Clinical trials: Muscle Dysfunction
Temporomandibular Joint Disorders, Temporomandibular Joint Internal Derangement
Intra-Articular PRP Versus Dexamethasone for TMJ Internal Derangement
This study looked at whether an injection into the jaw joint (temporomandibular joint, or TMJ) can help people who have pain, clicking, and difficulty opening their mouth due to a slipped joint disc.
- Conditions
- Temporomandibular Joint Disorders, Temporomandibular Joint Internal Derangement, Temporomandibular Joint Dysfunction Syndrome
- Trial name
- NCT07691684
- Testing
- Platelet-Rich Plasma (PRP), Dexamethasone with Local Anaesthetic
- Where
- Iraq
- Volunteers
- 30 people
- Sponsor
- University Of Anbar
Diaphragmatic Dysfunction, Muscle Weakness
Recovery of Diaphragmatic Function After Neuromuscular Blockade and Sugammadex
The effect of neuromuscular blocking agents (NMBA, e.g. rocuronium) on respiratory muscle activity is well known. However, since the availability of sugammadex, to our knowledge, no study has been conducted to evaluate the effect…
- Conditions
- Diaphragmatic Dysfunction, Muscle Weakness, Muscle Fatigue
- Trial name
- SUDIA (NCT01962298)
- Testing
- sugammadex 2mg/kg, neostigmine, sugammadex 4mg/kg
- Where
- Belgium
- Volunteers
- 75 people
- Sponsor
- University Hospital, Antwerp
Persistent Physical Symptoms (PPS), Functional Disorder
The Pilot of the Turku Outpatient Clinic for Functional and Fatigue Disorders
This study examined 125 working-age patients from the Turku Outpatient Clinic for Functional and Fatigue Disorders. "Patients participate in the clinic's biopsychosocial, multidisciplinary, and individually tailored…
- Conditions
- Persistent Physical Symptoms (PPS), Functional Disorder, Fatigue Syndrome, Chronic
- Trial name
- TOCliFFD (NCT07272148)
- Testing
- Biopsychosocial, multidisciplinary, and individually tailored rehabilitation for patients with persisten symptoms
- Where
- Finland
- Volunteers
- 125 people
- Sponsor
- Turku University Hospital
Post Prostatectomy Incontinence, Erectile Dysfunction Following Radical Prostatectomy
Pelvic Floor Muscle Training With Aerobic Exercise and Relaxation After Radical Prostatectomy
Post-prostatectomy urinary incontinence (PP-UI) and erectile dysfunction (ED) are common complications after radical prostatectomy, negatively affecting quality of life.
- Trial name
- PFMTinPPUI (NCT07172854)
- Testing
- Pelvic Floor Muscle Training, Aerobic Exercise, Relaxation Training
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Hacettepe University
Statin Intolerance
Effects of Epicatechin on Statins for Mitochondrial Dysfunction and Impaired Exercise Capacity
The purpose of this study is to gain insight into the side-effects of statin consumption, and assess the ability of epicatechin (a compound in dark chocolate) to counteract or reverse these changes.
- Trial name
- NCT02490527
- Testing
- Pure epicatechin capsules (50mg), Simvastatin (40mg)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Diastasis Recti, Post-partum
Postural Stability, Pelvic Floor Dysfunction, Respiratory Muscle Strength in Post-partum Women With Diastasis Recti
The aim of this study is to determine the effect of inter-rectus distance on postural stability, pelvic floor dysfunction and respiratory muscle strength in women with diastasis recti abdominis.
- Conditions
- Diastasis Recti, Post-partum, Postural Stability
- Trial name
- NCT04181554
- Testing
- Measurement of postural stability
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Sexual Dysfunction, Myofascial Pain Syndrome
Sexual Dysfunction in Patients With Myofascial Pain Syndrome
This study evaluates the frequency of sexual dysfunction in women with myofascial pain syndrome and its relationship with clinical parameters.
- Trial name
- NCT05727566
- Testing
- visual pain scale (VASpain/fatigue), Beck depression index (BDI), the sexuality-importance score, sexual intercourse frequency
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Konya Beyhekim Training and Research Hospital
Diastasis Recti
Low Back Pain and Motor Control Dysfunction After Pregnancy- the Possible Role of Abdominal Rectus Muscle Diastasis
The aim of this study was to compare participants with increased symptoms after index pregnancy with those reporting no change in back pain or subjective movement control and analyzed their inter rectus distance (IRD).
- Trial name
- D2 (NCT05485844)
- Where
- Finland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Septic Shock
Muscle Ultrasound Study in Shock Patients
Intensive Care Unit (ICU) patients are known to lose muscle mass and function for many reasons, ranging from prolonged immobilization, to the effects of ICU treatments such as mechanical ventilation (MV), to the critical illness…
- Trial name
- MUSiShock (NCT04550143)
- Testing
- Diaphragm ultrasound (DUS), Peripheral Muscle Ultrasound (PMUS), Airway occlusion pressure (P0.1)
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Type 1 Diabetes
Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1
The proposed study is designed to test the hypothesis that treatment of resveratrol for 12 weeks will improve both endothelin-B receptor (aim 1) and skeletal muscle mitochondrial function (aim 2) in people with type 1 diabetes.
- Trial name
- T-St1M (NCT04449198)
- Testing
- Resveratrol
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Augusta University
Fibromyalgia
Heart Rate Variability in Fibromyalgia - Effects of Strengthening Exercises
Abstract Objective: Autonomic dysfunction is an important mechanism that could explain many symptoms observed in fibromyalgia (FM).
- Trial name
- NCT02004405
- Testing
- strengthening exercise, flexibility exercise
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Federal University of Espirito Santo
Pelvic Organ Prolapse
Effects of Pelvic Floor Muscle Training With & Without Hypopressive Exercises
Pelvic Organ Prolapse (POP) is a prevalent condition affecting women's quality of life due to the descent of pelvic organs caused by weak pelvic floor muscles (PFMs).
- Trial name
- NCT07440875
- Testing
- hypopressive excercises, pelvic training excercises
- Where
- Pakistan
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Postpartum Period, Pelvic Floor Muscle Weakness
Comparative Analysis of Hypopressive Versus Core Stability Exercises in Postpartum Women
The purpose of this study is to compare the effectiveness of Hypopressive exercises versus Core Stability exercises in restoring pelvic floor and abdominal muscle function in postpartum women.
- Conditions
- Postpartum Period, Pelvic Floor Muscle Weakness, Pelvic Floor Dysfunction
- Trial name
- NCT07710911
- Testing
- Hypopressive Exercises
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- University of Lahore
Breast Cancer Survivors, Cognitive Impairment
Motor-cognitive Training Effects on Cognition in Breast Cancer Survivors: the BRAINonFIT Study (BRAINonFIT).
The goal of this interventional study is to assess the effects of either physical exercise program or combined with cognitive training (dual motor and cognitive training program) on breast cancer survivors.
- Conditions
- Breast Cancer Survivors, Cognitive Impairment, Executive Dysfunction
- Trial name
- BRAINonFIT (NCT06073717)
- Testing
- Exercise, Motor-cognitive Training, Health and Wellness
- Where
- 3 sites in Spain
- Volunteers
- 108 people
- Sponsor
- University of Seville
Fibromyalgia Syndrome, Fibromyalgia
Can a Relaxometer Improve Cognitive Impairment of Fibromyalgia Patients
The aim of the study is to evaluate the differences in cognitive performance and quality of life, after a cycle of treatment with the relaxometer, between a group of patients affected by fibromyalgia and a control group.
- Conditions
- Fibromyalgia Syndrome, Fibromyalgia, Pain, Chronic, Impairment
- Trial name
- Fibrorilax (NCT04170387)
- Testing
- Relaxometer
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Upper Crossed Syndrome, Postural Dysfunction
Effect of a Comprehensive Corrective Exercise Program With and Without Instrument-Assisted Soft Tissue Mobilization on Cervical Range of Motion, Muscle Strength, Disability, and Postural Alignment in Individuals With Upper-Crossed Syndrome
This study is a double-blind, parallel-group randomized controlled trial designed to evaluate the effectiveness of a Comprehensive Corrective Exercise Program (CCEP) with and without Instrument-Assisted Soft Tissue Mobilization…
- Trial name
- NCT07702604
- Testing
- Instrument-Assisted Soft Tissue Mobilization (IASTM) + Comprehensive Corrective Exercise Program (CCEP), Comprehensive Corrective Exercise Program (CCEP)
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Fibromyalgia
Mechanism of Fatigue in Fibromyalgia and Cortical Motor Neuron Dysfunction
The goal of this study is to test whether cortical motor neuron dysfunction plays a role in the pathogenesis of fatigue in fibromyalgia patients.
- Trial name
- NCT06778681
- Testing
- Cheer
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Atrial Remodeling, Myocardial Dysfunction
Personalised Prospective Comparison of ARni With ArB in Patients With Natriuretic Peptide eLEvation
Sacubitril-valsartan, an Angiotensin Receptor Blocker-Neprilysin Inhibitor (ARNI), currently marketed for the management of heart failure, has been shown to reduce cardiovascular morbidity and mortality in stage C heart failure…
- Conditions
- Atrial Remodeling, Myocardial Dysfunction, Left Ventricular Remodeling, Left Ventricular Diastolic Dysfunction
- Trial name
- PARABLE (NCT04687111)
- Testing
- Sacubitril-Valsartan, Valsartan
- Where
- 2 sites in Ireland
- Volunteers
- 250 people
- Sponsor
- Mark Ledwidge
Diabetes Type 2, Frail Elderly Syndrome
Involvement of Muscle Mitochondrial Dysfunction in Frailty in Older Adults. Role of Exercise
This study aims to investigate the role of skeletal muscle mitochondrial dysfunction in the development of frailty in older adults and to evaluate whether a short-term, supervised resistance training intervention can improve…
- Conditions
- Diabetes Type 2, Frail Elderly Syndrome, Mitochondrial Function, Bioenergetics, Functionality
- Trial name
- MITOSTRENGTH (NCT07828847)
- Testing
- Short-duration resistance training
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Premature Ejaculation, Lifelong Premature Ejaculation
Pelvic Floor Therapies for Lifelong Premature Ejaculation
This randomized controlled trial will compare three pelvic floor-based treatment modalities in men with lifelong premature ejaculation: electromagnetic pelvic floor stimulation, biofeedback-assisted pelvic floor muscle training…
- Conditions
- Premature Ejaculation, Lifelong Premature Ejaculation, Male Sexual Dysfunction
- Trial name
- PE-PFMT (NCT07627438)
- Testing
- Electromagnetic Pelvic Floor Stimulation, Biofeedback-Assisted Pelvic Floor Muscle Training, Conventional Pelvic Floor Muscle Training
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Tanta University