Clinical trials: Muscle Disorders
Muscle Loss
Galactooligosaccharide and Aging
Sarcopenia is a progressive muscle disease, most commonly affecting older individuals, that is categorised by 1) low muscle strength, 2) low muscle quantity or quality, and 3) low physical performance.
- Trial name
- NCT06411964
- Testing
- Prebiotic
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Bath
Muscle Injury, Muscle Soreness
Effects of Wobenzym® Plus in Healthy, Sportive People After Eccentric Exercise
The aim of the current study is to investigate the therapeutic effect and especially the mode of action of Wobenzym® plus, an anti-inflammatory drug containing proteolytic enzymes, on exercise induced muscle damage (eiMD) and…
- Conditions
- Muscle Injury, Muscle Soreness, Exercise Induced Muscle Damage
- Trial name
- 2012-005003-40 (NCT01845558)
- Testing
- Wobenzym® plus
- Where
- Germany
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Mucos Pharma GmbH & Co. KG
Neck Pain
The Natural History of Upper Trapezius Myofascial Trigger Points: Comparison of Local and Remote Tissue Milieu in Normal Muscle, Latent and Active Myofascial Trigger Points Over Time
This study will use microdialysis to investigate myofascial pain. This pain is characterized by "trigger points" (exquisitely tender spots) in a group of tense muscle fibers that extend from the trigger point to the muscle…
- Trial name
- NCT00042276
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Rugby, Craniocerebral Trauma
Effectiveness of a Quick Release Dynamic Muscle-strengthening Program on Dynamic Stabilization of the Cervical Spine
The goal of this clinical trial is to learn if Quick Release dynamic strengthening of the cervical spine extensor muscles' reflex could improve dynamic stabilisation capacities of the cervical spine by reducing muscle activation…
- Conditions
- Rugby, Craniocerebral Trauma, Cervical Spine Injury
- Trial name
- CERVITRAIN (NCT06545006)
- Testing
- isometric contractions, stroboscopic glasses, Quick Release
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Spinal Muscular Atrophy (SMA), Neuromuscular Disease
Ultrasonographic Muscle Assessment and Functional Scales in Spinal Muscular Atrophy
This study aims to investigate the relationship between ultrasonographic muscle thickness measurement and echogenicity assessment with functional scales in children with spinal muscular atrophy (SMA).
- Trial name
- NCT06599606
- Testing
- Ultrasonographic Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Fibromyalgia, Pain
Effect of Temperature on Pain and Brown Adipose Activity in Fibromyalgia
The pathophysiology of pain related to fibromyalgia is not understood. This condition is difficult to diagnose and to treat. One clue may be that tender points (areas which hurt typical of fibromyalgia) are most densely located…
- Trial name
- NCT01322425
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Arthroplasty, Knee Replacement, Musculoskeletal Disorder
Changes in Quadriceps Muscular Activity in Patients After Total Knee Arthroplasty Compared to Healty Subjects
During Total Knee Arthroplasty (TKA), joint undergo considerable stress, which causes neuromuscular activation deficits of the quadriceps femoris muscle.The aim of the study is to investigate differences in quadriceps…
- Trial name
- NCT04152538
- Testing
- not intervention but investigation
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Spinal Muscular Atrophy (SMA)
Advanced Multi-omics and -System Approaches to Identify Novel Biomarkers for SMA
Spinal muscular atrophy (SMA) is an inherited neuromuscular disorder caused by mutations in the SMN1 gene, leading to motor neuron degeneration and progressive muscle atrophy.
- Trial name
- MOSAiC-SMA (NCT07883655)
- Where
- 3 sites in Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istituto Giannina Gaslini
Facioscapulohumeral Muscular Dystrophy, Facioscapulohumeral Muscular Dystrophy 1
Ultrasound Detection of Early Facial Muscle Changes in FSHD: Thickness and Echo Intensity Findings
Facioscapulohumeral muscular dystrophy (FSHD) is characterized by early and significant involvement of facial muscles; however, objective imaging data focusing on facial muscles are limited.
- Conditions
- Facioscapulohumeral Muscular Dystrophy, Facioscapulohumeral Muscular Dystrophy 1, Neuromuscular Disease
- Trial name
- FACIAL-FSHD (NCT07331025)
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Koç University
Sleep Apnea, Obstructive, Healthy
Swallowing in OSA & CPAP Intolerance
This study has two parts: an observational part and an interventional part. The goal of the observational part of the study is to look for variations in swallowing in adults with obstructive sleep apnea (OSA) and in adults who…
- Trial name
- SLP-PAP (NCT06786117)
- Testing
- SLP swallowing exercises, myofunctional exercises
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Denise Dewald
Sarcopenia
Effects of Eccentric Training Intervention in Older Adults
Sarcopenia leads to loss of muscle mass and muscle strength during the aging process. It has been reported that eccentric training has some positive effects on the preservation of eccentric strength, with less delayed onset…
- Trial name
- NCT04099316
- Testing
- Eccentric exercise, Conventional resistance exercise
- Where
- South Korea
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Frailty, Muscle Weakness
The Effects of Functional Power Training on Frail and Pre-frail Community - Dwelling Older Adults in Singapore
To investigate the efficacy of a 12-week Functional Power Training (FPT) program in pre-frail and frail community-dwelling older adults in Singapore for the management of physical frailty.
- Trial name
- NCT04438876
- Testing
- Functional Power Training, Usual care
- Where
- Singapore
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Geriatric Education and Research Institute
Physiological Responses, Pilates Exercise
Effect of Muscle Strengthening Training with Pilates Reformer on Overweight/obese and Normal Body Weight Women (PRET)
This study investigates the physiological responses and the metabolic burden of a Pilates Reformer strength training session in physically inactive premenopausal women with a body mass index of 18-24.9 and 25.01-39.9.
- Conditions
- Physiological Responses, Pilates Exercise, Overweight and Obese Women, Energy Expenditure
- Trial name
- PRET (NCT06675162)
- Testing
- Pilates Reformer Training
- Where
- 2 sites in Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Temporomandibular Disorder (TMD)
OMT vs Exercise in TMD
The goal of this clinical trial is to evaluate whether different rehabilitation approaches can improve pain, function, and postural control in individuals with temporomandibular disorders (TMD).
- Trial name
- NCT07534540
- Testing
- Home-based Exercise Program, Osteopathic Manipulative Treatment (OMT)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Alanya Alaaddin Keykubat University
Uterine Bleeding, Uterine Fibroid
Pain Reduction and Ovarian Perfusion Following Uterine Fibroid Embolization
The goal of this study is to assess of Pressure-Enabled Drug Delivery on fibroid treatment in patients undergoing UFE.
- Trial name
- PEDD-UFE (NCT06106633)
- Testing
- TriNaV
- Where
- 2 sites in United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Myopia, Physical Fitness
Influence of Strength Training on Myopia Care in Kindergarten Children
With the advancement of technology and changes in lifestyle, the physical activity levels of modern children have gradually decreased.
- Conditions
- Myopia, Physical Fitness, Muscle Strength
- Trial name
- NCT07121049
- Testing
- Strength training
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hungkuang University
Temporomandibular Disorder, Children, Only
DC/TMD Axis I for Children
The aim of the present investigation was to perform the content and construct validation of the diagnostic criteria for TMD (DC/TMD) Axis I, for children 7 to 11 years old.
- Conditions
- Temporomandibular Disorder, Children, Only, Pain Disorder, Joint Disorder, Temporomandibular
- Trial name
- NCT04256811
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- CES University
Fibromyalgia
Transcranial Magnetic Stimulation and Hyperbaric Chamber for Women Fibromyalgia
Fibromyalgia syndrome (FMS) is a multisystem disease, characterized by generalized chronic musculoskeletal pain. In addition, there is a lot of care for fatigue, sleep disorders, morning stiffness, cognitive disorders…
- Trial name
- NCT03801109
- Testing
- Hyperbaric group, Magnetic group, Physical group
- Where
- Spain
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Chronic Fatigue Syndrome
Use of a Monitor in ME/CFS
The use of an activity monitor to determine increase or decrease of activity in patients suffering from chronic fatigue syndrome.
- Trial name
- NCT01908036
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- New York CFS Association
Cervical Radiculopathy
Effect of Cervical Multifidus Muscle Area on Interlaminar Epidural Steroid Injection Outcomes
Cervical radiculopathy is one of the most important causes of chronic neck pain. Cervical epidural steroid injections including interlaminar approach are frequently used for treatment option in patients that more conservative…
- Trial name
- NCT05960487
- Testing
- Cervical multifidus muscle area measurement at 3 levels (C4-C5, C5-C6, C6-C7)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Marmara University
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