Clinical trials: Muscle Dysfunction
Diaphragmatic Dysfunction, Muscle Weakness
Recovery of Diaphragmatic Function After Neuromuscular Blockade and Sugammadex
The effect of neuromuscular blocking agents (NMBA, e.g. rocuronium) on respiratory muscle activity is well known. However, since the availability of sugammadex, to our knowledge, no study has been conducted to evaluate the effect…
- Conditions
- Diaphragmatic Dysfunction, Muscle Weakness, Muscle Fatigue
- Trial name
- SUDIA (NCT01962298)
- Testing
- sugammadex 2mg/kg, neostigmine, sugammadex 4mg/kg
- Where
- Belgium
- Volunteers
- 75 people
- Sponsor
- University Hospital, Antwerp
Type 1 Diabetes
Effects of Acipimox on Insulin Action, Vascular Function, and Muscle Function in Type 1 Diabetes
Insulin resistance (IR) is an important contributor to increased cardiovascular disease risk in type 1 diabetes (T1D). Non-esterified fatty acid elevation is a significant contributor to IR in T1D and may be a target of…
- Trial name
- AcT1 (NCT01816165)
- Testing
- Acipimox
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Heart Failure
The Effects of Sacubitril/Valsartan on Cardiac Oxygen Consumption and Efficiency of Cardiac Work in Heart Failure Patients
This is a phase IV, prospective, randomized, double-blind, double-dummy, parallel-group study. The study assessed the effects of 6 weeks of stable sacubitril/valsartan therapy, as compared with valsartan therapy, on the…
- Trial name
- TurkuPET (NCT03300427)
- Testing
- sacubitril/valsatran, valsartan
- Where
- Finland
- Volunteers
- 55 people
- Sponsor
- Novartis Pharmaceuticals
Prediabetes, Obese
Inflammation Inhibition in Prediabetic Humans
Prediabetes, characterized by elevated fasting blood sugar or exaggerated blood sugar response to sugar ingestion, effects over 79 million adult Americans and is a precursor to the development of Type 2 diabetes.
- Trial name
- INCITE (NCT01977417)
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce
Temporomandibular Joint Dysfunction Syndrome
Tailored Self-Management of Temporomandibular Disorders (TMD) Using Health Information Technology
The purpose of this pilot project is to determine the feasibility and acceptability of proposed methods for a subsequent clinical trial of a tailored self-management program (PACT) designed to decrease pain in participants with…
- Trial name
- TMDPACT (NCT03036215)
- Testing
- PACT Experimental Arm
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Temporomandibular Joint Dysfunction Syndrome, Burning Mouth Syndrome
Efficacy of Nalbuphine and Naloxone Administered as Nose Sprays in the Treatment of Orofacial Pain
Patients with chronic masticatory muscle pain (i.e., pain greater than three months) or patients with burning mouth syndrome participate in this study.
- Trial name
- NCT00716807
- Testing
- nalbuphine plus naloxone
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of California, San Francisco
Cardiovascular Disease, Sarcopenia
Trial of Oral Glutamine on Mitochondrial Function in CKD
The primary goal of proposed investigation is to study the impact of oral glutamine supplementation on muscle mitochondrial and endothelial cell function measured mitochondrial energetics and vascular function using 31P magnetic…
- Conditions
- Cardiovascular Disease, Sarcopenia, Endothelial Dysfunction, Muscle Mitochondrial Function
- Trial name
- NCT02838979
- Testing
- First Intervention (14 days), Washout (3 weeks), Second Intervention (14 days)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Washington
Activities of Daily Living, Accidental Fall
Bingocize: A Novel Mobile Application for Older Adult Health
This study tests the effectiveness of using a new mobile application (Bingocize®) to improve older adults' (a) adherence to an engaging exercise program, and (b) aspects of functional performance, health knowledge, dietary…
- Conditions
- Activities of Daily Living, Accidental Fall, Sarcopenia, Arteriosclerosis
- Trial name
- Bingocize (NCT03629912)
- Testing
- Socially-Based Exercise Intervention for Older Adults
- Where
- 4 sites in United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Western Kentucky University
Statin Intolerance
Effects of Epicatechin on Statins for Mitochondrial Dysfunction and Impaired Exercise Capacity
The purpose of this study is to gain insight into the side-effects of statin consumption, and assess the ability of epicatechin (a compound in dark chocolate) to counteract or reverse these changes.
- Trial name
- NCT02490527
- Testing
- Pure epicatechin capsules (50mg), Simvastatin (40mg)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Fibromyalgia
Growth Hormone in Neuroendocrine Dysfunction With Severe Fibromyalgia Syndrome
The purpose of this study is to evaluate the efficacy of recombinant human growth hormone (r-hGH) treatment in severe fibromyalgia subjects with growth axis dysfunction.
- Trial name
- NCT00933686
- Testing
- Saizen®
- Where
- Spain
- Volunteers
- 113 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Heart Failure
The Effect of Nicotinamide Riboside on Skeletal Muscle Function in Heart Failure Subjects
Background: People are living longer and are more likely to survive a heart attack if they have one. Longer life expectancy is good but it also means more people get chronic heart failure over time.
- Trial name
- NCT03565328
- Testing
- Nicotinamide Riboside
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Temporomandibular Joint Dysfunction Syndrome, Chronic Pain
Restoring Masticatory Function to Treat Chronic Pain
The primary endpoint will be the average change in pain score from baseline to the three- and six-month assessments. Efficacy will be demonstrated by superior pain relief with the active treatment compared with the placebo.
- Trial name
- MAP (NCT02144233)
- Testing
- Occlusal adjustment
- Where
- 2 sites in Spain
- Volunteers
- 77 people
- Sponsor
- Urbano Santana Penin, MD, DDS, PhD
Posterior Tibial Tendon Dysfunction
Bracing and Strengthening for Posterior Tibial Tendon Dysfunction
Posterior tibial tendon dysfunction (PTTD) is a problem with the tendon connecting one of the lower leg muscles to the foot bone. PTTD can cause pain, swelling, and a flattened foot and may require surgery if left untreated.
- Trial name
- NCT00756457
- Testing
- Bracing, Strengthening exercises, Stretching exercises
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Ithaca College
Covid19, Muscle Atrophy
Electrical Stimulation for Critically Ill Covid-19 Patients
Unfortunately, hospital-acquired weakness is highly prevalent among COVID-19 hospitalized patients, who often require prolonged bed-rest or paralytics for an extended period of time in order to maintain oxygenation.
- Conditions
- Covid19, Muscle Atrophy, Muscle Weakness
- Trial name
- Phase I (NCT04685213)
- Testing
- Electrical Stimulation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Baylor College of Medicine
Muscle Weakness
Controlled Trial of 3,4-Diaminopyridine (3-4DAP) in Lambert-Eaton Myasthenic Syndrome (LEMS)
The main purpose for this study is to provide access to 3,4 DAP, a drug which has demonstrated to be effective in treating weakness associated with Lambert-Eaton Myasthenic Syndrome.
- Trial name
- 3-4DAP (NCT02090725)
- Testing
- 3-4 Diaminopyridine
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Jeffrey A. Cohen, MD
Temporomandibular Joint Dysfunction, Pain
A Double Blind Study Comparing Hyaluronic Acid, Corticosteroid and Placebo During Arthrocentesis for Temporomandibular Joint (TMJ) Dysfunction
The purpose of this study is to determine whether the administration of hyaluronic acid or corticosteroid during arthrocentesis of the temporomandibular joint provides additional pain relief and improved function.
- Conditions
- Temporomandibular Joint Dysfunction, Pain, Arthrocentesis
- Trial name
- NCT01524913
- Testing
- Hyaluronic acid, Corticosteroid, Lactated Ringers
- Where
- 5 sites in United States
- Volunteers
- 102 people
- Sponsor
- Emory University
Temporomandibular Joint Dysfunction Syndrome
Immediate Effect of Ultrasound Therapy on Bilateral Masseter Myalgia: Randomized Single Blinded Investigational Trial
Introduction. Temporomandibular disorders (TMD) are a group of conditions that are multifactorial in nature, and it primarily presents with symptoms of pain and decreased functional capacity.
- Trial name
- NCT02295644
- Testing
- Ultrasound Sonicator 740
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- State University of New York at Buffalo
COVID-19, Muscle Atrophy
Electrical Stimulation for Critically Ill Post-Covid-19 Patients
Unfortunately, hospital-acquired weakness is highly prevalent among COVID-19 hospitalized patients, who often require prolonged bed-rest or paralytics for an extended period of time in order to maintain oxygenation.
- Conditions
- COVID-19, Muscle Atrophy, Muscle Weakness
- Trial name
- Phase II (NCT05198466)
- Testing
- Electrical Stimulation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Baylor College of Medicine
Fatigue, Musculoskeletal Pain
Complementary Neurosteroid Intervention in Gulf War Illnesses (GWVI)
This study will investigate the use of adjunctive pregnenolone for the following: 1. fatigue that has limited usual activity, 2. musculoskeletal pain involving 2 or more regions of the body and, 3.
- Conditions
- Fatigue, Musculoskeletal Pain, Cognitive Decline
- Trial name
- NCT01956279
- Testing
- Pregnenolone
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- VA Office of Research and Development
Vaginismus
Injection of Botox in the Perineal Muscles in Resistant Cases of Vaginal Spasm
During the first visit, the couple will be acquainted with their condition. This will include the epidemiology of their condition, some sex education tips, as well as the therapeutic modalities available.
- Trial name
- VginsmsBOTOX (NCT01859507)
- Testing
- Botox
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Abdel-Maguid Ramzy