Clinical trials: Muscle Dysfunction
Pelvic Floor Disorders, Lower Urinary Tract Symptoms
Respiratory and Pelvic Floor Muscle Functions of Children With Lower Urinary Tract Dysfunction
Lower urinary tract dysfunctions (LUTD) are disorders that can occur in the storage and voiding stages of bladder function other than neurological disease or lower urinary tract obstruction.
- Conditions
- Pelvic Floor Disorders, Lower Urinary Tract Symptoms, Physical Activity
- Trial name
- NCT06728540
- Testing
- Investigation of Physical Activity Levels, Respiratory and Pelvic Floor Muscle Function
- Where
- Turkey (Türkiye)
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Seda Yakit Yesilyurt
Sacroiliac Joint Dysfunction
Gluteus Maximus Versus Gluteus Medius Strength On Back Muscles Performance In Patients With Sacroiliac Dysfunction
This study will be conducted to compare between the effect of glutes maximus and glutes medius muscles strength on back muscle performance in patients with Sacroiliac joint dysfunction.
- Trial name
- NCT05809206
- Testing
- Glutes maximus strength protocol, Gluteus medius strength program, Corrective Exercises
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Aging, Mitochondrial Dysfunction
A Single and Multiple Dose Study of AMAZ-02 to Evaluate Safety and Pharmacokinetics in Elderly Subjects
Part A: The study is a double-blind, randomized, single ascending doses, study in 24 healthy elderly male and female volunteers. Each subject will be randomized for two subsequent doses in three cohorts.
- Conditions
- Aging, Mitochondrial Dysfunction, Muscle Function
- Trial name
- NCT02655393
- Testing
- Mitopure
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Aging, Frailty
Renal Ageing-sarcopenia Network
Frailty is a syndrome in which the accumulation of small, individually insignificant deficits leads to heightened vulnerability to adverse events and predisposes to potential catastrophic decompensation.
- Conditions
- Aging, Frailty, Hypertension, CKD
- Trial name
- NCT04630132
- Where
- Italy
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Temporomandibular Joint Dysfunction Syndrome
Manual Therapy and Exercises Applied to Cervical Spine in Patients With Temporomandibular Disorders
The objective of this study was to investigate the effect of a manual therapy and exercise program, focused on the rehabilitation of cervical function, on clinical signs and mandibular function in subjects with TMD.
- Trial name
- NCT01954511
- Testing
- Manual therapy, Pressure biofeedback device
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universidade Federal de Sao Carlos
Autoimmune Disease
Sudoscan in Patients With Autoimmune Disorders
The purpose of this study is to assess the diagnostic utility of Sudoscan in assessing small fiber nerve function, specifically those of the sudomotor, in patients with autoimmune disorders (i.e fibromyalgia and rheumatoid…
- Trial name
- NCT02434458
- Where
- 2 sites in South Korea
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Erectile Dysfunction
A Bioavailability Study of LY2452473 and Tadalafil
This study compares LY2452473 taken orally as a 5 milligram (mg) capsule at the same time as a 5 mg tadalafil tablet with three different combination tablets (LY900010) of 5 mg LY2452473 and 5 mg tadalafil taken orally.
- Trial name
- NCT01401543
- Testing
- LY2452473, Tadalafil, LY900010
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Massage, Inflammatory Response
Comparison of Different Forms of Recovery on the Functionality After Physical Exercise
Delayed onset muscle soreness (DOMS) and decrease of musculoskeletal function are due to high intensity training and / or sports activities. These occur due to micro lesions of muscle tissue resulting in nociceptor sensitization.
- Conditions
- Massage, Inflammatory Response, Muscle, Skeletal, Cryotherapy Effect
- Trial name
- NCT04201977
- Testing
- Foam Roller Recovery, Active recovery, Immersion in cold water
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Santa Maria
Muscle Weakness, Bone Health
Healthy Older People Everyday (HOPE) - Role of Healthy Diet on Muscle and Bone Health
Certain clinical syndromes eg frailty, sarcopenia, dementia, depression, cognitive impairment, vision impairment and falls in older adults carry an increased risk for poor health outcomes and if identified early, can be…
- Conditions
- Muscle Weakness, Bone Health, Cognitive Decline
- Trial name
- HOPE-DIET (NCT03786835)
- Testing
- Protein supplementation and regular physical activity
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Reactive Airways Dysfunction Syndrome (Disorder), Muscle Weakness
Efficacy of Inspiratory Muscle Training on Elite Swimmers
This study is a randomized controlled trial on the efficacy of inspiratory muscle training on swimming performance, airway dysfunction and perceived breathlessness in elite swimmers.
- Conditions
- Reactive Airways Dysfunction Syndrome (Disorder), Muscle Weakness, Dyspnea
- Trial name
- PEAK (NCT03062735)
- Testing
- Inspiratory Muscle Training
- Where
- Portugal
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Chronic Temporomandibular Disorders (TMD)
Endogenous Pain Inhibition Deficiency in Chronic TMD Pain
Temporomandibular disorders (TMDs) involve a range of conditions with varied causes, affecting a large portion of the U.S. population and posing challenges for diagnosis and management, especially in chronic cases.
- Trial name
- TMD-CPM (NCT06617494)
- Testing
- Pain modulation testing
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Long COVID, Post-COVID-19 Condition
Mitochondrial Function in Peripheral Blood Mononuclear Cells, Muscle, and Skin of Long COVID Patients
Mitochondria are structures inside cells that are responsible for producing energy from nutrients through a series of steps, using oxygen.
- Trial name
- MitoLoCo (NCT07134673)
- Where
- Belgium
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
COPD, Tetrahydrobiopterin Deficiency
O2 Transport and Utilization in Health and Lung Disease
Skeletal muscle dysfunction is a frequent and clinically relevant systemic manifestation of Chronic Pulmonary Obstructive Disease (COPD), which is still poorly understood.
- Conditions
- COPD, Tetrahydrobiopterin Deficiency, Oxidative Stress
- Trial name
- NCT04014712
- Testing
- Tetrahydrobiopterin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
COPD
Muscle Function After Lung Transplantation in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The purpose of the project is to investigate changes in the quadriceps muscle and cardiovascular regulation during exercise in relation to improved lung function after lung transplantation in patients with COPD.
- Trial name
- COPD (NCT03548857)
- Testing
- Lung transplantation
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Fatigue Syndrome, Cognitive Impairments
Efficacy and Safety of Lisdexamfetamine Dimesylate in Adults With Chronic Fatigue Syndrome
Over the past decade, the Rochester Center for Behavioral Medicine (RCBM) has evaluated many patients with attention deficit hyperactivity disorder (ADHD).
- Trial name
- NCT01071044
- Testing
- Lisdexamfetamine Dimesylate
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Rochester Center for Behavioral Medicine
Knee Osteoarthristis
Skeletal Muscle Atrophy and Dysfunction Following Total Knee Arthroplasty
Total knee replacement, or arthroplasty, is the final clinical intervention available to relieve pain and functional limitations related to advanced stage knee osteoarthritis.
- Trial name
- NCT03051984
- Testing
- Neuromuscular electrical stimulation
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Amyotrophic Lateral Sclerosis (ALS), Myasthenia Gravis
Innovative Measures of Speech and Swallowing Dysfunction in Neurological Disorders
This study is evaluating the use of two painless, non-invasive technologies in the assessment of muscle health over time in both healthy volunteers and patients who have diseases that affect the nervous system.
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Myasthenia Gravis, Myopathies, Stroke
- Trial name
- QUESST (NCT02118805)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Inflammation, Immune System
Design and Development of a Functional Plant-based Beverage to Improve Nutritional Status and Immunity for the Early Elderly People to Get Well-healthy Ageing
In 2018, for the first time, the number of people aged 65 and over exceeded the number of children under the age of 5. A rise in ageing societies is coming, and new efforts are needed to ensure that this increase in life…
- Trial name
- Immugold (NCT07409480)
- Testing
- Functional plant-based beverage, Control Beverage
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Sexual Dysfunction, Postmenopausal Symptoms
Examination of the Effects of Pelvic Floor Exercises on Vaginal and Sexual Health in Postmenopausal Women.
The purpose of this study; To investigate the effects of pelvic floor muscle exercises on vaginal and sexual health in postmenopausal women.
- Conditions
- Sexual Dysfunction, Postmenopausal Symptoms, Pelvic Floor Muscle Weakness
- Trial name
- NCT06294197
- Testing
- Pelvic Floor Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hatice Gulsah Kurne
Neurologic Diseases, Hemiparesis
NuroSleeve Powered Brace & Stimulation System to Restore Arm Function
The purpose of this study is to investigate if a person with weakness or paralysis in one or both arms, can use the NuroSleeve combined powered arm brace (orthosis) and muscle stimulation system to help restore movement in one…
- Conditions
- Neurologic Diseases, Hemiparesis, Quadriplegia, Muscular Dystrophies
- Trial name
- NCT04798378
- Testing
- Neurosleeve
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University