Clinical trials: Muscle Atrophy
Muscle Disuse Atrophy, Nutrition, Healthy
Effect of a Natural Source Supplementation on Muscle Mass
Periods of muscle disuse are commonly experienced in young and elderly individuals as a result of short-term hospitalization or leg casting after injury.
- Trial name
- NCT05369026
- Testing
- Single leg immobilization
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Burns
Feasibility and Reliability of Ultrasound in Acute Burns.
This trial investigates the feasibility and reliability of different ultrasound protocols to determine quadriceps muscle architecture in acutely admitted burn patients.
- Trial name
- NCT04852133
- Testing
- Burn subjects
- Where
- 2 sites in Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Muscle Function, Handgrip Strength Test
Muscle Assessment in Women Who Have Undergone Roux-en-Y Gastric Bypass Surgery
The purpose of this study is to assess muscle function in women at least two years after being submitted to Roux-en-Y Gastric Bypass Surgery and compare with a control group
- Trial name
- FUBA (NCT02811393)
- Testing
- Assess muscle function
- Where
- Chile
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Chile
Healthy
Evaluation of the Potential of Grape Consumption to Improve Muscle Strength and Cognitive Function
The goal of this clinical trial is to learn if eating grapes can improve muscle strength and thinking in generally healthy women over 65.
- Trial name
- NCT07208916
- Testing
- Grape Powder
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Western New England University
Spinal Muscular Atrophy
Quantitative Analysis of SMN1 and SMN2 Gene Based on DHPLC System
In this project, we will establish the efficient and accurate gene dose determination system by combining the heterodulex analysis and gene dose analysis on DHPLC platform based on various quantitative and multiplex PCR…
- Trial name
- NCT00155168
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Neuralgic Amyotrophy, Neuralgic Amyotrophy, Hereditary
Neuralgic Amyotrophy: Central Reorganization and Rehabilitation After Peripheral Dysfunction
This study evaluates the effect of a specific, multidisciplinary and personalized rehabilitation program compared to usual care, on motor control and functional disability in patients with neuralgic amyotrophy.
- Conditions
- Neuralgic Amyotrophy, Neuralgic Amyotrophy, Hereditary, Parsonage Turner Syndrome, Brachial Neuritis
- Trial name
- NA-CONTROL (NCT03441347)
- Testing
- Specific rehabilitation program, Usual Care
- Where
- Netherlands
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Cognitive Disorders, Muscular Disorders, Atrophic
Dietary Strategy to Tackle Cognitive and Locomotor Abilities in Early Elderly Subjects
Polyphenols, precisely resveratrol, with red wine as the most substantial source, was associated with improvements in cognitive function.
- Trial name
- WinAging (NCT06871384)
- Testing
- Nonalcoholic red wine group (Intervention group), Drinking water group (Control group)
- Where
- 3 sites in Spain
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Muscle Loss, Obesity
Dose-Finding Study Evaluating Effect on Body Composition of Enobosarm in Patients Taking a GLP-1 for Chronic Weight Mgmt
The primary objective of this study is to assess the effect of enobosarm on total lean mass as measured by DEXA in patients maintained on GLP-1 receptor agonists.
- Trial name
- QUALITY (NCT06282458)
- Testing
- Enobosarm, Semaglutide
- Where
- 14 sites in United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Veru Inc.
Body Weight, Body Image
WFPB Lifestyle and Muscle Mass Preservation
Body fat (BF) and muscle mass showed opposing association with mortality. Whole-food, plant-based (WFPB) lifestyle programs has been on the rise lately especially due to impressive health benefits.
- Conditions
- Body Weight, Body Image, Body Weight Changes, Muscle Loss
- Trial name
- WFPBmuscle (NCT04849689)
- Testing
- Whole-food, plant-based lifestyle
- Where
- Slovenia
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Barbara Jakše s.p.
Sarcopenia
Determining the Muscle Anabolic Properties of Phosphatidic Acid.
Ageing is characterized by a loss of muscle mass that is detrimental for physical function and metabolic health and increases the risk of mortality.
- Trial name
- PA-AGE (NCT03446924)
- Testing
- Phosphatidic Acid, Rice flour
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Duchenne Muscular Dystrophy, Becker Muscular Dystrophy
Characterization of Clinical Skeletal and Cardiac Impairment in Carriers of DMD and BMD
Longitudinal prospective observational study. This is a 24-month study with the possibility of extending the data time points. Initially baseline, then 12 and 24 months follow up studies will be completed.
- Trial name
- NCT02972580
- Testing
- Genetic characterization
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Sarcopenia
Habitual Protein Intake and Muscle Protein Synthesis
Protein intake stimulates muscle protein synthesis. From the standpoint of maintaining skeletal muscle mass with aging, it is important to optimize the adaptive response to food intake.
- Trial name
- Pro-Hab (NCT01986842)
- Testing
- Protein diet
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Muscular Atrophy, Immobility Syndrome
Mechanisms of Disuse Atrophy in Human Skeletal Muscle (iMOB)
Loss of muscle can be caused by a variety of stimuli and results in reduced mobility and strength and also impacts whole body health. Whilst it is known that muscles waste the process by which this occurs is not well understood.
- Trial name
- iMOB (NCT04199923)
- Testing
- Single leg immobilisation
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Immune Senescence, Sarcopenia
Effects of PS-IPC Supplementation on Muscle Mass and Functional Outcomes in Older Adults
Sarcopenia, the age-associated loss of skeletal muscle mass and strength, is a frequent precursor to functional impairment, disability, falls, and loss of independence in the elderly.
- Trial name
- PS-IPC (NCT00926250)
- Testing
- Oral PS-IPC supplement
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Sarcopenia, Skeletal Muscle Atrophy
Plant Protein Blend and Milk Protein Supplements in Older Individuals
Background Protein intake is important for skeletal muscle mass maintenance with aging and the ingestion of specifically-timed protein supplements could increase overall protein intake and thereby contribute to skeletal muscle…
- Conditions
- Sarcopenia, Skeletal Muscle Atrophy, Protein Malnutrition
- Trial name
- Blend-D2O (NCT06403137)
- Testing
- Resistance exercise, Standardized diet, Plant protein supplement
- Where
- Netherlands
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Sarcopenia
Mixed Exercise Training and Novel Multi-Nutrient Supplementation in Young Adults
This study aims to elucidate the effects of 12 weeks of novel multi-nutrient supplementation combined with mixed aerobic/resistance exercise training on skeletal muscle function in young adults.
- Trial name
- NCT06231069
- Testing
- Multi-nutrient supplement, Exercise
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Amyotrophic Lateral Sclerosis, Frontotemporal Dementia
Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular Disorders
The investigators laboratory has been studying families with a history of ALS for more than 30 years and is continuing to use new ways to understand how genes may play a role in ALS, motor neuron disease and other neuromuscular…
- Conditions
- Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, PLS, Motor Neuron Disease
- Trial name
- NCT01459302
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Muscular Diseases
The Role of Ischaemia-reperfusion Injury in the Pathogenesis of Muscle Wasting After Thoracic Aortic Surgery
Single-centre observational study over one year investigating the mechanisms of muscle homeostasis in patients with acute skeletal muscle atrophy following major aortic surgery
- Trial name
- RIMMAS (NCT03354767)
- Testing
- Aortic and aortic valve surgery
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Sarcopenia
Investigation of Impacts of Vibration on Muscular Strength and Functional Performance of Upper Limbs of Older Adults
The elderly population is increasing at worldwide. The need of health promotion and maintenance for elderly adults has become a critical issue.
- Trial name
- NCT04767932
- Testing
- vibration machine
- Where
- Taiwan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Muscular Dystrophies
Wearability, Saefty and Usability Assessment for the Upper Limb Exoskeleton BRIDGE/EMPATIA
The study is a feasibility study or pilot study, that is a clinical investigation to acquire the preliminary information on a motorized exoskeleton (BRIDGE / EMPATIA exoskeleton) for the movement of the upper limb in order to…
- Trial name
- NCT03951844
- Testing
- BRIDGE/EMPATIA exoskeleton
- Where
- 2 sites in Italy
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Alessandra Pedrocchi