Clinical trials: Muscle Hypertonia, open to volunteers
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Spinal Cord Injury, Spasticity
Shockwave for Elbow and Wrist Spasticity in People With Spinal Cord Injury
Approximately 305,000 people live with a spinal cord injury (SCI) in the United States. Sixty percent of these individuals have tetraplegia, which can cause significant dysfunction of the arms and hands.
- Conditions
- Spinal Cord Injury, Spasticity, Shockwave Therapy
- Trial name
- NCT07501429
- Testing
- Focused extracorporeal shockwave therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Kessler Foundation
Spastic/Dystonic Quadriplegia, Cerebral Palsy (CP)
Outcomes of Neurosurgical Tone Management
Patients with spastic/dystonic quadriplegia (GMFCS IV/V) are often severely disabled by their tone, and require surgical tone management to improve quality of life, allow for better function, improve comfort, and range of motion.
- Trial name
- NCT07817745
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Children's Hospital
Cerebral Palsy, Muscle
How Are the Muscles Affected in Cerebral Palsy? A Study of Muscle Biopsies Taken During Orthopaedic Surgery.
Cerebral palsy (CP) is a motor disorder caused by an injury to the immature brain. Even though the brain damage does not change, children with CP will have progressively weaker, shorter and stiffer muscles that will lead to…
- Conditions
- Cerebral Palsy, Muscle, Muscle Contracture, Muscle Spasticity
- Trial name
- CPTDBiopsy (NCT05506228)
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Eva Ponten
Multiple Sclerosis
Evaluating the Effects of the EXOPULSE Suit on Mobility, Walking Ability, and Balance in People With Multiple Sclerosis
This clinical research study is investigating whether the EXOPULSE Suit, a wearable device that delivers electrical stimulation, can help improve movement difficulties caused by spasticity in adults with multiple sclerosis (MS).
- Trial name
- EXO-MS (NCT07897760)
- Testing
- Electrostimulation suit
- Where
- 2 sites in United States, Germany
- Volunteers
- 100 people
- Sponsor
- Otto Bock Healthcare Products GmbH
Cerebral Palsy, Spasticity
Lateral Cord Stimulation as a New Treatment for Refractory Spastic Cerebral Palsy
The aim of our work is to investigate whether electrical Lateral Cord Stimulation (LCS) causes an inhibitory and modulatory action by indirect cerebellar activation, so releasing spasticity and the spastic syndrome in selected…
- Trial name
- Andreani1 (NCT02199015)
- Testing
- Lateral spinal cord surgical implant of electrodes
- Where
- 2 sites in Argentina, Germany
- Volunteers
- 40 people
- Sponsor
- Juan Carlos M. Andreani MD
Stroke
Effect of Neural Constraints on Movement in Stroke
This study investigates the effects of Tizanidine on the voluntary movement controls of the arms of participants who have had a stroke and have not had a stroke by measuring medication-induced changes in upper extremity…
- Trial name
- ENCMS (NCT06666673)
- Testing
- Tizanidine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Cerebral Palsy, Muscle Contracture
The Muscle in Cerebral Palsy; Sarcomere Length in Vivo and Microscopic Characterization of Biopsies.
Cerebral palsy (CP) is a motor impairment due to a brain malformation or a brain lesion before the age of two. Spasticity, hypertonus in flexor muscles, dyscoordination and an impaired sensorimotor control are cardinal symptoms.
- Conditions
- Cerebral Palsy, Muscle Contracture, Spasticity, Muscle
- Trial name
- CPMuscleSL (NCT05518565)
- Testing
- No intervention
- Where
- 3 sites in Sweden
- Volunteers
- 150 people
- Sponsor
- Eva Ponten
Subacute Stroke, Ischemic Stroke
Segmental Vibrator With NMES on Lower Limb Function in Subacute Stroke
Stroke is one of the world's leading causes of death and disability. It can cause a variety of motor disorders, such as apraxia, sensory deficits, abnormal muscle tone, inadequate weight transfer, lack of fine motor skills…
- Trial name
- NCT06927206
- Testing
- Experimental Group A: Segmental vibrator only on dorsiflexor, Experimental Group B: Segmental vibrator + Electrical stimulation on dorsiflexors
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Cerebral Palsy (CP)
Fascial Manipulation in Cerebral Palsy Rehabilitation
The purpose of the study is to investigate the potential additional benefits of a relatively new physiotherapy method, fascial manipulation, in the rehabilitation of movement difficulties or other problems caused by CP (cerebral…
- Trial name
- CP fascia (NCT06837025)
- Testing
- Fascial manipulation
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Orton Orthopaedic Hospital
Multiple Sclerosis
Smart Monitoring Assessing Spasticity-related Health
This observational study seeks to investigate the underlying of spasticity in patients with multiple sclerosis (MS) by employing multimodal monitoring techniques.
- Trial name
- SMASH (NCT06937723)
- Testing
- Device: Smartwatch (Withings Scanwatch)
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Myofacial Pain, Pelvic Pain
Measuring Pelvic Floor Muscle Fitness Before and After Treatment
This study is being done to better understand and improve treatment for myofascial pelvic pain, a common cause of long-lasting pelvic pain in women.
- Conditions
- Myofacial Pain, Pelvic Pain, Myofascial Pelvic Pain, Chronic Pelvic Pain
- Trial name
- NCT07605598
- Testing
- Near Infrared Imaging
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Los Angeles
Muscle Spasticity, Gait Disorders, Neurologic
Ultrasonographic Assessment of Muscle Morphology, Function, and Clinical Findings in Spastic Cerebral Palsy
This study focuses on children with spastic cerebral palsy and aims to examine how muscle morphology and tissue characteristics, as assessed by ultrasound, may relate to functional motor abilities.
- Conditions
- Muscle Spasticity, Gait Disorders, Neurologic, Cerebral Palsy, Spastic
- Trial name
- US-sCP (NCT07118228)
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Kocaeli University
Stroke, Equinovarus Foot
Evaluation of Percutaneous Cryoneurotomy Compared to Surgical Open Neurotomy for the Management of Equinovarus Foot Deformity in Patients With Refractory Lower Limb Spasticity After Stroke
CRYOSTROKE study is designed : to compare the efficacy and safety of percutaneous CryoNeurotomie (CN) versus surgical neurotomy (SN) on spasticity, 90 days after intervention, in post-stroke patients presenting with spastic…
- Conditions
- Stroke, Equinovarus Foot, Refractory Lower Limb Spasticity
- Trial name
- CRYOSTROKE (NCT06726434)
- Testing
- Surgical neurotomy (SN), Cryoneurotomy (CN)
- Where
- 7 sites in France
- Volunteers
- 114 people
- Sponsor
- Poitiers University Hospital
Stroke, Post-stroke Spasticity of the Lower Limb
Extracorporeal Shock Wave Therapy in Botulinum Toxin-Treated Patients With Post-Stroke Ankle Plantar Flexor Spasticity
The goal of this clinical trial is to learn if radial Extracorporeal Shock Wave Therapy (rESWT) is effective in reducing ankle plantar flexor spasticity and improving walking functions in stroke patients who have already received…
- Conditions
- Stroke, Post-stroke Spasticity of the Lower Limb, Post-Stroke Spasticity, Spasticity of the Plantar Flexors
- Trial name
- NCT07695038
- Testing
- Radial Extracorporeal Shock Wave Therapy (rESWT), Conventional Physical Therapy and Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Pamukkale University
Cerebral Palsy, Spastic
Muscle-tendon Pathology and Metabolic Dysregulation in CP
The main aim of this project is to gain knowledge about the muscle-tendon pathology of moderately to severely affected young people with cerebral palsy and their risk for cardiometabolic diseases and chronic inflammation.
- Trial name
- NCT06330922
- Testing
- Cardiorespiratory fitness training
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Graz
HSP, Hereditary Spastic Paraplegia
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47)
Safety and Efficacy of AAV9/AP4B1 For Patients with AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47): A Phase 1/2 Single-Center, Open-Label Study of Stereotactic Intra-cisterna Magna Administration.
- Conditions
- HSP, Hereditary Spastic Paraplegia, Hereditary Spastic Paraparesis, Hereditary Spastic Paraplegia Type 50
- Trial name
- NCT06948019
- Testing
- BFB-101 (AAV9-CBh-AP4B1)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- BlackfinBio Ltd
Cerebral Palsy, Spasticity, Muscle
Investıgatıon Of The Effectıveness Of The Mollıı Suıt In Chıldren Wıth Ambulatory Cerebral Palsy
Cerebral Palsy (CP) is the most common developmental disorder in childhood. Individuals' independence in daily living activities and participation in education, games, social and community activities are restricted.
- Trial name
- NCT06109129
- Testing
- EXOPULSE Mollii Suit
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Kastamonu University
Multiple Sclerosis, Spasticity
Classification of Upper and Lower Limb Spasticity Patterns and Their Impact on Quality of Life in Patients With Multiple Sclerosis
Multiple sclerosis (MS) is a chronic neurological disease frequently associated with spasticity, which may lead to functional limitations and reduced quality of life.
- Conditions
- Multiple Sclerosis, Spasticity, Spasticity With Multiple Sclerosis
- Trial name
- NCT07466823
- Testing
- Observational Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Marmara University
Cerebral Palsy
Pully System Exercise Role in Management of Spasticity
The goal of this clinical trial is to investigate the effect of pully system exercise in in management of spasticity in cerebral palsy children Does pully system exercise has role in management of spasticity in cerebral palsy…
- Trial name
- NCT06927869
- Testing
- designed physical therapy , pully system exercise
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Kafrelsheikh University