Clinical trials: Multiple Sclerosis, MS
Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting
Patient Experiences of Multiple Sclerosis (PExMS)
Besides coping with the diagnosis, people with multiple sclerosis have to make complex decisions such as deciding about immunotherapies.
- Conditions
- Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Patient Engagement, Self Efficacy
- Trial name
- PExMS (NCT04236544)
- Testing
- PExMS and DECIMS-Wiki, DECIMS-Wiki
- Volunteers
- 55 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Progressive Multiple Sclerosis
G-EO Gait Rehabilitation Training in Progressive Multiple Sclerosis
The logistic advantages and advanced training capabilities of the G-EO System, as well as the benefits reported in other populations, support this strategy as a potentially potent rehabilitation tool for restoring and maintaining…
- Trial name
- NCT03980145
- Testing
- G-EO System (Reha Technology AG: Olten, Switzerland), Conventional Physical Therapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Indiana University
Multiple Sclerosis
The Effect of Inspiratory Muscle Training on Balance and Postural Control in Multiple Sclerosis Patients
The goal of this study is to investigate the effect of inspiratory muscle training (IMT) in Multiple Sclerosis (MS) patients on balance and postural control.
- Trial name
- NCT06075472
- Testing
- Inspiratory Muscle Training, Balance Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Marmara University
Multiple Sclerosis
Avonex-evaluation of Quality of Life and Convenience in Belgian Participants - The AVAIL Study
The primary objective is to assess the quality of life of intramuscular (IM) Interferon Beta-1a in participants with relapsing remitting multiple sclerosis (RRMS) or Clinically Isolated Syndrome (CIS) in a clinical practice…
- Trial name
- AVAIL (NCT01272128)
- Testing
- Interferon beta-1a
- Where
- 17 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- Biogen
Multiple Sclerosis
VR and Orthoses for Rehabilitation in Multiple Sclerosis
This non-drug, non-medical device, interventional study explores the feasibility of integrating virtual reality (VR) with wearable sensors to support gait training using a passive orthosis in individuals with multiple sclerosis…
- Trial name
- VIRTUE (NCT07096700)
- Testing
- VR and walking brace-based gait rehabilitation
- Where
- 2 sites in Italy
- Volunteers
- 12 people
- Sponsor
- Azienda Usl di Bologna
Multiple Sclerosis
Physical Activity in Multiple Sclerosis (MS): A Novel Approach to Study Outcomes
Physical activity and exercise interventions in multiple sclerosis (MS) have received great attention most recently and there exists several randomized clinical trials (RCTs) addressing the outcomes associated with such…
- Trial name
- PHYSACTINMS (NCT02297932)
- Testing
- Strength training, Stretching
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Kessler Foundation
Multiple Sclerosis
Investigating the Relationship Between Sleep, Quality of Life,Other Disorders and Therapies in MS Patients on Betaferon
The study aims to investigate the relationship between sleep quality, quality of life,other disorders and therapies in Multiple Sclerosis (MS) patients treated with Betaferon.
- Trial name
- BetaSleep (NCT01766063)
- Testing
- Interferon beta-1b (Betaferon, BAY 86-5046)
- Where
- Germany
- Volunteers
- 138 people
- Sponsor
- Bayer
Multiple Sclerosis, Major Depressive Disorder
Acceptability and Feasibility of Transcranial Magnetic Stimulation (TMS) for Depression in Multiple Sclerosis
The goal of this single-arm, observational pilot study is to learn about the safety, feasibility, preliminary efficacy of TMS for the treatment of depression in people with MS.
- Conditions
- Multiple Sclerosis, Major Depressive Disorder, Treatment Resistant Depression
- Trial name
- NCT06329414
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Utah
Multiple Sclerosis, Magnetic Resonance Imaging
Risk Factors in Early Multiple Sclerosis
The central hypothesis of this protocol is that it is possible, using First Degree Relatives (FDRs) of patients with Multiple Sclerosis (MS) and assessing a variety of both known and unknown risk factors for MS, to define a risk…
- Conditions
- Multiple Sclerosis, Magnetic Resonance Imaging, Biomarkers, Clinically Isolated Syndrome
- Trial name
- RISEMS (NCT03586986)
- Testing
- Brain MRI
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Multiple Sclerosis, Exercise Intervention
Regular Exercise Improves Physical Capacity and Promotes Neurotrophins in Patients With Multiple Sclerosis
ABSTRACT Objective: The investigators aimed to determine the effect of regular exercise on aerobic capacity, strength values, and plasma levels of nerve growth factor (NGF) and Neurotrophin-3 (NT-3) in patients with multiple…
- Conditions
- Multiple Sclerosis, Exercise Intervention, Neuro-Degenerative Disease
- Trial name
- NCT04944251
- Testing
- Regular Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Ege University
Multiple Sclerosis
Protective Stepping in People With MS
Falls are common in Veterans with multiple sclerosis (MS), and current rehabilitation approaches to reduce falls are inadequate.
- Trial name
- PRO-STEP (NCT03551665)
- Testing
- Protective step training
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Multiple Sclerosis, Dysphagia
Effects of CTAR and PNF Exercises on Swallowing in Multiple Sclerosis
This study compares two exercise programs for people with multiple sclerosis (MS) who have trouble swallowing. One group did chin exercises against resistance (CTAR), and the other group did neck exercises based on a technique…
- Conditions
- Multiple Sclerosis, Dysphagia, Deglutition Disorders
- Trial name
- CTAR-PNF-MS (NCT07726667)
- Testing
- CTAR exercise, PNF exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Sanko University
Multiple Sclerosis, Gait Disorders, Neurologic
"Balance, Gait, and Motion Analysis in Multiple Sclerosis"
The goal of this observational cross-sectional study is to investigate the relationship between functional measures of balance and gait and objective kinetic and kinematic parameters in people with Multiple Sclerosis (MS).
- Conditions
- Multiple Sclerosis, Gait Disorders, Neurologic, Postural Balance, Motion Analysis
- Trial name
- MS-BALGAIT (NCT07630311)
- Where
- 2 sites in Greece
- Volunteers
- 40 people
- Sponsor
- University of Patras
Multiple Sclerosis, Foot Drop
Walking With FES or AFO in People With MS With Foot Drop
This investigation consists of two parallel groups of participants who will follow the same protocol. The aim of the study is to investigate the effects of using Functional Electrical Stimulation/Ankle Foot Orthosis (AFO) or…
- Trial name
- NCT01977287
- Testing
- Functional Electrical Stimulation, Ankle Foot Orthosis
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Queen Margaret University
Multiple Sclerosis, Fatigue
Pilot Study for the Evaluation of the More Stamina in Persons With Multiple Sclerosis
The overall study aims are to explore the feasibility, acceptability, and usability of More Stamina, a mobile app for fatigue self-management for persons with MS.
- Conditions
- Multiple Sclerosis, Fatigue, Chronic Conditions, Multiple
- Trial name
- NCT04244214
- Testing
- More Stamina
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Hospital Italiano de Buenos Aires
Multiple Sclerosis, Intermittent Fasting
Intermittent Fasting and Mediterranean Diet in Patient With Multiple Sclerosis
When the literature was reviewed, there is no study in which the effects of intermittent fasting and Mediterranean diet on quality of life, sleep, circadian rhythm and appetite hormones leptin and ghrelin levels in MS patients…
- Trial name
- NCT06546033
- Testing
- application of different types of diet
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Nigde Omer Halisdemir University
Multiple Sclerosis, Gait Disorders, Neurologic
Conventional Multidisciplinary Gait Rehabilitation VR Robotic Self-balancing Based Gait Rehabilitation
This trial is a prospective, randomized, rater-blinded study (cRHB (N=30) vs RAGT (N=30)). For the control group, this protocol includes 24 one-hour sessions of cRHB training during 8 weeks three times per week, under the…
- Trial name
- NCT06615947
- Testing
- Robotic gait training, tRHB
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Multiple Sclerosis Center of Catalonia
Multiple Sclerosis
The Utilization of Yoga as a Therapeutic Tool to Promote Physical Activity Behavior Change and Improved Postural Control in Individuals With Multiple Sclerosis
This randomized control trial will investigate whether using yoga as physical activity improves quality of life, self-efficacy for physical activity, reactive balance, and dual tasking more than education, journaling, and…
- Trial name
- NCT04113135
- Testing
- Yoga, Control
- Where
- United States
- Sponsor
- Winston Salem State University
Multiple Sclerosis
Intervention for Employed Women With Multiple Sclerosis
Unemployment is particularly common among women with multiple sclerosis (MS). This study uses a vocational rehabilitation program involving neuropsychological testing as an intervention.
- Trial name
- NCT04100525
- Testing
- Neuropsychological testing intervention plus follow up
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Holy Name Medical Center, Inc.
Multiple Sclerosis
A Biosimilar Trial to Investigate PK, PD, Safety With PB018 Versus US-licensed Ocrevus and EU-approved Ocrevus
This is a randomized, parallel group, double-blind, active-controlled, clinical pharmacology study to compare Pharmacokinetics, Pharmacodynamics and safety of PB018 versus Ocrevus in patients with Multiple Sclerosis.
- Trial name
- NCT07606521
- Testing
- US-Ocrevus, PB018, EU-Ocrevus
- Volunteers
- 222 people
- Sponsor
- Polpharma Biologics International AG
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