Clinical trials: Muscle Function, Mitochondrial Function
Mitochondrial Function, Bioenergetics, Muscle Function
Bioenergetics and Muscle Function Improvement With AMAZ-02 in Elderly Skeletal Muscle (ENERGIZE Trial)
This is a randomized, double-blind, single-center, placebo-controlled Phase 2 trial enrolling 66 healthy elderly subjects (33 placebo and 33 AMAZ-02 administration) who are ≥65 and ≤ 90 years of age with evidence of low…
- Conditions
- Mitochondrial Function, Bioenergetics, Muscle Function, Aging
- Trial name
- NCT03283462
- Testing
- Mitopure
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Type 2 Diabetes
Exercise Resistance in Type 2 Diabetes
The purpose of this study is to collect data to help researchers identify factors that prevent certain individuals from receiving the beneficial effects of exercise.
- Trial name
- RESIST (NCT01911104)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
COPD (Chronic Obstructive Pulmonary Disease), Hypoxemia
Non Invasive Evaluation of Muscle Hypoxia in COPD Patient (EVANIMUS)
Peripheral muscle oxidative function is altered in COPD(chronic obstrutive pulmonary disease) patients. Multiple factors could contribute to this dysfunction including chronic hypoxia and deconditioning (sedentarity).
- Trial name
- EVANIMUS (NCT03921983)
- Testing
- Oxygen supplementation
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Clermont-Ferrand
Aging, Sarcopenia
Assessing the Impact of Age, and a Short-term High-intensity Interval Training (HIIT) on Skeletal Muscle Mass and Mitochondrial Activity
The goal of this interventional study is to learn about the role of mitochondrial function in healthy aging, and then go on and assess the role of a home-based exercise program on the changes seen.
- Trial name
- Mi-HIIT (NCT05934760)
- Testing
- High intensity interval training (HIIT), Resistance based training (RET)
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Mitochondrial Diseases, Mitochondrial Myopathy
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy
The goal of this observational study is to learn how exercise training affects molecular processes in skeletal muscle in adults with mitochondrial myopathy, compared with healthy adults.
- Trial name
- MM-EX (NCT07450690)
- Testing
- Unilateral high-intensity interval training (HIIT)
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Pain, Neck, Pain, Back
Evaluation of Mitochondrial Function in Myofascial Trigger Points Cohort Pilot Study Using High-resolution Respirometry
This pilot study established a minimally invasive biopsy technique to obtain high-quality MTrP tissue samples to evaluate mitochondrial function via high-resolution respirometry.
- Conditions
- Pain, Neck, Pain, Back, Myofascial Trigger Point Pain, Myofascial Pain
- Trial name
- MitoTrigger (NCT03704311)
- Testing
- Muscle biopsy
- Volunteers
- 20 people
- Sponsor
- Medical University Innsbruck
Moderate-severe Chronic Kidney Disease Not Treated With Dialysis, Diabetic Kidney Disease, HgbA1c Less Than 8.5
Exercise Study Testing Enhanced Energetics of Mitochondria Video Integrated Delivery of Activity Training in CKD
Skeletal muscle dysfunction (sarcopenia) is an under-recognized target organ complication of CKD with substantial adverse clinical consequences of disability, hospitalization, and death.
- Trial name
- ESTEEM-VIDA (NCT02923063)
- Testing
- Combined Aerobic and Resistance Exercise via videoconferencing
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, Davis
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Impaired Mitochondrial Function, Muscle Performance
Assessing the Effects of Increased Mitochondrial Function Exercise Training on Muscle Performance
As people grow older skeletal muscle gradually becomes smaller and weaker, causing reduced mobility and quality of life. To understand and reverse this negative process investigators need to find new ways of improving the ability…
- Trial name
- Rejuvenate2 (NCT03325491)
- Testing
- Acipimox
- Where
- United Kingdom
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Diabetes Mellitus, Type 2, Cardiomyopathy, Dilated
Cross-over Study on Effect of Lipid Lowering by Acipimox on Cardiac and Skeletal Muscle Mitochondrial Function
Accumulation of lipid in skeletal and cardiac muscle has been associated with insulin resistance and diabetic cardiomyopathy. In skeletal muscle, lipotoxic damage has been suggested to lead to dysfunction of mitochondria.
- Trial name
- ACP (NCT00943059)
- Testing
- Acipimox, Cellulosum Mycrocryst
- Where
- Netherlands
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy
Effects of Vitamin C on Skeletal Muscle
As part of the ageing process muscles become weaker. One of the reasons for this is that mitochondria, the 'engines' that provide energy to fuel muscles, age and work less efficiently.
- Trial name
- VICS (NCT06262711)
- Testing
- Vitamin C
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Parkinson Disease, Mitochondrial
Measures of Mitochondria Dysfunction in PD
This study evaluates metabolic and functional parameters in the skeletal muscle of Parkinson's disease patients for comparison to a set of healthy age-matched controls.
- Trial name
- NCT04300608
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Washington
Prader-Willi Syndrome
Mitochondrial Complex I Dysfunction in PWS
Prader-Willi Syndrome (PWS) is characterized by profound infantile hypotonia, growth delay, cognitive impairment, muscle weakness and exercise intolerance.
- Trial name
- NCT03831425
- Testing
- Coenzyme Q10
- Where
- Canada
- Sponsor
- The Hospital for Sick Children
Mitochondrial Diseases
Impact of Statin Therapy on Muscle Mitochondrial Function and Aerobic Capacity
The purpose of this study is to test how different doses of a statin, Lipitor, affect muscle health and function, and cardiovascular fitness.
- Trial name
- NCT03351998
- Testing
- Lipitor 20Mg Tablet, Lipitor 80Mg Tablet
- Where
- 2 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Aging, Mitochondrial Dysfunction
A Single and Multiple Dose Study of AMAZ-02 to Evaluate Safety and Pharmacokinetics in Elderly Subjects
Part A: The study is a double-blind, randomized, single ascending doses, study in 24 healthy elderly male and female volunteers. Each subject will be randomized for two subsequent doses in three cohorts.
- Conditions
- Aging, Mitochondrial Dysfunction, Muscle Function
- Trial name
- NCT02655393
- Testing
- Mitopure
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Mitochondrial Myopathies, Mitochondrial Diseases
Validation of Oxygen Nanosensor in Mitochondrial Myopathy
Past mitochondrial disease treatment studies have been unsuccessful in determining treatment efficacy, and a major factor has been the lack of validated biomarkers in mitochondrial myopathy (MM).
- Trial name
- NCT04086329
- Testing
- Nanosensor
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Malnutrition, Sarcopenia
Maintaining Immune and Mitochondrial Functions in Old Adults With SAfe Nutrition.
Aging is associated with an increased inflammation named "inflammageing" and with an altered immune response. Different mechanisms have been proposed to explain the phenomenon of inflammageing and increased oxidative stress…
- Trial name
- MIMOSA (NCT05324475)
- Testing
- BCAA, Micronutriments
- Where
- Switzerland
- Volunteers
- 240 people
- Sponsor
- Patrizia D'Amelio
Long COVID, Post-COVID-19 Condition
Mitochondrial Function in Peripheral Blood Mononuclear Cells, Muscle, and Skin of Long COVID Patients
Mitochondria are structures inside cells that are responsible for producing energy from nutrients through a series of steps, using oxygen.
- Trial name
- MitoLoCo (NCT07134673)
- Where
- Belgium
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
COPD, Tetrahydrobiopterin Deficiency
O2 Transport and Utilization in Health and Lung Disease
Skeletal muscle dysfunction is a frequent and clinically relevant systemic manifestation of Chronic Pulmonary Obstructive Disease (COPD), which is still poorly understood.
- Conditions
- COPD, Tetrahydrobiopterin Deficiency, Oxidative Stress
- Trial name
- NCT04014712
- Testing
- Tetrahydrobiopterin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
Impaired Mitochondrial Function, Muscle Performance
Increasing Mitochondrial Function on Skeletal Muscle Performance in Older Men
As people grow older skeletal muscle gradually becomes smaller and weaker, causing reduced mobility and quality of life. To understand and reverse this negative process investigators need to find new ways of improving the ability…
- Trial name
- Rejuvenate (NCT02792621)
- Testing
- Acipimox
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust