Clinical trials: Multiple Trauma/Injuries
Ankle Injuries
Operative Versus Non Operative Treatment for Unstable Ankle Fractures
The purpose of the study is to compare functional outcomes and recovery following surgical and non surgical treatment of potentially unstable , isolated fibula fractures.
- Trial name
- NCT00336752
- Testing
- non operative treatment, operative treatment of ankle fractures
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Drug-Induced Acute Liver Injury
The Multi Center, Randomized, Double-blind, Positive Controlled Study of Bicyclol in the Treatment of Acute DILI
The study adopted the superiority design of multi center, randomized, double-blind, positive control drug, dose finding, using two simulation skills.
- Trial name
- NCT02944552
- Testing
- bicyclol tablet 25mg, bicyclol tablet 50mg, polyene phosphatidylcholine capsule 456mg
- Where
- 17 sites in China
- Volunteers
- 244 people
- Sponsor
- Drug Induced Liver Disease Study Group
Critical Illness, Hyperglycemia
Prognostic Value of Stress Hyperglycemia Ratio in Critically Ill Patients
Critically ill patients admitted to intensive care units (ICUs) frequently develop elevated blood sugar levels (hyperglycemia) as a result of acute illness-related stress, even if they do not have diabetes.
- Conditions
- Critical Illness, Hyperglycemia, Acute Kidney Injury, Multiple Organ Failure
- Trial name
- NCT07853911
- Volunteers
- 230 people
- Sponsor
- Assiut University
Non Union Fracture
A Comparative Study of 2 Doses of BM Autologous H-MSC+Biomaterial vs Iliac Crest AutoGraft for Bone Healing in Non-Union
ORTHOUNION is a multi-centre, open, comparative, randomized, clinical trial with three parallel arms that aims to compare the efficacy of three treatments to enhance bone healing in patients with long bone non-union.
- Trial name
- ORTHOUNION (NCT03325504)
- Testing
- Cultured Mesenchymal Stem Cells, Autologous iliac crest graft
- Where
- 19 sites in France, Germany and 2 more
- Volunteers
- 46 people
- Sponsor
- Universidad Autonoma de Madrid
Pain, Traumatic Brain Injury
The NRC Dataset. Developing a Minimum Dataset for Multidisciplinary Rehabilitation: a Modified E-Delphi Study
Several rehabilitation datasets are presently in use for specific patient groups in England. The 'National Clinical Audit of Specialist Rehabilitation for patients with complex needs following major injury' (NCASRI) evaluated…
- Conditions
- Pain, Traumatic Brain Injury, Major Trauma, Multiple Sclerosis
- Trial name
- NCT06726135
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- ThomasCorbett
COVID-19, Organ Dysfunction Syndrome Sepsis
Mechanisms for Organ Dysfunction in Covid-19
The study aims to investigate organ dysfunction and biomarkers in patients with suspected or verified COVID-19 during intensive care at Uppsala University Hospital.
- Conditions
- COVID-19, Organ Dysfunction Syndrome Sepsis, Organ Dysfunction Syndrome, Multiple, Septic Shock
- Trial name
- UMODCOVID19 (NCT04316884)
- Where
- Sweden
- Volunteers
- 380 people
- Sponsor
- Uppsala University
Heat Stroke, Early Waking
Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Heat Stroke
Heat stroke is a clinical syndrome with high incidence and high fatality rate in summer. Patients with liver, kidney, and brain damage are prone to secondary MODS, and the prognosis is poor due to high medical costs.
- Conditions
- Heat Stroke, Early Waking, MODS, Proteinosis
- Trial name
- NCT05155358
- Testing
- Peripheral blood test
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Concussion, Mild
Cervicogenic Concussion Rehabilitation With TopSpin360
Concussions occur most frequently in adolescents and often result in significant disruption to daily living for prolonged periods of time.
- Trial name
- NCT04159298
- Testing
- Top Spin 360
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- Western University, Canada
Rib Fractures, Rib Trauma
PVB vs Ketamine/Lidocaine in Rib Fracture Patients
Rib fractures are a common admission to the trauma service. The mainstay of treatment is pain control to improve respiratory effort in order to offset the risk of pneumonia and mechanical ventilation.
- Conditions
- Rib Fractures, Rib Trauma, Rib Fracture Multiple, Pain, Acute
- Trial name
- NCT04413799
- Testing
- lidocaine, ketamine intravenous infusion, paravertebral block with ropivicaine
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- George Washington University
Breast Neoplasms, Cardiotoxicity
The Safety Management of Cardiac Toxicity in Breast Cancer Patients Under Multidiscipline Therapy.
This trial is to explore the optimal strategies for guaranteeing the cardiac safety of breast cancer patients following adjuvant radiotherapy in the modern era of multidisciplinary treatment.
- Trial name
- NCT02942615
- Testing
- limit heart dose
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Ruijin Hospital
Acute Traumatic Injury
Clinical Trial to Evaluate the Efficacy and Safety of 'Pelubiprofen Controlled Released Tab.' in Acute Traumatic Injury
A randomized, double-blind, placebo-controlled, parallel, multi-center phase III clinical trial
- Trial name
- NCT03874247
- Testing
- pelubiprofen 45mg
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Daewon Pharmaceutical Co., Ltd.
Post Traumatic Stress Disorder, Critical Illness
Eye Movement Desensitisation and Reprocessing (EMDR) to Improve Mental Health Following Intensive Care Admission
The goal of this multi-centre, randomised, pilot feasibility study is to assess the feasibility of recruiting intensive care survivors, with symptoms of traumatic stress, to a study evaluating the use of eye movement…
- Conditions
- Post Traumatic Stress Disorder, Critical Illness, Eye Movement Desensitisation and Reprocessing, Depression, Anxiety
- Trial name
- EMERALD (NCT05591625)
- Testing
- Eye Movement Desensitisation and Reprocessing
- Where
- 2 sites in United Kingdom
- Volunteers
- 160 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Traumatic Brain Injury, Stroke
Remote Neuropsychological Assessment of Patients With Neurological Disorders and Injuries
For the last decades, many aspects of human life have been altered by digital technology. For health care, this have opened a possibility for patients who have difficulties travelling a long distance to a hospital to meet with…
- Conditions
- Traumatic Brain Injury, Stroke, Multiple Sclerosis, Parkinson Disease
- Trial name
- NCT05819008
- Testing
- Neuropsychological Assessment
- Where
- Sweden
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Umeå University
Trauma, Adult Stem Cells
MultiStem® for Treatment of Trauma Induced Multiple Organ Failure/Systemic Inflammatory Response Syndrome
Single center, prospective, randomized, double-blind, pragmatic Phase 2 clinical study in severely injured trauma patients within hours of hospitalization who have survived initial resuscitation.
- Trial name
- NCT04533464
- Testing
- MultiStem
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Healios K.K.
Tibia Fracture
Infection Rates Following Internal Fixation of Open and Closed Tibia Fractures in India
The objectives of this study are to investigate infection rates and management for open and closed tibia fracture subjects in India treated with internal fixation.
- Trial name
- NCT01691599
- Where
- 11 sites in India
- Volunteers
- 800 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Neurologic Disorders, Nervous System Diseases
Neurologic Stem Cell Treatment Study
This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will…
- Conditions
- Neurologic Disorders, Nervous System Diseases, Neurodegenerative Diseases, Neurological Disorders
- Trial name
- NEST (NCT02795052)
- Testing
- Intravenous and Intranasal BMSC
- Where
- 3 sites in United States, United Arab Emirates
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Rupture of Posterior Cruciate Ligament, Rupture of Anterior Cruciate Ligament
Simultaneous Multiple Cruciate Ligament Reconstructions Using a Single Achilles Allograft
This study introduce cases of simultaneous multiple cruciate ligament reconstructions with a single free tendon Achilles allograft using new technique.
- Trial name
- NCT01440348
- Testing
- cruciate ligament reconstruction
- Where
- South Korea
- Volunteers
- 51 people
- Sponsor
- National Police Hospital
Ankle and Hindfoot Arthrodesis
Long-term Safety and Effectiveness of AUGMENT® Bone Graft Compared to Autologous Bone Graft
The objective of this long-term study is to evaluate the long term effectiveness and safety of AUGMENT® Bone Graft vs. autologous bone graft.
- Trial name
- NCT02879149
- Testing
- AUGMENT® Bone Graft, Standard of Care
- Where
- 26 sites in United States, Canada
- Volunteers
- 150 people
- Sponsor
- BioMimetic Therapeutics
Sepsis Syndrome, MODS
Nafamostat Mesilate for Anticoagulation During CRRT in Critically Ill Patients
Continuous renal replacement therapy is widely used in intensive care medicine, which is known as an alternative therapy to save injured kidney . Anticoagulation is an important part of this therapy.
- Conditions
- Sepsis Syndrome, MODS, AKI, Hemorrhage
- Trial name
- NMFADCICIP (NCT05382078)
- Where
- China
- Volunteers
- 188 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Surgical Wound, Trauma-related Wound
A Prospective, Multi Centre, Interventional, Non-comparator, Open Label Study to Demonstrate the Efficacy, Performance and Safety of ConvaFoam™ Silicone, ConvaFoam™ Border and ConvaFoam™ Non-Adhesive Dressings in the Management of Surgical and Traumatic Wounds
A prospective, multi centre, interventional, non-comparator, open label study to demonstrate the efficacy, performance and safety of ConvaFoam™ Silicone, ConvaFoam™ Border and ConvaFoam™ Non-Adhesive dressings in the management…
- Trial name
- MATILDA (NCT05632276)
- Testing
- ConvaFoam
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- ConvaTec Inc.
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