Clinical trials: Multisystem Inflammatory Syndrome in Children (MIS-C)
Paediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-Cov-2
Paediatric Inflammatory Multisystem Syndrome During COVID-19 Pandemic
During the COVID-19 pandemic, a small minority of children have been presenting to acute paediatric services with a new syndrome, Paediatric Inflammatory Multisystem Syndrome temporally associated with SARS-Cov-2 (PIMS-TS).
- Trial name
- NCT04761913
- Where
- 6 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- Anglia Ruskin University
Pims-Ts
PIMS-TS in Intensive Care: Retrospective Cohort Trial
Pediatric Multisystem Inflammatory Syndrome Temporally associated with SARS-CoV-2, (PMIS-TS) represents the new unit, partially imitating the previously described Kawasaki disease.
- Trial name
- PIMS-TS INT (NCT05388396)
- Testing
- PIMS-TS diagnostic a treatment
- Where
- Czechia
- Volunteers
- 180 people
- Sponsor
- Brno University Hospital
Multisystem Inflammatory Syndrome in Children (MIS-C)
Long-Term Outcomes After the Multisystem Inflammatory Syndrome in Children
Multi-system Inflammatory Syndrome in Children (MIS-C) is a new condition related to COVID-19, the study investigators are still learning about its causes, effects, and long-term impact.
- Trial name
- MUSIC (NCT05287412)
- Where
- 33 sites in United States, Canada
- Volunteers
- 1,200 people
- Sponsor
- Carelon Research
MIS-C Associated With COVID-19
Genetic Basis of SARS-CoV-2 Infection-Associated Multisystem Inflammatory Syndrome in Children (MIS-C)
The project aims to investigate the molecular basis of pediatric inflammatory conditions associated with COVID-19 identified by the IDEA network, with the objectives of characterizing their genetic background, pathophysiology…
- Trial name
- MIS-C IDEA (NCT07881068)
- Where
- 3 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Giannina Gaslini
Kawasaki Disease, Inflammation
Characterization of Multisystem Inflammatory Syndrome in Children (MIS-C) and Its Relationship to Kawasaki Disease
Beginning in mid-March 2020, pediatricians in communities in Western Europe, the UK, and the Eastern U.S. that had been severely affected by the Covid-19 pandemic noted an increased number of children presenting with fever and…
- Trial name
- NCT04538495
- Where
- United States
- Volunteers
- 268 people
- Sponsor
- University of California, San Diego
SARS-CoV2 Infection, Multisystem Inflammatory Syndrome in Children
MISC COVID-19 Study in Pediatric Population
Rationale: Severe Acute Respiratory Syndrome - Coronavirus - 2 (SARS-CoV2) and its related Coronavirus Disease - 19 (COVID-19) has become a health emergency worldwide.
- Trial name
- COVID-19 (NCT04844242)
- Where
- India
- Volunteers
- 180 people
- Sponsor
- Tuberculosis Research Centre, India
Multisystem Inflammatory Syndrome in Children
Multisystem Inflammatory Syndrome In Children at Sohag University Hospital
Since its initial description in December 2019 in Wuhan , China, Corona virus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), has rapidly evolved into a worldwide…
- Trial name
- NCT05382234
- Testing
- CBC, ESR ,CRP,Liver Function ,renal function ,ABG,Na,K,D-dimmer ,cardiac enzyme,ferritin ,blood and urine culture in negative cases
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Multisystem Inflammatory Syndrome in Children
Infusions of Mesenchymal Stromal Cells in Children With Multisystem Inflammatory Syndrome
The purpose of this multi-site, pilot study is to test whether infusions of human cord tissue mesenchymal stromal cells (hCT-MSC) are safe in children with multi system inflammatory syndrome (MIS-C).
- Trial name
- MISTIC (NCT04549285)
- Testing
- Human Cord Tissue Mesenchymal Stromal Cells (hCT-MSCs)
- Where
- 3 sites in United States
- Sponsor
- Joanne Kurtzberg, MD
SARS CoV 2 Infection, Multisystem Inflammatory Disease, Pediatric, COVID-19 Related
Incidence of MIS-C and Other Complications Following SARS-CoV-2 Infection
Multisystem inflammatory syndrome in children (MIS-C) is a rare severe complication to SARS-CoV-2 infection in children. It has been reported to occur in approximately one of 3,000 to 4,000 unvaccinated children during the…
- Conditions
- SARS CoV 2 Infection, Multisystem Inflammatory Disease, Pediatric, COVID-19 Related, Multisystem Inflammatory Syndrome in Children, COVID-19 Pandemic
- Trial name
- NCT05186597
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sars-CoV-2 Infection, MIS-C
COVID-19 and Multisystem Inflammatory Syndrome in Children (MIS-C) Risk / World Health Organization (WHO)
This study is a multicenter, international, non interventional, retrospective study about SARS-CoV-2 and Multisystem Inflammatory Syndrome (MIS-C) reinfection risk in children.
- Trial name
- REPI (NCT06255860)
- Where
- France
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Association Clinique Thérapeutique Infantile du val de Marne
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose…
- Conditions
- Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension
- Trial name
- POPS or POP02 (NCT04278404)
- Testing
- The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke University
MIS-C Multisystem Inflammatory Syndrome in Children
Immun Response in Children With MIS-C
Multi-system inflammatory syndrome in children (MIS-C) is a post-viral inflammatory vasculopathy of children and adolescents following Covid-19 infection. It affects one of 1000-5000 children.
- Trial name
- NCT05052424
- Testing
- Analysis of cytokines and immun cell related markers
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Cologne
Paediatric Inflammatory Multisystem Syndrome-Temporally Associated With SARS-CoV-2 (PIMS-TS)
Randomised Evaluation of COVID-19 Therapy (RECOVERY) in Children With PIMS-TS in Switzerland (SWISSPED-RECOVERY)
The study is to provide reliable estimates of the effect of study treatment on hospital length of stay through to 28 days after randomisation.
- Trial name
- NCT04826588
- Testing
- Methylprednisolone sodium succinate 10 mg/kg intravenously, Human normal immunoglobulin (IVIg)
- Where
- 10 sites in Switzerland
- Volunteers
- 76 people
- Sponsor
- University Children's Hospital Basel
COVID-19, Post-Acute COVID-19
Genetic Risk Factors for Multi-system Inflammatory Syndrome in Children and Pediatric Post COVID Condition
We will perform Whole Exome Sequencing on DNA from saliva. We will include: Children with a history of MIS-C; children with post-COVID condition; and controls in order to identify rare, high impact genetic variants in…
- Conditions
- COVID-19, Post-Acute COVID-19, Post-Acute COVID19 Syndrome, Multi-System Inflammatory Syndrome in Children
- Trial name
- GRIP (NCT05722717)
- Testing
- Saliva collection at home
- Where
- Netherlands
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Covid19
MultiOrgan Inflammatory Syndromes COVID-19 Related Study
The study comprise a nationwide, voluntary, on-line survey of inflammatory syndromes in children for retrospective (since 4th March 2020) and prospective data collection.
- Trial name
- MOIS-CoR (NCT04811456)
- Testing
- multisystem inflammatory syndrome in children (MIS-C)
- Where
- 2 sites in Poland
- Volunteers
- 1,000 people
- Sponsor
- Medical University of Warsaw
COVID - 19, Diabetes Mellitus
DIFFERENT SARS-COV-2 VARIANTS' EFFECT ON THE COURSE OF COVID-19 IN ESTONIAN CHILDREN
The study focuses on Estonian children under 18 who had COVID-19 from 27.02.2020 to 01.03.2023. The main aim is to find out the risk factors for severe COVID-19 in children.
- Conditions
- COVID - 19, Diabetes Mellitus, Post-COVID Conditions, MIS-C Associated With COVID-19
- Trial name
- NCT06784713
- Where
- Estonia
- Volunteers
- 127,277 people
- Sponsor
- University of Tartu
COVID, Corona Virus Infection
Seroprevalence of SARS-Cov-2 Antibodies in Children
It is unknown what proportion of healthy children have been exposed to SARS-Cov-2 and how many have antibodies. The aim of this study is to follow a cohort of healthy children over six months and measure their antibodies to…
- Conditions
- COVID, Corona Virus Infection, Multisystem Inflammatory Syndrome in Children
- Trial name
- NCT04347408
- Testing
- Covid-19 Antibody testing (IgG and IgM), Blood Storage
- Where
- 5 sites in United Kingdom
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Covid19, Corona Virus Infection
Adolescents With COVID-19/MIS-C at HCFMUSP
This is a protocol aimed at children and adolescents contaminated with COVID, treated at the Hospital das Clínicas, University of Sao Paulo, Brazil (HCFMUSP), in the recovery phase.
- Conditions
- Covid19, Corona Virus Infection, SARS (Severe Acute Respiratory Syndrome), SARS-CoV Infection
- Trial name
- NCT04659486
- Testing
- Home-based exercise training
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo
Myocarditis, Pediatric Inflammatory Multisystem Syndrome
Multiparametric Echocardiography and Cardiac Biomarkers in Pediatric Inflammatory Heart Diseases
Acquired inflammatory or infectious cardiac diseases, in pediatrics, include Kawasaki disease, myocarditis, and Covid-19-related Pediatric Multisystemic Inflammatory Syndrome (PIMS).
- Conditions
- Myocarditis, Pediatric Inflammatory Multisystem Syndrome, Kawasaki Disease
- Trial name
- NCT05911386
- Testing
- study of biological samples and echocardiographic data and link with need of hemodynamic support
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
Long Covid19, COVID-19 Pneumonia
Clinical Characteristics and Long Term Impact on Pediatric COVID-19 in Taiwan
This project will study severe COVID-19 related factors, host genes, biomarkers, and prognosis of severe encephalitis in children, and conduct: 1.
- Conditions
- Long Covid19, COVID-19 Pneumonia, Multisystem Inflammatory Syndrome in Children
- Trial name
- NCT05582512
- Testing
- sequelae tracking
- Where
- Taiwan
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital