Clinical trials: Multiple Trauma/Injuries
Multiple Trauma, Injury Traumatic
The BIG Score and In-Hospital Trauma Mortality
This study investigated the efficacy and reliability of the BIG score, calculated based on the base deficit (BD), International Normalized Ratio (INR), and Glasgow coma scale (GCS), in comparison with the GCS, Revised trauma…
- Trial name
- BIGstd (NCT06574464)
- Testing
- BIG SCORE, Glasgow coma scale, Revised Trauma Score
- Where
- Turkey (Türkiye)
- Volunteers
- 563 people
- Sponsor
- Haseki Training and Research Hospital
Hepatorenal Syndrome, Liver Cirrhosis
Endothelin Receptor Antagonism With Ambrisentan to Treat Hepatorenal Syndrome
Patients with advanced cirrhosis of the liver develop kidney problems occasionally. This condition is called Hepatorenal Syndrome, requires hospitalization and frequently results in death.
- Conditions
- Hepatorenal Syndrome, Liver Cirrhosis, Acute Kidney Injury, Ascites Hepatic
- Trial name
- NCT06256432
- Testing
- Ambrisentan, Terlipressin
- Where
- 6 sites in India
- Volunteers
- 54 people
- Sponsor
- Noorik Biopharmaceuticals AG
Acute Kidney Injury
Prognosis and Risk Factors for Acute Kidney Injury
The aim of our study is to analyze the accurate diagnosis and prognosis of acute kidney injury (AKI) based on its severity and to define long-term clinical and socioeconomic outcomes.
- Trial name
- NCT06898944
- Where
- South Korea
- Volunteers
- 320,000 people
- Sponsor
- Seoul National University Hospital
Wound; Head, Multiple, Wound; Head, Scalp
Short Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
This study will evaluate the use of free autologous dermal fat grafting (also called free dermal fat autografting) to treat complex craniofacial wounds that have failed standard treatment and to understand how well these grafts…
- Conditions
- Wound; Head, Multiple, Wound; Head, Scalp, Wound; Head, Wound Infection
- Trial name
- FTFDT3 (NCT03872544)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dufresne, Craig, MD, PC
Neurogenic Detrusor Overactivity
Safety and Tolerability of TAR-302-5018 in Subjects With Neurogenic Detrusor Overactivity Resulting From Spinal Cord Injury
The purpose of this study is to determine if TAR-302-5018, an investigational drug-delivery system, is safe and tolerable in patients with neurogenic detrusor overactivity (NDO) resulting from spinal cord injury (SCI).
- Trial name
- NCT03168828
- Testing
- Trospium-Releasing Intravesical System (TAR-302-5018)
- Where
- 4 sites in United States
- Volunteers
- 7 people
- Sponsor
- Taris Biomedical LLC
Traumatic Brain Injury, Cerebral Palsy
Real World Outcomes of Intranasal MuSE Exosomes and Stem Cells in Neurological Regenerative Therapy
This prospective observational study collects real world data on participants receiving regenerative therapies administered internationally and delivered intranasally via the Kurve Therapeutics ViaNase device.
- Conditions
- Traumatic Brain Injury, Cerebral Palsy, Hypoxic Ischemic Encephalopathy, Neurologic Disorders
- Trial name
- MuSE-INSIGHT (NCT07521384)
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Healing Hope International
Severe Bronchopulmonary Dysplasia
PNEUMOSTEM for the Prevention and Treatment of Severe BPD in Premature Infants
This study is to evaluate the efficacy and safety of PNEUMOSTEM® for the Prevention and Treatment of Severe Bronchopulmonary Dysplasia (Severe BPD) in Premature Infants.
- Trial name
- NCT03392467
- Testing
- PNEUMOSTEM
- Where
- 2 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Medipost Co Ltd.
Multiple Sclerosis, Vertigo
Gaze and Postural Stability in Multiple Sclerosis
In order to provide information that will improve therapy, the goals of this project are to determine if persons with MS with complaints of dizziness and at risk for falls can improve their balance and vision stability as a…
- Conditions
- Multiple Sclerosis, Vertigo, Dizziness, Falls Injury
- Trial name
- GPS (NCT03521557)
- Testing
- Gaze and Postural Stability, Standard Care Control
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Utah
Burns
The RE-ENERGIZE Study: RandomizEd Trial of ENtERal Glutamine to minimIZE Thermal Injury
The purpose of this study is to test the following hypotheses: 1. Enteral glutamine administration decreases in-hospital mortality in adult patients with severe thermal burn injuries. 2.
- Trial name
- RE-ENERGIZE (NCT00985205)
- Testing
- Enteral Glutamine
- Where
- 53 sites in United States, Austria and 12 more
- Volunteers
- 1,201 people
- Sponsor
- Daren K. Heyland
Stroke, Cerebral Oxygenation
Multi-channel Time-resolved Functional Near Infrared Spectroscopy for Prevention of Perioperative Brain Injury
Covert stroke occurs in one out of fourteen patients during or shortly after surgery, and may result in long-term disability. Fortunately, stroke that occurs during non-cardiac surgery is most commonly caused by inadequate blood…
- Trial name
- NCT05752981
- Testing
- multichannel time-resolved (tr) functional near infrared spectroscopy (fNIRS) (tr-fNIRS)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Head Trauma, Polytrauma
Comparative Study for the Validity of Various Severity Scoring System
Scoring systems for use in intensive care unit (ICU) patients have been introduced and developed over the last 30 years. They allow an assessment of the severity of disease and provide an estimate of in-hospital mortality
- Conditions
- Head Trauma, Polytrauma, Pre-Eclampsia, Sepsis
- Trial name
- NCT04683094
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Aswan University Hospital
Autosomal Dominant Polycystic Kidney Disease
NOX4 and Related Biomarkers in ADPKD
To determine the value of NOX4, markers of mitochondria injury and function, and oxidative stress as real-time biomarkers to assess disease severity in patients with early autosomal dominant polycystic kidney disease (ADPKD).
- Trial name
- NCT04630613
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Hip Fractures, Stroke
Accuracy Activity Monitors for Inhospital Activity Monitoring of Geriatric Patients
The focus of this study will be to determine the accuracy of the MOX, the Axivity and Fitbit, Empatica and Chill+ activity monitors (with both custom-made and available algorithms) for the classification of lying, sitting…
- Conditions
- Hip Fractures, Stroke, Abdominal Injury
- Trial name
- NCT04865627
- Testing
- activity monitor
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- KU Leuven
Rib Fractures, Rib Fracture Multiple
Ketamine vs Lidocaine in Traumatic Rib Fractures
Rib fractures continue to be a common occurrence in trauma patients of all ages. Traumatic rib fractures can cause severe pain in patients and lead to shallow breathing and further complications such as the need for mechanical…
- Conditions
- Rib Fractures, Rib Fracture Multiple, Rib Trauma
- Trial name
- NCT04781673
- Testing
- Ketamine, Lidocaine
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Brittany Hoyte
Injuries, Spinal Cord, Pain
Levetiracetam in Chronic Neuropathic Pain Following Spinal Cord Injury
Purpose: To evaluate the efficacy and safety of levetiracetam on chronic neuropathic pain after spinal cord injury, and to examine its effect on spasms and evoked pain.
- Trial name
- NCT00252954
- Testing
- Levetiracetam
- Where
- 3 sites in Denmark
- Volunteers
- 36 people
- Sponsor
- Danish Pain Research Center
Pain Management, Rib Fracture Multiple
Assessment of Morbidity and Mortality Following Serratus Anterior Plane Block (SAPB) for Unilateral Rib Fractures
The goal of this observational study is to learn about the long-term effects of the serratus anterior plane block (SAPB) in adult patients who suffered multiple unilateral anterolateral rib fractures within 24 hours of patient…
- Conditions
- Pain Management, Rib Fracture Multiple, Serratus Anterior Plane Block
- Trial name
- SAPB (NCT07032766)
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Albert Einstein College of Medicine
Dental Caries, Pulp Exposure, Dental
Clinical Study Evaluating Solventum™ Vitrebond™ Pulp Protect Liner/Base for Direct Capping of Pulpal Exposure
This research study is looking at the safety and effectiveness of Solventum™ Vitrebond™ Pulp Protect Liner/Base for direct pulp capping (DPC) on permanent teeth that have pulp exposure due either to deep cavities, trauma, or…
- Conditions
- Dental Caries, Pulp Exposure, Dental, Tooth Decay, Dental Decay
- Trial name
- NCT07231237
- Testing
- Vitrebond™ Pulp Protect Liner/Base
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Solventum US LLC
Drug-Induced Liver Injury
Efficacy and Safety Study of Magnesium Isoglycyrrhizinate Injection in Subjects With Acute Drug-induced Liver Injury
The purpose of this study is to investigate the safety, effective dosage and treatment of Magnesium Isolycyrrhizinate Injection to cure the acute drug-induced liver injury compared with the Tiopronin Injection.
- Trial name
- NCT02734966
- Testing
- Magnesium Isoglycyrrhizinate Injection 100mg OD, Magnesium Isoglycyrrhizinate Injection 200mg OD, Tiopronin Injection
- Where
- 8 sites in China
- Volunteers
- 174 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Polytrauma
Genderspecific Differences in Hormone Levels After Trauma
The goal of this prospective study with the aim to establish a registry is to learn about the role of steroid hormones in severely injured patients.
- Trial name
- SteroPoly (NCT05794256)
- Testing
- No interventions are planned
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Technical University of Munich
Spinal Injury
IONSYS Feasibility Study
The treatment of postoperative pain continues to be a challenge after posterior spinal fusions. There is considerable evidence demonstrating that a multi-modality approach including patient controlled analgesia (PCA) with opioids…
- Trial name
- IONSYS Pilot (NCT03021083)
- Testing
- IONSYS Patch
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
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