Clinical trials: Multiple Primary Neoplasm
Insomnia
Investigation of the Efficacy and Safety of CHI-921 in Insomnia.
Insomnia is a disorder where people are having trouble sleeping and can include difficulty falling asleep, staying asleep and waking up too early, as well as having unrefreshing sleep.
- Trial name
- NCT03984604
- Testing
- CHI-921
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Canopy Growth Corporation
Glaucoma, Primary Open Angle, Ocular Hypertension
Evaluation of Safety and Efficacy of TUG (Therapeutic Ultrasound for Glaucoma) in the Treatment of Primary Open Angle Glaucoma or Ocular Hypertension
The purpose of this study is to evaluate whether the TUG device is safe and effective in patients with primary open angle glaucoma or ocular hypertension.
- Trial name
- NCT02858284
- Testing
- TUG
- Volunteers
- 25 people
- Sponsor
- EyeSonix
Multiple System Atrophy
Comprehensive Swallowing Rehabilitation in Patients With MSA
The purpose of this study is to investigate the effect of comprehensive swallowing rehabilitation in patients with multiple system atrophy.
- Trial name
- NCT04782284
- Testing
- Comprehensive swallowing rehabilitation, Swallowing education
- Where
- South Korea
- Volunteers
- 24 people
- Sponsor
- Seoul National University Hospital
Primary Osteoarthritis, Post-Traumatic Arthritis
AVANTAGE® RELOAD Double Mobility Acetabular Cup -Clinical Study
This is a Post Marketing Clinical Follow Up study (PMCF) on the AVANTAGE RELOAD dual mobility system cup.
- Conditions
- Primary Osteoarthritis, Post-Traumatic Arthritis, Inflammatory Joint Disease, Femoral Neck Fracture
- Trial name
- NCT03357445
- Testing
- Avantage Reload cup
- Where
- 4 sites in France, Slovenia
- Volunteers
- 500 people
- Sponsor
- Zimmer Biomet
Sleep Disorders
Study to Investigate Safety, Tolerability, Pharmacokinetics and Cardiac Function After Repeat Doses of SB-649868 in Healthy-volunteers
The purpose of this study is to determine whether SB-649868 is safe, tolerable after repeated administrations in adult and elderly healthy volunteers. Pharmacokinetics and effects on cardiac function of repeated doses are studied
- Trial name
- NCT01030939
- Testing
- SB-649868
- Where
- Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Down Syndrome, Intellectual Disability
Parents as the Primary Sexuality Educators for Their Young Adults With Down Syndrome
By integrating sexuality and disability literatures, theories, and research methodologies, this study aims to: 1) contribute to the limited knowledge professionals have of parents as the primary sexuality educators; 2) create a…
- Conditions
- Down Syndrome, Intellectual Disability, Sexuality, Parent-Child Relations
- Trial name
- NCT03135236
- Testing
- Parent training
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Postural Tachycardia Syndrome
Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Natural History With Its Numerous Co-morbidities?
This study is being conducted to see how people with Postural tachycardia syndrome (POTS) make sense of the things they see. The information may help doctors to learn more about how the different parts of people's brains…
- Trial name
- NCT05618054
- Testing
- Looming task
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
SARS-CoV Infection
Chemoprevention Clinical Trial of COVID-19: Hydroxychloroquine Post Exposure Prophylaxis
Protocol summary Title A Prospective, randomized, adaptive phase II/III clinical trial, controlled, open-label, chemoprevention, 3-arms, parallel, multi-centred, to A Prospective, randomized, clinical trial, controlled…
- Trial name
- APCC-19 (NCT04597775)
- Testing
- hydroxychloroquine
- Volunteers
- 93 people
- Sponsor
- Regional Center for Disease Control and Prevention, Jordan
Brain Neoplasms
Phase II Randomized Study of Stereotactic Radiosurgery Plus Fractionated Whole-Brain Radiotherapy Vs Fractionated Whole-Brain Radiotherapy Alone for Multiple Primary or Metastatic Brain Tumors
OBJECTIVES: I. Evaluate whether stereotactic radiosurgery provides local control at multiple sites in patients with primary or metastatic brain tumors, controlled systemic disease, and preserved neurologic function. II.
- Trial name
- NCT00004659
- Testing
- irradiation, radiosurgery
- Volunteers
- 40 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cystic Fibrosis (CF), Primary Ciliary Dyskinesia (PCD)
Upper Extremity Exercise Capacity, Muscle Oxygenation, and Balance in Pediatric CF and PCD
The number of studies evaluating respiratory functions and upper extremity functional exercise capacity in patients with CF and PCD is limited in the literature.
- Trial name
- NCT07148362
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Gazi University
Healthy
Metabolic Availability of Methionine From Mung Beans in Healthy Adults
The research study is being done so we can determine the quality of the protein present in Mung beans. Amino acids are the building blocks of protein and protein quality is determined by the amount of amino acids present and by…
- Trial name
- NCT03674723
- Testing
- Dietary Intakes
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Chronic Kidney Disease
Multi-disciplinary Participatory Design of a Process to Deliver a CKD Diagnosis in Primary Care
This study will use an adapted education worksheet to support patient-centered chronic kidney disease (CKD) communication, shared decision making, and patient engagement and will test its impact on intermediate patient modifiable…
- Trial name
- EPIK (NCT03084159)
- Testing
- Education worksheet
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- University of Michigan
Primary Hypercholesterolemia
Efficacy and Safety of HS-25 or in Combination With Atorvastatin in Chinese Adults With Primary Hypercholesterolemia
To determine the efficacy of the HS-25 (10mg or 20mg) or in combination with Atorvastatin (10mg)in reducing low density lipoprotein-cholesterol (LDL-C) levels after a 12-week period of treatment in adults with primary…
- Trial name
- HS-25-C-01 (NCT03464682)
- Testing
- HS-25 10mg, HS-25 10mg combination with Atorvastatin, HS-25 20mg combination with Atorvastatin
- Volunteers
- 720 people
- Sponsor
- Zhejiang Hisun Pharmaceutical Co. Ltd.
Chronic Disease, Multi-morbidity
Minnesota Care Coordination Effectiveness Study
Medical care has improved greatly over the past 50 years. Treatments for most medical conditions can help us lead longer and healthier lives, but there are still problems.
- Conditions
- Chronic Disease, Multi-morbidity, Care Coordination
- Trial name
- MNCARES (NCT04957979)
- Testing
- Nursing/Medical Model of Care Coordination, Medical/Social Model of Care Coordination
- Where
- 3 sites in United States
- Volunteers
- 25,507 people
- Sponsor
- HealthPartners Institute
OBESITY, HYPERTENSION
The Autonomic Nervous System and Obesity
In its simplest terms, obesity is the results of a positive balance between food intake and energy expenditure (EE). I.e., we take in more energy, in the form of food, than we expend, e.g., by exercise.
- Conditions
- OBESITY, HYPERTENSION, PURE AUTONOMIC FAILURE, SHY-DRAGER SYNDROME
- Trial name
- NCT00179023
- Testing
- Trimethaphan, Pseudoephedrine
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Tuberous Sclerosis Complex
Potential EEG Biomarkers and Antiepileptogenic Strategies for Epilepsy in TSC
To determine whether EEGs during infancy is a reliable biomarker to identify TSC patients that will develop infantile spasms/epilepsy in the near future and thus are appropriate candidates for an antiepileptogenic drug trial.
- Trial name
- NCT01767779
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Exercise, Physical Fitness
PEPAF: Evaluation of Family Physician's Effectiveness for Physical Activity Promotion
The potential health gains from active lifestyles are very well-known and it is recommended that all adults dedicate at least 30 minutes to activities of at least moderate intensity at least five days a week.
- Conditions
- Exercise, Physical Fitness, Quality of Life
- Trial name
- NCT00131079
- Testing
- Experimental Programme for Physical Activity Promotion, Control
- Volunteers
- 4,317 people
- Sponsor
- Basque Health Service
Primary Plasma Cell Leukemia
Lenalidomide and Dexamethasone in Primary Plasma Cell Leukemia
This is an open label, multicenter, exploratory, single arm, two-stage study aiming to explore efficacy and safety of lenalidomide and dexamethasone combination (LD) as first line therapy in previously untreated patients with…
- Trial name
- NCT01553357
- Testing
- Lenalidomide, dexamethasone
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- IRCCS Centro di Riferimento Oncologico della Basilicata
Primary Progressive Multiple Sclerosis, Multiple Sclerosis
A Study of Allogeneic Hematopoietic Cell Transplantation for Primary Progressive Multiple Sclerosis
A study of alloHCT with Orca-Q for the treatment of primary progressive multiple sclerosis (MS).
- Conditions
- Primary Progressive Multiple Sclerosis, Multiple Sclerosis, Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Secondary Progressive
- Trial name
- NCT06900192
- Testing
- Orca-Q, myeloablative regimen
- Volunteers
- 10 people
- Sponsor
- Stanford University
Hypertension, Diabetes Mellitus
Community Based Multiple Risk Factors Intervention Strategy
Randomized controlled trial of CORFIS Programme. The study objectives are as follows: 1. To determine the efficacy of a community based multiple risk factors interventional strategy (CORFIS) for a treatment period of 6 months in…
- Conditions
- Hypertension, Diabetes Mellitus, Hyperlipidemia
- Trial name
- CORFIS (NCT00490672)
- Testing
- No Active Intervention., Community Based Multiple Risk Factor Intervention Strategies
- Where
- 78 sites in Malaysia
- Volunteers
- 770 people
- Sponsor
- Ministry of Health, Malaysia
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