Clinical trials: Multivessel Coronary Disease
Coronary Syndrome, Acute, Non-ST Elevation, High Risk Patients
Management Tactics for Patients High Risk With Acute Coronary Syndrome Without ST Segment Elevation and Multivessel Coronary Artery Disease
The study will include patients with acute coronary syndrome without ST segment elevation and multivessel CA lesion, who are subject to surgical treatment according to KG data (Syntax Score 23 - 32 points with significant damage…
- Trial name
- NSTE-ACSMT (NCT06279663)
- Testing
- Revascularization
- Where
- 2 sites in Russia
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Institution National Medical Research Center named after academician E.N. Me
Chronic Kidney Disease, Multivessel Coronary Artery Disease
Randomized Comparison of xiEnce and visioN Coronary Stents in the sAme muLtivessel Patient With Chronic kiDnEy diSease
Percutaneous coronary intervention (PCI) with bare metal stent (BMS) in patients with renal insufficiency has shown unsatisfactory results.
- Trial name
- RENAL-DES (NCT00818792)
- Testing
- Coronary stent
- Where
- 2 sites in Italy
- Volunteers
- 215 people
- Sponsor
- European Hospital
Diabetes Mellitus, Ischemic Heart Disease
Allopurinol in Diabetes Mellitus and Multivessel Coronary Artery Disease
Atherosclerosis is a progressive disease of the arterial wall, arising from the combination of endothelial dysfunction and inflammation. This link is exacerbated in diabetic patients.
- Conditions
- Diabetes Mellitus, Ischemic Heart Disease, Multi Vessel Coronary Artery Disease
- Trial name
- NCT03700645
- Testing
- Allopurinol
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Multi Vessel Coronary Artery Disease, Percutaneous Coronary Intervention
Clinical Impact of DCB-based Versus DES-based Intervention in Patients With MVCAD
This study aimes to compare the clinical outcomes of drug-coated balloon-based percutaneous coronary intervention (DCB-based PCI) and drug-eluting stent-based percutaneous coronary intervention (DES-based PCI) in patients with…
- Trial name
- DCBMultivessel (NCT07539324)
- Testing
- GENOSS® DCB (Paclitaxel-coated PTCA balloon catheter), Contemporary Drug-Eluting Stents (DES)
- Where
- South Korea
- Volunteers
- 892 people
- Sponsor
- Genoss Co., Ltd.
Acute Coronary Syndrome
PCSK9 Inhibitor on ACS Patients With Multivessel Disease and Relatively Low LDL-C Level in Chinese Population
The study is an open-label, multicenter, and randomized study. The objective of this study is to demonstrate the effect of PCSK9 inhibitor on ACS patients with multivessel disease and relatively low LDL-C levels or LDL-C levels…
- Trial name
- NCT05043740
- Testing
- Repatha or Praluent
- Volunteers
- 1,360 people
- Sponsor
- Second Xiangya Hospital of Central South University
Multivessel Coronary Artery Disease
Ten-Year Outcomes of Randomized Comparison of Coronary Artery Bypass Surgery and Everolimus-Eluting Stent Implantation in the Treatment of Patients With Multivessel Coronary Artery Disease
The primary objective of the BEST extended 10Y follow-up study is to compare the safety and effectiveness of coronary stent implantation using everolimus-eluting balloon-expandable stents with bypass grafting for the treatment of…
- Trial name
- BEST Extended (NCT05125367)
- Testing
- coronary stent implantation, bypass grafting
- Where
- 24 sites in China, Malaysia and 2 more
- Volunteers
- 880 people
- Sponsor
- Seung-Jung Park
Coronary Artery Disease, Myocardial Infarction
MAGnesIum Alloy Scaffold for Coronary Artery Disease (MAGIC)
The retrospective study will investigate the clinical performance and long-term safety of scaffold implantation in a real world setting including high volume PCI centers in Italy
- Trial name
- MAGIC (NCT04098042)
- Testing
- Scaffold
- Where
- 2 sites in Italy
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- San Luigi Gonzaga Hospital
Coronary Artery Disease, NSTEMI - Non-ST Segment Elevation MI
FFR Driven Complete Revascularization Versus Usual Care in NSTEMI Patients and Multivessel Disease
To compare FFR guided complete revascularization during the index procedure with usual care in non-STEMI patients with multivessel disease.
- Conditions
- Coronary Artery Disease, NSTEMI - Non-ST Segment Elevation MI, Fractional Flow Reserve, Myocardial, Myocardial Revascularization
- Trial name
- SLIM (NCT03562572)
- Testing
- Ischemia driven revascularization, Usual care group
- Where
- 9 sites in Czechia, Hungary and 1 more
- Volunteers
- 476 people
- Sponsor
- Zuyderland Medisch Centrum
Cardiogenic Shock, Acute Myocardial Infarction
Revascularization Strategy of Multivessel Disease for Patients with Acute Myocardial Infarction Complicated by Cardiogenic Shock Undergoing Veno-arterial Extracorporeal Membrane Oxygenator
This study is a prospective, open-label, two-arm, randomized multicenter trial to identify whether immediate multi-vessel PCI would be better in clinical outcomes compared with culprit lesion-only PCI for AMI and multi-vessel…
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction, Multi Vessel Coronary Artery Disease, Extracorporeal Membrane Oxygenation
- Trial name
- RESCUE-SHOCK (NCT05527717)
- Testing
- Culprit lesion only PCI, Immediate multi-vessel PCI
- Where
- South Korea
- Volunteers
- 560 people
- Sponsor
- Samsung Medical Center
Multivessel Coronary Artery Disease, Acute Coronary Syndrome
Revascularization Strategies in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome (NSTE-ACS) and Severe Coronary Artery Disease
MILESTONE STUDY is dedicated to problems connected with patients with multivessel coronary artery disease and/or with left main narrowing who present symptoms of acute ischemia.
- Trial name
- MILESTONE (NCT01311323)
- Testing
- PCI, CABG
- Where
- 9 sites in Poland
- Volunteers
- 1,000 people
- Sponsor
- American Heart of Poland
Multi Vessel Coronary Artery Disease, Non-ST Elevation Myocardial Infarction
PRospective Evaluation of Complete Revascularization in Patients With multiveSsel Disease Excluding chroNic Total Occlusions
This prospective, multicenter, non-randomized, single arm, objective performance goal (OPG) study is designed to evaluate clinical outcomes after complete revascularization by PCI and imaging guidance (OCT) in patients with…
- Conditions
- Multi Vessel Coronary Artery Disease, Non-ST Elevation Myocardial Infarction, Unstable Angina, Stable Angina
- Trial name
- PRESENT (NCT05230446)
- Testing
- PCI with OCT guidance
- Where
- Netherlands
- Volunteers
- 609 people
- Sponsor
- Erasmus Medical Center
Multivessel Coronary Artery Disease
Revascularization With BVS or CABG in Patients With Advanced CAD
The purpose of the study is to investigate the extent of ischemia and left ventricular function in cardiovascular magnetic resonance (CMR), as well as patency of coronary arteries and grafts in coronary computed tomography…
- Trial name
- RELEASE-BVS (NCT02334826)
- Testing
- PCI -BVS, CABG
- Where
- Poland
- Volunteers
- 11 people
- Sponsor
- Poznan University of Medical Sciences
STEMI With Multivessel Coronary Disease
Safety and Efficacy of Bivalirudin During Short-term Intervention of Non-infarction Related Artery After PPCI of STEMI
This is a randomized, open label, cohort study, in which a total of 100 patients will be enrolled and randomly assigned to receive bivalirudin or heparin in a 1:1 ratio during short-term intervention of non-infarction related…
- Trial name
- NCT04475835
- Testing
- Bivalirudin, Heparin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Coronary Artery Disease, Stable Coronary Artery Disease
Cardiovascular Events Related to Treated Coronary Arteries in Stable Multivessel CAD
This retrospective cohort study evaluates cardiovascular events directly related to treated coronary arteries in patients with stable multivessel coronary artery disease.
- Conditions
- Coronary Artery Disease, Stable Coronary Artery Disease, Multivessel Coronary Artery Disease, Myocardial Ischemia
- Trial name
- NCT07362108
- Testing
- Coronary Artery Bypass Grafting, Percutaneous Coronary Intervention, Optimized Medical Therapy
- Volunteers
- 1,695 people
- Sponsor
- Instituto do Coracao
Conservative Pharmacotherapy, Staged Percutaneous Coronary Intervention
Non-culprit Vessels for ST-Segment Elevation Myocardial Infarction
To compare the different effect of conservative pharmacotherapy and Staged Percutaneous Coronary Intervention (SPCI) on significant non-culprit lesions in patients with ST-segment elevation myocardial infarction (STEMI) at…
- Conditions
- Conservative Pharmacotherapy, Staged Percutaneous Coronary Intervention, Non-culprit Vessels, ST-Segment Elevation Myocardial Infarction
- Trial name
- CPVsSPCI (NCT02154919)
- Testing
- Percutaneous coronary intervention
- Where
- China
- Volunteers
- 306 people
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University
Myocardial Infarction
Functional Coronary Angiography Guided Revascularization in STEMI
The goal of this multicenter randomized clinical trial is to test the superiority in terms of efficacy of the Angiography-derived fractional flow reserve (AIR) over that based on conventional angiography (ANGIO) strategy in the…
- Trial name
- AIR-STEMI (NCT05818475)
- Testing
- Angiography-guided PCI, Angiography-derived FFR PCI indication and planning
- Where
- 22 sites in Italy, Pakistan
- Volunteers
- 1,823 people
- Sponsor
- University Hospital of Ferrara
Multivessel Coronary Artery Disease
Myocardial Hybrid Revascularization Versus Coronary artERy Bypass GraftING for Complex Triple-vessel Disease
This is a pilot randomized study that aim to assess the safety and feasibility of a hybrid myocardial revascularization strategy (coronary artery by-pass graft and percutaneous intervention) in comparison with conventional…
- Trial name
- MERGING (NCT02226900)
- Testing
- Hybrid Revascularization, Conventional Coronary Artery Bypass Surgery
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- InCor Heart Institute
Cardiac Ischemia, Acute Coronary Syndrome
Instantaneous Wave-free Ratio Guidance Strategy Evaluation in the Treatment of Multivessel Acute Coronary Syndrome.
A single-center, prospective, randomized, open-label, blinded end-point clinical trial of instantaneous wave-free ratio (iFR) guidance strategy impact on clinical outcomes in multivessel acute coronary syndrome (ACS) patients.
- Trial name
- iStrategy (NCT05006183)
- Testing
- PCI
- Where
- Latvia
- Volunteers
- 150 people
- Sponsor
- Daugavpils Regional Hospital
Acute Myocardial Infarction
FFR Versus Angiography-Guided Strategy for Management of AMI With Multivessel Disease
The aim of the study is to compare clinical outcomes following fractional flow reserve (FFR)-guided versus angiography only guided strategy in treatment of non-infarction related artery (non-IRA) stenosis in patients with acute…
- Trial name
- FRAME-AMI (NCT02715518)
- Testing
- PCI using 2nd generation drug-eluting stent
- Where
- South Korea
- Volunteers
- 1,292 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease
Bypass Surgery Versus Everolimus-Eluting Stent Implantation for Multivessel Coronary Artery Disease (BEST)
The purpose of this study is to determine whether the safety and efficacy of coronary stent implantation using Everolimus-Eluting Coronary Stent System (Abbott, Boston Scientific) is not inferior to coronary artery bypass…
- Trial name
- BEST (NCT00997828)
- Testing
- everolimus-eluting stent, coronary artery bypass graft surgery
- Where
- 27 sites in China, Malaysia and 2 more
- Volunteers
- 888 people
- Sponsor
- Seung-Jung Park