Clinical trials: Muscle Disuse
Muscular Atrophy
A Study of LY2495655 in Older Participants Undergoing Elective Total Hip Replacement
The primary objective of this study is to test the hypothesis that appendicular lean body mass (aLBM) will increase after 12 weeks of LY2495655 treatment versus placebo in older participants undergoing elective total hip…
- Trial name
- NCT01369511
- Testing
- LY2495655
- Where
- 45 sites in United States, Austria and 9 more
- Volunteers
- 400 people
- Sponsor
- Eli Lilly and Company
Proteomics, Exercise
Dynamic Proteomics and Integrated Rates of Muscle Protein Synthesis During an Acute Period of Loading and Unloading
Skeletal muscle plays several different roles in the promotion and maintenance of health and well-being. The loss of muscle mass that occurs with aging, chronic muscle wasting diseases, and physical inactivity puts people at an…
- Conditions
- Proteomics, Exercise, Atrophy, Disuse, Hypertrophy
- Trial name
- HYPAT (NCT04514744)
- Testing
- Knee bracing, Unilateral Resistance Exercise Training
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscle Atrophy, Aging
The Impact of Energy Intake and Short-term Disuse on Muscle Protein Synthesis Rates and Skeletal Muscle Mass in Middle-aged Adults.
In healthy middle-aged men and women, what is the effect of dietary energy restriction and energy surplus on daily muscle protein synthesis rates and muscle morphology, compared to energy balance, during free-living and…
- Conditions
- Muscle Atrophy, Aging, Energy Malnutrition Protein
- Trial name
- PIE (NCT04900701)
- Testing
- Energy status
- Where
- 2 sites in United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Healthy, Muscle Disuse Atrophy
The Effects of Protein Supplementation With or Without Urolithin A During Single-leg Immobilization
There are times in life when people cannot use their muscles, such as during illness or injury. Muscle and mitochondria (the 'energy factory' in cells) health decline very quickly when people cannot use their muscles, but certain…
- Trial name
- NCT05814705
- Testing
- Protein supplement, Protein supplement with Urolithin A
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Disuse Atrophy
Bed-rest, Muscle Mass and Insulin Sensitivity
In the present study, the effects of 7 days of bed rest on muscle mass, muscle fiber characteristics and insulin sensitivity will be determined.
- Trial name
- NCT02109380
- Testing
- Bed rest
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Muscle Atrophy, Muscle Weakness
FIT Exercise in 30d of ULLS-induced Muscle Disuse
This study aims to determine how flywheel-based inertial training (FIT) implemented according to principles of velocity-based training (VBT) and High-Intensity Interval Training (HIIT) affects disuse-induced physical…
- Trial name
- NCT06631053
- Testing
- velocity-based FIT (VBFIT), No Exercise
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Lance Bollinger
Chronic Kidney Disease (CKD)
Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength
The aging Veteran population has more frequent inpatient hospitalization than non-Veterans. In addition, older Veterans have an inability to fully recover muscle mass and function after hospital-acquired weakness.
- Trial name
- EMPHASIS (NCT06607913)
- Testing
- Exercise
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- VA Office of Research and Development
Muscle Disuse Atrophy
Can Supplemental Leucine Offset Disuse-induced Muscle Atrophy?
Ageing is associated with a gradual decline in muscle mass that is detrimental to both physical function and metabolic health, increasing the risk of morbidity and mortality.
- Trial name
- LEU-DIMA (NCT03762278)
- Testing
- Leucine
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Healthy, Skeletal Muscle Atrophy
Evaluating Changes in Skeletal Muscle Proteins Following Resistance Exercise and Single-Leg Disuse
Skeletal muscle plays a critical role in supporting human health. Beyond its role in providing the force to move, skeletal muscle accounts for a large proportion of metabolic rate, glucose disposal, and amino acid storage.
- Conditions
- Healthy, Skeletal Muscle Atrophy, Skeletal Muscle Hypertrophy
- Trial name
- NCT06350591
- Testing
- Immobilization, Resistance training
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Queen's University
Hip Fractures, Muscle Atrophy
The Role of Blood Flow Restriction Therapy in Postoperative Elderly Patients With Hip Fracture
The investigators aim to study the use of blood flow restriction therapy (BFR) to augment routine post-operative physical therapy in elderly patients (age >= 65) after recovering from surgical treatment of hip fractures.
- Trial name
- NCT04809714
- Testing
- Blood Flow Restriction with Delfi Tourniquet System Cuff, Routine Post-operative Physical Therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Aging, Oxidative Stress
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse
Prolonged periods of reduced activity are associated with decreased vascular function and muscle atrophy. Physical inactivity due to acute hospitalization is also associated with impaired recovery, hospital readmission, and…
- Conditions
- Aging, Oxidative Stress, Vascular Endothelium, Skeletal Muscle
- Trial name
- NCT04351113
- Testing
- MITO-AO, PB-125, Passive Leg Movement (PLM)
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Joel Trinity
Atrophy, Disuse, Muscle Atrophy
Molecular Mechanisms Underlying Anabolic Resistance to Protein Intake During Muscle Disuse
This study will characterize intramuscular molecular mechanisms underlying anabolic resistance to protein ingestion during muscle disuse.
- Conditions
- Atrophy, Disuse, Muscle Atrophy, Muscular Disorders, Atrophic, Disuse Atrophy
- Trial name
- NCT06228742
- Testing
- Unilateral leg immobilization, Contralateral active leg
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Muscle Disuse Atrophy
Muscle Damage and Disuse Atrophy
Limb injury generally requires a period of recovery during which time the limb is often immobilised (e.g. with a cast or brace) resulting in a rapid loss of skeletal muscle.
- Trial name
- NCT03559452
- Testing
- Eccentric exercise
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Muscle Disuse
Immune Cells During Disuse and Recovery
This is an interventional study enrolling healthy individuals aged 18-35 and 60-85 to understand the recovery of muscle health following a period of inactivity. The enrollment goal is 45 participants.
- Trial name
- NCT04416191
- Testing
- Limb immobilization
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Utah
Atrophy of Muscle Due to Disuse, Rehabilitation
Sex-specific Determinants of Early-phase Recovery From Skeletal Muscle Disuse
This project is a 2-phase, randomized clinical trial that includes 7 days of unilateral leg disuse (Phase 1), immediately followed by 1 week of bilateral leg rehabilitation (Phase 2).
- Trial name
- MAC (NCT04151901)
- Testing
- Resistance Exercise Rehabilitation, Walking-based rehabilitation
- Where
- 2 sites in United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Physical Inactivity, Vascular Dysfunction
Heat Therapy During Reduced Physical Activity
The purpose of this randomized controlled trial is to determine whether daily Finnish dry sauna therapy attenuates the adverse cardiovascular, muscular, and metabolic effects of seven days of experimentally reduced physical…
- Conditions
- Physical Inactivity, Vascular Dysfunction, Skeletal Muscle Atrophy
- Trial name
- HEAT-RPA (NCT07847424)
- Testing
- Sauna, Reduced Physical Activity
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brigham Young University
Muscular Atrophy, Immobility Syndrome
Mechanisms of Disuse Atrophy in Human Skeletal Muscle (iMOB)
Loss of muscle can be caused by a variety of stimuli and results in reduced mobility and strength and also impacts whole body health. Whilst it is known that muscles waste the process by which this occurs is not well understood.
- Trial name
- iMOB (NCT04199923)
- Testing
- Single leg immobilisation
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Muscle Wasting
The Effect of Repeated Whole-body NMES Sessions With or Without Protein Intake on Muscle Protein Synthesis During 3 Days of Bed Rest in Healthy Young Volunteers
The goal of this clinical trial is to examine the effect of whole-body electrostimulation with protein intake on muscle protein synthesis, muscle mass and function during bed rest in healthy young adults (18-35 years).
- Trial name
- SPRINT (NCT07062562)
- Testing
- NMES, Protein bolus (20g), Standard nutrition
- Where
- Netherlands
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Disuse Osteoporosis, Atrophy, Disuse
Activity Dependent Rehabilitation Model to Improve Bone and Muscle Outcomes
For many after spinal cord injury (SCI) there is immobilization, muscle atrophy, bone loss, fracture risk during transferring (or falls), and the risk of secondary complications, and increase in attendance care and cost.
- Conditions
- Disuse Osteoporosis, Atrophy, Disuse, Nervous System, Structural; Marker
- Trial name
- NCT02309983
- Testing
- Electrical Stimulation, Stand Retraining with Body Weight Support (BWS)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Kessler Foundation
Disuse Atrophy, Immobilization
Cross-education of Skill and Strength in Healthy People Subjected to an Upper-limb Disuse Model
This randomized controlled trial aims to compare manual dexterity and strength between a group undergoing a contralateral manual dexterity training program and a no-intervention control group in healthy, physically inactive…
- Trial name
- IMMO-CROSS (NCT07615062)
- Testing
- Contralateral Manual Dexterity Training
- Where
- Chile
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universidad Catolica de Temuco