Clinical trials: Muscle Breakdown
Muscle Atrophy, Insulin Sensitivity
Metabolic and Muscular Adaptations During Inactivity in 3 Days of Bed-rest
Space flight is associated with detrimental changes to the human body, including bone and muscle loss, fluid changes and deconditioning of muscles in the heart and blood vessels.
- Trial name
- NCT03495128
- Testing
- Bed Rest, Reconditioning
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Ketosis, Resistance Exercise
Acute Effects of Ketone Monoester Co-Ingestion With Dietary Protein on Whole-Body Phenylalanine Oxidation, Phenylalanine Retention, and Myofibrillar Protein Breakdown Following Resistance Exercise in Older Males
The goal of this trial is to determine if ketone monoester supplementation in conjunction with protein supplementation in the post exercise period can augment whole-body protein metabolism following resistance exercise in older…
- Conditions
- Ketosis, Resistance Exercise, Dietary Protein, Aging
- Trial name
- KET-OLD-M (NCT07884513)
- Testing
- Ketone Monoester + Dietary Protein (KET+PRO), Dietary Protein (PRO), Resistance Exercise
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- McGill University
Congenital Heart Disease, ICU Acquired Weakness
Muscle Catabolism and Outcomes in Children Following Cardiac Surgery
Background \& Significance. Children with congenital heart disease (CHD) have experienced improved postoperative survival shifting the focus away from minimizing mortality to curtailing morbidities.
- Conditions
- Congenital Heart Disease, ICU Acquired Weakness, Catabolic State
- Trial name
- MOCHI (NCT04998643)
- Testing
- Muscle ultrasound to estimate lean body mass
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Boston Children's Hospital
Sarcopenia, Muscle Atrophy
Concurrent Assessment of Skeletal Muscle Mass and Synthesis/Breakdown in Old Age
This study involves minimally-invasive techniques to measure muscle mass, muscle protein breakdown and synthesis simultaneously in older age.
- Trial name
- NCT04114383
- Testing
- D3-Creatine, Deuterium Oxide, D3-3-methylhistidine
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Type 2 Diabetes Mellitus (T2DM), Sarcopenia
HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide
This randomized, double-blind, placebo-controlled trial will evaluate whether daily calcium beta-hydroxy-beta-methylbutyrate (calcium-HMB) plus vitamin D3 preserves muscle mass, physical function, and resting metabolism in adults…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Sarcopenia, Obesity, Muscle Loss
- Trial name
- PRESERVE-HMB (NCT07760948)
- Testing
- Calcium-HMB Plus Vitamin D3
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Vanderbilt University Medical Center
Sepsis
Project 4A: Inspiratory Muscle Training and Diaphragm Strength
Investigators will assess the effect of exercise on markers of inflammation and protein catabolism. This research study will further our understanding of how treating Chronic Critical illness (CCI) - related respiratory muscle…
- Trial name
- NCT02367170
- Testing
- Bilateral phrenic nerve stimulation and measurement of transdiaphragmatic pressure, Midazolam, Volitional Measurement of Maximal Inspiratory Pressure (MIP)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Florida
Sarcopenia
Dose Response of Whey and Soy Protein Ingestion With and Without Resistance Exercise in Elderly Men
When we age, we lose muscle. It is not exactly clear why this happens, but we do know that this muscle loss can increase health risks and lead to health problems. Lifting weights (i.e.
- Trial name
- NDC (NCT01062711)
- Testing
- Whey or soy protein
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Obstructive Pulmonary
Involvement of Plasmatic Factors in the Peripheral Muscle Dysfunction of COPD Patients - In Vitro Study
Chronic Obstructive Pulmonary Patients is a defined by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or…
- Trial name
- NCT03197909
- Testing
- Determination of pro-inflammatory plasma factors
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Sarcopenia
The Role of Muscle Protein Breakdown in the Regulation of Muscle Quality in Frail Elderly Individuals
The purpose of this study is to investigate mechanisms underlying the reduction in muscle quality (the ratio between muscle strength and muscle size) with aging, and to investigate how these factors are affected by strength…
- Trial name
- NCT03326648
- Testing
- Strength training, Protein supplementation
- Where
- Norway
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Truls Raastad
Myotonic Dystrophy 1
Myotonic Dystrophy Type 1 and Resistance Exercise
The purpose of this study is to investigate the response after one bout of moderate-heavy resistance exercise in patients suffering from Myotonic Dystrophy type 1.
- Trial name
- STYRK DM1 (NCT05036447)
- Testing
- Moderate-Heavy Resistance Exercise
- Where
- Norway
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Muscle Damage, Healthy
Exploring Muscle Breakdown During Exercise Recovery
This study will allow researchers to explore how muscle responds to heavy exercise. The researchers will characterise rates of muscle protein breakdown and synthesis 24hours after heavy exercise with a post exercise protein…
- Trial name
- EMBER (NCT04841772)
- Testing
- Recover Vegan Protein Supplement
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Critical Illness, Muscle Weakness
Can Beta-Hydroxy-beta-Methylbutyrate Supplementation Counteract Muscle Catabolism in Critically Ill Patients?
The rapid decline of muscle mass and function in mechanically ventilated critically ill patients is associated with prolonged length of mechanical ventilation, prolonged intensive care (ICU) and hospital stay, increased ICU and…
- Trial name
- HMB-ICU-CH (NCT03628365)
- Testing
- HMB (beta-hydroxy beta-methylbutyrate)
- Where
- Switzerland
- Volunteers
- 37 people
- Sponsor
- Mette M Berger
Exercise Training
Impact of Muscle Temperature on Muscle Growth and Breakdown: Cooling During Resistance Training
The purpose of this study is to examine the effect of human skeletal muscle temperature during resistance exercise on myogenic and proteolytic signaling.
- Trial name
- NCT05302791
- Testing
- Muscle Cooling, Resistance Exercise
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Knee Osteoarthritis (Knee OA), Falls Prevention
Analysis of the Loss of Muscle Force, Power and Motor Control to Predict the Risk of Falls in Patients With Knee OA
The twofold goal of this study is to understand the link between muscle power, muscle strength, and muscle control degradation with the risk of falling, and to develop a framework for the comprehensive and quantitative assessment…
- Trial name
- PowerAGING (NCT06611618)
- Testing
- Muscle power assessment, Muscle force assessment, Home-based mobility monitoring
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Ortopedico Rizzoli
Healthy
Effect of Nutrition on Muscle Protein Synthesis
The present proposal is designed to examine the effect of carbohydrate and protein co-ingestion on muscle protein synthesis during endurance type exercise activities.
- Trial name
- NCT00604929
- Testing
- carbohydrate and protein
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Muscle Atrophy
Protein Supplementation During Luteal Phase to Stop Protein Degradation
The purpose of this research is to determine if increasing 12% of daily protein intake during the luteal phase mitigates the potential catabolic effects of progesterone on skeletal muscle.
- Trial name
- Protein (NCT07843095)
- Testing
- protein supplement
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Sam Houston State University
Muscular Atrophy
Randomized, Controlled Study to Investigate the Effect of Neuromuscular Electrical Stimulation (NMES) on Muscle Metabolism of Abdominal Surgical Patients
Skeletal muscle atrophy is associated with catabolic conditions such as major surgical interventions and leads to reduced muscle strength, increased clinical complications and prolonged convalescence.
- Trial name
- NCT00635440
- Testing
- neuromuscular electrical stimulation: Cefar-Sport (CefarCompex Scandinavia AB)
- Where
- Austria
- Volunteers
- 26 people
- Sponsor
- Medical University of Vienna
Obesity
Impact of Whey and Soy Protein Ingestion in Conjunction With Energy Restriction in Overweight/Obese Individuals
It is known that dieting (restricted energy intake) without resistance training leads to a reduced metabolic rate, and the loss of both fat and muscle mass.
- Trial name
- NCT01530646
- Testing
- Weight loss, Soy, Whey
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- McMaster University
Burns - Multiple, Critical Illness
Reduction of Muscle Catabolism Through Brain Activation in Burn Patients
Patients with extensive burn injuries frequently develop severe skeletal muscle wasting and weakness as part of critical illness-related myopathy and neuropathy.
- Conditions
- Burns - Multiple, Critical Illness, Muscle Weakness
- Trial name
- REMBRANT (NCT07435402)
- Testing
- Burn-Bundle Extended Rehabilitation Program, Isoflurane Inhalational Sedation, Functional Proprioceptive Stimulation
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- Charles University, Czech Republic
Muscle Atrophy, Disuse Atrophy
Effect of Knee Position on Muscle Loss During Leg Immobilization
This study looks at what happens to leg muscles when the knee is kept straight or bent during five days of wearing a brace. We want to find out if keeping the knee bent (so the thigh muscle is stretched) helps prevent muscle loss…
- Conditions
- Muscle Atrophy, Disuse Atrophy, Immobilization
- Trial name
- NCT07690150
- Testing
- Knee immobilization brace (0°) for 5 days, Knee immobilization brace (60°) for 5 days
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wageningen University