Clinical trials: Muscle Disuse
Muscle Atrophy, Postoperative Complications
Postoperative Electrical Muscle Stimulation (POEMS)
Patients lose a significant amount of muscle following major abdominal surgery. This is partly due to a catabolic response to the surgical insult and inflammation, but is also probably due to a lack of muscle use secondary to…
- Trial name
- POEMS (NCT04199936)
- Testing
- Electrical Muscle stimulation
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Nottingham
Significance of Latissimus Dorsi Flap Innervation in Delayed Breast Reconstruction
The Significance of Latissimus Dorsi Flap Innervation in Delayed Breast Reconstruction
Breast reconstruction with a pedicled myocutaneous latissimus dorsi (LD) flap is a widely used reconstruction method. It is controversial if surgical denervation by transecting the thoracodorsal nerve should be performed or not.
- Trial name
- NCT01239524
- Testing
- denervation of thoracodorsal nerve or saving the nerve
- Volunteers
- 28 people
- Sponsor
- Tampere University Hospital
Muscular Atrophy, Insulin Resistance
Human Skeletal Muscle Response to 5 Days of Bedrest in Young Adults
The goal of this intervention trial is to characterize skeletal muscle atrophy in healthy, young adults during short term bedrest.
- Conditions
- Muscular Atrophy, Insulin Resistance, Muscle Protein Synthesis
- Trial name
- FABRIC (NCT07178353)
- Testing
- Bedrest
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Queen's University
Sarcopenia, Skeletal Muscle Atrophy
Prehabilitative Exercise Prior to Immobilization
This is a 10-week human study involving 24 younger (20-35 y) and 24 older (65-85 y) healthy individuals. All participants will undergo unilateral immobilization of a knee for 7-10 days, followed by 4 weeks of heavy resistance…
- Conditions
- Sarcopenia, Skeletal Muscle Atrophy, Disuse Atrophy
- Trial name
- PREHAB (NCT06205784)
- Testing
- Prehabilitative exercise
- Where
- Denmark
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Muscle Disuse Atrophy, Nutrition, Healthy
Effect of a Natural Source Supplementation on Muscle Mass
Periods of muscle disuse are commonly experienced in young and elderly individuals as a result of short-term hospitalization or leg casting after injury.
- Trial name
- NCT05369026
- Testing
- Single leg immobilization
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Mitochondrial Energetics, Dietary Nitrate
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men
Diminished use of skeletal muscle, such as occurs with many chronic diseases (e.g., heart failure or cancer cachexia), denervation, bedrest, immobilization (e.g., limb casting or bracing), etc., is a common clinical condition…
- Conditions
- Mitochondrial Energetics, Dietary Nitrate, Disuse Atrophy (Muscle) of Lower Leg
- Trial name
- NCT07161973
- Testing
- Beetroot Juice - Active
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Indiana University
Muscle Atrophy
Protein Ingestion and Skeletal Muscle Atrophy
The effect of different protein intakes on skeletal muscle atrophy during short term unilateral leg immobilisation.
- Trial name
- NCT03797781
- Testing
- Lower limb immobilisation (leg brace) with varying levels of protein intake
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Rehabilitation Strategies for Elderly Post-Operative Patients
Muscle Function in Elderly Postoperative Patients
During the last decades there has been an increase in the relative proportion and life expectancy of elderly people in the industrialised countries.
- Trial name
- NCT00559780
- Testing
- Resistance training, Neuromuscular electrical stimulation of the quadriceps muscle, Standard rehabilitation
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- Bispebjerg Hospital
Muscular Atrophy
Timecourse of Immobilization Experiment
The effect of unilateral lower limb immobilisation over one week on muscle atrophy
- Trial name
- TIME (NCT02984332)
- Testing
- Lower limb immobilisation (leg brace)
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Muscle Atrophy, Muscle Weakness
Evaluating Muscle Function After Ankle Surgery
Patients who are forced to rest or reduce activity as a result of illness, injury, or surgery often experience resulting muscle weakness.
- Conditions
- Muscle Atrophy, Muscle Weakness, Fractures
- Trial name
- NCT00060970
- Testing
- Physical Therapy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Healthy
A Study of the Effect of BIIB023 on Muscle Atrophy in Healthy Male Volunteers
The primary objective of this study is to determine whether muscle atrophy induced by immobilization of the lower limb can be attenuated by BIIB023 in healthy male volunteers.
- Trial name
- NCT01943513
- Testing
- BIIB023
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Biogen
Healthy Volunteers
A Clinical Pharmacology Study to Evaluate the Effect of GYM329 on Disuse Muscle Atrophy in Healthy Volunteer
This study will induce disuse atrophy through unilateral immobilization of the thigh and lower leg in healthy male volunteers to evaluate the PD of a single subcutaneous dose of GYM329 prior to or after unilateral thigh and lower…
- Trial name
- NCT04708847
- Testing
- GYM329
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chugai Pharmaceutical
Disuse Atrophy, Immobilization
Electrical Stimulation During Immobilization
In the present study, the effects of 5 days of lower limb immobilization with or without daily neuromuscular electrical stimulation on muscle mass and muscle fiber characteristics will be determined.
- Conditions
- Disuse Atrophy, Immobilization, Neuromuscular Electrical Stimulation
- Trial name
- ESDIM (NCT01513486)
- Testing
- immobilization
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Muscle Loss, Disuse Atrophy
Preventing Bed-rest Induced Muscle Loss in the Elderly
Episodes of inactivity due to hospitalisation, as short as 5 days, are associated with rapid muscle and strength loss in the elderly.
- Conditions
- Muscle Loss, Disuse Atrophy, Protein Metabolism, Prehabilitation
- Trial name
- NCT04422665
- Testing
- Resistance exercise
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Muscle Disuse, Muscle Disuse Atrophy
Muscle Response to Different Amounts of Dietary Protein During Leg Immobilization
Individuals who sustain musculoskeletal injuries (MSKI) can experience a rapid loss of muscle mass due to declines in muscle loading and activation that occur post-injury (i.e., disuse atrophy).
- Trial name
- NCT07069426
- Testing
- 20 grams protein, 40 grams protein
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Osteoarthritis
Chronic Muscle Disuse in the Elderly
The purpose of this study is to define the effects of chronic disuse on skeletal muscle structure and function in elderly individuals at the cellular and molecular level by examining elderly characterized by chronic muscle disuse…
- Trial name
- NCT01190046
- Testing
- Resistance exercise training
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Muscle Atrophy
n3 PUFA and Muscle-disuse Atrophy in Young Women
This study will examine the influence of n3 PUFA supplementation on the rate of muscle atrophy in women undergoing 2 weeks of unilateral limb immobilization.
- Trial name
- NCT03059836
- Testing
- n3 PUFA-enriched fish oil
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscle Atrophy, Muscle Disuse Atrophy
n3 PUFA and Muscle-disuse Atrophy in Older Women
This study will examine the influence of n3 PUFA supplementation on the rate of muscle atrophy in older women undergoing 1 week of unilateral limb immobilization.
- Conditions
- Muscle Atrophy, Muscle Disuse Atrophy, Sarcopenia
- Trial name
- NCT03808519
- Testing
- n3 PUFA-enriched fish oil
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- McMaster University
Disuse Atrophy
The Efficacy of Protein Supplementation on Attenuating Muscle Atrophy Following Disuse in the Collegiate Population
Following orthopedic surgery and/or injury, a significant loss of muscle mass is generally observed. While this loss of muscle mass appears to be the norm, it causes significant problems in both the athletic and general…
- Trial name
- NCT03454347
- Testing
- Profile Perform, Lower Limb Suspension
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- South Dakota State University
Atrophy, Disuse, Atrophy, Muscular
Effects of Resistance Training Preconditioning on Skeletal Muscle Recovery From a Period of Disuse in Young Adults
The goal of this clinical trial is to compare the effects of resistance training (RT) preconditioning vs no training on disuse-induced atrophy and post-disuse resistance training in young healthy individuals.
- Trial name
- NCT05760066
- Testing
- Resistance Training Preconditioning, Control
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Auburn University