Clinical trials: Multiple Trauma/Injuries
Rib Fractures
Ultrasound-Guided Mid-Point Transverse Process to Pleura Block Versus Thoracic Paravertebral Block for Pain Management in Patients With Multiple Rib Fractures (A Prospective Randomized Double- Blinded, Non-inferiority Trial )
The aim of our study is to investigate whether the analgesic effect of MTPB is non inferior to that of TPVB in trauma patients with multiple rib fractures.
- Trial name
- NCT06981728
- Testing
- Mid point transverse to pleura block
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Assiut University
Surgical Wound Closure Technique
Evaluation of Aesthetic Surgical Wound Closure by a Single Layer in Comparison With Traditional Multi-layer Closure
the study is comparing the results of aesthetic surgery wound closure by a single layer versus the traditional multi-layer closure as regards the wound healing time, local wound complications, and the scar formed.
- Trial name
- NCT05166681
- Testing
- surgical wound suturing
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Abouqir General Hospital
Rotator Cuff Tears
BioBrace® Implant for Arthroscopic Repair of Full Thickness Rotator Cuff Tears
This study aims to evaluate the safety and effectiveness of arthroscopic rotator cuff repair augmented with the BioBrace® Implant vs.
- Trial name
- REinForce (NCT05997381)
- Testing
- Arthroscopic rotator cuff repair with BioBrace® Implant augmentation., Arthroscopic rotator cuff repair
- Where
- United States
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- CONMED Corporation
Posttraumatic Stress Disorder, Depression
Evaluation of a MCYI as Adjunct to Psychiatric Treatment for Vietnam Veterans With PTSD - RCT
The principal aim of this project is to conduct a Randomized Controlled Trial (RCT) to examine whether adding a twelve-session Multi-Component Yoga Intervention (MCYI) to the treatment regimen of Australian Vietnam Veterans…
- Trial name
- NCT00256464
- Testing
- Multi-component Yoga Intervention
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Bimalleolar Ankle Fractures
CMF Bone Stimulation as Adjunct to Surgical Treatment of Ankle Fractures
The OL1000 is intended to be used as a non-invasive adjunctive treatment for adult males or females that have sustained a closed, unstable ankle fracture that requires surgical treatment for stabilization.
- Trial name
- NCT02688855
- Testing
- Active Combined Magnetic Field OL1000 Bone Growth Stimulator
- Where
- 9 sites in United States
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Encore Medical, L.P.
Tennis Elbow, Lateral Epicondylitis
Multiple Platelet-Rich Plasma Lateral Epidondylitis Injections Versus a Single Platelet-Rich Plasma Injection
To determine the ideal dose of PRP for lateral epicondylitis. To see if 2 PRP injections are better than a single PRP injection or a saline injection to improve function and pain in patients with lateral epicondylitis.
- Trial name
- PRPLE (NCT02343822)
- Testing
- Platelet Rich Plasma Injection, Saline Injection
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Wound Heal
The Efficacy of Hyaluronic Acid and Honey in Healing of Multiple Extraction Sockets of Primary Teeth Compared to Saline
This study aims to evaluate the effect of hyaluronic acid and honey compared to saline in healing of multiple extraction sockets of primary teeth in a group of children aging from Two to Seven years old.
- Trial name
- NCT05161403
- Testing
- Hyaluronic acid, honey
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Cairo University
Concussion
Cortical Plasticity Assessment in Athletes With a History of Concussion
The purpose of this research is to determine whether athletes with concussion have changes in cortical excitability. Single and paired transcranial magnetic stimulation (TMS) can be used as reliable neurophysiological marker of…
- Trial name
- NCT01112761
- Testing
- Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Muscle Strain, Multiple Sites, Inflammation
Optimal Treatment of Acute Skeletal Muscle Injury
Acute muscle strain injuries occur both during sports, in leisure time activities and during manual occupation and represent a major clinical challenge and has societal economic costs.
- Trial name
- NCT06274151
- Testing
- Naproxen 500 Mg, Rehabilitation
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Stress, Emotional, Stress-related Mental Disorders
Effects of Parent-Adolescent Joint Interventions for Adolescents With Adverse Childhood Experiences
The study aims to examine the effectiveness of joint parent-adolescent intervention in improving the mental health outcomes of participants, specifically by reducing symptoms of depression, anxiety, and PTSD, as measured by the…
- Conditions
- Stress, Emotional, Stress-related Mental Disorders, Adverse Childhood Experiences
- Trial name
- EASY-PEP (NCT06619821)
- Testing
- Emotiaonl skill enhancement, PCE promotion, Psychoeducation
- Where
- 2 sites in China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Peking University
Traumatic Injuries, Traumatic Injury of Spine
Human Impact Exposure Onboard High-Speed Boats
Operating high-speed boats is dangerous. The purpose of this study is to establish what levels and what characteristics of impact exposure cause injuries.
- Conditions
- Traumatic Injuries, Traumatic Injury of Spine, Traumatic Head Injury
- Trial name
- MASHIEN (NCT05299736)
- Where
- Sweden
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Post Traumatic Stress Disorder
Department of Defense PTSD Adaptive Platform Trial - Intervention A - Fluoxetine
This is a Phase 2 randomized, double-blinded, placebo-controlled study that will evaluate multiple potential pharmacotherapeutic interventions for PTSD utilizing an adaptive platform trial design.
- Trial name
- NCT05948553
- Testing
- Intervention A Fluoxetine Hydrochloride (HCl)
- Where
- 9 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Global Coalition for Adaptive Research
Injury of Multiple Muscles and Tendons at Lower Leg Level
The Effect of Supplementing Different Solutions on Firefighters' Simulated Fire Rescue Training
One of the three major tasks of firefighters is disaster rescue, and fire rescue accounts for the majority. They must wear personal protective equipment (PPE) at the fire site during execution.
- Trial name
- NCT04727905
- Testing
- energy drink
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Taiwan Sport University
Muscle Spasticity, Hypertonia, Muscle
Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals
To assess the safety and tolerability of single and multiple doses of MTR-601 in normal healthy volunteers under fed and fasted conditions. To evaluate the plasma and urine pharmacokinetics (PK) of MTR-601.
- Conditions
- Muscle Spasticity, Hypertonia, Muscle, Cerebral Palsy, Multiple Sclerosis
- Trial name
- NCT06117020
- Testing
- MTR-601
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Motric Bio
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Multiple Trauma
Danger Response in Polytrauma Patients
The NTF_PT_2014 multicenter study aims to collect, store, and analyse plasma and serum from polytrauma-patients (injury severity score ≥25) and corresponding clinical data to address 1) how trauma modulates the release of danger…
- Trial name
- NTF-PT (NCT02682550)
- Testing
- blood drawing
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Trauma
Metabonomics Fingerprinting of Multiple Trauma
The aim of this study is to establish plasma metabonomics fingerprinting atlas for severe multiple trauma patient using 1H nuclear magnetic resonance (NMR) based metabonomics methodology and advanced mathematics tools.
- Trial name
- NCT01279239
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sichuan Academy of Medical Sciences
Cardiovascular Diseases, Cardiovascular Complication
Colchicine in Patients at Cardiac Risk Undergoing Major Non-Cardiac Surgery
Perioperative myocardial injury and major adverse cardiovascular events (MACE) are common causes of morbidity and mortality in patients at increased cardiovascular risk undergoing non-cardiac surgery.
- Conditions
- Cardiovascular Diseases, Cardiovascular Complication, Perioperative Complication, Myocardial Injury
- Trial name
- COLCAT (NCT06279000)
- Testing
- Colchicine
- Where
- Switzerland
- Volunteers
- 880 people, healthy volunteers welcome
- Sponsor
- Cantonal Hospital of St. Gallen
Disaster, PTSD
Feasibility and Efficacy of a Digital Mental Health Intervention for Teen Wildfire Survivors
In October, 2017, Northern California experienced devastating and historic wildfires. Sonoma Rises is an app designed for anyone who was impacted by this event and is intended to help survivors of disaster find their new normal.
- Conditions
- Disaster, PTSD, Adolescent Behavior, Trauma
- Trial name
- NCT03868761
- Testing
- Sonoma Rises
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Stanford University
Subarachnoid Hemorrhage, Optical Imaging
A New Multi-parameter Neuromonitoring System to Save Patients' Lives in Stroke and Brain Injury
To assess the feasibility of a new neuromonitoring system (NeMoSystem including NeMo Probe and NeMo Patch) and the accuracy of the measurement values (cerebral blood flow (CBF); cerebral blood volume (CBV)) obtained.
- Trial name
- NCT01802762
- Testing
- NeMo Patch and NeMo Probe
- Where
- 2 sites in Austria, Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- NeMoDevices AG