Clinical trials: Multivessel Coronary Disease
STEMI (ST Elevation MI)
Inhibition of Late Sodium Current (INa) to Prevent Coronary MICROvascular Dysfunction in Patients Presenting With ST-Elevation Myocardial Infarction and Multivessel Disease: INaMICRON Study
This is a Phase IIb, multicentric, prospective, randomized (1:1 ratio), open label, and no profit study, with the aim of evaluating the efficacy of late INa current inhibition to improve coronary microcirculation in patients…
- Trial name
- INaMICRON (NCT07380919)
- Testing
- Ranolazine
- Where
- 3 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Federico II University
Acute Coronary Syndrome
OCT Guided vs COmplete Pci in patieNts With sT Segment Elevation myocArdial infarCtion and mulTivessel Disease
STEMI patients with multivessel disease will be randomized to complete PCI versus PCI driven by high risk criteria of plaques evaluated with OCT
- Trial name
- OCT-CONTACT (NCT04878133)
- Testing
- OCT - optical coherence tomography
- Where
- 6 sites in Italy
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- A.O.U. Città della Salute e della Scienza
NSTEMI - Non-ST Segment Elevation MI, Multi Vessel Coronary Artery Disease
Culprit Lesions in NSTEMI With Multi Vessel Disease (NSTEMI-CULPRIT)
Acute myocardial infarction owes to a plaque rupture resulting in total (STEMI) or partial occlusion (NSTEMI) of the coronary artery.
- Trial name
- NS-CULPRIT (NCT03479593)
- Testing
- CMR and OCT in NSTEMI patients with MVD
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Coronary Arteriosclerosis
Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (F.A.M.E.)
In this multicenter, international study we are evaluating two approaches to determine which coronary artery narrowings require stent placement in patients with multivessel coronary artery disease.
- Trial name
- NCT00267774
- Testing
- Fractional flow reserve, Angio-guided PCI
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 1,005 people
- Sponsor
- Stanford University
Percutaneous Coronary Intervention, Multivessel Coronary Artery Disease
Residual Inflammatory Risk-Guided colcHicine in Elderly Trial
The goal of this clinical trial is to compare low-dose colchicine (0.5 mg Once Daily) with no specific intervention in selected elderly patients (60-80 years old) with residual inflammatory risk (hs-CRP≥ 2mg/L) and multivessel…
- Conditions
- Percutaneous Coronary Intervention, Multivessel Coronary Artery Disease, Elderly Patients, C-Reactive Protein
- Trial name
- RIGHT (NCT06025071)
- Testing
- colchicine
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
ST-elevation Myocardial Infarction, Multi Vessel Disease
Primary PCI in Patients With ST-elevation Myocardial Infarction and Multivessel Disease: Treatment of Culprit Lesion Only or Complete Revascularization
In patients with ST-elevation myocardial infarction (STEMI) the primary treatment is acute angioplasty of the acute occlusion (culprit lesion).
- Trial name
- PRIMULTI (NCT01960933)
- Testing
- Percutaneous coronary intervention, FFR
- Where
- 2 sites in Denmark
- Volunteers
- 650 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Myocardial Infarction
Functional Assessment in Elderly MI Patients With Multivessel Disease
Elderly patients presenting with myocardial infarction (MI) and multivessel disease are the highest risk population with the worst prognosis. No trial has ever been designed to optimize their outcome.
- Trial name
- FIRE (NCT03772743)
- Testing
- Culprit-only revascularization, Complete functionally-guided revascularization
- Where
- 37 sites in Italy, Poland and 1 more
- Volunteers
- 1,445 people
- Sponsor
- Consorzio Futuro in Ricerca
Multivessel Coronary Artery Disease
Efficacy and Safety of One-Stage Hybrid Coronary Revascularization
Coronary revascularization could be accomplished either by percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG).
- Trial name
- HCR-EAST (NCT04811586)
- Testing
- coronary revascularization
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai East Hospital
Non-ST-elevation Myocardial Infarction, Multivessel Coronary Artery Disease
Complete Revascularization Versus Culprit Lesion Only PCI in NSTEMI
Prospective, randomized, controlled, multicenter, open-label trial to study whether multivessel percutaneous coronary intervention (PCI) is superior over culprit-lesion only PCI in patients with non-ST-segment elevation…
- Trial name
- CompleteNSTEMI (NCT05786131)
- Testing
- Culprit-lesion revascularization, Non-culprit-lesion revascularization
- Where
- 58 sites in Austria, Germany
- Volunteers
- 3,390 people
- Sponsor
- Leipzig Heart Science gGmbH
Multivessel Coronary Artery Disease, Hypertension Resistant to Conventional Therapy
Expand Management of Blood Pressure With Renal Denervation in Patients Undergoing Staged PCI for Advanced Coronary Artery diseasE
EMBRACE is a randomized, controlled, multicenter clinical study evaluating the effect of renal denervation on clinical adverse events in hypertensive patients undergoing staged percutaneous coronary intervention (PCI) for…
- Trial name
- EMBRACE (NCT07602790)
- Testing
- Renal denervation
- Volunteers
- 1,000 people
- Sponsor
- Ceric Sàrl
Coronary Disease, Coronary Stenosis
A Comparison of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention and Coronary Artery Bypass Graft Surgery in Patients With Multivessel Coronary Artery Disease
The purpose of this study is to determine whether Fractional flow reserve (FFR, (coronary pressure wire-based index for assessing the ischemic potential of a coronary lesion)-guided percutaneous coronary intervention (PCI) in…
- Trial name
- FAME 3 (NCT02100722)
- Testing
- FFR guided PCI, CABG, Resolute Integrity Stent
- Where
- 46 sites in United States, Australia and 14 more
- Volunteers
- 1,500 people
- Sponsor
- Stanford University
Multivessel Coronary Artery Disease, STEMI
The Use Of FFR Guided PCI Versus Complete Revascularization and Treatment Of Infarct Related Artery Only In Patients With STEMI
In patients with ST elevation myocardial infarction (STEMI) the treatment goal is revascularization of the occluded artery with the use of primary percutaneous coronary intervention (PCI).
- Conditions
- Multivessel Coronary Artery Disease, STEMI, FFR Guided PCI
- Trial name
- FAIO (NCT02637440)
- Testing
- FFR guided PCI, Angio guided PCI
- Where
- 2 sites in Ireland
- Volunteers
- 560 people
- Sponsor
- University of Limerick
Myocardial Infarction, Coronary Artery Disease
One-Time Complete Revascularization Versus Staged PCI in MVD During Pharmaco-Invasive STEMI Strategy
This study compares two treatment strategies in patients with ST-elevation myocardial infarction (STEMI) and multivessel coronary artery disease (MVD) undergoing a pharmaco-invasive approach after successful fibrinolysis.
- Trial name
- NCT07519590
- Testing
- One-Time Complete Revascularization, Staged Percutaneous Coronary Intervention
- Where
- Egypt
- Volunteers
- 112 people
- Sponsor
- Tanta University
Multivessel Coronary Artery Disease
A Multicentre, Pilot Study to Evaluate the Safety and the Feasibility of Planning and Execution of Surgical Revascularization in Patients With Complex Coronary Artery Disease, Based Solely on MSCT Imaging Utilizing GE Healthcare Revolution CT and HeartFlow FFRCT.
The CABG-REVOLUTION study is an investigator-initiated single-arm, multicentre, prospective study for patients with 3-vessel disease (with or without left-main involvement) referred to CABG treatment.
- Trial name
- CABGRevolution (NCT03851276)
- Testing
- Multi-sliced computed tomography (MSCT)
- Where
- 4 sites in Belgium, Germany and 2 more
- Sponsor
- ECRI bv
Cardiogenic Shock, Acute Myocardial Infarction
Culprit Lesion Only PCI Versus Multivessel PCI in Cardiogenic Shock
The study compares the therapies of instant multivessel balloon angioplasty plus stent implantation or the balloon angioplasty plus stent implantation of the infarct artery alone with any possible graduated later treatment of the…
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction, Complications
- Trial name
- CULPRIT-SHOCK (NCT01927549)
- Testing
- Immediate multivessel PCI, Culprit Lesion only PCI
- Where
- 3 sites in Germany
- Volunteers
- 706 people
- Sponsor
- University of Luebeck
Coronary Artery Disease (CAD)
Hybrid Revascularisation by Combined Coronary Artery Bypass Graft (CABG) and PCI in Multivessel Coronary Disease
The present study is designed as a prospective, single centre, open label, observational trial. The study will collect information about the medical care patients receive during their planned procedure(s).
- Trial name
- HYBRID (NCT01443754)
- Testing
- LIMA-LAD surgical revascularization, PCI
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Ettore Sansavini Health Science Foundation
Multivessel Coronary Artery Disease
The Catholic University BIMA Grafting Study
The present study hypothesizes that the systematic use of bilateral internal mammary artery (BIMA) grafting is feasible in the practice of a University Cardiac Surgery Institution for the treatment of multivessel coronary artery…
- Trial name
- CATHEXIS (NCT01593865)
- Testing
- BIMA Grafting, Left-only mammary artery grafting
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Catholic University, Italy
Myocardial Infarction
Timing of Complete Revascularization for Multivessel Coronary Artery Disease in STEMI
The study will compare clinical outcomes between complete revascularization during hospitalization for ST elevation myocardial infarction (STEMI) and intervention after 30 days and intervention based on outpatient non-invasive…
- Trial name
- MVD (NCT02756000)
- Testing
- PCI, dobutamine stress echocardiography
- Where
- 4 sites in Serbia
- Volunteers
- 120 people
- Sponsor
- Clinical Hospital Center Zemun
Coronary Artery Disease, Multi Vessel Coronary Artery Disease
Practice Change With Drug-coated Balloon in Patients With multiVessel Coronary Artery Disease
This study is a prospective, multicenter, open-label, observational study to investigate the impact of using drug-coated balloons (DCBs) in the treatment of coronary artery lesions in patients with multivessel coronary artery…
- Trial name
- DCB-MVD (NCT06104033)
- Testing
- drug-coated balloon, drug-eluting stent
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Bon-Kwon Koo
Coronary Artery Disease
Multicenter Study to Evaluate the Procedural Safety and Efficacy of ELCA in CAD
This is a Prospective, Open label, Non-randomized, Single-Arm, Multicenter Study to Evaluate the Procedural Safety and Efficacy of ELCA® in Treatment of Patients with Single or Multivessel Coronary Artery Disease (CAD).
- Trial name
- ELCA-CAD (NCT03284229)
- Testing
- Excimer Laser Coronary Atherectomy
- Where
- 5 sites in India
- Volunteers
- 28 people
- Sponsor
- Spectranetics Corporation