiple Primary Neoplasm
Nocturnal Enuresis
A Study of Oral Desmopressin in Previously Untreated Children Aged 5 to 15 Years With Primary Nocturnal Enuresis
To evaluate the overall response to desmopressin treatment among previously untreated enuretic children aged 5-15 years after 3 and 6 months of treatment.
- Trial name
- DRIP (NCT00245479)
- Testing
- Primary nocturnal enuresis
- Where
- France
- Volunteers
- 802 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Diabetes Mellitus, Type 2, Exercise
Implementation of a Multi-component, Supervised Exercise Program for Patients With Type 2 Diabetes Mellitus.
This quality improvement study aims to implement a supervised, multi-component exercise program for patients type 2 diabetes mellitus (T2DM) from a primary care practice.
- Trial name
- NCT04030364
- Testing
- CrossFit group exercise classes
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Overweight and Obesity
UCSD Get Fit, Be Fit Study
The purpose of the Get Fit, Be Fit Study is to examine the effect of incorporating pistachios in an intensive 4-month cognitive-behavioral weight loss intervention in overweight and obese men and women, to examine effects on…
- Trial name
- NCT03387709
- Testing
- Pistachio-enriched diet, General dietary guidance diet
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Healthy
Metabolic Availability of Methionine and Lysine From Rice, Wheat, Chickpea and Lentil in Adult Men
The research study is being done so we can determine the quality of the protein present in Rice, Wheat, Chickpeas and Lentils. Amino acids are the building blocks of protein and protein quality is determined by the amount of…
- Trial name
- NCT03674736
- Testing
- Dietary Intakes
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Health Behavior, Health Promotion
Complex Multiple Risk Behavior Intervention in People Between 45 to 75 Years (EIRA Study)
This study examines the effectiveness and the costs of a complex multiple risk behavior intervention to promote healthy behaviors in people aged between 45 and 75 years attended in Primary Health Care services.
- Conditions
- Health Behavior, Health Promotion, Primary Health Care, Implementation Research
- Trial name
- EIRA (NCT03136211)
- Testing
- EIRA intervention
- Where
- Spain
- Volunteers
- 3,062 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Infections, Meningococcal
Study to Assess the Safety and Immunogenicity of a Single Dose of GlaxoSmithKline's (GSK) Meningococcal MenACWY-CRM Vaccine (Menveo), Administered to Subjects 15 Through 55 Years of Age, Approximately 4-6 Years After Primary ACWY Vaccination
The purpose/aim of this study is to assess the safety and antibody response to vaccination with a booster dose of Menveo given 4-6 years after primary MenACWY vaccination and to assess the safety and antibody response to a single…
- Trial name
- NCT02986854
- Testing
- Meningococcal (groups A, C, W and Y) oligosaccharide diphtheria CRM-197 conjugate Vaccine (Menveo)
- Where
- 37 sites in United States, Puerto Rico
- Volunteers
- 704 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Volunteers, Sjögren's Syndrome
A Study to Evaluate the Effects of ASP5502 in Healthy Adults and Adults With Primary Sjögren's Syndrome
Primary Sjögren's syndrome (pSS) is a condition when the body's immune system attacks glands that produce fluids, such as the tear and saliva glands. This leads to dry eyes and a dry mouth.
- Trial name
- NCT06544642
- Testing
- ASP5502
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Global Development, Inc.
Primary Ciliary Dyskinesia
A Longitudinal, Observational Study of Primary Ciliary Dyskinesia in Adults
The goal of this observational study is to characterize clinical measures and biomarkers of airway disease in adults with primary ciliary dyskinesia (PCD) and in a group of healthy volunteers (HV) to establish normative values.
- Trial name
- NCT05685186
- Testing
- Spirometry, Multiple Breath Washout (MBW), Mucociliary Clearance (MCC)
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- ReCode Therapeutics
Multi-modality Echocardiography, Primary Electrical Disease
Multi-modality Echocardiography for Cardiac Assessment in Primary Electrical Disease
From 2020 to 2023, patients with primary electrical disease (idiopathic ventricular fibrillation, long QT syndrome, Andersen-Tawil syndrome type I, Brugada syndrome, early repolarization syndrome, CPVT, and short QT syndrome)…
- Trial name
- NCT06172842
- Testing
- Echocardiography
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Obesity
Strength Training for Men Living With Obesity
Emerging evidence suggests that alternative obesity management strategies need to address barriers to engaging with regular physical activity to adopt healthier lifestyles.
- Trial name
- NCT04680455
- Testing
- Online home-based strength training
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of New Brunswick
Migraine Disorders, Pain
The Role of Cytokines and Regulatory T Lymphocytes in Migraine Pathophysiology.
Migraine is a frequent and debilitating neurologic disorder. It is more frequent in women, and more prevalent in patients with autoimmune and/or inflammatory diseases such as multiple sclerosis (MS), rheumatoid arthritis (RA)…
- Conditions
- Migraine Disorders, Pain, Autoimmune Diseases, Multiple Sclerosis
- Trial name
- SIIM (NCT06426316)
- Testing
- Blood test
- Where
- France
- Volunteers
- 396 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Parkinson Disease, Progressive Supranuclear Palsy(PSP)
Parkinson Atypical Rating of Oculometric Patterns Evaluated Routinely
This is an observational longitudinal study in 4 cohorts of patients with Parkinsonian syndromes, who are visiting the Movement Disorders outpatient clinics.
- Conditions
- Parkinson Disease, Progressive Supranuclear Palsy(PSP), Multiple System Atrophy
- Trial name
- PARATROOPER (NCT06597071)
- Testing
- NeuraLight PD, NeuraLight PSP, NeuraLight MSA
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- NeuraLight
Primary Ciliary Dyskinesia
Physiological Responses to Exercise Tests in Primary Ciliary Dyskinesia Compared With Healthy Individuals
The individuals with primary ciliary dyskinesia (PCD) have lower aerobic fitness and anaerobic performance than healthy individuals.
- Trial name
- NCT05712798
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Primary Sclerosing Cholangitis, Inflammatory Bowel Diseases
Statin Therapy in Primary Sclerosing Cholangitis (PSC): a Multi-omics Study
PSC is a liver disease that has no medical cure. Patients with PSC are at a greatly increased risk of cancer and infection. Additionally, many patients require a liver transplant.
- Trial name
- NCT05912387
- Testing
- Rosuvastatin
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Stanford University
Men, Diet Modification
Dietary Guide in Active Older Adult Men
The present study aimed to determine the effects of negative-calorie diet supplemented with exercise, on weight loss and lipid profile, and to compare its efficiency with low-calorie diet with exercise among elderly adult men…
- Conditions
- Men, Diet Modification, Obesity, Overweight
- Trial name
- NCT03082807
- Testing
- NCDsport, LCDsport
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- P.L.Shupik National Medical Academy of Post-Graduate Education
Multiple Primary Lung Cancer, Microbial Colonization
Exploratory Study of the Microbiome of Upper Gastrointestinal in the Pathogenesis of Multiple Primary Lung Cancer
This is an exploratory, single-center, being conducted at Beijing Haidian Hospital in order to detect the relationship between microbiome of upper gastrointestinal and pathogenesis of multiple primary lung cancer.
- Trial name
- NCT06973499
- Testing
- Microbiome Profiling and Symptom Assessment
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beijing Haidian Hospital
HIV Infections
Motiv82Change: an HIV Prevention Study for Young Latino Men
The purpose of this study is to develop and pilot test a culturally and developmentally tailored Motivational Enhancement Intervention (MEI) to reduce risky sex (unprotected anal sex and multiple partners) among young Hispanic…
- Trial name
- Motiv82Change (NCT00877695)
- Testing
- Entre Culturas: Navigating Culture, Identity, and HIV Risk
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Hereditary Angioedema
First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BCX7353 in Healthy Western and Japanese Volunteers
This is a 3-part Phase 1 dose-ranging study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single (Part 1) and multiple (Part 2) ascending doses of BCX7353 in healthy subjects, and single and…
- Trial name
- NCT02448264
- Testing
- BCX7353
- Where
- United Kingdom
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- BioCryst Pharmaceuticals
Healthy Volunteers
A Drug-Drug Interaction Study to Assess the CYP1A2 and CYP3A4 Interaction Potential of TEV-56286 (anle138b)
The purpose of this healthy volunteers drug-drug interaction study is to assess the CYP1A2 and CYP3A4 perpetrator interaction potential and CYP1A2 victim potential of TEV-56286 (anle138b).
- Trial name
- NCT05532358
- Testing
- anle138b (TEV-56286), Fluvoxamine 100 mg QD for 5 days
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- MODAG GmbH
Multiple System Atrophy
Investigation of the Serotoninergic System in Multiple System Atrophy: a Positron Emission Tomography (PET) Study
Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder of the adult associated to a poor prognosis. MSA is clinically characterized by the association of extra-pyramidal, dysautonomic, cerebellar and pyramidal…
- Trial name
- SEROTAMS (NCT01136213)
- Testing
- PET (Positron Emission Tomography) Study, Brain MRI (magnetic resonance imaging)
- Where
- 3 sites in France
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux