Clinical trials: Multiple Sclerosis (MS)
Multiple Sclerosis
Molecular Imaging of NET Using [C-11]MRB-PET in MS
This study aims to use [C-11]MRB PET (positron emission tomography) imaging to look at brain injury in patients with Multiple Sclerosis (MS) and healthy individuals.
- Trial name
- NCT03207464
- Testing
- [C-11]Methylreboxetine
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Multiple Sclerosis
Cognitive-motor Interference in Persons With MS
Dual tasking such as walking while talking on the phone or while remembering a shopping list is very frequently required in everyday life.
- Trial name
- NCT04158063
- Testing
- Dual Task Training, Single Mobility Training
- Where
- Belgium
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Pediatric Multiple Sclerosis
Cognitive Dysfunction in MS: Using Altered Brain Oscillation to Link Molecular Mechanisms With Clinical Outcomes
Up to 65% of patients with multiple sclerosis (MS) experience cognitive dysfunction. Diminution of mental capacity has a pervasive and profound impact on their quality of life.
- Trial name
- NCT03066752
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Multiple Sclerosis
Effects of Training on Central Auditory Function in Multiple Sclerosis
The purpose of this study is to characterize the central auditory processing (CAP) deficits that result from multiple sclerosis (MS).
- Trial name
- NCT01023074
- Testing
- Auditory training, MS: Control Activity
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Positron-Emission Tomography, Multiple Sclerosis
Evaluation of the Positron Emission Tomography (PET) Tracer ZK 6032924 in Patients With Multiple Sclerosis Compared to Healthy Volunteers
PET (positron emission tomography) imaging with BAY85-8101 for investigation in patients with Multiple Sclerosis compared to healthy volunteers
- Trial name
- NCT01031199
- Testing
- F-18 FEDAA1106 (BAY85-8101)
- Where
- 2 sites in Australia, Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Bayer
Multiple Sclerosis, Healthy Controls
Influence of High Intensity Exercise on Insulin Resistance, Muscle Contractile Properties, Aerobic Capacity and Body Composition in Multiple Sclerosis
The purpose of this study is to investigate the effects of a combined training programme and a high intensity interval training programme on insulin resistance, muscle strength/ muscle contractile properties, aerobic capacity and…
- Trial name
- NCT01845896
- Testing
- Training
- Where
- Belgium
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Bert Op't Eijnde
Multiple Sclerosis
Correlation Between Relapses in Multiple Sclerosis (MS) and Vitamin D Intake
The correlation between relapses in MS and vitamin D intake will be examined.
- Trial name
- NCT01994018
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- OSF Healthcare System
Multiple Sclerosis
Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)
Studies performed under 89-N-0045 are designed to examine the natural history of multiple sclerosis (MS) using MRI and immunological measures.
- Trial name
- NCT00001248
- Where
- United States
- Volunteers
- 3,750 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Relapsing Remitting Multiple Sclerosis, Fatigue
Correlation Between Daily Physical Activity and Disability, Fatigue, Cognition and Quality of Life in MS Patients
The main purpose of the study is to assess the fatigue, cognition, quality of life and disability correlation to MS-patients daily physical activity.
- Conditions
- Relapsing Remitting Multiple Sclerosis, Fatigue, Quality of Life, Physical Activity
- Trial name
- PAMS (NCT04115930)
- Testing
- Physical Activity measurement:
- Where
- 4 sites in Finland
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Multiple Sclerosis
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of VT7208 in Healthy Participants and MS Patients
Part 1 of this study will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of VT7208 in healthy volunteers.
- Trial name
- NCT07085507
- Testing
- VT7208
- Where
- Australia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vidya Therapeutics Inc
Multiple Sclerosis, Fatigue
Physiological Responses in Experimentally Induced Cognitive Fatigue in People With Multiple Sclerosis (MS)
The current study will add to the current knowledge by combining several electrophysiological techniques to examine the relationship between physiological responses and cognitive fatigue and daily activity performance in a…
- Conditions
- Multiple Sclerosis, Fatigue, Stress
- Trial name
- PREFIMS (NCT05003375)
- Testing
- High-challenging cognitive protocol to provoke stress and (cognitive) fatigue
- Where
- 2 sites in Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Multiple Sclerosis
Novel Immune Markers in Patients With Multiple Sclerosis
The investigators hypothesize that the endogenous cannabinoid signalling system has lost homeostasis in the disease multiple sclerosis (MS).
- Trial name
- NIMMS (NCT01026272)
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Washington
Multiple Sclerosis (MS), Fatigue
Increasing Physical Activity for Adults With Multiple Sclerosis (MS)
This study aims to advance the scientific understanding and potential future implementation of physical activity promotion by testing the efficacy of a phone-based app for increasing activity in insufficiently active patients…
- Conditions
- Multiple Sclerosis (MS), Fatigue, Physical Inactivity
- Trial name
- NCT06270641
- Testing
- ExerciseRx intervention
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Washington
Healthy Volunteer
MS PATHS Normative Sub-Study
The primary objective of this study is to determine the normative range of brain volume and brain volume change in healthy control (HC) participants whose age, race, and gender distribution is approximately matched to the age…
- Trial name
- NCT02996084
- Where
- 6 sites in United States, Germany and 1 more
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- Biogen
Multiple Sclerosis
An Eight-week RCT of Home-based Pilates for Symptoms of Anxiety, Depression, and Fatigue Among People With MS
This study will investigate the effects of eight-weeks home-based Pilates on symptoms of anxiety, depression, and fatigue among people with Multiple Sclerosis.
- Trial name
- NCT04120207
- Testing
- Home-based Pilates, Delayed-start Pilates
- Where
- Ireland
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Multiple Sclerosis
MS Mosaic: A Longitudinal Research Study on Multiple Sclerosis
The purpose of this study is to better characterize the fluctuations in multiple sclerosis symptoms and their relationship to medications, to length/extent of disease, and to a variety of physiologic measures.
- Trial name
- NCT02845635
- Testing
- Personal history of multiple sclerosis
- Where
- United States
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- Duke University
Multiple Sclerosis
Evaluation of the Microbiome in Multiple Sclerosis
To access the small intestinal microbiome and find abnormal microbiome/metabolome signature in luminal fluid samples from small bowel in MS compared to HC that could be used as biomarkers for MS.
- Trial name
- NCT05844826
- Testing
- SIMBA Capsule
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nimble Science Ltd.
Multiple Sclerosis
Protective Stepping in People With MS
Falls are common in Veterans with multiple sclerosis (MS), and current rehabilitation approaches to reduce falls are inadequate.
- Trial name
- PRO-STEP (NCT03551665)
- Testing
- Protective step training
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Multiple Sclerosis, COVID-19
COVID-19 Vaccine Biomarker Study in Multiple Sclerosis
SARS CoV-2 is the virus responsible for the pandemic COVID-19, which has resulted in nearly five million deaths worldwide since its spread in the beginning of 2020.
- Trial name
- NCT05121662
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Columbia University
Multiple Sclerosis, Healthy
Immune Profiles in Multiple Sclerosis (MS) Patients and Healthy Volunteers Through Thoracic Duct Cannulation
In this study, lymph fluid will be collected by cannulation of the thoracic duct, a minimally invasive procedure performed by interventional radiologists.
- Trial name
- NCT05162638
- Testing
- thoracic duct cannulation
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania